amitriptyline has been researched along with Spasm in 12 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 9.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "To assess the efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15 and 30 mg in relieving acute muscle spasm." | 9.14 | Efficacy and tolerability of cyclobenzaprine extended release for acute muscle spasm: a pooled analysis. ( Altman, CA; Nalamachu, S; Ruoff, GE; Taylor, DR; Weil, AJ; Xie, F, 2010) |
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 9.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 9.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| "Cyclobenzaprine hydrochloride became available for the treatment of acute skeletal muscle spasm ten years ago." | 8.77 | Cyclobenzaprine in the treatment of acute muscle spasm: review of a decade of clinical experience. ( Dube, J; Katz, WA, 1988) |
| "This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc." | 7.77 | Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011) |
| "To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions." | 5.14 | Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design. ( Altman, CA; Borenstein, DG; Malanga, GA; Ruoff, GE; Weil, AJ; Xie, F, 2009) |
| "To assess the efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15 and 30 mg in relieving acute muscle spasm." | 5.14 | Efficacy and tolerability of cyclobenzaprine extended release for acute muscle spasm: a pooled analysis. ( Altman, CA; Nalamachu, S; Ruoff, GE; Taylor, DR; Weil, AJ; Xie, F, 2010) |
| "This prospective, randomized, open-label, multicenter, community-based study was conducted to compare cyclobenzaprine 5 mg three times daily (TID) orally (CYC5) given for 7 days as monotherapy or in combination with ibuprofen 400 mg TID (CYC5/IBU400) or 800 mg TID (CYC5/IBU800) in adults with acute neck or back pain with muscle spasm." | 5.11 | Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial. ( Borenstein, D; Brown, RL; Childers, MK; Gershon, S; Hale, ME; Harrison, DD; Laudadio, C; Petri, M; Wan, GJ, 2005) |
| "Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions." | 5.10 | Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials. ( Borenstein, DG; Korn, S, 2003) |
| "Cyclobenzaprine immediate-release (CIR) is a widely prescribed skeletal muscle relaxant with an established efficacy and safety profile in patients with muscle spasm associated with acute, painful conditions, although it is commonly associated with sedation." | 4.86 | Pharmacokinetic profile of once-daily cyclobenzaprine extended-release. ( Darwish, M; Hellriegel, ET, 2010) |
| "Cyclobenzaprine hydrochloride became available for the treatment of acute skeletal muscle spasm ten years ago." | 4.77 | Cyclobenzaprine in the treatment of acute muscle spasm: review of a decade of clinical experience. ( Dube, J; Katz, WA, 1988) |
| "This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc." | 3.77 | Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malanga, GA | 1 |
| Ruoff, GE | 2 |
| Weil, AJ | 2 |
| Altman, CA | 3 |
| Xie, F | 3 |
| Borenstein, DG | 2 |
| Nalamachu, S | 1 |
| Taylor, DR | 1 |
| Darwish, M | 1 |
| Hellriegel, ET | 1 |
| Landy, S | 1 |
| Turturro, MA | 1 |
| Frater, CR | 1 |
| D'Amico, FJ | 1 |
| Korn, S | 1 |
| Childers, MK | 1 |
| Borenstein, D | 1 |
| Brown, RL | 1 |
| Gershon, S | 1 |
| Hale, ME | 1 |
| Petri, M | 1 |
| Wan, GJ | 1 |
| Laudadio, C | 1 |
| Harrison, DD | 1 |
| Beeber, AR | 1 |
| Manring, JM | 1 |
| Goldblatt, D | 1 |
| Katz, WA | 1 |
| Dube, J | 1 |
| Barth, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Flexeril� (Cyclobenzaprine Hydrochloride) Community Based Study - An Evaluation of Cyclobenzaprine HCl Monotherapy and in Combination With Ibuprofen for Acute Back or Neck Muscle Pain With Muscle Spasm[NCT00246389] | Phase 4 | 1,000 participants (Actual) | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amitriptyline and Spasm
| Article | Year |
|---|---|
Pharmacokinetic profile of once-daily cyclobenzaprine extended-release.
Topics: Aged; Amitriptyline; Animals; Delayed-Action Preparations; Drug Administration Schedule; Food-Drug I | 2010 |
Cyclobenzaprine in the treatment of acute muscle spasm: review of a decade of clinical experience.
Topics: Amitriptyline; Humans; Muscle Relaxants, Central; Spasm | 1988 |
5 trials available for amitriptyline and Spasm
| Article | Year |
|---|---|
Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design.
Topics: Adolescent; Adult; Aged; Algorithms; Amitriptyline; Delayed-Action Preparations; Double-Blind Method | 2009 |
Efficacy and tolerability of cyclobenzaprine extended release for acute muscle spasm: a pooled analysis.
Topics: Acute Disease; Adolescent; Adult; Aged; Amitriptyline; Chi-Square Distribution; Delayed-Action Prepa | 2010 |
Cyclobenzaprine with ibuprofen versus ibuprofen alone in acute myofascial strain: a randomized, double-blind clinical trial.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method | 2003 |
Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials.
Topics: Acute Disease; Adult; Amitriptyline; Back Pain; Dose-Response Relationship, Drug; Double-Blind Metho | 2003 |
Low-dose cyclobenzaprine versus combination therapy with ibuprofen for acute neck or back pain with muscle spasm: a randomized trial.
Topics: Adolescent; Adult; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Dose-Response | 2005 |
5 other studies available for amitriptyline and Spasm
| Article | Year |
|---|---|
Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine.
Topics: Acute Disease; Administration, Oral; Adult; Amitriptyline; Delayed-Action Preparations; Disorders of | 2011 |
Extended-release cyclobenzaprine (Amrix).
Topics: Amitriptyline; Delayed-Action Preparations; Drug Interactions; Humans; Muscle Relaxants, Central; Sp | 2007 |
Psychosis following cyclobenzaprine use.
Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Muscle Relaxants, Central; Psychoses, Substa | 1983 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |
[The treatment of psycho-autonomic syndromes in a gynecological outpatient department with Limbatril].
Topics: Amitriptyline; Autonomic Nervous System; Chlordiazepoxide; Dysmenorrhea; Female; Humans; Menopause; | 1968 |