amitrole has been researched along with Experimental Hepatoma in 3 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was performed to investigate whether three amino compounds, 1-methyl-9H-pyrido[3,4-b]indole (harman), 9H-pyrido[3,4-b]indole (norharman) and 2-amino-1,3,4-triazole (amitrole), might be converted in vivo to compounds capable of promoting hepatocarcinogenesis when given with NaNO(2)." | 1.33 | Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat. ( Asamoto, M; Hirose, M; Ichihara, T; Imaida, K; Kawabe, M; Miyashita, K; Ogiso, T; Shirai, T; Tamano, S, 2005) |
| "Amitrole was administered to mice in drinking water at a dose of 1% for 6 months." | 1.27 | Amitrole: strain differences in morphological response of the liver following subchronic administration to mice. ( Hayashi, Y; Makino, S; Mori, S; Ohhara, T; Takeuchi, Y; Tochino, Y; Toyama, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HOSHINO, M | 1 |
| Ichihara, T | 1 |
| Miyashita, K | 1 |
| Kawabe, M | 1 |
| Imaida, K | 1 |
| Asamoto, M | 1 |
| Ogiso, T | 1 |
| Tamano, S | 1 |
| Hirose, M | 1 |
| Shirai, T | 1 |
| Mori, S | 1 |
| Takeuchi, Y | 1 |
| Toyama, M | 1 |
| Makino, S | 1 |
| Ohhara, T | 1 |
| Tochino, Y | 1 |
| Hayashi, Y | 1 |
3 other studies available for amitrole and Experimental Hepatoma
| Article | Year |
|---|---|
Effect of 3-amino-1,2,4-triazole on the experimental production of liver cancer.
Topics: Amitrole; Animals; Bile Ducts, Intrahepatic; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; | 1960 |
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
Topics: Amitrole; Animals; Carbolines; Harmine; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344 | 2005 |
Amitrole: strain differences in morphological response of the liver following subchronic administration to mice.
Topics: Amitrole; Animals; Female; Hyperplasia; Immunity, Cellular; Liver; Liver Neoplasms, Experimental; Mi | 1985 |