amitriptyline has been researched along with Postherpetic Neuralgia in 10 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline was administered in a dose of 25 mg once daily and pregabalin in a dose of 75 mg twice daily." | 6.77 | Comparative study of clinical efficacy of amitriptyline and pregabalin in postherpetic neuralgia. ( Achar, A; Bisai, S; Biswas, A; Chakraborty, PP; Guharay, T, 2012) |
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 5.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| "In 47 patients with postherpetic neuralgia (PHN) who had never had an adequate trial of any antidepressant, we performed a randomized, double-blind, parallel design trial comparing desipramine, amitriptyline, and fluoxetine." | 5.11 | Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial. ( Davies, PS; Fields, HL; Reisner, LA; Rowbotham, MC, 2005) |
| "We conducted a single-center, retrospective observational study, and evaluated 87 patients (65 amitriptyline, 22 nortriptyline) who underwent 12-lead electrocardiogram (ECG) examinations both before and after receiving TCAs for herpes zoster pain or postherpetic neuralgia from May 2007 to January 2012." | 3.80 | Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval. ( Funai, Y; Funao, T; Hase, I; Ikenaga, K; Nishikawa, K; Takahashi, R, 2014) |
| "Amitriptyline was administered in a dose of 25 mg once daily and pregabalin in a dose of 75 mg twice daily." | 2.77 | Comparative study of clinical efficacy of amitriptyline and pregabalin in postherpetic neuralgia. ( Achar, A; Bisai, S; Biswas, A; Chakraborty, PP; Guharay, T, 2012) |
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 1.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| "Amitriptyline was the only antidepressant prescribed commonly as a first-line treatment." | 1.39 | An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. ( Carroll, D; Gabriel, ZL; Hall, GC; McQuay, HJ; Morant, SV, 2013) |
| "(1) The first-line treatment for partial epilepsy is carbamazepine monotherapy; gabapentin monotherapy is an alternative, given its lower risk of drug-drug interactions." | 1.33 | Pregabalin: new drug. Very similar to gabapentin. ( , 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, GC | 1 |
| Morant, SV | 1 |
| Carroll, D | 1 |
| Gabriel, ZL | 1 |
| McQuay, HJ | 1 |
| Hearn, L | 1 |
| Moore, RA | 1 |
| Derry, S | 1 |
| Wiffen, PJ | 1 |
| Phillips, T | 1 |
| Funai, Y | 1 |
| Funao, T | 1 |
| Ikenaga, K | 1 |
| Takahashi, R | 1 |
| Hase, I | 1 |
| Nishikawa, K | 1 |
| Griffin, JR | 1 |
| Davis, MD | 1 |
| Pi, ZB | 1 |
| Lin, H | 1 |
| He, GD | 1 |
| Cai, Z | 1 |
| Xu, XZ | 1 |
| Sawynok, J | 1 |
| Zinger, C | 1 |
| Achar, A | 1 |
| Chakraborty, PP | 1 |
| Bisai, S | 1 |
| Biswas, A | 1 |
| Guharay, T | 1 |
| Rowbotham, MC | 1 |
| Reisner, LA | 1 |
| Davies, PS | 1 |
| Fields, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for amitriptyline and Postherpetic Neuralgia
| Article | Year |
|---|---|
Desipramine for neuropathic pain in adults.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Pain; Clomipramine; Desip | 2014 |
3 trials available for amitriptyline and Postherpetic Neuralgia
| Article | Year |
|---|---|
Randomized and controlled prospective trials of Ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment for lower back post-herpetic neuralgia.
Topics: Administration, Oral; Adult; Aged; Amines; Amitriptyline; Analgesics; Celecoxib; Cyclohexanecarboxyl | 2015 |
Comparative study of clinical efficacy of amitriptyline and pregabalin in postherpetic neuralgia.
Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Female; gamma-Aminobutyric Acid; Humans; Male; | 2012 |
Treatment response in antidepressant-naïve postherpetic neuralgia patients: double-blind, randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepress | 2005 |
6 other studies available for amitriptyline and Postherpetic Neuralgia
| Article | Year |
|---|---|
An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, | 2013 |
Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Electrocardiog | 2014 |
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
[Shingles symptoms are gone but not the pain].
Topics: Administration, Cutaneous; Administration, Oral; Aged; Amines; Amitriptyline; Analgesics; Anti-Infla | 2015 |
Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain.
Topics: Administration, Topical; Amitriptyline; Analgesics; Animals; Diabetic Neuropathies; Drug Combination | 2016 |
Pregabalin: new drug. Very similar to gabapentin.
Topics: Amines; Amitriptyline; Anticonvulsants; Clinical Trials as Topic; Cost-Benefit Analysis; Cyclohexane | 2005 |