amitriptyline has been researched along with Retinal Diseases in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The accumulation of a nontoxic drug in the eye is not necessarily of clinical significance, but ocular damage can occur in patients on long-term tricyclic agents when the amount, duration, and frequency of dosage are sufficiently high." | 2.36 | Ocular accumulation and toxicity of certain systemically administered drugs. ( Mason, CG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mason, CG | 1 |
| Lüllmann-Rauch, R | 1 |
1 review available for amitriptyline and Retinal Diseases
| Article | Year |
|---|---|
Ocular accumulation and toxicity of certain systemically administered drugs.
Topics: Amitriptyline; Animals; Chloroquine; Cornea; Eye; Eye Diseases; Female; Haplorhini; Humans; Lens, Cr | 1977 |
1 other study available for amitriptyline and Retinal Diseases
| Article | Year |
|---|---|
Retinal lesions in rat after treatment with chlorphentermine or with tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Appetite Depressants; Chlorphentermine; Cytoplasm; Di | 1974 |