amitriptyline has been researched along with Serotonin Syndrome in 16 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate." | 7.77 | Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. ( Mestres, J; Oprea, TI; Seifert, SA, 2011) |
| "A case of venlafaxine-induced serotonin syndrome is described with relapse following the introduction of amitriptyline, despite a 2-week period between the discontinuation of one drug and the commencement of the other." | 7.70 | Venlafaxine-induced serotonin syndrome with relapse following amitriptyline. ( Perry, NK, 2000) |
| "Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications." | 5.33 | Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. ( Brown, DR; Keegan, MT; Rabinstein, AA, 2006) |
| " We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone." | 3.79 | Neuropsychiatric side effects of cyclobenzaprine. ( Sederholm, B; Shprecher, D; Sloan, CT, 2013) |
| "The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate." | 3.77 | Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. ( Mestres, J; Oprea, TI; Seifert, SA, 2011) |
| "A case of venlafaxine-induced serotonin syndrome is described with relapse following the introduction of amitriptyline, despite a 2-week period between the discontinuation of one drug and the commencement of the other." | 3.70 | Venlafaxine-induced serotonin syndrome with relapse following amitriptyline. ( Perry, NK, 2000) |
| "The serotonin syndrome is a rare toxicological emergency increasingly seen in emergency practice, secondary to increased use of proserotinergic drugs." | 1.35 | Serotonin syndrome in a patient taking Lexapro and Flexeril: a case report. ( Day, LT; Jeanmonod, RK, 2008) |
| "Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications." | 1.33 | Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs. ( Brown, DR; Keegan, MT; Rabinstein, AA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prakash, S | 1 |
| Adroja, B | 1 |
| Parekh, H | 1 |
| Ellison, C | 1 |
| Lyndon, S | 1 |
| Shprecher, D | 1 |
| Sloan, CT | 1 |
| Sederholm, B | 1 |
| Picksak, G | 1 |
| Stichtenoth, DO | 1 |
| May, M | 1 |
| Kawai, Y | 1 |
| DeMonbrun, AG | 1 |
| Chambers, RS | 1 |
| Nolan, DA | 1 |
| Dolcourt, BA | 1 |
| Malas, NM | 1 |
| Quasney, MW | 1 |
| Day, LT | 1 |
| Jeanmonod, RK | 1 |
| Gillman, PK | 1 |
| Mestres, J | 1 |
| Seifert, SA | 1 |
| Oprea, TI | 1 |
| Abernethy, DR | 1 |
| Bai, JP | 1 |
| Burkhart, K | 1 |
| Xie, HG | 1 |
| Zhichkin, P | 1 |
| Lamberg, JJ | 1 |
| Gordin, VN | 1 |
| Dougherty, JA | 1 |
| Young, H | 1 |
| Shafi, T | 1 |
| Kitson, R | 1 |
| Carr, B | 1 |
| Gillman, K | 1 |
| Rachid, F | 1 |
| Golaz, J | 1 |
| Bondolfi, G | 1 |
| Bertschy, G | 1 |
| Keegan, MT | 1 |
| Brown, DR | 1 |
| Rabinstein, AA | 1 |
| Perry, NK | 1 |
16 other studies available for amitriptyline and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome in patients with headache disorders.
Topics: Acetaminophen; Adult; Amitriptyline; Analgesics; Cluster Headache; Drug Therapy, Combination; Flunar | 2017 |
Staying Topical: An Unusual Case of Serotonin Syndrome.
Topics: Amitriptyline; Female; Humans; Middle Aged; Neck Pain; Serotonin Syndrome | 2017 |
Neuropsychiatric side effects of cyclobenzaprine.
Topics: Amitriptyline; Antidepressive Agents; Delirium; Humans; Male; Middle Aged; Movement Disorders; Muscl | 2013 |
[Sweating under polypharmacy with tramadol, amitriptyline and duloxetine?].
Topics: Amitriptyline; Analgesics, Opioid; Antidepressive Agents; Antidepressive Agents, Tricyclic; Duloxeti | 2013 |
A Previously Healthy Adolescent With Acute Encephalopathy and Decorticate Posturing.
Topics: Acute Febrile Encephalopathy; Adolescent; Amitriptyline; Brain; Bupropion; Decerebrate State; Diagno | 2017 |
Serotonin syndrome in a patient taking Lexapro and Flexeril: a case report.
Topics: Adult; Amitriptyline; Citalopram; Female; Humans; Selective Serotonin Reuptake Inhibitors; Serotonin | 2008 |
Is there sufficient evidence to suggest cyclobenzaprine might be implicated in causing serotonin toxicity?
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Overdose; Humans; Selective Serotonin Reuptake | 2009 |
Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Norepinephrine Plasma Membrane Transport Pr | 2011 |
Integration of diverse data sources for prediction of adverse drug events.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Serotonin Syndrome | 2011 |
Serotonin syndrome in a patient with chronic pain polypharmacy.
Topics: Adult; Amitriptyline; Anti-Allergic Agents; Antidepressive Agents; Carisoprodol; Cetirizine; Chronic | 2014 |
Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine.
Topics: Adult; Amitriptyline; Analgesics; Antifungal Agents; Cyclohexanols; Drug Interactions; Female; Fluco | 2002 |
Tramadol and severe serotonin syndrome.
Topics: Aged; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Drug Interactions; Female | 2005 |
A response to 'Tramadol and severe serotonin syndrome'.
Topics: Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Drug Interactions; Humans; Sero | 2006 |
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs.
Topics: Aged; Amitriptyline; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; | 2006 |
Venlafaxine-induced serotonin syndrome with relapse following amitriptyline.
Topics: Adrenergic Uptake Inhibitors; Aged; Amitriptyline; Antidepressive Agents, Second-Generation; Cyclohe | 2000 |