Page last updated: 2024-10-22

amitriptyline and Tremor

amitriptyline has been researched along with Tremor in 16 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"Fluoxetine, a specific serotonin reuptake inhibitor, was compared to amitriptyline in the treatment of 51 outpatients with primary major depressive disorder."9.05A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder. ( Chouinard, G, 1985)
"Postural tremor is a regularly encountered side effect of amitriptyline which can be strong enough to cause discontinuation of therapy."7.71Amitriptyline enhances the central component of physiological tremor. ( Deuschl, G; Krack, P; Lemke, MR; Lindemann, M; Raethjen, J; Wenzelburger, R, 2001)
" Tremor activity was assessed weekly, quantitatively by accelerometry and qualitatively with the Dosage Record and Treatment Emergent Symptom Scale."6.70Changes in quantitatively assessed tremor during treatment of major depression with lithium augmented by paroxetine or amitriptyline. ( Bauer, M; Jobert, M; Müller-Oerlinghausen, B; Zaninelli, R, 2001)
"Fluoxetine, a specific serotonin reuptake inhibitor, was compared to amitriptyline in the treatment of 51 outpatients with primary major depressive disorder."5.05A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder. ( Chouinard, G, 1985)
"Postural tremor is a regularly encountered side effect of amitriptyline which can be strong enough to cause discontinuation of therapy."3.71Amitriptyline enhances the central component of physiological tremor. ( Deuschl, G; Krack, P; Lemke, MR; Lindemann, M; Raethjen, J; Wenzelburger, R, 2001)
"Tremor is the most common movement disorder and there are numerous causes of tremor."2.82Drug-induced tremor, clinical features, diagnostic approach and management. ( Baizabal-Carvallo, JF; Morgan, JC, 2022)
" Tremor activity was assessed weekly, quantitatively by accelerometry and qualitatively with the Dosage Record and Treatment Emergent Symptom Scale."2.70Changes in quantitatively assessed tremor during treatment of major depression with lithium augmented by paroxetine or amitriptyline. ( Bauer, M; Jobert, M; Müller-Oerlinghausen, B; Zaninelli, R, 2001)
"Haloperidol was implicated in 47 patients (37%), followed by amitriptyline/perphenazine in 30%, thioridazine in 27%, and chlorpromazine in 20%."1.28Neurologic approach to drug-induced movement disorders: a study of 125 patients. ( Jankovic, J; Miller, LG, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's3 (18.75)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Baizabal-Carvallo, JF1
Morgan, JC1
WHITE, AG1
James, B1
Katoh, A1
Eigyo, M1
Ishibashi, C1
Naitoh, Y1
Takeuchi, M1
Ibii, N1
Ikeda, M1
Matsushita, A1
Bocchetta, A1
Bernardi, F1
Burrai, C1
Pedditzi, M1
Del Zompo, M1
Raethjen, J1
Lemke, MR1
Lindemann, M1
Wenzelburger, R1
Krack, P1
Deuschl, G1
Zaninelli, R1
Bauer, M1
Jobert, M1
Müller-Oerlinghausen, B1
Cendrowski, W1
Rehavi, M1
Maayani, S1
Sokolovsky, M1
Miller, LG1
Jankovic, J1
Goumentouk, AD1
Hurwitz, TA1
Zis, AP1
Overstreet, DH1
Janowsky, DS1
Gillin, JC1
Shiromani, PJ1
Sutin, EL1
Chouinard, G1
Zlatníková, J1
Consbruch, U1
Degkwitz, R1
Hampel, R1
Náhunek, K1
Svestka, J1
Rodová, A1
Achari, G1
Sinha, SP1

Reviews

1 review available for amitriptyline and Tremor

ArticleYear
Drug-induced tremor, clinical features, diagnostic approach and management.
    Journal of the neurological sciences, 2022, 04-15, Volume: 435

    Topics: Amitriptyline; Humans; Male; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin and Norad

2022

Trials

5 trials available for amitriptyline and Tremor

ArticleYear
A double-blind comparative clinical study of amoxapine and amitriptyline in depressed, hospitalised patients.
    The New Zealand medical journal, 1982, Jun-09, Volume: 95, Issue:709

    Topics: Adolescent; Adult; Aged; Amitriptyline; Amoxapine; Body Weight; Cardiovascular Diseases; Clinical Tr

1982
A double-blind study of L-sulpiride versus amitriptyline in lithium-maintained bipolar depressives.
    Acta psychiatrica Scandinavica, 1993, Volume: 88, Issue:6

    Topics: Ambulatory Care; Amitriptyline; Bipolar Disorder; Constipation; Double-Blind Method; Drug Administra

1993
Changes in quantitatively assessed tremor during treatment of major depression with lithium augmented by paroxetine or amitriptyline.
    Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:2

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Antimanic Agents; Depressive Disorder, Major; Dou

2001
A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:3 Pt 2

    Topics: Adult; Ambulatory Care; Amitriptyline; Anxiety; Body Weight; Clinical Trials as Topic; Depressive Di

1985
[Effect of amitriptyline in long-term autoexperiments. Psychophysiologic studies and duration of excretion].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:8

    Topics: Achievement; Administration, Oral; Adult; Amitriptyline; Analysis of Variance; Blood Pressure; Clini

1974

Other Studies

10 other studies available for amitriptyline and Tremor

ArticleYear
METHYLDOPA AND AMITRIPTYLINE.
    Lancet (London, England), 1965, Aug-28, Volume: 2, Issue:7409

    Topics: Amitriptyline; Depression; Depressive Disorder; Drug Synergism; Drug Therapy; Hypertension; Methyldo

1965
Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: 5-Hydroxytryptophan; Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Antidepressive Agents; Be

1995
Amitriptyline enhances the central component of physiological tremor.
    Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 70, Issue:1

    Topics: Amitriptyline; Electromyography; Female; Humans; Male; Muscles; Tremor

2001
[Attempts at pharmacological and surgical treatment of intentional and postural tremor in patients with disseminated sclerosis (authors transl)].
    Przeglad lekarski, 1976, Volume: 33, Issue:9

    Topics: Adult; Amitriptyline; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Mu

1976
Tricyclic antidepressants as antimuscarinic drugs: in vivo and in vitro studies.
    Biochemical pharmacology, 1977, Sep-01, Volume: 26, Issue:17

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Cholinesterase In

1977
Neurologic approach to drug-induced movement disorders: a study of 125 patients.
    Southern medical journal, 1990, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amitriptyline; Antipsychotic Agents; Chorea

1990
Primidone in drug-induced tremor.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:6

    Topics: Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fem

1989
Stress-induced immobility in rats with cholinergic supersensitivity.
    Biological psychiatry, 1986, Volume: 21, Issue:7

    Topics: Amitriptyline; Animals; Arousal; Hippocampus; Kinetics; Male; Motor Activity; Oxotremorine; Quinucli

1986
Clinical test of protriptyline in endogenous and involutional depressions.
    Activitas nervosa superior, 1970, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Amitriptyline; Depression; Depressive Disorder, Major; Female; Hallucinatio

1970
Evaluation of certain psychoanaleptic drugs as anti-parkinsonian agent: an experimental study.
    The Indian journal of medical research, 1968, Volume: 56, Issue:4

    Topics: Amitriptyline; Animals; Female; Imipramine; Male; Rats; Tremor

1968