amitrole has been researched along with Disease Models, Animal in 11 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glomerular epithelial cell injury is thought to be the primary reason for the development of proteinuria in puromycin aminonucleoside nephrosis (PAN), the rat model of nephrotic syndrome." | 3.69 | Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species. ( Ailenberg, M; Downey, GP; Silverman, M; Waddell, TK; Zent, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ramhøj, L | 1 |
| Svingen, T | 1 |
| Frädrich, C | 1 |
| Rijntjes, E | 1 |
| Wirth, EK | 1 |
| Pedersen, K | 1 |
| Köhrle, J | 1 |
| Axelstad, M | 1 |
| Dietl, AM | 1 |
| Amich, J | 1 |
| Leal, S | 1 |
| Beckmann, N | 1 |
| Binder, U | 1 |
| Beilhack, A | 1 |
| Pearlman, E | 1 |
| Haas, H | 1 |
| Correa, M | 1 |
| Manrique, HM | 1 |
| Font, L | 1 |
| Escrig, MA | 1 |
| Aragon, CM | 1 |
| Zmijewski, JW | 1 |
| Lorne, E | 1 |
| Zhao, X | 1 |
| Tsuruta, Y | 1 |
| Sha, Y | 1 |
| Liu, G | 1 |
| Abraham, E | 1 |
| Shanley, PF | 1 |
| Johnson, GC | 1 |
| Chen, X | 1 |
| Patel, K | 1 |
| Connors, SG | 1 |
| Mendonca, M | 1 |
| Welch, WJ | 1 |
| Wilcox, CS | 1 |
| Zent, R | 1 |
| Ailenberg, M | 1 |
| Waddell, TK | 1 |
| Downey, GP | 1 |
| Silverman, M | 1 |
| Shapkina-Gun'ko, VA | 1 |
| Leus, NF | 2 |
| Drozhzhina, GI | 1 |
| Hoidal, JR | 1 |
| Niewoehner, DE | 1 |
| Rao, NV | 1 |
| Hibbs, MS | 1 |
| Panchenko, LF | 1 |
| Antonenkov, VD | 1 |
| Metelitsyna, IP | 1 |
| Tsymbaliuk, NA | 1 |
| Titarchuk, EF | 1 |
| Shapkina, VA | 1 |
11 other studies available for amitrole and Disease Models, Animal
| Article | Year |
|---|---|
Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Topics: Amitrole; Animals; Animals, Newborn; Antithyroid Agents; Disease Models, Animal; Enzyme Inhibitors; | 2022 |
Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus.
Topics: Amitrole; Animals; Aspergillosis; Aspergillus fumigatus; Copper; Cornea; Disease Models, Animal; Gen | 2016 |
Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde: the role of catalase inhibitors and acetaldehyde-sequestering agents.
Topics: Acetaldehyde; Amitrole; Animals; Anti-Anxiety Agents; Anxiety; Catalase; Central Nervous System Depr | 2008 |
Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.
Topics: Acatalasia; Acute Lung Injury; Amitrole; Animals; Catalase; Disease Models, Animal; Enzyme Inhibitor | 2009 |
Oxygen metabolites and hypoxic renal injury: effect of mitochondrial electron transport blockade.
Topics: Amitrole; Animals; Catalase; Cell Membrane; Chemotherapy, Cancer, Regional Perfusion; Disease Models | 2002 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromak | 2007 |
Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species.
Topics: Amitrole; Animals; Catalase; Collagen; Culture Techniques; Disease Models, Animal; Extracellular Mat | 1995 |
[Characteristics of the development of cataract models against a background of poisoning].
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Cataract; Disease Models, Animal; Free Radicals; | 1989 |
The role of neutrophils in the development of cadmium chloride-induced emphysema in lathyrogen-fed hamsters.
Topics: Aminopropionitrile; Amitrole; Animals; Cadmium; Cadmium Chloride; Cricetinae; Disease Models, Animal | 1985 |
[Role of peroxisomal enzymes and lipid peroxidation in the pathogenesis of alcoholic cardiomyopathy].
Topics: Amitrole; Animals; Cardiomyopathy, Alcoholic; Disease Models, Animal; Ethanol; Heart; Lipid Peroxide | 1987 |
[Enzyme study of the antiradical system in the development of cataract].
Topics: Amitrole; Animals; Catalase; Cataract; Disease Models, Animal; Eye; Free Radicals; Glutathione Perox | 1985 |