amitriptyline has been researched along with Spinal Cord Injuries in 13 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 9.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| " Although secondary hypertension is a known side effect of amitriptyline and duloxetine, neither drug has been previously associated with AD." | 5.51 | Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report. ( Parke, SC; Reyes, MR, 2019) |
| "Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants." | 5.28 | Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992) |
| "To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine." | 5.12 | Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007) |
| " This study examined the association of patient and research nurse/physician pretreatment expectations of pain relief with actual pain relief, the accuracy of patient and research nurse guesses about patient medication assignment, and changes in research nurse and patient pain relief expectations over the course of a randomized double-blind trial of amitriptyline versus an active placebo for patients with chronic pain and spinal cord injuries (SCI)." | 5.10 | Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial. ( Cardenas, DD; Jensen, MP; Turner, JA; Warms, CA, 2002) |
| "Participants in a clinical trial of amitriptyline for pain (n = 84 with spinal cord injury [SCI], n = 38 with amputation) provided responses to the study measures via telephone interview." | 3.73 | Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain. ( Cardenas, DD; Ehde, D; Hanley, M; Jensen, MP; Masedo, AI, 2005) |
| "Amitriptyline was administered orally at doses of 25, 50 and 100 mg once daily at night time, and lamotrigine was administered orally at doses of 25, 50 and 100 mg twice daily, both for 1 week by means of optional titration." | 2.84 | Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study. ( Agarwal, N; Joshi, M, 2017) |
| " Although secondary hypertension is a known side effect of amitriptyline and duloxetine, neither drug has been previously associated with AD." | 1.51 | Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report. ( Parke, SC; Reyes, MR, 2019) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| "Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants." | 1.28 | Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Asgardoon, MH | 1 |
| Jazayeri, SB | 1 |
| Behkar, A | 1 |
| Dabbagh Ohadi, MA | 1 |
| Yarmohammadi, H | 1 |
| Ghodsi, Z | 1 |
| Pomerani, TI | 1 |
| Mojtahedzadeh, M | 1 |
| Rahimi-Movaghar, V | 1 |
| Parke, SC | 1 |
| Reyes, MR | 1 |
| Mehta, S | 1 |
| Guy, S | 1 |
| Lam, T | 1 |
| Teasell, R | 1 |
| Loh, E | 1 |
| Agarwal, N | 1 |
| Joshi, M | 1 |
| Jiang, CJ | 1 |
| Tan, YC | 1 |
| Yang, YJ | 1 |
| Zhang, EZ | 1 |
| Liu, J | 1 |
| Yao, SQ | 1 |
| Yu, JL | 1 |
| Densmore, VS | 1 |
| Kalous, A | 1 |
| Keast, JR | 1 |
| Osborne, PB | 1 |
| Turner, JA | 2 |
| Jensen, MP | 2 |
| Warms, CA | 2 |
| Cardenas, DD | 3 |
| Masedo, AI | 1 |
| Hanley, M | 1 |
| Ehde, D | 1 |
| Rintala, DH | 1 |
| Holmes, SA | 1 |
| Courtade, D | 1 |
| Fiess, RN | 1 |
| Tastard, LV | 1 |
| Loubser, PG | 1 |
| Anand, J | 1 |
| Sivaraman Nair, KP | 1 |
| Taly, AB | 1 |
| Murali, T | 1 |
| Marshall, H | 1 |
| Brooke, MM | 1 |
| Loeser, JD | 1 |
| Kim, SP | 1 |
| Davis, SW | 1 |
| Sell, GH | 1 |
| Sandford, PR | 1 |
| Lindblom, LB | 1 |
| Haddox, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Management of Chronic Pain in Rehabilitation Project I - Management of Chronic Pain in Persons With Spinal Cord Injury[NCT00006428] | Phase 4 | 100 participants | Interventional | 1996-08-31 | Completed | ||
| Subcutaneous Injection of Botulinum Toxin A for At--Level Back Pain in Patients With Spinal Cord Injury[NCT02736890] | Phase 2 | 8 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to funding not available to continue) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Mean change from baseline. Participants are asked Taking into account your pain level and how it affects your life, are you feeling better, the same or worse than when you started treatment? and then to quantify the magnitude of the change. with the 7-Point guy Farrar which measures the global treatment effect from with scale from 0 to 6, higher score indicates worse outcomes." (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 2.2 | 2.4 | 2 | 2 | 0 | 0 | 0 | 0 |
