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amitriptyline and Tachyarrhythmia

amitriptyline has been researched along with Tachyarrhythmia in 33 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

ExcerptRelevanceReference
" Exacerbating factors, including diuretic-induced hypokalemia and the concomitant administration of perphenazine, were present."7.65Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine. ( Bahler, A; Pincus, J; Schneider, RR; Stimmel, B, 1977)
"Amitriptyline was infused i."5.27Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs. ( Mittleman, M; Nattel, S, 1984)
" Here we report a 25-year-old female presenting with coma and hemodynamic instability following intentional ingestion of amitriptyline."3.78Lipid therapy for the treatment of a refractory amitriptyline overdose. ( Kiberd, MB; Minor, SF, 2012)
" To compare the effects of antidepressant drugs, the electrocardiogram (ECG), vectorcardiogram (VCG), and body surface maps (BSM) were recorded in psychiatric patients without cardiovascular diseases treated by a) TCA amitriptyline or dosulepin (daily dose 50-200 mg, 22 patients), b) lithium (serum level 0."3.70Antidepressant drugs and heart electrical field. ( Hamplová, J; Horácek, BM; Kittnar, O; Paclt, I; Slavícek, J; Trefný, Z, 1998)
"Overdose with amitriptyline and other tricyclic antidepressants can result in ventricular conduction abnormalities as well as severe ventricular arrhythmias."3.67Experimental amitriptyline intoxication: treatment of cardiac toxicity with sodium bicarbonate. ( Jhamandas, V; Sasyniuk, BI; Valois, M, 1986)
" Exacerbating factors, including diuretic-induced hypokalemia and the concomitant administration of perphenazine, were present."3.65Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine. ( Bahler, A; Pincus, J; Schneider, RR; Stimmel, B, 1977)
"Amitriptyline was infused i."1.27Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs. ( Mittleman, M; Nattel, S, 1984)
"Phenytoin has been proposed as a prophylaxis and treatment of these dysrhythmias, since it is thought to improve conduction in this setting."1.27Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning. ( Callaham, M; Pentel, P; Schumaker, H, 1988)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199029 (87.88)18.7374
1990's2 (6.06)18.2507
2000's0 (0.00)29.6817
2010's2 (6.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ramasubbu, B1
James, D1
Scurr, A1
Sandilands, EA1
Kiberd, MB1
Minor, SF1
FEKETE, M1
BORSY, J1
BLACHLY, PH1
EDWARDS, AL1
SORENSEN, NS1
ANDREASSEN, J1
SCHAERER, K1
LISSAC, J1
SAVIER, CH1
DUREPAIRE, H1
AUZEPY, P1
BROCARD, H1
Nymark, M1
Rasmussen, J1
Nattel, S1
Mittleman, M1
Hultén, BA1
Heath, A1
Stiff, JL1
Harris, DB1
Langou, RA1
Van Dyke, C1
Tahan, SR1
Cohen, LS1
Slavícek, J1
Paclt, I1
Hamplová, J1
Kittnar, O1
Trefný, Z1
Horácek, BM1
Harrigan, RA1
Brady, WJ1
Schneider, RR1
Bahler, A1
Pincus, J1
Stimmel, B1
Tobis, J1
Das, BN1
Raymond, CW1
Rickels, K1
Feighner, JP1
Smith, WT1
Hamilton, TC1
Norton, J1
Poyser, RH1
Thormählen, D1
Sasyniuk, BI1
Jhamandas, V1
Valois, M1
Hancock, EW1
Callaham, M1
Schumaker, H1
Pentel, P1
Davison, ET1
Weinbroum, A1
Heifetz, M1
Bursztein, S1
White, AG1
Parkin, JM1
Fraser, MS1
Bojanovsky, J1
Tölle, R1
Vajda, L1
Bossaert, L1
Vermeire, P1
van Durme, JP1
Pannier, R1
Slovis, TL1
Ott, JE1
Teitebaum, DT1
Lipscomb, W1
Burda, CD1

