amitrole has been researched along with Abnormalities, Autosome in 6 studies
Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The induction of chromosomal aberrations by PQ was enhanced by a 1-h pretreatment with diethyldithiocarbamate, an inhibitor of superoxide dismutase." | 1.27 | Induction of chromosomal aberrations in active oxygen-generating systems. I. Effects of paraquat in Chinese hamster cells in culture. ( Ishidate, M; Sofuni, T, 1988) |
| "Amitrole was highly toxic at early larval stages of Drosophila (LD50 is 40 ppm in medium)." | 1.26 | Mutangenicity and toxicity of amitrole. I. Drosophila tests. ( Bamford, D; Gripenberg, U; Laamanen, I; Meretoja, T; Sorsa, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lynch, AM | 1 |
| Robinson, SA | 1 |
| Wilcox, P | 1 |
| Smith, MD | 1 |
| Kleinman, M | 1 |
| Jiang, K | 1 |
| Rees, RW | 1 |
| Scott, D | 1 |
| Gellard, PA | 1 |
| Hendry, JH | 1 |
| Tayama, S | 1 |
| Nakagawa, Y | 1 |
| Laamanen, I | 2 |
| Sorsa, M | 2 |
| Bamford, D | 2 |
| Gripenberg, U | 2 |
| Meretoja, T | 2 |
| Sofuni, T | 1 |
| Ishidate, M | 1 |
6 other studies available for amitrole and Abnormalities, Autosome
| Article | Year |
|---|---|
Cycloheximide and disulfoton are positive in the photoclastogencity assay but do not absorb UV irradiation: another example of pseudophotoclastogenicity?
Topics: Amitrole; Animals; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Cycloheximide; Disulfo | 2008 |
Differential rates of loss of chromosomes aberrations in rat thyroids after X rays or neutrons.
Topics: Amitrole; Anaphase; Animals; Antithyroid Agents; Chromosome Aberrations; Fast Neutrons; Male; Neutro | 1984 |
Cytogenetic effects of propyl gallate in CHO-K1 cells.
Topics: Amitrole; Animals; Catalase; Cell Cycle; CHO Cells; Chromatography, High Pressure Liquid; Chromosome | 2001 |
Mutangenicity and toxicity of amitrole. I. Drosophila tests.
Topics: Amitrole; Animals; Chromosome Aberrations; Drosophila melanogaster; Female; Genes, Lethal; Genes, Re | 1976 |
Mutagenicity and toxicity of amitrole. II. Human lymphocyte culture tests.
Topics: Amitrole; Chromosome Aberrations; Dose-Response Relationship, Drug; Female; Humans; Lymphocyte Activ | 1976 |
Induction of chromosomal aberrations in active oxygen-generating systems. I. Effects of paraquat in Chinese hamster cells in culture.
Topics: Amitrole; Animals; Catalase; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Ditiocarb; H | 1988 |