Page last updated: 2024-10-22

amitriptyline and Pregnancy

amitriptyline has been researched along with Pregnancy in 70 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" After excluding other diagnoses, we administered amitriptyline, which had been discontinued temporarily at the time of pregnancy diagnosis."7.81Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline. ( Kinugasa, M; Tamai, H, 2015)
"The study determined whether oral administration of amitriptyline for 6 weeks from before puberty to prenatally stressed (PS) male and female rats could prevent hyperanxiety in adulthood."7.72Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline. ( Poltyrev, T; Weinstock, M, 2004)
"Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain."3.91Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure. ( Baker, T; Burra, B; Datta, P; Hale, TW; Rewers-Felkins, K, 2019)
" After excluding other diagnoses, we administered amitriptyline, which had been discontinued temporarily at the time of pregnancy diagnosis."3.81Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline. ( Kinugasa, M; Tamai, H, 2015)
" Treatment with oral contraceptive (OC) for endometriosis and later with cyclophosphamide, methotrexate, fluorouracil (CMF) for breast cancer produced a higher number of attacks."3.74Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. ( Maggioni, F; Palmieri, A; Tropea, M; Zanchin, G, 2008)
"The study determined whether oral administration of amitriptyline for 6 weeks from before puberty to prenatally stressed (PS) male and female rats could prevent hyperanxiety in adulthood."3.72Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline. ( Poltyrev, T; Weinstock, M, 2004)
"d-Amphetamine and amitriptyline (AT) were administered daily to female rats from day 7 of pregnancy until birth of the litters."3.66The effect of d-amphetamine and amitriptyline administered to pregnant rats on the locomotor activity and neurotransmitters of the offspring. ( Biesold, D; Bigl, V; Dalitz, E; Kunert, E; Leonard, BE, 1982)
" We concluded that both tramadol and meperidine show a significantly faster response rate in the treatment of postepidural anesthetic shivering when compared with amitriptyline in the dosage used; tramadol had a decreased incidence of somnolence when compared with meperidine."2.70A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients. ( Chu, KS; Tsai, YC, 2001)
"Drug prevention of migraine is recommended if more than three attacks occur per month, acute drug treatment is insufficient, or very severe attacks with aura are the main problem."2.44[Alternatives to beta blockers in preventive migraine treatment]. ( Evers, S, 2008)
" Severe toxicity usually occurs at supratherapeutic plasma levels and might be prevented by tailoring the dosage according to the individual's drug hydroxylating capacity."2.37Clinical pharmacology of antidepressant drugs: pharmacogenetics. ( Bertilsson, L; Sjöqvist, F, 1984)
" The accumulation of a nontoxic drug in the eye is not necessarily of clinical significance, but ocular damage can occur in patients on long-term tricyclic agents when the amount, duration, and frequency of dosage are sufficiently high."2.36Ocular accumulation and toxicity of certain systemically administered drugs. ( Mason, CG, 1977)
"Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period."1.42Contribution of in utero drug exposure when interpreting hair results in young children. ( Kintz, P, 2015)
"Tricyclic antidepressants (TCAs) are the non-selective amine re-uptake inhibitors, well absorbed from small intestine, cross the blood-brain barrier, distributed in the brain, and are bound to glutathione S-transferase-π (GST-π)."1.37The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine. ( Dalmizrak, O; Kulaksiz-Erkmen, G; Ozer, N, 2011)
"Thanatophoric dwarfism is not as rare as once thought."1.28Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report. ( Meehan, FP; Rafla, NM, 1991)
" To determine the long term effects of cocaine on a developing fetus, gravid rats were dosed SC throughout pregnancy with either saline, amfonelic acid (AFA, 1."1.28Effects of prenatal exposure to cocaine or related drugs on rat developmental and neurological indices. ( Henderson, MG; McMillen, BA, 1990)
"Total external ophthalmoplegia, unresponsive to caloric stimulation, was observed in a gravid woman who had ingested approximately 1."1.26Amitriptyline-induced ophthalmoplegia. ( Schnapper, R; Spector, RH, 1981)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199037 (52.86)18.7374
1990's12 (17.14)18.2507
2000's10 (14.29)29.6817
2010's10 (14.29)24.3611
2020's1 (1.43)2.80

