Page last updated: 2024-10-22

amitriptyline and Psychoses, Drug

amitriptyline has been researched along with Psychoses, Drug in 28 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

ExcerptRelevanceReference
"This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression."5.29Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders? ( Kamijima, K; Miyaoka, H, 1995)
" The relative safety of different antidepressants has been assessed by looking at answers to the questions: how safe is the drug in overdose; how dangerous are its side effects at therapeutic dose; and does it have any dangerous interactions with other drugs or substances? Based on current data it can be said with reasonable confidence that fluvoxamine, fluoxetine, paroxetine and moclobemide are "safe" antidepressants, and mianserin and trazodone are also "safe" but to a lesser extent (mainly because of hypnosedation)."2.39Safety of antidepressants. ( de Jonghe, F; Swinkels, JA, 1995)
"Successful treatment of delirium depends on the detection of the reversible contributors."1.72Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016. ( Engel, R; Frey, R; Friedrich, ME; Grohmann, R; Kasper, S; Konstantinidis, A; Rabl, U; Seifert, J; Stübner, S; Toto, S; Winkler, D, 2022)
"This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression."1.29Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders? ( Kamijima, K; Miyaoka, H, 1995)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199023 (82.14)18.7374
1990's2 (7.14)18.2507
2000's1 (3.57)29.6817
2010's1 (3.57)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Friedrich, ME1
Grohmann, R1
Rabl, U1
Winkler, D1
Konstantinidis, A1
Engel, R1
Seifert, J1
Toto, S1
Stübner, S1
Frey, R1
Kasper, S1
Cohen, JY1
Guilbault, A1
Arnold, OH1
Krypsin-Exner, K1
Bach, O1
Kästner, I1
Beeber, AR1
Manring, JM1
Pies, R1
Van Sweden, B1
Dumon-Radermecker, M1
Antelman, SM1
Chiodo, LA1
Swinkels, JA1
de Jonghe, F1
Miyaoka, H1
Kamijima, K1
O'Neil, BA1
Knudson, GA1
Bhaskara, SM1
Rollin, P1
Antaki, AJ1
Waghray, S1
Granacher, RP1
Baldessarini, RJ2
Foerstl, J1
Hohagen, F1
Hewer, W1
Pohlmann-Eden, B1
Soloff, PH1
George, A1
Nathan, RS1
Schulz, PM1
Perel, JM1
Lajeunesse, BS1
Chiu, E1
Asnes, DP1
Knopp, W1
Man, PL1
Aleem, A1
O'Connel, GJ1
Campbell, PB1
Anath, JV1
Sedal, L1
Korman, MG1
Williams, PO1
Mushin, G1
Rawson, RA1
Lipscomb, WR1
Rozynko, J1
Davies, RK1
Tucker, GJ1
Harrow, M1
Detre, TP1
Aderhold, RM1
Muniz, CE1
Willmuth, RL1
Abenson, MH1

Reviews

2 reviews available for amitriptyline and Psychoses, Drug

ArticleYear
Safety of antidepressants.
    International clinical psychopharmacology, 1995, Volume: 9 Suppl 4

    Topics: Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug In

1995
[Poisoning due to tricyclic antidepressants in children and adolescents].
    Canadian Medical Association journal, 1979, Apr-21, Volume: 120, Issue:8

    Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Cardiovascular Diseases; Central Nervou

1979

Trials

2 trials available for amitriptyline and Psychoses, Drug

ArticleYear
Paradoxical effects of amitriptyline on borderline patients.
    The American journal of psychiatry, 1986, Volume: 143, Issue:12

    Topics: Aggression; Amitriptyline; Borderline Personality Disorder; Clinical Trials as Topic; Double-Blind M

1986
Psychiatric changes in patients treated with levodopa. I. The clinical experiment.
    Neurology, 1970, Volume: 20, Issue:12

    Topics: Activities of Daily Living; Adjustment Disorders; Aged; Amitriptyline; Clinical Trials as Topic; Dia

1970

Other Studies

24 other studies available for amitriptyline and Psychoses, Drug

ArticleYear
Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016.
    The international journal of neuropsychopharmacology, 2022, 08-04, Volume: 25, Issue:7

    Topics: Adverse Drug Reaction Reporting Systems; Amitriptyline; Antidepressive Agents; Antipsychotic Agents;

2022
Induction of Psychosis by Cyclobenzaprine.
    Psychopharmacology bulletin, 2018, 06-20, Volume: 48, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Borderline Personality Dis

2018
[Spontaneous and experimental delirium].
    Arzneimittel-Forschung, 1966, Volume: 16, Issue:2

    Topics: Alcoholism; Amitriptyline; Brain; Delirium; Hallucinations; Hallucinogens; Humans; Judgment; Psychos

1966
[Undesired drug side effects and drug-induced damage. II. Centrally acting drugs].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Jan-01, Volume: 39, Issue:1

    Topics: Adult; Amitriptyline; Autonomic Nervous System Diseases; Basal Ganglia Diseases; Central Nervous Sys

