amitrole has been researched along with Central Hypothyroidism in 10 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Measurements of 131I uptake by the thyroid gland, thyroid acinar cell height and protein-bound iodine failed to reveal an effect of theophylline in either control or hypothyroid animals although theophylline increased thyroid to body weight ratio in both groups." | 7.66 | Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. ( Dasler, R; Fregly, MJ; Lutherer, LO; Tyler, PE, 1978) |
| " Measurements of 131I uptake by the thyroid gland, thyroid acinar cell height and protein-bound iodine failed to reveal an effect of theophylline in either control or hypothyroid animals although theophylline increased thyroid to body weight ratio in both groups." | 3.66 | Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. ( Dasler, R; Fregly, MJ; Lutherer, LO; Tyler, PE, 1978) |
| "Hypothyroidism was induced by aminotriazole administration for 10 wk." | 1.33 | Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism. ( Cadnapaphornchai, MA; Chen, YC; Falk, S; Li, C; Schrier, RW; Summer, SN; Wang, W; Yang, J, 2005) |
| "Hypo- and hyperthyroidism were induced in adult male rats, and the mRNA content of cocaine- and amphetamine-regulated transcript and agouti-related peptide was determined using in situ hybridization." | 1.31 | Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus. ( Diéguez, C; López, M; Señarís, RM; Seoane, L; Tovar, S, 2002) |
| "Hypo- and hyperthyroidism were induced in adult male rats, and the levels of hypothalamic prepro-OX and OXRs mRNA, and adrenal OXRs mRNA were determined using semiquantitative reverse transcription-polymerase chain reaction and/or in situ hybridization." | 1.31 | Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. ( Diéguez, C; López, M; Señarís, RM; Seoane, L, 2001) |
| "Hypothyroidism is associated with abnormalities in renal water handling, which include a delay in excretion of an acute water load, decreased urinary concentrating ability, and increased urine volume." | 1.28 | Short-term hypothyroidism and vasopressin gene expression in the rat. ( Howard, RL; Kim, JK; Rossi, N; Schrier, RW; Summer, S, 1992) |
| "Hypothyroidism is associated with changes in renal function and a decrease in kidney weight." | 1.27 | Kidney structure in hypothyroidism. ( Davis, RG; Fregly, MJ; Madsen, KM; Tisher, CC, 1983) |
| "Hypothyroidism was induced by feeding aminotriazole (ATZ), 0." | 1.27 | Response of the medullary thick ascending limb to hypothyroidism in the rat. ( Bentley, AG; Davis, RG; Madsen, KM; Tisher, CC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carneiro, I | 1 |
| Castro-Piedras, I | 1 |
| Muñoz, A | 1 |
| Labandeira-García, JL | 1 |
| Devesa, J | 1 |
| Arce, VM | 1 |
| López, M | 2 |
| Seoane, L | 2 |
| Tovar, S | 1 |
| Señarís, RM | 2 |
| Diéguez, C | 2 |
| Lisi, S | 1 |
| Pinchera, A | 1 |
| McCluskey, RT | 1 |
| Willnow, TE | 1 |
| Refetoff, S | 1 |
| Marcocci, C | 1 |
| Vitti, P | 1 |
| Menconi, F | 1 |
| Grasso, L | 1 |
| Luchetti, F | 1 |
| Collins, AB | 1 |
| Marino, M | 1 |
| Chen, YC | 1 |
| Cadnapaphornchai, MA | 1 |
| Yang, J | 1 |
| Summer, SN | 1 |
| Falk, S | 1 |
| Li, C | 1 |
| Wang, W | 1 |
| Schrier, RW | 2 |
| Davis, RG | 2 |
| Madsen, KM | 2 |
| Fregly, MJ | 2 |
| Tisher, CC | 3 |
| Lutherer, LO | 1 |
| Tyler, PE | 1 |
| Dasler, R | 1 |
| Howard, RL | 1 |
| Summer, S | 1 |
| Rossi, N | 1 |
| Kim, JK | 1 |
| Garg, LC | 1 |
| Bentley, AG | 1 |
10 other studies available for amitrole and Central Hypothyroidism
| Article | Year |
|---|---|
Hypothyroidism is associated with increased myostatin expression in rats.
Topics: Amitrole; Animals; Blotting, Western; Cell Line; Gene Expression Regulation; Hyperthyroidism; Hypoth | 2008 |
Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus.
Topics: Agouti-Related Protein; Amitrole; Animals; Appetite Regulation; Body Weight; Down-Regulation; Enzyme | 2002 |
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release.
Topics: Adult; Amitrole; Animals; Dose-Response Relationship, Drug; Endocytosis; Enzyme-Linked Immunosorbent | 2003 |
Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism.
Topics: Amitrole; Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 1; Aquaporin 2; Aquaporin 4; | 2005 |
Kidney structure in hypothyroidism.
Topics: Amitrole; Animals; Body Weight; Female; Glomerular Filtration Rate; Hypothyroidism; Kidney; Nephrons | 1983 |
Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status.
Topics: Adrenal Glands; Amitrole; Animals; Enzyme Inhibitors; Hyperthyroidism; Hypothalamus; Hypothyroidism; | 2001 |
Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats.
Topics: Amitrole; Animals; Blood Pressure; Body Weight; Diet; Drug Evaluation, Preclinical; Growth; Heart Ra | 1978 |
Short-term hypothyroidism and vasopressin gene expression in the rat.
Topics: Amitrole; Animals; Arginine Vasopressin; Euthanasia; Gene Expression; Hypothalamus; Hypothyroidism; | 1992 |
Effects of thyroid hormone on Na-K-adenosine triphosphatase activity along the rat nephron.
Topics: Amitrole; Animals; Ca(2+) Mg(2+)-ATPase; Female; Glomerular Filtration Rate; Hypothyroidism; Kidney | 1985 |
Response of the medullary thick ascending limb to hypothyroidism in the rat.
Topics: Amitrole; Animals; Cell Membrane; Female; Hypothyroidism; Kidney Medulla; Microscopy, Electron; Rats | 1985 |