Authors

AuthorsStudies
Wang, XY1
Ying, XH1
Jiang, HY1
Dandjinou, M1
Sheehy, O1
Bérard, A1
Tang, KY1
Burra, B1
Datta, P1
Rewers-Felkins, K1
Baker, T1
Hale, TW1
Moreira, A1
Barbin, C1
Martinez, H1
Aly, A1
Fonseca, R1
Kintz, P1
Tamai, H1
Kinugasa, M1
Borras, L1
Constant, E1
De Timary, P1
Huguelet, P1
Khazaal, Y1
Evers, S1
Dalmizrak, O1
Kulaksiz-Erkmen, G1
Ozer, N1
Abdul Aziz, NH1
Kendall, DA1
Pardon, MC1
Hernández-Díaz, S1
Su, YC1
Mitchell, AA1
Kelley, KE1
Calafat, AM1
Hauser, R1
Lai, M1
McCormick, JA1
Chapman, KE1
Kelly, PA1
Seckl, JR1
Yau, JL1
Poltyrev, T1
Weinstock, M1
Wessler, I1
Herschel, S1
Bittinger, F1
Kirkpatrick, CJ1
Maggioni, F1
Palmieri, A1
Tropea, M1
Zanchin, G1
Rees, WD1
Bigl, V1
Dalitz, E1
Kunert, E1
Biesold, D1
Leonard, BE1
Rose, D1
Duron, B1
Sjöqvist, F1
Bertilsson, L1
Beyer, BK1
Guram, MS2
Geber, WF2
Damasio, H1
Brixen-Rasmussen, L1
Halgrener, J1
Jørgensen, A1
Gill, TS1
Spector, RH1
Schnapper, R1
Rasmussen, KL1
Reite, M1
Bader, TF1
Newman, K1
Henderson, MG3
McMillen, BA3
Breyer-Pfaff, U1
Nill, K1
Entenmann, KN1
Gaertner, HJ1
Watanabe, M1
Kodama, Y1
Hagino, Y1
Nonaka, R1
Kaichi, Y1
Alonso, SJ1
Castellano, MA1
Quintero, M1
Navarro, E1
Yung, M1
Herrema, I1
Heikkinen, T1
Ekblad, U1
Laine, K1
Roberts, LJ1
Goucke, CR1
Tsai, YC1
Chu, KS1
Friehe, H1
Fontaine, R1
Beumont, P1
Bruwer, J1
Pimstone, B1
Vinik, A1
Utian, W1
Mason, CG1
Erickson, SH1
Smith, GH1
Heidrich, F1
Mason, BD1
Van Petten, GR1
Shuey, DL1
Sadler, TW1
Lauder, JM1
Bal, AK1
Bird, MM2
Shimizu, M1
Nishida, A1
Yamawaki, S1
Welder, AA1
Grant, R1
Kutschke, RL1
Anthony, M1
Bradlaw, J1
Acosta, D1
McConnaughey, MM1
Rafla, NM1
Meehan, FP1
Bal-Klara, A1
Vree, PH1
Zwart, P1
Pittard, WB1
O'Neal, W1
Idänpään-Heikkilä, J1
Saxén, L1
Lanza, M1
Chichmanian, RM1
Goude, F1
Lewis, DO1
Morrow, AW2
Teisberg, P1
Hognestad, J1
Sarteschi, P1
Cassano, GB2
Placidi, GF1
Hill, RM1
Verniaud, WM1
Horning, MG1
McCulley, LB1
Morgan, NF1
Mascherpa, P2
Kuenssberg, EV1
Knox, JD1
Freeman, R1
Pitt, DB1
Wilkins, GD1
Hussain, MZ1
Harinath, M1
Murphy, J1
Di Carlo, R1
Pagnini, G1
Pelagalli, GV1
Scanlon, FJ1
Sjöstrand, SE1
Hansson, E1
Artner, J1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.[NCT00011713]1,474 participants (Actual)Observational1999-10-31Completed
Traitement Des Frissons Lors de la césarienne Sous anesthésie péridurale Durant le Travail - un Essai Clinique randomisé Comparant la dexmédétomidine et la mépéridine[NCT03115047]Phase 380 participants (Actual)Interventional2017-05-07Completed
Comparative Study Between Nefopam and Ondansteron for Prevention of Post Spinal Shivering. A Randomized Controlled Trial.[NCT04870541]Phase 4150 participants (Anticipated)Interventional2020-12-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for amitriptyline and Pregnancy

