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amitriptyline and Tachycardia, Ventricular

amitriptyline has been researched along with Tachycardia, Ventricular in 21 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).

Research Excerpts

ExcerptRelevanceReference
"However, ventricular tachycardia was detected which did not respond to lidocaine, bicarbonate and cardioversion treatment."5.31Efficacy of long duration resuscitation and magnesium sulphate treatment in amitriptyline poisoning. ( Citak, A; Karaböcüoğlu, M; Soysal, DD; Uçsel, R; Uzel, N, 2002)
"Our data suggest that amitriptyline-induced inhibition of I(Na) unmasks the Brugada ECG phenotype and facilitates development of an arrhythmogenic substrate only in the setting of a genetic predisposition by creating repolarization heterogeneities that give rise to phase 2 reentry and VT."3.78Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants. ( Antzelevitch, C; Barajas-Martínez, H; Di Diego, JM; Hu, D; Minoura, Y; Sicouri, S; Zygmunt, AC, 2012)
"In the present case, arrhythmia and circulatory shock responded neither to alkalization and elevated sodium levels after infusion of sodium bicarbonate, nor to any other established therapies."1.48[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication]. ( Fischer, B; Otte, S; Sayk, F, 2018)
"Recently, we managed ventricular tachycardia in a young female presented with an impaired consciousness 10 h after intentionally ingesting 2500 mg amitriptyline."1.46Amitriptyline-induced ventricular tachycardia: a case report. ( Chowdhury, AW; Islam, MS; Kabir, SR; Kawser, S; Sabah, KMN; Saha, BP, 2017)
"Amitriptyline has the potential to cause unusual serious complications, such as abdominal compartment syndrome, irreversible central nervous system disability and lethal arrhythmia."1.46Unusual complications from amitriptyline intoxication. ( Maruguchi, H; Nakao, A; Nakayama, S; Nishimura, T, 2017)
"Cyclobenzaprine has potential for sodium channel blockade and ventricular dysrhythmias although cardiac toxicity due to cyclobenzaprine alone is rare."1.42Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. ( Cao, D; Chua-Tuan, JL; Hoyte, CO; Iwanicki, JL, 2015)
"She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes."1.35Treatment of severe amitriptyline intoxication with plasmapheresis. ( Akyüz, M; Aydemir, C; Cabuk, H; Eldes, N; Kolsal, E; Numanoglu, V; Piskin, E; Tekin, IO, 2009)
"Magnesium sulfate is a very effective treatment in intractable arrhythmias caused by high-dose amitriptyline intoxication."1.34Efficacy of magnesium sulfate for treatment of ventricular tachycardia in amitriptyline intoxication. ( Babaoglu, K; Barn, E; Gokalp, AS; Sarisoy, O; Tugay, S, 2007)
"However, ventricular tachycardia was detected which did not respond to lidocaine, bicarbonate and cardioversion treatment."1.31Efficacy of long duration resuscitation and magnesium sulphate treatment in amitriptyline poisoning. ( Citak, A; Karaböcüoğlu, M; Soysal, DD; Uçsel, R; Uzel, N, 2002)
"After the appearance of ventricular tachycardia, they were treated with magnesium sulfate (45 mg/kg + 15 mg/kg/min) or lidocaine (1 mg/kg + 0."1.29Effects of magnesium sulfate and lidocaine in the treatment of ventricular arrhythmias in experimental amitriptyline poisoning in the rat. ( Abrahamsson, J; Knudsen, K, 1994)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's4 (19.05)18.2507
2000's6 (28.57)29.6817
2010's7 (33.33)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Garrett, P1
Klupfel, S1
Ryan, K1
Benz, P1
Zosel, A1
Farkas, A1
Theobald, J1
Yang, XY1
Song, XT1
Zhang, Y1
Sabah, KMN1
Chowdhury, AW1
Islam, MS1
Saha, BP1
Kabir, SR1
Kawser, S1
Otte, S1
Fischer, B1
Sayk, F1
Nishimura, T1
Maruguchi, H1
Nakao, A1
Nakayama, S1
Butt, K1
Ambati, S1
Chua-Tuan, JL1
Cao, D1
Iwanicki, JL1
Hoyte, CO1
Abeyaratne, DD1
Liyanapathirana, C1
Gamage, A1
Karunarathne, P1
Botheju, M1
Indrakumar, J1
Kolsal, E1
Tekin, IO1
Piskin, E1
Aydemir, C1
Akyüz, M1
Cabuk, H1
Eldes, N1
Numanoglu, V1
Minoura, Y1
Di Diego, JM1
Barajas-Martínez, H1
Zygmunt, AC1
Hu, D1
Sicouri, S1
Antzelevitch, C1
Srinivasa, V1
Gerner, P1
Haderer, A1
Abdi, S1
Jarolim, P1
Wang, GK1
LISSAC, J1
SAVIER, CH1
DUREPAIRE, H1
AUZEPY, P1
BROCARD, H1
Baysal, T1
Oran, B1
Doğan, M1
Cimen, D1
Elmas, S1
Karaaslan, S1
Sarisoy, O1
Babaoglu, K1
Tugay, S1
Barn, E1
Gokalp, AS1
Algren, DA1
Sutter, ME1
Ansel, GM2
Coyne, K1
Arnold, S1
Nelson, SD2
Meimer, JP1
Knudsen, K1
Abrahamsson, J1
Coumbe, A1
Perez-Martinez, AL1
Fegan, AW1
Hill, IR1
Citak, A1
Soysal, DD1
Uçsel, R1
Karaböcüoğlu, M1
Uzel, N1

