amitriptyline has been researched along with Peripheral Nerve Injury in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burke, NN | 1 |
| Finn, DP | 1 |
| Roche, M | 1 |
| Matsuoka, H | 1 |
| Suto, T | 1 |
| Saito, S | 1 |
| Obata, H | 1 |
| Sanna, MD | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Arsenault, A | 1 |
| Sawynok, J | 1 |
| Mao, QX | 1 |
| Yang, TD | 1 |
| Cheng, KI | 1 |
| Wang, HC | 1 |
| Chang, LL | 1 |
| Wang, FY | 1 |
| Lai, CS | 1 |
| Chou, CW | 1 |
| Tsai, HP | 1 |
| Kwan, AL | 1 |
| Shin, SW | 1 |
| Eisenach, JC | 1 |
| Hur, YK | 1 |
| Choi, IS | 1 |
| Cho, JH | 1 |
| Park, EJ | 1 |
| Choi, JK | 1 |
| Choi, BJ | 1 |
| Jang, IS | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Analgesia With Amitryptyline for Prevention of Post-operative Pain in Women After Total Abdominal Hysterectomy: a Randomized Clinical Trial[NCT03587025] | Phase 3 | 150 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for amitriptyline and Peripheral Nerve Injury
| Article | Year |
|---|---|
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Glial | 2015 |
Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats.
Topics: Adrenergic Neurons; Amitriptyline; Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, | 2016 |
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.
Topics: Amitriptyline; Analgesics; Animals; Astrocytes; Biocatalysis; Enzyme Activation; Gene Expression Reg | 2017 |
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotroph | 2009 |
Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Blotting, Western; Excitatory Amino Acid Transport | 2010 |
Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Hyperalgesia; Injections, Intraperitoneal; Injecti | 2012 |
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
Topics: Amitriptyline; Animals; Antidepressive Agents; Catheterization; Cyclopropanes; Dose-Response Relatio | 2004 |
Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neurons.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Drug Resis | 2008 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |