amitriptyline has been researched along with Stroke in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain." | 9.10 | Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002) |
| "We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain." | 5.10 | Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002) |
| " She suffered from central poststroke pain and reactive depression as poststroke complications, for which amitriptyline was prescribed." | 3.78 | Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug? ( Ahmad, S; Aziz, NA; Tan, EC, 2012) |
| "To conduct population-based analyses comparing the risk of serious cardiovascular (CV) events (eg, acute myocardial infarction, stroke, congestive heart failure) associated with treatment with milnacipran compared with venlafaxine and amitriptyline, 2 other commonly prescribed drugs that also inhibit reuptake of norepinephrine and serotonin." | 3.77 | Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data. ( Boerstoel-Streefland, M; Duh, MS; Guérin, A; Jiang, W; Lefebvre, P; Mease, PJ; Vekeman, F; Zimetbaum, PJ, 2011) |
| "Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients." | 2.45 | Post-stroke pain. ( Kim, JS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birns, J | 1 |
| Henderson, K | 1 |
| Bhalla, A | 1 |
| Esin, RG | 1 |
| Sitnova, MA | 1 |
| Esin, OR | 1 |
| Kim, JS | 1 |
| Mease, PJ | 1 |
| Zimetbaum, PJ | 1 |
| Duh, MS | 1 |
| Vekeman, F | 1 |
| Guérin, A | 1 |
| Boerstoel-Streefland, M | 1 |
| Jiang, W | 1 |
| Lefebvre, P | 1 |
| Tan, EC | 1 |
| Aziz, NA | 1 |
| Ahmad, S | 1 |
| Lampl, C | 1 |
| Yazdi, K | 1 |
| Röper, C | 1 |
| Yen, HL | 1 |
| Chan, W | 1 |
| Arnold, G | 1 |
| Schuh-Hofer, S | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
3 reviews available for amitriptyline and Stroke
| Article | Year |
|---|---|
Post-stroke pain.
Topics: Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Humans; Pain; Stroke | 2009 |
[Comorbidities in migraine patients].
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Anxiety Disorders; Carotid Artery, | 2007 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
1 trial available for amitriptyline and Stroke
| Article | Year |
|---|---|
Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study.
Topics: Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycli | 2002 |
5 other studies available for amitriptyline and Stroke
| Article | Year |
|---|---|
Recreational amitriptyline toxicity mimicking basilar artery stroke.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Basilar Artery; Blood Chemical Analysis; Dia | 2013 |
[The principles of pharmacotherapy of poststroke shoulder pain].
Topics: Amines; Amitriptyline; Anti-Inflammatory Agents; Clonidine; Cyclohexanecarboxylic Acids; Drug Therap | 2015 |
Epidemiologic Evaluation of Cardiovascular Risk in Patients Receiving Milnacipran, Venlafaxine, or Amitriptyline: Evidence from French Health Data.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; | 2011 |
Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Female; Humans; Middl | 2012 |
An East-West approach to the management of central post-stroke pain.
Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon | 2003 |