Reviews

1 review available for amitriptyline and Tachyarrhythmia

ArticleYear
Principles of antidepressant therapy and results obtained with Hungarian thymoleptics in hospitalized psychiatric patients.
    Therapia Hungarica (English edition), 1974, Volume: 22, Issue:3

    Topics: Amitriptyline; Antidepressive Agents; Anxiety; Depression; Electroconvulsive Therapy; Humans; Methot

1974

Trials

2 trials available for amitriptyline and Tachyarrhythmia

ArticleYear
Alprazolam, amitriptyline, doxepin, and placebo in the treatment of depression.
    Archives of general psychiatry, 1985, Volume: 42, Issue:2

    Topics: Adult; Alcoholism; Alprazolam; Ambulatory Care; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines;

1985
[Dihydroergotamine for treatment of vascular side-effects of thymoleptics (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, May-17, Volume: 99, Issue:20

    Topics: Amitriptyline; Brachial Artery; Clinical Trials as Topic; Depression; Drug Interactions; Ergotamine;

1974

Other Studies

30 other studies available for amitriptyline and Tachyarrhythmia

ArticleYear
Serum alkalinisation is the cornerstone of treatment for amitriptyline poisoning.
    BMJ case reports, 2016, Apr-11, Volume: 2016

    Topics: Adult; Amitriptyline; Antacids; Antidepressive Agents, Tricyclic; Drug Overdose; Female; Humans; Sod

2016
Lipid therapy for the treatment of a refractory amitriptyline overdose.
    CJEM, 2012, Volume: 14, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antidotes; Coma; Drug Overdose; Fat Emulsion

2012
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10

    Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound

1964
ON DEPRESSIVE REACTIONS.
    Medical times, 1964, Volume: 92

    Topics: Amitriptyline; Antidepressive Agents; Depression; Depressive Disorder; Drug Therapy; Electroconvulsi

1964
IMIPRAMINE MYOCARDIAL TOXICITY.
    New York state journal of medicine, 1964, Aug-01, Volume: 64

    Topics: Amitriptyline; Atrial Fibrillation; Electrocardiography; Imipramine; Myocardium; Tachycardia; Toxico

1964
[AMITRIPTYLINE POISONING].
    Ugeskrift for laeger, 1964, Oct-08, Volume: 126

    Topics: Alanine Transaminase; Amitriptyline; Antidepressive Agents; Aspartate Aminotransferases; Clinical En

1964
[TOXICITY STUDIES WITH AMITRIPTYLINE. THERAPEUTIC GUIDE LINES FROM EXPERIMENTAL STUDIES].
    Schweizerische medizinische Wochenschrift, 1965, Jan-30, Volume: 95

    Topics: Amitriptyline; Chlordiazepoxide; Dogs; Electrocardiography; Mice; Parasympathomimetics; Pharmacology

1965
[ACUTE INTOXICATION BY AMITRIPTYLINE WITH VENTRICULAR TACHYCARDIA. RECOVERY AFTER CARDIO-RESPIRATORY RESUSCITATION].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1965, Mar-19, Volume: 116

    Topics: Amitriptyline; Heart; Humans; Poisoning; Resuscitation; Tachycardia; Tachycardia, Ventricular; Toxic

1965
Effect of certain drugs upon amitriptyline induced electrocardiographic changes.
    Acta pharmacologica et toxicologica, 1966, Volume: 24, Issue:2

    Topics: Acetylcholine; Amitriptyline; Animals; Atropine; Blood Pressure; Bradycardia; Bundle-Branch Block; E

1966
Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:2

    Topics: Amitriptyline; Animals; Bicarbonates; Dogs; Female; Hyperventilation; Lidocaine; Male; Saline Soluti

1984
Clinical aspects of tricyclic antidepressant poisoning.
    Acta medica Scandinavica, 1983, Volume: 213, Issue:4

    Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Amitriptyline; Antidepressive Agents, Tricyclic; Be

1983
Clonidine withdrawal complicated by amitriptyline therapy.
    Anesthesiology, 1983, Volume: 59, Issue:1

    Topics: Aged; Amitriptyline; Anxiety; Clonidine; Female; Humans; Hypertension; Intraoperative Care; Methyldo

