amitriptyline has been researched along with Trigeminal Neuralgia in 17 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was moderate evidence for amitriptyline in patients with atypical facial pain." | 5.12 | Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. ( Ananth, A; Do, TM; Kattar, N; McCoul, ED; Unis, GD, 2021) |
| "There is low-quality evidence that the effect of tizanidine is not significantly different than that of carbamazepine in treating trigeminal neuralgia." | 4.89 | Non-antiepileptic drugs for trigeminal neuralgia. ( Chen, N; He, L; Yang, M; Zakrzewska, JM; Zhang, J; Zhou, M, 2013) |
| "This report presents two cases diagnosed with atypical odontalgia (AO) and successfully treated with amitriptyline as well as providing a review of the current literature on the subject." | 4.84 | Diagnosis and treatment of atypical odontalgia: a review of the literature and two case reports. ( Melis, M; Secci, S, 2007) |
| "The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine." | 3.78 | Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. ( Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M, 2012) |
| "Clomipramine was better tolerated." | 2.65 | Clomipramine and amitriptyline in the treatment of severe pain. ( Carasso, RL; Streifler, M; Yehuda, S, 1979) |
| "Tizanidine was investigated in two trials." | 2.43 | Non-antiepileptic drugs for trigeminal neuralgia. ( He, L; Wu, B; Zhou, M, 2006) |
| "The numbness was predominantly located in the innervated mental area and extended in some cases to the first and second trigeminal divisions." | 1.35 | Idiopathic trigeminal neuropathies: a presentation of 15 cases. ( Bagán, JV; García, B; Mora, E; Peñarrocha, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Do, TM | 1 |
| Unis, GD | 1 |
| Kattar, N | 1 |
| Ananth, A | 1 |
| McCoul, ED | 1 |
| Collet, C | 1 |
| Haen, P | 1 |
| Laversanne, S | 1 |
| Brignol, L | 1 |
| Thiéry, G | 1 |
| Zhang, J | 1 |
| Yang, M | 2 |
| Zhou, M | 3 |
| He, L | 3 |
| Chen, N | 2 |
| Zakrzewska, JM | 2 |
| Haviv, Y | 1 |
| Zadik, Y | 1 |
| Sharav, Y | 1 |
| Benoliel, R | 1 |
| Peñarrocha, M | 2 |
| Mora, E | 1 |
| Bagán, JV | 1 |
| García, B | 1 |
| Lux, EA | 1 |
| Ariyawardana, A | 1 |
| Pallegama, R | 1 |
| Sitheeque, M | 1 |
| Ranasinghe, A | 1 |
| Wu, B | 1 |
| Felicio, AC | 1 |
| Godeiro, Cde O | 1 |
| Borges, V | 1 |
| Silva, SM | 1 |
| Ferraz, HB | 1 |
| Melis, M | 1 |
| Secci, S | 1 |
| Dalessio, DJ | 1 |
| Schaefer, MC | 1 |
| Reimann, I | 1 |
| Brune, GG | 1 |
| Wallace, JR | 1 |
| Carasso, RL | 1 |
| Yehuda, S | 1 |
| Streifler, M | 1 |
| Gayford, JJ | 1 |
| Redpath, TH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for amitriptyline and Trigeminal Neuralgia
| Article | Year |
|---|---|
Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis.
Topics: Adult; Amitriptyline; Botulinum Toxins, Type A; Carbamazepine; Facial Nerve; Facial Pain; Female; Hu | 2021 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Anticonvulsants; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans | 2013 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propo | 2011 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Ran | 2006 |
Diagnosis and treatment of atypical odontalgia: a review of the literature and two case reports.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dental Pulp Diseases; Diagnosis, Differentia | 2007 |
The side-effects of carbamazepine.
Topics: Amitriptyline; Anemia, Aplastic; Carbamazepine; Dibenzazepines; Gastrointestinal Diseases; Humans; I | 1969 |
1 trial available for amitriptyline and Trigeminal Neuralgia
| Article | Year |
|---|---|
Clomipramine and amitriptyline in the treatment of severe pain.
Topics: Adult; Aged; Amitriptyline; Clomipramine; Female; Headache; Humans; Male; Middle Aged; Neuralgia; Pa | 1979 |
10 other studies available for amitriptyline and Trigeminal Neuralgia
| Article | Year |
|---|---|
Trigeminal neuralgia: a new therapy?
Topics: Adipose Tissue; Amitriptyline; Cosmetic Techniques; Demyelinating Diseases; Face; Female; Humans; Li | 2013 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto | 2014 |
Idiopathic trigeminal neuropathies: a presentation of 15 cases.
Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Cohort Studies; Facial Pain; Female; Humans; H | 2009 |
Case report: successful treatment of a patient with trigeminal neuropathy using ziconotide.
Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Azabicyclo Compounds; Calcium Channel B | 2010 |
Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Carbamazepine; Cyclohexanecarboxy | 2012 |
Bilateral hemifacial spasm and trigeminal neuralgia: a unique form of painful tic convulsif.
Topics: Aged; Amines; Amitriptyline; Analgesics; Arachnoid Cysts; Botulinum Toxins, Type A; Cyclohexanecarbo | 2007 |
Chronic pain syndromes and disordered cortical inhibition: effects of tricyclic compounds.
Topics: Amitriptyline; Animals; Anticonvulsants; Cerebral Cortex; Humans; Imipramine; Mice; Pain; Paresthesi | 1967 |
A regimen of tricyclic compounds and carbamazepine for treating trigeminal neuralgia pain.
Topics: Amitriptyline; Carbamazepine; Chlordiazepoxide; Drug Combinations; Humans; Pain; Trigeminal Neuralgi | 1981 |
[Short-term and long-term effects of psychotropic drugs in the treatment of trigeminal neuralgia (author's transl)].
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Benperidol; Carbamazepi | 1979 |
Trigeminal neuropathy.
Topics: Adult; Amitriptyline; Drug Combinations; Female; Humans; Male; Mandible; Middle Aged; Perphenazine; | 1977 |