Page last updated: 2024-10-21

amitrole and Goiter

amitrole has been researched along with Goiter in 8 studies

Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.

Goiter: Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freyberger, A1
Ahr, HJ1
Wynford-Thomas, D1
Stringer, BM1
Harach, HR1
Williams, ED1
MarinĂ², M1
Chiovato, L1
Mitsiades, N1
Latrofa, F1
Andrews, D1
Tseleni-Balafouta, S1
Collins, AB1
Pinchera, A1
McCluskey, RT1
Tsuda, H1
Hananouchi, M1
Tatematsu, M1
Hirose, M1
Hirao, K1
Groch, KM2
Clifton, KH2
Smith, AG1
Dinsdale, D1
Cabral, JR1
Wright, AL1
Cartier, LJ1
Williams, IK1
Holloszy, J1
Premachandra, BN1

Trials

1 trial available for amitrole and Goiter

ArticleYear
Circulating thyroglobulin transcytosed by thyroid cells in complexed with secretory components of its endocytic receptor megalin.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:9

    Topics: Adult; Aged; Amitrole; Animals; Autoantigens; Blotting, Western; Cells, Cultured; Epithelial Cells;

2000

Other Studies

7 other studies available for amitrole and Goiter

ArticleYear
Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea.
    Toxicology, 2006, Jan-16, Volume: 217, Issue:2-3

    Topics: Amitrole; Animals; Antithyroid Agents; Chromatography, High Pressure Liquid; Dose-Response Relations

2006
Investigation of putative control mechanisms for thyroid growth.
    Virchows Archiv. B, Cell pathology including molecular pathology, 1982, Volume: 40, Issue:3

    Topics: Amitrole; Animals; Goiter; Male; Organ Size; Rats; Regeneration; Thyroid Gland; Thyroidectomy; Thyro

1982
Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid.
    Journal of the National Cancer Institute, 1976, Volume: 57, Issue:4

    Topics: Amitrole; Animals; Cystadenoma; Female; Goiter; Hyperplasia; Neoplasms, Experimental; Rats; Thyroid

1976
The effects of goitrogenesis, involution, and goitrogenic rechallenge on the clonogenic cell content of the rat thyroid.
    Acta endocrinologica, 1992, Volume: 126, Issue:6

    Topics: Amitrole; Animals; Cell Division; Chlorates; Clone Cells; DNA; Goiter; Hyperplasia; Male; Rats; Rats

1992
The plateau phase rat goiter contains a sub-population of TSH-responsive follicular cells capable of proliferation following transplantation.
    Acta endocrinologica, 1992, Volume: 126, Issue:1

    Topics: Amitrole; Animals; Cell Division; Chlorates; Goiter; Male; Rats; Rats, Inbred F344; Thyroid Gland; T

1992
Goitre and wasting induced in hamsters by hexachlorobenzene.
    Archives of toxicology, 1987, Volume: 60, Issue:5

    Topics: Adipose Tissue; Amitrole; Animals; Chlorobenzenes; Cricetinae; Dealkylation; Goiter; Hexachlorobenze

1987
Potentiation of thyroxine 5-deiodination by aminotriazole.
    Biochimica et biophysica acta, 1985, Nov-22, Volume: 843, Issue:1-2

    Topics: Amitrole; Animals; Goiter; Iodine; Male; Rats; Rats, Inbred Strains; Thyroxine; Triazoles; Triiodoth

1985