ArticleYear
Antidepressant use during pregnancy and the risk for gestational diabetes: a systematic review and meta-analysis.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2023, Volume: 36, Issue:1

    Topics: Amitriptyline; Antidepressive Agents; Diabetes, Gestational; Female; Humans; Pregnancy; Selective Se

2023
Prevention of migraine attacks. First-choice treatments.
    Prescrire international, 2015, Volume: 24, Issue:157

    Topics: Adrenergic beta-Antagonists; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tric

2015
[Long-term psychiatric consequences of carbon monoxide poisoning: a case report and literature review].
    La Revue de medecine interne, 2009, Volume: 30, Issue:1

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Carbon Monoxide Poisoning; Child, Pres

2009
[Alternatives to beta blockers in preventive migraine treatment].
    Der Nervenarzt, 2008, Volume: 79, Issue:10

    Topics: Adrenergic beta-Antagonists; Adult; Amitriptyline; Anticonvulsants; Botulinum Toxins, Type A; Calciu

2008
Clinical pharmacology of antidepressant drugs: pharmacogenetics.
    Advances in biochemical psychopharmacology, 1984, Volume: 39

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Depressive Disorder

1984
Drug management of adult vascular headaches (migraine and cluster headache): Part II--Prevention and attacks.
    Iowa medicine : journal of the Iowa Medical Society, 1984, Volume: 74, Issue:12

    Topics: Adult; Amitriptyline; Belladonna Alkaloids; Cluster Headache; Cyproheptadine; Drug Combinations; Erg

1984
Ocular accumulation and toxicity of certain systemically administered drugs.
    Journal of toxicology and environmental health, 1977, Volume: 2, Issue:5

    Topics: Amitriptyline; Animals; Chloroquine; Cornea; Eye; Eye Diseases; Female; Haplorhini; Humans; Lens, Cr

1977
The pharmacodynamics of depression and its relation to therapy.
    The British journal of clinical practice, 1974, Volume: 28, Issue:1

    Topics: Adrenal Glands; Amitriptyline; Animals; Biological Transport, Active; Blood-Brain Barrier; Brain Che

1974

Trials

2 trials available for amitriptyline and Pregnancy

ArticleYear
A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes

2001
A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes

2001
A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes

2001
A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthes

2001
Triavil and Etrafon.
    The Medical letter on drugs and therapeutics, 1966, Feb-25, Volume: 8, Issue:4

    Topics: Amitriptyline; Chlordiazepoxide; Clinical Trials as Topic; Depression; Diazepam; Female; Humans; Mep

1966

Other Studies

60 other studies available for amitriptyline and Pregnancy

ArticleYear
Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case-control study.
    BMJ open, 2019, 10-01, Volume: 9, Issue:9

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Case-Control Studies; Cohort Studies; Depre

2019
Amitriptyline poisoning at 34 weeks of pregnancy.
    Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Female; Humans; Pregnancy; Pregn

2018
Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure.
    Journal of human lactation : official journal of International Lactation Consultant Association, 2019, Volume: 35, Issue:3

    Topics: Adult; Amitriptyline; Breast Feeding; Diagnosis, Differential; Female; Humans; Infant, Newborn; Mass

2019
Maternal use of cyclobenzaprine (Flexeril) may induce ductal closure and persistent pulmonary hypertension in neonates.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:11

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Antidepressive Agents, Tricyclic; Ductus Arteriosus; Fem

2014
Contribution of in utero drug exposure when interpreting hair results in young children.
    Forensic science international, 2015, Volume: 249

    Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hai

2015
Pregnancy complicated by cyclic vomiting syndrome successfully treated with amitriptyline.
    Obstetrics and gynecology, 2015, Volume: 125, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Pregnancy; Pregnancy Complic

2015
The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine.
    Molecular and cellular biochemistry, 2011, Volume: 355, Issue:1-2

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Dinitrochlorobenzene; Enzyme Assays;

2011
Prenatal exposure to chronic mild stress increases corticosterone levels in the amniotic fluid and induces cognitive deficits in female offspring, improved by treatment with the antidepressant drug amitriptyline.
    Behavioural brain research, 2012, May-16, Volume: 231, Issue:1