| Placebo Then Botulinum Toxin A | 0.3 | 0.3 | 0 | 0 | 5 | 5 | 3 | 1 |
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting day-to-day activities subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 4.2 | 5.4 | 5 | 5 | 4.8 | 7 | 6.7 | 7 | 6.7 |
| Placebo Then Botulinum Toxin A | 5.3 | 2.7 | 2.7 | 2.7 | 2.7 | 2 | 3 | 4 | 5 |
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting mood subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 5.6 | 6.6 | 5.8 | 5.2 | 5.6 | 7 | 7 | 7.3 | 6.7 |
| Placebo Then Botulinum Toxin A | 5.7 | 2.7 | 2.7 | 4.3 | 5.7 | 2 | 3 | 4 | 7 |
The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting sleep subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 5.8 | 4.6 | 5 | 6 | 6.2 | 8 | 8 | 8 | 7.3 |
| Placebo Then Botulinum Toxin A | 6.7 | 4.7 | 3.3 | 6 | 6.7 | 1 | 3 | 4 | 5 |
Participant rated pain intensity from 0-10, with higher score indicating more pain (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 7.6 | 6.4 | 5.6 | 5.6 | 5.6 | 8 | 8 | 6.7 | 8 |
| Placebo Then Botulinum Toxin A | 8 | 8 | 8 | 8 | 8 | 5 | 5 | 6 | 7 |
PGI measures activity affected by pain. Full score is 0 to 10000, with higher score indicating better function (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline
| Intervention | score on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 2 week post injection | 4 week post injection | 8 week post injection | 12 week post injection | crossover 2 week follow up | crossover 4 week follow up | crossover 8 week follow up | crossover 12 week follow up | |
| Botulinum Toxin A Then Placebo | 4250 | 5240 | 5219 | 3725 | 4330 | 3333.3 | 3333.3 | 3333.3 | 3333.3 |
| Placebo Then Botulinum Toxin A | 1500 | 1550 | 1825 | 2800 | 1800 | 3500 | 3750 | 3000 | 1500 |
2 reviews available for amitriptyline and Spinal Cord Injuries
| Article | Year |
|---|---|
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries | 2022 |
Antidepressants Are Effective in Decreasing Neuropathic Pain After SCI: A Meta-Analysis.
Topics: Amitriptyline; Antidepressive Agents; Databases, Factual; Duloxetine Hydrochloride; Humans; Neuralgi | 2015 |
4 trials available for amitriptyline and Spinal Cord Injuries
| Article | Year |
|---|---|
Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study.
Topics: Administration, Oral; Adolescent; Adult; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tric | 2017 |
Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Attitude of Health Personnel; Double-Blind Method; F | 2002 |
Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury.
Topics: Adult; Aged; Amines; Amitriptyline; Analgesics; Analysis of Variance; Antidepressive Agents, Tricycl | 2007 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged; | 2002 |
7 other studies available for amitriptyline and Spinal Cord Injuries
| Article | Year |
|---|---|
Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report.
Topics: Adult; Amitriptyline; Analgesics; Autonomic Dysreflexia; Drug Therapy, Combination; Duloxetine Hydro | 2019 |
[Sequential drugs treatment for central pain following spinal cord injury].
Topics: Adult; Amitriptyline; Carbamazepine; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; | 2009 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain.
Topics: Adult; Amitriptyline; Amputation, Surgical; Analgesics, Non-Narcotic; Chronic Disease; Disability Ev | 2005 |
Spontaneous expulsion of large vesicle calculi in a woman with paraparesis.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; India; Myelitis, Transverse; | 1999 |
Amitriptyline in severely depressed spinal cord-injured patients: rapidity of response.
Topics: Adjustment Disorders; Adult; Amitriptyline; Female; Humans; Male; Psychiatric Status Rating Scales; | 1977 |
Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury.
Topics: Adult; Amitriptyline; Carbamazepine; Female; Humans; Pain; Spinal Cord Injuries | 1992 |