amitriptyline has been researched along with Stress Disorders, Post-Traumatic in 15 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 5.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| "Posttraumatic stress disorder (PTSD) is a prevalent and disabling disorder." | 2.82 | Pharmacotherapy for post traumatic stress disorder (PTSD). ( Ipser, JC; Phillips, NJ; Stein, DJ; Williams, T, 2022) |
| "Amitriptyline hydrochloride was compared with placebo in 46 veterans with chronic posttraumatic stress disorder." | 2.67 | Treatment of posttraumatic stress disorder with amitriptyline and placebo. ( Cavenar, JO; Davidson, J; Hammett, E; Kudler, H; Lipper, S; Mahorney, SL; Saunders, WB; Smith, R, 1990) |
| "Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness." | 1.39 | Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. ( Diamond, DM; Fleshner, M; Zoladz, PR, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, T | 1 |
| Phillips, NJ | 1 |
| Stein, DJ | 1 |
| Ipser, JC | 1 |
| Sullivan, GM | 1 |
| Gendreau, RM | 1 |
| Gendreau, J | 1 |
| Peters, P | 1 |
| Peters, A | 1 |
| Engels, J | 1 |
| Daugherty, BL | 1 |
| Vaughn, B | 1 |
| Weathers, FW | 1 |
| Lederman, S | 1 |
| Stock, EM | 1 |
| Zeber, JE | 1 |
| McNeal, CJ | 1 |
| Banchs, JE | 1 |
| Copeland, LA | 1 |
| Nakimuli-Mpungu, E | 1 |
| Odokonyero, R | 1 |
| Laker, J | 1 |
| Alderman, S | 1 |
| Zoladz, PR | 1 |
| Fleshner, M | 1 |
| Diamond, DM | 1 |
| Bourgeois, M | 1 |
| Holsboer, F | 1 |
| Grasser, A | 1 |
| Friess, E | 1 |
| Wiedemann, K | 1 |
| Davidson, JR | 2 |
| Kudler, HS | 2 |
| Saunders, WB | 2 |
| Erickson, L | 2 |
| Smith, RD | 1 |
| Stein, RM | 1 |
| Lipper, S | 2 |
| Hammett, EB | 1 |
| Mahorney, SL | 2 |
| Cavenar, JO | 2 |
| Thompson, GN | 1 |
| Burdon, AP | 1 |
| Sutker, PB | 1 |
| Foulks, EF | 1 |
| Crane, MU | 1 |
| Thompson, KE | 1 |
| Davidson, J | 1 |
| Kudler, H | 1 |
| Smith, R | 1 |
| Hammett, E | 1 |
| Stein, R | 1 |
| Falcon, S | 1 |
| Ryan, C | 1 |
| Chamberlain, K | 1 |
| Curtis, G | 1 |
| Goethe, JW | 1 |
| Edelman, SL | 1 |
| Marin, A | 1 |
| Trapet, P | 1 |
| Brenot, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "A Phase 2, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken at Bedtime in Subjects With Military-Related PTSD and Related Conditions (Protocol No. TNX-CY-P201) -AtEase STUDY"[NCT02277704] | Phase 2 | 247 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amitriptyline and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Pharmacotherapy for post traumatic stress disorder (PTSD).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antidepressive Age | 2022 |
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Benzamides; Brain; Corticotropin-Releasing Hormone; Dexa | 1994 |
5 trials available for amitriptyline and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Randomized clinical trial of bedtime sublingual cyclobenzaprine (TNX-102 SL) in military-related PTSD and the role of sleep quality in treatment response.
Topics: Amitriptyline; Double-Blind Method; Humans; Military Personnel; Sleep; Stress Disorders, Post-Trauma | 2021 |
Predicting response to amitriptyline in posttraumatic stress disorder.
Topics: Amitriptyline; Anxiety Disorders; Comorbidity; Depressive Disorder; Double-Blind Method; Humans; Lif | 1993 |
Treatment of posttraumatic stress disorder with amitriptyline and placebo.
Topics: Ambulatory Care; Amitriptyline; Analysis of Variance; Anxiety Disorders; Clinical Trials as Topic; C | 1990 |
Measuring results of treatment of PTSD.
Topics: Amitriptyline; Clinical Trials as Topic; Combat Disorders; Desipramine; Double-Blind Method; Humans; | 1989 |
Tricyclics: possible treatment for posttraumatic stress disorder.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Combat Disorders; | 1985 |
8 other studies available for amitriptyline and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Arrhythmias, Cardiac; Buspirone; Female; Humans; Male | 2018 |
Major depression in postconflict northern Uganda: a case report.
Topics: Amitriptyline; Anti-Retroviral Agents; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; | 2014 |
Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antihypertens | 2013 |
[Study of an antidepressive agent in psychiatry: Mutabon F].
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Bipolar Disorder; D | 1967 |
Post-traumatic psychoneurosis: evaluation of drug therapy.
Topics: Amitriptyline; Drug Evaluation; Humans; Perphenazine; Stress Disorders, Post-Traumatic | 1977 |
Pilot program of treatment for PTSD.
Topics: Amitriptyline; Behavior Therapy; Combined Modality Therapy; Family Therapy; Fluoxetine; Humans; Male | 1991 |
Chlordiazepoxide toxicity in Limbitrol overdose.
Topics: Adult; Amitriptyline; Chlordiazepoxide; Depressive Disorder; Drug Combinations; Humans; Male; Stress | 1985 |
[Antidepressive and tranquilizing therapy in post-traumatic neuroses].
Topics: Adult; Aged; Amitriptyline; Female; Humans; Male; Middle Aged; Perphenazine; Stress Disorders, Post- | 1970 |