amitriptyline has been researched along with Shingles in 39 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-two patients older than 60 years of age who received a diagnosis of herpes zoster (HZ) were entered into a randomized, double-blind, placebo-controlled trial of daily amitriptyline 25 mg." | 9.08 | The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. ( Bowsher, D, 1997) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 9.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN)." | 9.07 | Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. ( Birkett, N; Chipman, M; Evans, RJ; Reed, K; Watson, PNC, 1992) |
| "In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12." | 9.06 | Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. ( Culnane, M; Dubner, R; Gracely, RH; Max, MB; Schafer, SC; Smoller, B, 1988) |
| "This retrospective study was designed to assess the effects of acyclovir treatment of acute herpes zoster on subsequent postherpetic neuralgia, and to examine the effects of amitriptyline in the treatment of postherpetic neuralgia." | 7.68 | Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline. ( Bowsher, D, 1992) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 7.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 6.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 5.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| "Seventy-two patients older than 60 years of age who received a diagnosis of herpes zoster (HZ) were entered into a randomized, double-blind, placebo-controlled trial of daily amitriptyline 25 mg." | 5.08 | The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. ( Bowsher, D, 1997) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 5.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN)." | 5.07 | Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. ( Birkett, N; Chipman, M; Evans, RJ; Reed, K; Watson, PNC, 1992) |
| "In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12." | 5.06 | Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. ( Culnane, M; Dubner, R; Gracely, RH; Max, MB; Schafer, SC; Smoller, B, 1988) |
| " 2 weeks prior to his symptoms, he had developed right-sided cervical herpes zoster for which he was prescribed oral acyclovir by his general practitioner." | 3.85 | A rash and a rare cause of unilateral diaphragmatic paralysis. ( Ashkir, ZM; Tsaknis, G, 2017) |
| "We conducted a single-center, retrospective observational study, and evaluated 87 patients (65 amitriptyline, 22 nortriptyline) who underwent 12-lead electrocardiogram (ECG) examinations both before and after receiving TCAs for herpes zoster pain or postherpetic neuralgia from May 2007 to January 2012." | 3.80 | Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval. ( Funai, Y; Funao, T; Hase, I; Ikenaga, K; Nishikawa, K; Takahashi, R, 2014) |
| " She was diagnosed with motor radiculopathy following herpes zoster infection that was effectively managed by physiotherapy and amitriptyline." | 3.78 | Motor radiculopathy. ( Camilleri, J; Khan, A, 2012) |
| "This retrospective study was designed to assess the effects of acyclovir treatment of acute herpes zoster on subsequent postherpetic neuralgia, and to examine the effects of amitriptyline in the treatment of postherpetic neuralgia." | 3.68 | Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline. ( Bowsher, D, 1992) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 3.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "The most common risk factor for shingles and its potential sequela, PHN, is advanced age." | 2.42 | Post-herpetic neuralgia case study: optimizing pain control. ( Baron, R, 2004) |
| "Our goal was to determine if any treatment of acute herpes zoster alters the incidence or duration of postherpetic neuralgia (PHN), a common sequela in elderly patients." | 2.41 | Does treatment of acute herpes zoster prevent or shorten postherpetic neuralgia? ( Alper, BS; Lewis, PR, 2000) |
| "Postherpetic neuralgia is defined as pain persisting, or recurring, at the site of shingles at least three months after the onset of the acute rash." | 2.40 | The management of postherpetic neuralgia. ( Bowsher, D, 1997) |