1983
Cardiovascular manifestations of tricyclic antidepressant overdose.
    American heart journal, 1980, Volume: 100, Issue:4

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Pressure; Cardiac Ou

1980
Antidepressant drugs and heart electrical field.
    Physiological research, 1998, Volume: 47, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cardiovascular Diseas

1998
ECG abnormalities in tricyclic antidepressant ingestion.
    The American journal of emergency medicine, 1999, Volume: 17, Issue:4

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; An

1999
Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine.
    Chest, 1977, Volume: 71, Issue:2

    Topics: Amitriptyline; Bretylium Tosylate; Electrocardiography; Female; Heart Ventricles; Humans; Hypokalemi

1977
Cardiac complications in amitriptyline poisoning. Successful treatment with physostigmine.
    JAMA, 1976, Apr-05, Volume: 235, Issue:14

    Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Bundle-Branch Block; Female; Humans; Injections, Intrave

1976
Letter: Neostigmine methysulfate in the treatment of cardiac arryhthmia induced by perphenazine-amitriptyline.
    Canadian Medical Association journal, 1976, Jan-24, Volume: 114, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child, Preschool; Drug Combin

1976
Comparison of some effects of paroxetine with amitriptyline on the cardiovascular system in animals.
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Drug Evaluation, Preclinical; Electrocardiograp

1986
Experimental amitriptyline intoxication: treatment of cardiac toxicity with sodium bicarbonate.
    Annals of emergency medicine, 1986, Volume: 15, Issue:9

    Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Bicarbonates; Dogs; Electrocardiography; Heart Conduct

1986
Wide-complex tachycardia after a suicide attempt.
    Hospital practice (Office ed.), 1986, Jun-15, Volume: 21, Issue:6

    Topics: Adult; Amitriptyline; Electrocardiography; Humans; Male; Suicide, Attempted; Tachycardia

1986
Phenytoin prophylaxis of cardiotoxicity in experimental amitriptyline poisoning.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dogs; Electrocardiography; Heart; Hypotens

1988
Amitriptyline-induced Torsade de Pointes. Successful therapy with atrial pacing.
    Journal of electrocardiology, 1985, Volume: 18, Issue:3

    Topics: Aged; Amitriptyline; Cardiac Pacing, Artificial; Electric Countershock; Electrocardiography; Female;

1985
[Poisoning by tricyclic antidepressants and antidotes].
    Harefuah, 1985, Volume: 109, Issue:5-6

    Topics: Adolescent; Amitriptyline; Female; Humans; Phenytoin; Physostigmine; Seizures; Suicide, Attempted; T

1985
Letter: Amitriptyline and imipramine poisoning in children.
    British medical journal, 1974, Mar-23, Volume: 1, Issue:5907

    Topics: Amitriptyline; Cardiac Complexes, Premature; Child; Humans; Imipramine; Phenytoin; Tachycardia

1974
Amitriptyline and cardiac disease.
    Lancet (London, England), 1970, Oct-03, Volume: 2, Issue:7675

    Topics: Amitriptyline; Blood Pressure; Humans; Tachycardia

1970
Poisoning as a complication of enuresis.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:6

    Topics: Amitriptyline; Antidepressive Agents; Child, Preschool; Enuresis; Humans; Imipramine; Ipecac; Nortri

1972
[Cardiovascular complications in acute poisoning with tricyclic antidepressives].
    Acta clinica Belgica, 1971, Volume: 26, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmia, Sinus; Bundle-Branch Block; Dibenzocyclohep

1971
Physostigmine therapy in acute tricyclic antidepressant poisoning.
    Clinical toxicology, 1971, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Barbiturates; Blood P

1971
Cardiotoxic effects of Mellaril.
    American heart journal, 1970, Volume: 80, Issue:1

    Topics: Amitriptyline; Bradycardia; Electrocardiography; Humans; Imipramine; Tachycardia; Thioridazine

1970