    Topics: Amitriptyline; Amniotic Fluid; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Fem

2012
Medications as a potential source of exposure to phthalates among women of childbearing age.
    Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 37

    Topics: Adolescent; Adult; Amitriptyline; Drug Utilization; Environmental Exposure; Female; Humans; Mesalami

2013
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.
    Neuroscience, 2003, Volume: 118, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Amitriptyline; Animals; Animals

2003
Gender difference in the prevention of hyperanxiety in adult prenatally stressed rats by chronic treatment with amitriptyline.
    Psychopharmacology, 2004, Volume: 171, Issue:3

    Topics: Amitriptyline; Animals; Anxiety; Female; Locomotion; Male; Pregnancy; Prenatal Exposure Delayed Effe

2004
Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants.
    Life sciences, 2007, May-30, Volume: 80, Issue:24-25

    Topics: Acetylcholine; Amitriptyline; Antidepressive Agents; Dose-Response Relationship, Drug; Doxepin; Fema

2007
Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura.
    The journal of headache and pain, 2008, Volume: 9, Issue:2

    Topics: Amitriptyline; Analgesics; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Pro

2008
Lactation and ovarian cyst formation following treatment with amitriptyline.
    The Practitioner, 1967, Volume: 198, Issue:188

    Topics: Adult; Amitriptyline; Cystadenoma; Female; Humans; Lactation Disorders; Ovarian Neoplasms; Pregnancy

1967
The effect of d-amphetamine and amitriptyline administered to pregnant rats on the locomotor activity and neurotransmitters of the offspring.
    Psychopharmacology, 1982, Volume: 77, Issue:4

    Topics: Amitriptyline; Animals; Animals, Newborn; Brain Chemistry; Dextroamphetamine; Dopamine; Female; Fetu

1982
[Effect of various anxiolytics on sleep, apropos of the polygraph study of a case of insomnia].
    LARC medical, 1981, Volume: 1, Issue:1

    Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Female; Humans; Lie Detection; Methotrimeprazine; Pregnan

1981
Incidence and potentiation of external and internal fetal anomalies resulting from chlordiazepoxide and amitriptyline alone and in combination.
    Teratology, 1984, Volume: 30, Issue:1

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Animals; Chlordiazepoxide; Cricetinae; Drug Synergism; E

1984
Amitriptyline and nortriptyline excretion in human breast milk.
    Psychopharmacology, 1982, Volume: 76, Issue:1

    Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Milk, Human; Nortriptyline; Pregnancy; Pu

1982
Comparative teratogenicity of chlordiazepoxide, amitriptyline, and a combination of the two compounds in the fetal hamster.
    Neurotoxicology, 1982, Volume: 3, Issue:3

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Animals; Chlordiazepoxide; Cricetinae; Dose-Response Rel

1982
Amitriptyline-induced ophthalmoplegia.
    Neurology, 1981, Volume: 31, Issue:9

    Topics: Adult; Amitriptyline; Coma; Female; Humans; Ophthalmoplegia; Physostigmine; Pregnancy; Pregnancy Com

1981
Loss-induced depression in an adult macaque monkey.
    The American journal of psychiatry, 1982, Volume: 139, Issue:5

    Topics: Amitriptyline; Animals; Depressive Disorder; Disease Models, Animal; Female; Grief; Humans; Macaca n

1982
Amitriptyline in human breast milk and the nursing infant's serum.
    The American journal of psychiatry, 1980, Volume: 137, Issue:7

    Topics: Adult; Amitriptyline; Depression; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Pregn

1980
Changes in dopamine, serotonin and their metabolites in discrete brain areas of rat offspring after in utero exposure to cocaine or related drugs.
    Teratology, 1993, Volume: 48, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amitriptyline; Amygdala; Analysis of Variance; Animals; Brain

1993
Secretion of amitriptyline and metabolites into breast milk.
    The American journal of psychiatry, 1995, Volume: 152, Issue:5

    Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline;

1995
Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly.
    Brain research, 1998, Mar-23, Volume: 787, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkylating Agents; Amitriptyline; Animals; Antidepressive Ag

1998
Action of antidepressant drugs on maternal stress-induced hypoactivity in female rats.
    Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Dose-Response Relationsh