| "However, patients with PHN whose acute shingles were treated with aciclovir obtain pain relief with antidepressants in half the time required by those patients who did not receive aciclovir for their acute shingles." | 2.39 | Post-herpetic neuralgia in older patients. Incidence and optimal treatment. ( Bowsher, D, 1994) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 2.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "The acute course of herpes zoster is generally benign, but systemic complications may be fatal." | 2.38 | Treatment of herpes zoster and postherpetic neuralgia. ( Carmichael, JK, 1991) |
| " Nine adverse drug reactions, mostly mild, nonserious, and nonpreventable, were reported." | 1.48 | An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster-Associated Pain. ( Desai, CK; Desai, MK; Kapadia, JD; Nayak, MK; Shah, BJ, 2018) |
| "A 62-year-old-man treated for nephrotic syndrome with steroid developed acute pain of herpes zoster after immobility of the shoulder." | 1.38 | [Case of acute pain of herpes zoster with preceding immobility of the shoulder]. ( Takekawa, K, 2012) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 1.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.51) | 18.7374 |
| 1990's | 16 (41.03) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nayak, MK | 1 |
| Kapadia, JD | 1 |
| Desai, CK | 1 |
| Desai, MK | 1 |
| Shah, BJ | 1 |
| Funai, Y | 1 |
| Funao, T | 1 |
| Ikenaga, K | 1 |
| Takahashi, R | 1 |
| Hase, I | 1 |
| Nishikawa, K | 1 |
| Griffin, JR | 1 |
| Davis, MD | 1 |
| Ashkir, ZM | 1 |
| Tsaknis, G | 1 |
| Takekawa, K | 1 |
| Khan, A | 1 |
| Camilleri, J | 1 |
| Lancaster, T | 2 |
| Wareham, D | 3 |
| Yaphe, J | 2 |
| Herr, H | 1 |
| Baron, R | 1 |
| Weis, O | 1 |
| Sriwatanakul, K | 1 |
| Weintraub, M | 1 |
| Bowsher, D | 4 |
| Rudra, A | 1 |
| Mitra, A | 1 |
| Pan, AK | 1 |
| Roy, M | 1 |
| Hassan, I | 1 |
| Donohue, JH | 1 |
| Bryson, HM | 1 |
| Wilde, MI | 1 |
| Chasuk, R | 1 |
| Scholz, MJ | 1 |
| Watson, CP | 1 |
| Vernich, L | 1 |
| Chipman, M | 2 |
| Reed, K | 2 |
| Marples, IL | 1 |
| Murray, P | 1 |
| Alper, BS | 1 |
| Lewis, PR | 1 |
| Graff-Radford, SB | 1 |
| Shaw, LR | 1 |
| Naliboff, BN | 1 |
| Marshall, T | 1 |
| Raftery, H | 1 |
| Herxheimer, A | 1 |
| Avery, AJ | 1 |
| Reeves, J | 1 |
| Gonzales, GR | 1 |
| Carmichael, JK | 1 |
| Watson, PNC | 1 |
| Evans, RJ | 2 |
| Birkett, N | 1 |
| Bianchetti, L | 1 |
| Watson, CPN | 1 |
| Max, MB | 1 |
| Schafer, SC | 1 |
| Culnane, M | 1 |
| Smoller, B | 1 |
| Dubner, R | 1 |
| Gracely, RH | 1 |
| Milligan, NS | 1 |
| Nash, TP | 1 |
| Woodforde, JM | 1 |
| Dwyer, B | 1 |
| McEwen, BW | 1 |
| De Wilde, FW | 1 |
| Bleasel, K | 1 |
| Connelley, TJ | 1 |
| Ho, CY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
10 reviews available for amitriptyline and Shingles
| Article | Year |
|---|---|
Postherpetic neuralgia.
Topics: Amitriptyline; Analgesics; Antiviral Agents; Herpes Zoster; Humans; Neuralgia; Randomized Controlled | 2002 |
Post-herpetic neuralgia case study: optimizing pain control.
Topics: Acetates; Aged; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarb | 2004 |
Postherpetic neuralgia.
Topics: Acyclovir; Adrenal Cortex Hormones; Amitriptyline; Antidepressive Agents, Tricyclic; Antiviral Agent | 2003 |
Postherpetic neuralgia.
Topics: 2-Aminopurine; Acyclovir; Adrenal Cortex Hormones; Adult; Amines; Amitriptyline; Analgesics, Non-Nar | 2003 |
Post-herpetic neuralgia in older patients. Incidence and optimal treatment.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Herpes Zoster; Humans; Incidence; Midd | 1994 |
Postherpetic neuralgia and its managements.
Topics: Amitriptyline; Analgesics; Desipramine; Herpes Zoster; Humans; India; Neuralgia | 1993 |
Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states.
Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Chronic Di | 1996 |
The management of postherpetic neuralgia.
Topics: Acyclovir; Amitriptyline; Analgesics; Antidepressive Agents; Antiviral Agents; Herpes Zoster; Humans | 1997 |
Does treatment of acute herpes zoster prevent or shorten postherpetic neuralgia?
Topics: Acute Disease; Acyclovir; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antiviral Agents; Drug Ther | 2000 |
Treatment of herpes zoster and postherpetic neuralgia.
