amitriptyline has been researched along with Ventricular Fibrillation in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our data suggest that amitriptyline-induced inhibition of I(Na) unmasks the Brugada ECG phenotype and facilitates development of an arrhythmogenic substrate only in the setting of a genetic predisposition by creating repolarization heterogeneities that give rise to phase 2 reentry and VT." | 3.78 | Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. ( Antzelevitch, C; Barajas-Martínez, H; Di Diego, JM; Hu, D; Minoura, Y; Sicouri, S; Zygmunt, AC, 2012) |
| "A patient with severe tricyclic antidepressant poisoning who showed recurrent ventricular fibrillation and wide QRS complexes on the ECG, failed to respond to intravenous physostigmine and lidocaine." | 3.66 | Hyperventilation in tricyclic antidepressant poisoning. ( Kingston, ME, 1979) |
| "Amitriptyline has the potential to cause unusual serious complications, such as abdominal compartment syndrome, irreversible central nervous system disability and lethal arrhythmia." | 1.46 | Unusual complications from amitriptyline intoxication. ( Maruguchi, H; Nakao, A; Nakayama, S; Nishimura, T, 2017) |
| "On examination she was comatose, had ventricular tachycardia and multifocal clonic seizures." | 1.33 | Hemoperfusion in a child with amitriptyline intoxication. ( Canbek, R; Cetinkaya, M; Dönmez, O, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Nishimura, T | 1 |
| Maruguchi, H | 1 |
| Nakao, A | 1 |
| Nakayama, S | 1 |
| Minoura, Y | 1 |
| Di Diego, JM | 1 |
| Barajas-Martínez, H | 1 |
| Zygmunt, AC | 1 |
| Hu, D | 1 |
| Sicouri, S | 1 |
| Antzelevitch, C | 1 |
| Srinivasa, V | 1 |
| Gerner, P | 1 |
| Haderer, A | 1 |
| Abdi, S | 1 |
| Jarolim, P | 1 |
| Wang, GK | 1 |
| FEKETE, M | 1 |
| BORSY, J | 1 |
| Dönmez, O | 1 |
| Cetinkaya, M | 1 |
| Canbek, R | 1 |
| Knudsen, K | 1 |
| Abrahamsson, J | 1 |
| Kingston, ME | 1 |
| Xin, HB | 1 |
| Liu, SF | 1 |
9 other studies available for amitriptyline and Ventricular Fibrillation
| Article | Year |
|---|---|
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Unusual complications from amitriptyline intoxication.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain Damage, Chronic; Coma; Humans; Intestinal Obs | 2017 |
Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants.
Topics: Action Potentials; Adrenergic beta-Agonists; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidep | 2012 |
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Bupiva | 2003 |
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
Hemoperfusion in a child with amitriptyline intoxication.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Electric Countershock; Female; Hemoperfusion; | 2005 |
Magnesium sulphate in the treatment of ventricular fibrillation in amitriptyline poisoning.
Topics: Adult; Amitriptyline; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Combined Modality Th | 1997 |
Hyperventilation in tricyclic antidepressant poisoning.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Lidocaine; Physostigmine; Re | 1979 |
[Effects of amitriptyline on the ventricular fibrillation threshold, effective refractory period, diastolic threshold and sinus node function in dogs].
Topics: Amitriptyline; Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Female; Male; Neural Cond | 1986 |