amitriptyline has been researched along with Sensitivity and Specificity in 28 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Painful bladder syndrome/interstitial cystitis (PBS/IC) is a controversial subject." | 2.44 | What's new in the diagnosis and management of painful bladder syndrome/interstitial cystitis? ( Seth, A; Teichman, JM, 2008) |
| "Five modified multivariate calibration models based on classical least squares (CLS) in addition to traditional CLS model are developed and validated for assaying cyclobenzaprine HCl (CZ) with its major degradants; dibenzocycloheptatrienone (DZ) and anthraquinone (AQ), whether in its pure form or in pharmaceutical dosage form." | 1.48 | Five modified classical least squares based models for stability indicating analysis of cyclobenzaprine HCl with its major degradation products: A comparative study. ( Darwish, HW; Darwish, IA; Naguib, IA, 2018) |
| "A sensitive, rapid and simple liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS/MS) method was developed for the quantitative determination of cyclobenzaprine in human plasma, to study the pharmacokinetic behavior of cyclobenzaprine capsule in healthy Chinese volunteers." | 1.38 | Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study. ( Chen, X; Jiang, H; Li, D; Peng, K; Qian, Z; Xiang, Y; Zheng, H; Zhou, L, 2012) |
| "Amitriptyline was used as internal standard." | 1.37 | [Determination of doxepin in whole blood by SPE-LC-MS/MS]. ( Gong, FJ; Wu, ZP; Yan, SM; Zhang, RS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 12 (42.86) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Darwish, HW | 1 |
| Naguib, IA | 1 |
| Darwish, IA | 1 |
| Walash, MI | 1 |
| El Abass Mohamed, SA | 1 |
| Zheng, Y | 1 |
| Wang, Q | 1 |
| Wang, X | 2 |
| Chen, Y | 1 |
| Zhang, X | 1 |
| Bai, Z | 1 |
| Han, X | 1 |
| Zhang, Z | 1 |
| Zad, ZR | 1 |
| Davarani, SSH | 1 |
| Taheri, AR | 1 |
| Bide, Y | 1 |
| Yazdi, AS | 1 |
| Razavi, N | 1 |
| Yazdinejad, SR | 1 |
| Jiang, Z | 1 |
| Smith, NW | 1 |
| Ferguson, PD | 1 |
| Taylor, MR | 1 |
| Seth, A | 1 |
| Teichman, JM | 1 |
| Xiong, C | 1 |
| Ruan, J | 1 |
| Cai, Y | 1 |
| Tang, Y | 1 |
| Rousu, T | 1 |
| Herttuainen, J | 1 |
| Tolonen, A | 1 |
| Bhatt, M | 1 |
| Shah, S | 1 |
| Xiang, Y | 1 |
| Zhou, L | 1 |
| Qian, Z | 1 |
| Peng, K | 1 |
| Li, D | 1 |
| Chen, X | 1 |
| Jiang, H | 1 |
| Zheng, H | 1 |
| Gong, FJ | 1 |
| Yan, SM | 1 |
| Wu, ZP | 1 |
| Zhang, RS | 1 |
| Mallet, CR | 1 |
| Lu, Z | 1 |
| Fisk, R | 1 |
| Mazzeo, JR | 1 |
| Neue, UD | 1 |
| Nenov, VD | 1 |
| Marinov, P | 1 |
| Sabeva, J | 1 |
| Nenov, DS | 1 |
| Quisel, A | 1 |
| Gill, J | 1 |
| Walters, D | 1 |
| Estorch, M | 1 |
| Carrió, I | 1 |
| Mena, E | 1 |
| Flotats, A | 1 |
| Camacho, V | 1 |
| Fuertes, J | 1 |
| Kulisewsky, J | 1 |
| Narula, J | 1 |
| Cantú, MD | 1 |
| Toso, DR | 1 |
| Lacerda, CA | 1 |
| Lanças, FM | 1 |
| Carrilho, E | 1 |
| Queiroz, ME | 1 |
| Samanidou, VF | 1 |
| Nika, MK | 1 |
| Papadoyannis, IN | 1 |
| Perry, PJ | 1 |
| Zeilmann, C | 1 |
| Arndt, S | 1 |
| Adamczyk, M | 1 |
| Fishpaugh, J | 1 |
| Harrington, C | 1 |
| Hartter, D | 1 |
| Johnson, D | 1 |
| Vanderbilt, A | 1 |
| Ulrich, S | 1 |
| Isensee, T | 1 |
| Pester, U | 1 |
| Ghahramani, P | 1 |
| Lennard, MS | 1 |
| Aymard, G | 1 |
| Livi, P | 1 |
| Pham, YT | 1 |
| Diquet, B | 1 |
| de la Torre, R | 1 |
| Ortuño, J | 1 |
| Pascual, JA | 1 |
| González, S | 1 |
| Ballesta, J | 1 |
| Kaivosaari, S | 1 |
| Salonen, JS | 1 |
| Mortensen, J | 1 |
| Taskinen, J | 1 |
| Heard, K | 1 |
| Cain, BS | 1 |
| Dart, RC | 1 |
| Cairns, CB | 1 |
| Hultén, BA | 1 |
| Heath, A | 1 |
| Knudsen, K | 1 |
| Nyberg, G | 1 |
| Svensson, C | 1 |
| Mårtensson, E | 1 |
| Krulík, R | 1 |
| Exner, J | 1 |
| Fuksová, K | 1 |
| Píchová, D | 1 |
| Beitlová, D | 1 |
| Sikora, J | 1 |
4 reviews available for amitriptyline and Sensitivity and Specificity
| Article | Year |
|---|---|
What's new in the diagnosis and management of painful bladder syndrome/interstitial cystitis?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Cystoscopy; Glycoproteins; Humans; | 2008 |
Current applications of plasmapheresis in clinical toxicology.