Topics: Acupuncture Therapy; Acyclovir; Amitriptyline; Anesthetics, Local; Anticonvulsants; Antipsychotic Ag | 1991 |
6 trials available for amitriptyline and Shingles
| Article | Year |
|---|---|
The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Aged; Aged, 80 and over; Amitriptyline; Chi-Square Distribution; Dose- | 1997 |
Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial.
Topics: Aged; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Cross-Over Studies; Depre | 1998 |
Amitriptyline and fluphenazine in the treatment of postherpetic neuralgia.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Anxiety; Dose-Response | 2000 |
Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial.
Topics: Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Female; Herpes Zoster; Humans; Male; Ma | 1992 |
A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Drug Therapy, Combination; Female; Herpes Zost | 1985 |
Amitriptyline, but not lorazepam, relieves postherpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Female; Herpes Zoster; Humans; Lorazepam; Male; Mid | 1988 |
23 other studies available for amitriptyline and Shingles
| Article | Year |
|---|---|
An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster-Associated Pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; | 2018 |
Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Electrocardiog | 2014 |
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
A rash and a rare cause of unilateral diaphragmatic paralysis.
Topics: Acyclovir; Amitriptyline; Diaphragm; Exanthema; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; | 2017 |
[Case of acute pain of herpes zoster with preceding immobility of the shoulder].
Topics: Acute Pain; Amitriptyline; Anticonvulsants; Antidepressive Agents; Autonomic Nerve Block; Herpes Zos | 2012 |
Motor radiculopathy.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Female; Gait Disorders, Neurologic; Herpes Zoster; Humans; | 2012 |
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans; | 2002 |
Prognostic factors of postherpetic neuralgia.
Topics: Acyclovir; Adolescent; Adult; Aged; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepr | 2002 |
Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine.
Topics: Adult; Aged; Amitriptyline; Drug Combinations; Female; Herpes Zoster; Humans; Male; Middle Aged; Neu | 1982 |
Herpes zoster mistaken for biliary colic and treated by laparoscopic cholecystectomy: a cautionary case report.
Topics: Aged; Amitriptyline; Analgesics; Anti-Inflammatory Agents; Antiviral Agents; Cholecystectomy, Laparo | 1996 |
Treatments for postherpetic neuralgia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Capsaicin; Desipramine; Herpes Zoster; Humans; Meta | 1997 |
Managing the aftermath of shingles.
Topics: Acyclovir; Amitriptyline; Antidepressive Agents, Tricyclic; Antiviral Agents; Drug Therapy, Combinat | 1998 |
Neuropathic pain.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Antiviral Agents; Cyclohexanecarboxylic Acids; Drug The | 1999 |
Postherpetic neuralgia. Treatment with amitriptyline is cheaper than with aciclovir.
Topics: Acyclovir; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antiviral Agents; Drug Costs; Herpes Zoste | 2001 |
The management of post herpetic pain using sodium valproate and amitriptyline.
Topics: Amitriptyline; Herpes Zoster; Humans; Pain; Valproic Acid | 1979 |
Shingles: a belt of roses from Hell.
Topics: Amitriptyline; Anticonvulsants; Herpes Zoster; Humans; Immunosuppression Therapy; Prednisolone | 1979 |
Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline.
Topics: Acute Disease; Acyclovir; Aged; Amitriptyline; Herpes Zoster; Humans; Middle Aged; Neuralgia; Retros | 1992 |
Acute herpes zoster, postherpetic neuralgia, acyclovir and amitriptyline.
Topics: Acyclovir; Amitriptyline; Herpes Zoster; Humans; Neuralgia | 1992 |
Acute herpes zoster, postherpetic neuralgia, acyclovir and amitriptyline.
Topics: Acute Disease; Acyclovir; Amitriptyline; Herpes Zoster; Humans; Neuralgia | 1992 |
Postherpes simplex type 1 neuralgia simulating postherpetic neuralgia.
Topics: Amitriptyline; Chronic Disease; Diagnosis, Differential; Female; Herpes Simplex; Herpes Zoster; Huma | 1992 |
[Drug therapy of so-called postherpetic neuralgia, the only valid alternative. Clinical experience in 43 treated cases].
Topics: Administration, Oral; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; D | 1986 |
Treatment of post-herpetic neuralgia. A review of 77 consecutive cases.
Topics: Adult; Aged; Amitriptyline; Analgesics; Autonomic Nerve Block; Carbamazepine; Combined Modality Ther | 1985 |
Treatment of post-herpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Female; Herpes Zoster; Humans; Male; Middle Aged; | 1965 |