Page last updated: 2024-10-22

amitriptyline and Syncope

amitriptyline has been researched along with Syncope in 13 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)

Research Excerpts

ExcerptRelevanceReference
"To report on a 12-year-old white male with prostatic rhabdomyosarcoma who experienced episodes of syncope attributed to concurrent amitriptyline and fluconazole therapy, confirmed by readministration."7.70Syncope associated with concurrent amitriptyline and fluconazole therapy. ( Nahata, MC; Olshefski, RS; Robinson, RF, 2000)
" Exacerbating factors, including diuretic-induced hypokalemia and the concomitant administration of perphenazine, were present."7.65Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine. ( Bahler, A; Pincus, J; Schneider, RR; Stimmel, B, 1977)
"A 57 year-old man treated with amitriptyline was admitted because of several episodes of syncope."3.79[Bilateral bundle branch block during treatment with amitriptyline]. ( Foryś, M; Kramarz, E, 2013)
"To report on a 12-year-old white male with prostatic rhabdomyosarcoma who experienced episodes of syncope attributed to concurrent amitriptyline and fluconazole therapy, confirmed by readministration."3.70Syncope associated with concurrent amitriptyline and fluconazole therapy. ( Nahata, MC; Olshefski, RS; Robinson, RF, 2000)
" Exacerbating factors, including diuretic-induced hypokalemia and the concomitant administration of perphenazine, were present."3.65Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine. ( Bahler, A; Pincus, J; Schneider, RR; Stimmel, B, 1977)
"Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment."1.33Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby. ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19902 (15.38)18.7374
1990's3 (23.08)18.2507
2000's4 (30.77)29.6817
2010's2 (15.38)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Shah, RS1
Mayuga, KA1
Gabbard, S1
Fernández-Anguita, MJ1
Martínez-Mateo, V1
Cejudo Díaz Del Campo, L1
Galindo-Andugar, MÁ1
Kramarz, E1
Foryś, M1
Woźniak, A1
Sredniawa, B1
Kalarus, Z1
Rosenlicht, NZ1
Riley-Lazo, KP1
Bednarek, N1
Arbuès, AS1
Motte, J1
Sabouraud, P1
Plouin, P1
Morville, P1
Alim, M1
Edelson, GW1
Cook, DJ1
Guyatt, GH2
Davis, C1
Willan, A1
McIlroy, W1
Dorsey, ST1
Biblo, LA1
Robinson, RF1
Nahata, MC1
Olshefski, RS1
Schneider, RR1
Bahler, A1
Pincus, J1
Stimmel, B1
Keller, JL1
Jaeschke, R1
Rosenbloom, D1
Adachi, JD1
Newhouse, MT1
Sethna, ER1

Reviews

1 review available for amitriptyline and Syncope

ArticleYear
Syncope in a young woman with chronic back pain.
    Hospital practice (Office ed.), 1993, Jun-15, Volume: 28, Issue:6

    Topics: Adult; Amitriptyline; Back Pain; Diagnosis, Differential; Emergency Medical Services; Female; Humans

1993

Trials

1 trial available for amitriptyline and Syncope

ArticleYear
A study of refractory cases of depressive illnesses and their response to combined antidepressant treatment.
    The British journal of psychiatry : the journal of mental science, 1974, Volume: 124, Issue:0

    Topics: Adult; Amitriptyline; Body Weight; Clinical Trials as Topic; Depression; Drug Therapy, Combination;

1974

Other Studies

11 other studies available for amitriptyline and Syncope

ArticleYear
Management of an Unusual Case of Dysphagia.
    Dysphagia, 2020, Volume: 35, Issue:2

    Topics: Amitriptyline; Cardiac Conduction System Disease; Deglutition Disorders; Diagnosis, Differential; Hu

2020
The Brugada pattern in a patient treated with amitriptyline.
    Neurologia, 2020, Volume: 35, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cognitive Dysfunction; Cold Tempe

2020
[Bilateral bundle branch block during treatment with amitriptyline].
    Kardiologia polska, 2013, Volume: 71, Issue:6

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bundle-Branch Block; Electrocardiography; Humans; M

2013
[Editorial comment].
    Kardiologia polska, 2013, Volume: 71, Issue:6

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bundle-Branch Block; Humans; Male; Syncope

2013
Interactions of cyclobenzaprine and tricyclic antidepressants.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:1

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal

2005
Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby.
    Epileptic disorders : international epilepsy journal with videotape, 2005, Volume: 7, Issue:4

    Topics: Amitriptyline; Anticonvulsants; Apnea; Autonomic Nervous System Diseases; Bradycardia; Bronchial Spa

2005
A diagnostic and therapeutic N-of-1 randomized trial.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:4

    Topics: Adult; Amitriptyline; Depressive Disorder; Female; Heart Rate; Humans; Placebo Effect; Randomized Co

1993
Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptyline.
    The American journal of emergency medicine, 2000, Volume: 18, Issue:2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Drug Interactions; Electrocardio

2000
Syncope associated with concurrent amitriptyline and fluconazole therapy.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:12

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Child; Drug Interactions; Flucon

2000
Asymptomatic idiopathic syndrome of prolonged Q-T interval in a 45-year-old woman. Ventricular tachyarrhythmias precipitated by hypokalemia and therapy with amitriptyline and prephenazine.
    Chest, 1977, Volume: 71, Issue:2

    Topics: Amitriptyline; Bretylium Tosylate; Electrocardiography; Female; Heart Ventricles; Humans; Hypokalemi

1977
The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience.
    Annals of internal medicine, 1990, Feb-15, Volume: 112, Issue:4

    Topics: Adult; Amitriptyline; Double-Blind Method; Female; Humans; Patient Compliance; Physician's Role; Pro

1990