amitriptyline has been researched along with Restless Legs Syndrome in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 7.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 3.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goerke, M | 1 |
| Rodenbeck, A | 1 |
| Cohrs, S | 1 |
| Kunz, D | 1 |
| Sandyk, R | 1 |
| Iacono, RP | 1 |
| Bamford, CR | 1 |
1 trial available for amitriptyline and Restless Legs Syndrome
| Article | Year |
|---|---|
The influence of the tricyclic antidepressant amitriptyline on periodic limb movements during sleep.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug | 2013 |
1 other study available for amitriptyline and Restless Legs Syndrome
| Article | Year |
|---|---|
Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease.
Topics: Amitriptyline; Humans; Male; Middle Aged; Parkinson Disease; Restless Legs Syndrome; Spinal Cord; Sy | 1988 |