amitrole has been researched along with Acute Liver Injury, Drug-Induced in 7 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carbon tetrachloride (CCl(4)) has been used extensively to study xenobiotic-induced oxidative liver injury." | 1.38 | Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. ( Deng, X; Jia, M; Jiang, R; Jing, Y; Li, L; Wan, J; Wu, K; Zhang, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, Y | 2 |
| Wu, K | 2 |
| Liu, J | 1 |
| Ai, Q | 1 |
| Ge, P | 1 |
| Dai, J | 1 |
| Jiang, R | 2 |
| Zhou, D | 1 |
| Che, Q | 1 |
| Wan, J | 2 |
| Zhang, L | 2 |
| Deng, X | 1 |
| Li, L | 1 |
| Jia, M | 1 |
| Chen, C | 1 |
| Hennig, GE | 1 |
| Whiteley, HE | 1 |
| Manautou, JE | 1 |
| Magos, L | 1 |
| Butler, WH | 1 |
| Snowden, R | 1 |
| Ishii, H | 1 |
| Suga, T | 1 |
| Ninobe, S | 1 |
| Inatsu, Y | 1 |
| Traiger, GJ | 1 |
| Plaa, GL | 1 |
| Stenger, RJ | 1 |
| Johnson, EA | 1 |
7 other studies available for amitrole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation.
Topics: Amitrole; Animals; Body Weight; Catalase; Chemical and Drug Induced Liver Injury; Cytochrome P-450 C | 2015 |
Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice.
Topics: Alanine Transaminase; Amitrole; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Catalase | 2012 |
Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
Topics: Acetaminophen; Administration, Oral; Amitrole; Analgesics, Non-Narcotic; Animals; Bile; Catalase; Ch | 2002 |
The hepatotoxicity of 3-amino-1,2,4-triazole and carbon disulphide in phenobarbitone-treated starved rats.
Topics: Alanine Transaminase; Amitrole; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; L | 1978 |
Effect of 3-amino-1,2,4-triazole on carbon tetrachloride-induced necrosis.
Topics: Alanine Transaminase; Amitrole; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning | 1977 |
Effect of aminotriazole on isopropanol- and acetone-induced potentiation of CCl 4 hepatotoxicity.
Topics: 1-Propanol; Acetone; Alanine Transaminase; Amitrole; Aniline Compounds; Animals; Carbon Tetrachlorid | 1973 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrom | 1972 |