amitriptyline has been researched along with Polyneuropathies in 6 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 9.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 5.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "This neuropathy causes pain, paresthesias and burning sensations and/or numbness in the feet, which sometimes occurs in the hands as well." | 2.41 | [Sensory neuropathy in HIV infection: pathogenesis and therapy]. ( Portegies, P; Rosenberg, NR, 2001) |
| "Electroneurography demonstrated distal motor polyneuropathy with segmental demyelination associated with axonal degeneration prominent in the distal parts of both lower extremities." | 1.35 | Myeloneuritis due to acute organophosphate (DDVP) intoxication. ( Kekec, Z; Koc, F; Yerdelen, D, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sachau, J | 1 |
| Fabig, SC | 1 |
| Rehm, S | 1 |
| Baron, R | 1 |
| Koc, F | 1 |
| Yerdelen, D | 1 |
| Kekec, Z | 1 |
| Lynch, ME | 1 |
| Clark, AJ | 1 |
| Sawynok, J | 1 |
| Sullivan, MJ | 1 |
| van Doorn, PA | 1 |
| Portegies, P | 1 |
| Rosenberg, NR | 1 |
| Boudouresques, J | 1 |
| Khalil, R | 1 |
| Pellissier, JF | 1 |
| Alicherif, A | 1 |
| Boudouresques, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
3 reviews available for amitriptyline and Polyneuropathies
| Article | Year |
|---|---|
[Treatment of polyneuropathy: autonomic symptoms and pain].
Topics: Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents; Calcium Channel Blockers; Humans; | 2020 |
[Guideline on polyneuropathy].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Chronic Disease; Diabetes Complications; Ele | 2007 |
[Sensory neuropathy in HIV infection: pathogenesis and therapy].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Carba | 2001 |
1 trial available for amitriptyline and Polyneuropathies
| Article | Year |
|---|---|
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
2 other studies available for amitriptyline and Polyneuropathies
| Article | Year |
|---|---|
Myeloneuritis due to acute organophosphate (DDVP) intoxication.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Amitriptyline; Dichlorvos; Female; Humans; Insecticides; M | 2009 |
[Polyneuritis following amitriptyline poisoning].
Topics: Adult; Amitriptyline; Humans; Male; Polyneuropathies | 1977 |