1999
Persistent mydriasis following intravenous atropine in a neonate.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Apnea; Atropine; Bronchodilator Agents; Drug

2000
Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta.
    Psychopharmacology, 2001, Volume: 153, Issue:4

    Topics: Adult; Algorithms; Amitriptyline; Antidepressive Agents, Tricyclic; Blood Gas Analysis; Female; Huma

2001
Retro-orbital tumour--an uncommon cause of headache in pregnancy.
    Anaesthesia and intensive care, 2001, Volume: 29, Issue:3

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Female; Headache; Hemangioma, Ca

2001
Toxicology of amitriptylinoxide.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:10b

    Topics: Amitriptyline; Animals; Cocaine; Dogs; Drug Hypersensitivity; Drug Interactions; Female; Fetus; Grow

1978
Brom-ergocryptine in the treatment of phenothiazine-induced galactorrhoea.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Adult; Amenorrhea; Amitriptyline; Antipsychotic Agents; Ergot Alkaloids; Female; Follicle Stimulatin

1975
Tricyclics and breast feeding.
    The American journal of psychiatry, 1979, Volume: 136, Issue:11

    Topics: Amitriptyline; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Pregnancy

1979
Effects of tricyclic antidepressants on cardiovascular responses to norepinephrine and phenylephrine during pregnancy.
    American journal of obstetrics and gynecology, 1978, Aug-15, Volume: 131, Issue:8

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Female; Imipramine; Norepi

1978
Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors.
    Teratology, 1992, Volume: 46, Issue:4

    Topics: 1-Naphthylamine; Abnormalities, Drug-Induced; Amitriptyline; Animals; Cell Death; Cell Division; Epi

1992
Changes in the amount and distribution of neuronal alkaline and acid phosphatase after chronic exposure of cultures of cingulate cortex to antidepressant drugs.
    Journal of neural transmission. General section, 1992, Volume: 90, Issue:1

    Topics: Acid Phosphatase; Alkaline Phosphatase; Amitriptyline; Animals; Antidepressive Agents; Cells, Cultur

1992
Antidepressants inhibit spontaneous oscillations of intracellular Ca2+ concentration in rat cortical cultured neurons.
    Neuroscience letters, 1992, Oct-26, Volume: 146, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium; Cerebral Cortex; Dose-Response Relationship,

1992
Effects of maternal calorie-restricted diet on development of the foetal heart, as evaluated in primary cultures of rat myocardial cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1991, Volume: 29, Issue:7

    Topics: Adenosine Triphosphate; Amitriptyline; Animals; Cells, Cultured; Diet, Reducing; Dietary Carbohydrat

1991
Long-term consequences of prenatal exposure to cocaine or related drugs: effects on rat brain monoaminergic receptors.
    Brain research bulletin, 1991, Volume: 26, Issue:6

    Topics: Aging; Amitriptyline; Animals; Brain; Cerebral Cortex; Cocaine; Corpus Striatum; Female; Male; Nalid

1991
Thanatophoric dwarfism; drugs and antenatal diagnosis; a case report.
    European journal of obstetrics, gynecology, and reproductive biology, 1991, Jan-30, Volume: 38, Issue:2

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Female; Humans; Infant, Newborn; Male; Phenobarbital; Ph

1991
The effects of various antidepressant drugs on the fine-structure of neurons of the cingulate cortex in culture.
    Neuroscience, 1990, Volume: 37, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Cytoskeleton; Desipramine; Female; Gyrus

1990
Effects of prenatal exposure to cocaine or related drugs on rat developmental and neurological indices.
    Brain research bulletin, 1990, Volume: 24, Issue:2

    Topics: Amitriptyline; Animals; Cocaine; Female; Hyperkinesis; Male; Nervous System; Pregnancy; Prenatal Exp

1990
[A newborn infant with amitriptyline poisoning].
    Nederlands tijdschrift voor geneeskunde, 1985, May-11, Volume: 129, Issue:19

    Topics: Adult; Amitriptyline; Antipsychotic Agents; Back Pain; Female; Humans; Infant, Newborn; Male; Matern

1985
Amitriptyline excretion in human milk.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:6

    Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Infant, Newborn; Milk, Human; Pregnancy;

1986
Rachelefsky GS, Flynt JW Jr,+FLYNT JW JR, Ebbin AJ, Wilson MG, Banister P, Dafoe C, Smith ES, Miller J:Possible teratogenicity of tricyclic antidepressants.
    Lancet (London, England), 1972, Apr-15, Volume: 1, Issue:7755

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Antidepressive Agents; Female; Humans; Imipramine; Infan

1972
Possible teratogenicity of imipramine-chloropyramine.
    Lancet (London, England), 1973, Aug-11, Volume: 2, Issue:7824

    Topics: Abnormalities, Drug-Induced; Adult; Amitriptyline; Antidepressive Agents; Benzyl Compounds; Drug Com

1973
[Action of various tricyclic antidepressive agents on the estrous cycle of the female rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1970, Volume: 164, Issue:6

    Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Dibenzazepines; Estrus; Female; Imiprami

1970
Imipramine and congenital abnormalities.
    The New Zealand medical journal, 1972, Volume: 75, Issue:479

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Female; Humans; Imipramine; Infant, Newborn; Limb Deform

1972
Primary pulmonary hypertension in infancy.
    Acta paediatrica Scandinavica, 1973, Volume: 62, Issue:1

    Topics: Amitriptyline; Autopsy; Female; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Lung; Male

1973
Placental penetration and foetal uptake of neuropharmacological agents.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1973, Volume: 6, Issue:1

    Topics: Amitriptyline; Animals; Animals, Newborn; Autoradiography; Carbon Radioisotopes; Chlordiazepoxide; C

1973
Infants exposed in utero to antiepileptic drugs. A prospective study.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro

1974
Studies on drug organotropism and drug-metabolizing activity in the fetus and the newborn.
    Bollettino chimico farmaceutico, 1968, Volume: 107, Issue:10

    Topics: Amitriptyline; Animals; Anti-Bacterial Agents; Brain; Enzymes; Extracorporeal Circulation; Female; F

1968
Imipramine in pregnancy.
    British medical journal, 1972, Apr-29, Volume: 2, Issue:5808

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amitriptyline; Female; Humans; Imipramine; Infan

1972
Limb deformities: possible association with drugs.
    The Medical journal of Australia, 1972, Mar-18, Volume: 1, Issue:12

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Arm; Female; Humans; Infant, Newborn; Leg; Male; Pregnan

1972
Limb deformities associated with iminodibenzyl hydrochloride.
    The Medical journal of Australia, 1972, Mar-25, Volume: 1, Issue:13

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Drug and Narcotic Control; Ectromelia; Female; Humans; I

1972
Tranquillizer-induced galactorrhea.
    Canadian Medical Association journal, 1972, May-20, Volume: 106, Issue:10

    Topics: Adolescent; Amitriptyline; Chlorprothixene; Diazepam; Female; Haloperidol; Humans; Lactation Disorde

1972
Effect of amitriptyline and butriptyline on fetal development in rats.
    Journal of medicine, 1971, Volume: 2, Issue:5

    Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzocycloheptenes; Embryo, Mammalian; Female; Fetu

1971
Use of antidepressant drugs during the first trimester.
    The Medical journal of Australia, 1969, Nov-22, Volume: 2, Issue:21

    Topics: Amitriptyline; Desipramine; Embryo, Mammalian; Female; Gestational Age; Humans; Imipramine; Nortript

1969
[Aspects of iatrogenic pharmacology and toxicology at the fetal level].
    Minerva ginecologica, 1969, Sep-30, Volume: 21, Issue:18

    Topics: Aminopyrine; Amitriptyline; Animals; Anti-Bacterial Agents; Antipyrine; Diazepam; Dogs; Female; Feta

1969
Distribution and fate of C-14-amitriptyline in mice and rats.
    Psychopharmacologia, 1965, Jun-01, Volume: 8, Issue:1

    Topics: Amitriptyline; Animals; Autoradiography; Biological Assay; Carbon Isotopes; Female; In Vitro Techniq

1965
[Use of psychopharmacologic drugs in gynecology and obstetrics].
    Geburtshilfe und Frauenheilkunde, 1966, Volume: 26, Issue:5

    Topics: Amitriptyline; Chlordiazepoxide; Diazepam; Female; Genital Diseases, Female; Humans; Hypnotics and S

1966