Topics: Amitriptyline; Female; Humans; Male; Mushroom Poisoning; Paraquat; Plasmapheresis; Poisoning; Risk A | 2003 |
Exercise and antidepressants improve fibromyalgia.
Topics: Amitriptyline; Antidepressive Agents; Complementary Therapies; Exercise; Fibromyalgia; Humans; Medic | 2004 |
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depres | 1994 |
1 trial available for amitriptyline and Sensitivity and Specificity
| Article | Year |
|---|---|
Challenging the neuronal MIBG uptake by pharmacological intervention: effect of a single dose of oral amitriptyline on regional cardiac MIBG uptake.
Topics: 3-Iodobenzylguanidine; Administration, Oral; Aged; Aged, 80 and over; Amitriptyline; Antidepressive | 2004 |
23 other studies available for amitriptyline and Sensitivity and Specificity
| Article | Year |
|---|---|
Five modified classical least squares based models for stability indicating analysis of cyclobenzaprine HCl with its major degradation products: A comparative study.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Drug Stability; Least-Squares Analysis; Linear | 2018 |
Green analytical chromatographic assay method for quantitation of cyclobenzaprine in tablets, spiked human urine and in-vitro dissolution test.
Topics: Amitriptyline; Chromatography, High Pressure Liquid; Gastric Juice; Green Chemistry Technology; Guid | 2019 |
Development and Application of Zirconia Coated Paper Substrate for High Sensitivity Analysis of Therapeutic Drugs in Dried Blood Spots.
Topics: Amitriptyline; Animals; Cattle; Dried Blood Spot Testing; Heterocyclic Compounds; Humans; Mass Spect | 2016 |
Highly selective determination of amitriptyline using Nafion-AuNPs@branched polyethyleneimine-derived carbon hollow spheres in pharmaceutical drugs and biological fluids.
Topics: Amitriptyline; Conductometry; Equipment Design; Equipment Failure Analysis; Fluorocarbon Polymers; G | 2016 |
Separation and determination of amitriptyline and nortriptyline by dispersive liquid-liquid microextraction combined with gas chromatography flame ionization detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Blood Chemical Analysis; Carbon Tetrachloride; Chro | 2008 |
Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC.
Topics: Acrylates; Amitriptyline; Aniline Compounds; Chromatography, High Pressure Liquid; Chromatography, I | 2008 |
Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Topics: Amitriptyline; Calibration; Chromatography, High Pressure Liquid; Clomipramine; Drug Combinations; D | 2009 |
Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds.
Topics: Amitriptyline; Biochemical Phenomena; Drug Discovery; False Negative Reactions; Humans; Mass Spectro | 2010 |
Development and validation of amitriptyline and its metabolite in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study.
Topics: Amitriptyline; Antidepressive Agents; Chromatography, High Pressure Liquid; Humans; Male; Sensitivit | 2010 |
Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.
Topics: Amitriptyline; Chromatography, Liquid; Citalopram; Drug Stability; Humans; Linear Models; Liquid-Liq | 2012 |
[Determination of doxepin in whole blood by SPE-LC-MS/MS].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomarkers; Chromatography, Liquid; Doxepin; Drug O | 2011 |
Performance of an ultra-low elution-volume 96-well plate: drug discovery and development applications.
Topics: Amitriptyline; Animals; Calibration; Chemical Precipitation; Chromatography, Liquid; Drug Evaluation | 2003 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liq | 2006 |
Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chemistry Techniques, Analytical; Chromatography, H | 2007 |
Immunoassay reagents for psychoactive drugs. I. The method for the development of antibodies specific to amitriptyline and nortriptyline.
Topics: Amitriptyline; Animals; Antibodies; Antibody Specificity; Chlorpromazine; Cross Reactions; Fluoresce | 1993 |
Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Drug Monitoring; | 1996 |
Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography.
Topics: Administration, Oral; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chromatography, High | 1996 |
Sensitive and rapid method for the simultaneous quantification of five antidepressants with their respective metabolites in plasma using high-performance liquid chromatography with diode-array detection.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatog | 1997 |
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Dru | 1998 |
High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.
Topics: Aminobiphenyl Compounds; Amitriptyline; Chromatography, High Pressure Liquid; Glucuronides; Glucuron | 2001 |
Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system.
Topics: Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Culture Techniques; Desiprami | 2001 |
Amitriptyline and amitriptyline metabolites in blood and cerebrospinal fluid following human overdose.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Dialysis; Drug Overdose; Erythrocytes; F | 1992 |
Radioimmunoassay of dibenzazepines and dibenzcycloheptanodienes in body fluids and tissues.
Topics: Amitriptyline; Erythrocyte Membrane; Humans; Imipramine; Ligands; Radioimmunoassay; Reproducibility | 1991 |