Other Studies

21 other studies available for amitriptyline and Tachycardia, Ventricular

ArticleYear
Esmolol for intractable ventricular arrhythmias in major amitriptyline toxicity.
    BMJ case reports, 2022, Jul-22, Volume: 15, Issue:7

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Humans; Propanolamines; Tachy

2022
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
    Cardiovascular toxicology, 2022, Volume: 22, Issue:9

    Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long

2022
Wide QRS Complex Tachycardia With a Dominant R-Wave in Lead aVR-Is It Ventricular Tachycardia?
    JAMA internal medicine, 2020, 12-01, Volume: 180, Issue:12

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Diagnosis, Differential; Doxepin; Drug Overdose; El

2020
Amitriptyline-induced ventricular tachycardia: a case report.
    BMC research notes, 2017, Jul-14, Volume: 10, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Suicide, Attempted; Tachycar

2017
[Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2018, Volume: 113, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Arrhythmias, Cardiac; Drug Overdose; Female; Hum

2018
Unusual complications from amitriptyline intoxication.
    BMJ case reports, 2017, Oct-10, Volume: 2017

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brain Damage, Chronic; Coma; Humans; Intestinal Obs

2017
A Peculiar Wide Complex Tachycardia.
    Circulation, 2019, 03-12, Volume: 139, Issue:11

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Cardiotoxicity; Drug Overdose; Electrocardiography;

2019
Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:6

    Topics: Acetamides; Adolescent; Amitriptyline; Anticonvulsants; Drug Interactions; Drug Overdose; Electrocar

2015
Survival after severe amitriptyline poisoning with prolonged ventricular tachycardia and cardiac arrest.
    BMC research notes, 2016, Mar-15, Volume: 9

    Topics: Adult; Amitriptyline; Electrocardiography; Female; Heart Arrest; Humans; Pulmonary Edema; Survival A

2016
Treatment of severe amitriptyline intoxication with plasmapheresis.
    Journal of clinical apheresis, 2009, Volume: 24, Issue:1

    Topics: Amitriptyline; Child, Preschool; Coma; Drug Overdose; Female; Humans; Plasmapheresis; Poisoning; Sei

2009
Ionic and cellular mechanisms underlying the development of acquired Brugada syndrome in patients treated with antidepressants.
    Journal of cardiovascular electrophysiology, 2012, Volume: 23, Issue:4

    Topics: Action Potentials; Adrenergic beta-Agonists; Amitriptyline; Animals; Anti-Arrhythmia Agents; Antidep

2012
The relative toxicity of amitriptyline, bupivacaine, and levobupivacaine administered as rapid infusions in rats.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:1

    Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Bupiva

2003
[ACUTE INTOXICATION BY AMITRIPTYLINE WITH VENTRICULAR TACHYCARDIA. RECOVERY AFTER CARDIO-RESPIRATORY RESUSCITATION].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1965, Mar-19, Volume: 116

    Topics: Amitriptyline; Heart; Humans; Poisoning; Resuscitation; Tachycardia; Tachycardia, Ventricular; Toxic

1965
Beta-blocker treatment in an adolescent with amitriptyline intoxication.
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2007, Volume: 7, Issue:3

    Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Diag

2007
Efficacy of magnesium sulfate for treatment of ventricular tachycardia in amitriptyline intoxication.
    Pediatric emergency care, 2007, Volume: 23, Issue:9

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child, Preschool; Humans; Magnesium Sulfate; Male;

2007
Treatment of tricyclic antidepressant cardiac toxicity.
    Pediatric emergency care, 2008, Volume: 24, Issue:3

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child, Preschool; Humans; Hydrogen-Ion Concentratio

2008
Mechanisms of ventricular arrhythmia during amitriptyline toxicity.
    Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:6

    Topics: Action Potentials; Amitriptyline; Animals; Blood Pressure; Dogs; Female; Heart Conduction System; He

1993
Prevention of tricyclic antidepressant-induced ventricular tachyarrhythmia by a specific bradycardic agent in a canine model.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2

    Topics: Amitriptyline; Animals; Benzazepines; Cardiovascular Agents; Dogs; Electrocardiography; Female; Male

1994
Effects of magnesium sulfate and lidocaine in the treatment of ventricular arrhythmias in experimental amitriptyline poisoning in the rat.
    Critical care medicine, 1994, Volume: 22, Issue:3

    Topics: Amitriptyline; Analysis of Variance; Animals; Blood Pressure; Electrocardiography; Heart Rate; Lidoc

1994
Arrhythmogenic right ventricular dysplasia (ARVD): an overlooked and underdiagnosed condition?
    Medicine, science, and the law, 1997, Volume: 37, Issue:3

    Topics: Adolescent; Amitriptyline; Death, Sudden; Diagnosis, Differential; Drug Overdose; Female; Heart Vent

1997
Efficacy of long duration resuscitation and magnesium sulphate treatment in amitriptyline poisoning.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2002, Volume: 9, Issue:1

    Topics: Amitriptyline; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Cardiopulmonary Resuscitati

2002