amitriptyline has been researched along with Pulmonary Fibrosis in 5 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of pulmonary fibrosis caused by paraquat (PQ) poisoning remains problematic." | 8.31 | Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis. ( Chen, J; Cheng, B; Jian, X; Li, C, 2023) |
| "Amitriptyline is a tricyclic antidepressant that was suggested to have antifibrotic potential." | 5.51 | Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2. ( Abdelhamid, AM; Haridy, AR; Zaafan, MA, 2019) |
| "Treatment of pulmonary fibrosis caused by paraquat (PQ) poisoning remains problematic." | 4.31 | Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis. ( Chen, J; Cheng, B; Jian, X; Li, C, 2023) |
| "Amitriptyline is a tricyclic antidepressant that was suggested to have antifibrotic potential." | 1.51 | Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2. ( Abdelhamid, AM; Haridy, AR; Zaafan, MA, 2019) |
| " However this increased prescribing was not specific to any particular class of antidepressant or individual drug, and there was no evidence of a dose-response relationship between exposure to amitriptyline (the most commonly prescribed antidepressant) and disease." | 1.31 | Exposure to antidepressants and the risk of cryptogenic fibrosing alveolitis: a case-control study. ( Britton, J; Hubbard, R; Venn, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Jian, X | 1 |
| Li, C | 1 |
| Cheng, B | 1 |
| Zaafan, MA | 1 |
| Haridy, AR | 1 |
| Abdelhamid, AM | 1 |
| Ziobro, R | 1 |
| Henry, B | 1 |
| Edwards, MJ | 1 |
| Lentsch, AB | 1 |
| Gulbins, E | 1 |
| Matek, W | 1 |
| Rösch, W | 1 |
| Becker, V | 1 |
| Hubbard, R | 1 |
| Venn, A | 1 |
| Britton, J | 1 |
5 other studies available for amitriptyline and Pulmonary Fibrosis
| Article | Year |
|---|---|
Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis.
Topics: Amitriptyline; Animals; Apoptosis; Cadherins; Caveolin 1; Interleukin-17; Lung; Mice; Mice, Inbred C | 2023 |
Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2.
Topics: Amitriptyline; Animals; Bleomycin; Lung; Male; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synt | 2019 |
Ceramide mediates lung fibrosis in cystic fibrosis.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Ceramides; Cystic Fibrosis; Cystic Fibrosis Tr | 2013 |
[Pathological changes in lungs and liver after therapy of ulcerative colitis].
Topics: Amitriptyline; Chlordiazepoxide; Colitis, Ulcerative; Humans; Jaundice; Male; Middle Aged; Penicilla | 1980 |
Exposure to antidepressants and the risk of cryptogenic fibrosing alveolitis: a case-control study.
Topics: Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Case-Control Studies; | 2000 |