1984
Psychosis following cyclobenzaprine use.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:4

    Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Muscle Relaxants, Central; Psychoses, Substa

1983
Capgras phenomenon, delirium, and transient hepatic dysfunction.
    Hospital & community psychiatry, 1982, Volume: 33, Issue:5

    Topics: Adolescent; Amitriptyline; Capgras Syndrome; Chemical and Drug Induced Liver Injury; Delirium; Drug

1982
The EEG in chronic psychotropic drug intoxications.
    Clinical EEG (electroencephalography), 1982, Volume: 13, Issue:4

    Topics: Adult; Aged; Amitriptyline; Chlorpromazine; Chlorprothixene; Chronic Disease; Drug Therapy, Combinat

1982
Dopamine autoreceptor subsensitivity: a mechanism common to the treatment of depression and the induction of amphetamine psychosis.
    Biological psychiatry, 1981, Volume: 16, Issue:8

    Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents, Tricyclic; Apomorphine; Depressive Disor

1981
Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?
    International clinical psychopharmacology, 1995, Volume: 10, Issue:4

    Topics: Amitriptyline; Brain Diseases; Depressive Disorder; Follow-Up Studies; Humans; Male; Middle Aged; Ne

1995
First episode psychosis following cyclobenzaprine use.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:8

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Psychoses, Subst

2000
Capgras' syndrome and cerebral dysfunction.
    The British journal of psychiatry : the journal of mental science, 1978, Volume: 133

    Topics: Aged; Amitriptyline; Delusions; Humans; Male; Psychoses, Substance-Induced; Syndrome

1978
Physostigmine. Its use in acute anticholinergic syndrome with antidepressant and antiparkinson drugs.
    Archives of general psychiatry, 1975, Volume: 32, Issue:3

    Topics: Acute Disease; Adult; Amitriptyline; Benztropine; Chemical Phenomena; Chemistry; Cholinesterase Inhi

1975
Another case of Creutzfeldt-Jakob like syndrome due to antidepressant toxicity.
    Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:7

    Topics: Amitriptyline; Creutzfeldt-Jakob Syndrome; Depressive Disorder; Dose-Response Relationship, Drug; Fe

1989
[True and false adverse effects of thymoanaleptic medications].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Dec-08, Volume: 44, Issue:51

    Topics: Amitriptyline; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Cholestasis; Depressio

1968
Psychiatric aspects of disseminated lupus erythematosus in Hong Kong Chinese--report of three cases.
    The Australian and New Zealand journal of psychiatry, 1971, Volume: 5, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Amitriptyline; Chlorpromazine; Epilepsy

1971
Psychopharmacology in the aged. Use of major psychotropic medications in treatment of the elderly: case examples.
    Journal of geriatric psychiatry, 1974, Volume: 7, Issue:2

    Topics: Adjustment Disorders; Aged; Alzheimer Disease; Amitriptyline; Benztropine; Bipolar Disorder; Cataton

1974
Are MAOI and other psychotropic drugs really compatible?
    The British journal of psychiatry : the journal of mental science, 1972, Volume: 120, Issue:554

    Topics: Adult; Amitriptyline; Barbiturates; Chlorpromazine; Drug Interactions; Humans; Male; Monoamine Oxida

1972
Amitriptyline: initial intolerance and subsequent psychosis.
    Canadian Medical Association journal, 1972, Jan-22, Volume: 106, Issue:2

    Topics: Adjustment Disorders; Amitriptyline; Female; Humans; Middle Aged; Psychoses, Substance-Induced

1972
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
    The Medical journal of Australia, 1972, Jul-08, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block;

1972
Acute delirium in amitriptyline-perphenazine therapy of alcoholism.
    Clinical toxicology, 1971, Volume: 4, Issue:1

    Topics: Acute Disease; Adult; Alcoholism; Amitriptyline; Delirium; Diazepam; Drug Combinations; Hallucinatio

1971
Confusional episodes and antidepressant medication.
    The American journal of psychiatry, 1971, Volume: 128, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents; Child; Cognition Disorde

1971
Acute psychosis with amitriptyline and furazolidone.
    JAMA, 1970, Sep-21, Volume: 213, Issue:12

    Topics: Acute Disease; Amitriptyline; Bipolar Disorder; Diarrhea; Female; Furazolidone; Humans; Middle Aged;

1970
Psychotic reactions during amitriptyline therapy.
    Canadian Psychiatric Association journal, 1968, Volume: 13, Issue:6

    Topics: Adult; Amitriptyline; Depression; Female; Humans; Male; Middle Aged; Psychoses, Substance-Induced

1968
An analysis of urinary amine values on routine admissions to a mental hospital.
    Acta psychiatrica Scandinavica, 1965, Volume: 41, Issue:4

    Topics: Amines; Amitriptyline; Amphetamine; Chemical Phenomena; Chemistry; Chlorpromazine; Humans; In Vitro

1965