amitriptyline has been researched along with Sepsis in 4 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary analysis quantified opioid overdose risk across 7 prescription opioid-skeletal muscle relaxant therapies and a negative control outcome (sepsis) to assess potential confounding by unmeasured illicit opioid use." | 1.72 | Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants. ( Barnett, ML; Bykov, K; Gagne, JJ; Glynn, RJ; Khan, NF; Vine, SM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, NF | 1 |
| Bykov, K | 1 |
| Barnett, ML | 1 |
| Glynn, RJ | 1 |
| Vine, SM | 1 |
| Gagne, JJ | 1 |
| Xia, BT | 2 |
| Beckmann, N | 3 |
| Winer, LK | 2 |
| Kim, Y | 1 |
| Goetzman, HS | 1 |
| Veile, RE | 1 |
| Gulbins, E | 3 |
| Goodman, MD | 1 |
| Nomellini, V | 2 |
| Caldwell, CC | 2 |
| Pugh, AM | 1 |
| Pritts, TA | 1 |
| Peng, H | 1 |
| Li, C | 1 |
| Kadow, S | 1 |
| Henry, BD | 1 |
| Steinmann, J | 1 |
| Becker, KA | 1 |
| Riehle, A | 1 |
| Wilker, B | 1 |
| Li, PL | 1 |
| Pritts, T | 1 |
| Edwards, MJ | 1 |
| Zhang, Y | 1 |
| Grassmé, H | 1 |
4 other studies available for amitriptyline and Sepsis
| Article | Year |
|---|---|
Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.
Topics: Amitriptyline; Analgesics, Opioid; Baclofen; Benzodiazepines; Carisoprodol; Chlorzoxazone; Cohort St | 2022 |
Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.
Topics: Amitriptyline; Animals; Blood Coagulation Disorders; Disease Models, Animal; Gene Expression Regulat | 2019 |
Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.
Topics: Amitriptyline; Animals; Bronchoalveolar Lavage Fluid; Ceramides; Chemokine CCL2; Cytokines; Disease | 2019 |
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
Topics: Amitriptyline; Animals; Anti-Bacterial Agents; Ceramides; Enzyme Inhibitors; Gene Knockout Technique | 2015 |