amitriptyline has been researched along with Parkinsonian Disorders in 5 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment of rotenone groups with AMI or IMI prevented rotenone-induced neuronal degeneration and increased striatal dopamine level with motor recovery." | 1.43 | Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats. ( Abdelkader, NF; El-Sayeh, BM; Kandil, EA; Saleh, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamińska, K | 1 |
| Lenda, T | 1 |
| Konieczny, J | 1 |
| Wardas, J | 1 |
| Lorenc-Koci, E | 1 |
| Paumier, KL | 1 |
| Sortwell, CE | 1 |
| