amitriptyline has been researched along with Phantom Limb in 8 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Phantom Limb: Perception of painful and nonpainful phantom sensations that occur following the complete or partial loss of a limb. The majority of individuals with an amputated extremity will experience the impression that the limb is still present, and in many cases, painful. (From Neurol Clin 1998 Nov;16(4):919-36; Brain 1998 Sep;121(Pt 9):1603-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 7.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| "To evaluate whether amitriptyline is more effective than placebo in improving phantom limb pain or residual limb pain." | 5.11 | Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study. ( Campbell, KM; Czerniecki, JM; Edwards, WT; Ehde, DM; Goldberg, ML; Jensen, MP; Judish, DA; Robinson, LR; Smith, DG, 2004) |
| "In treatment-naive patients, both amitriptyline and tramadol provided excellent and stable phantom limb and stump pain control with no major adverse events." | 5.11 | Postamputation pain and sensory changes in treatment-naive patients: characteristics and responses to treatment with tramadol, amitriptyline, and placebo. ( Hill, LT; Laurent, S; Wilder-Smith, CH, 2005) |
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 3.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| "Amitriptyline was the only antidepressant prescribed commonly as a first-line treatment." | 1.39 | An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. ( Carroll, D; Gabriel, ZL; Hall, GC; McQuay, HJ; Morant, SV, 2013) |
| "Amitriptyline is a tricyclic antidepressant that is historically indicated and used to manage depression." | 1.33 | Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline. ( Dukes, E; Gore, M; Leslie, DL; Rowbotham, D; Tai, KS, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Campo-Prieto, P | 1 |
| RodrÃguez-Fuentes, G | 1 |
| Hall, GC | 1 |
| Morant, SV | 1 |
| Carroll, D | 1 |
| Gabriel, ZL | 1 |
| McQuay, HJ | 1 |
| Robinson, LR | 1 |
| Czerniecki, JM | 1 |
| Ehde, DM | 1 |
| Edwards, WT | 1 |
| Judish, DA | 1 |
| Goldberg, ML | 1 |
| Campbell, KM | 1 |
| Smith, DG | 1 |
| Jensen, MP | 1 |
| Wilder-Smith, CH | 1 |
| Hill, LT | 1 |
| Laurent, S | 1 |
| Gore, M | 1 |
| Dukes, E | 1 |
| Rowbotham, D | 1 |
| Tai, KS | 1 |
| Leslie, DL | 1 |
| Bartusch, SL | 1 |
| Sanders, BJ | 1 |
| D'Alessio, JG | 1 |
| Jernigan, JR | 1 |
| Broughton, M | 1 |
| Rogers, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mindfulness-based Cognitive Therapy and Cognitive Behavioral Therapy for Chronic Pain in Multiple Sclerosis[NCT03782246] | 273 participants (Actual) | Interventional | 2018-11-28 | Active, not recruiting | |||
| A Randomized Controlled Trial of Lidocaine Patch for Lower Limb Amputation Pain[NCT02696720] | Phase 2 | 0 participants (Actual) | Interventional | 2016-05-13 | Withdrawn (stopped due to Lack of recruitment) | ||
| Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain: In-Person Treatment[NCT05296265] | 40 participants (Anticipated) | Interventional | 2022-05-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for amitriptyline and Phantom Limb
| Article | Year |
|---|---|
Effectiveness of mirror therapy in phantom limb pain: a literature review.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Gabapentin; Humans; Mirror Movement Therapy; Phanto | 2022 |
2 trials available for amitriptyline and Phantom Limb
| Article | Year |
|---|---|
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Trial of amitriptyline for relief of pain in amputees: results of a randomized controlled study.
Topics: Adult; Amitriptyline; Amputees; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Male; | 2004 |
Postamputation pain and sensory changes in treatment-naive patients: characteristics and responses to treatment with tramadol, amitriptyline, and placebo.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Amputation Stumps; Cytochrome P-450 CYP2D | 2005 |
5 other studies available for amitriptyline and Phantom Limb
| Article | Year |
|---|---|
An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, | 2013 |
Prevalence of contraindicated medical conditions and use of precluded medications in patients with painful neuropathic disorders prescribed amitriptyline.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Analgesics, | 2006 |
Clonazepam for the treatment of lancinating phantom limb pain.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clonazepam; Disarticulation; Drug Therapy, Co | 1996 |
Controlling phantom limb pain in Sierra Leone.
Topics: Amitriptyline; Amputees; Analgesics, Non-Narcotic; Humans; Male; Pain Clinics; Phantom Limb; Sierra | 2001 |
Use of amitriptyline (Elavil) for phantom limb pain in younger children.
Topics: Administration, Oral; Amitriptyline; Amputation, Surgical; Child; Femoral Neoplasms; Humans; Male; O | 1989 |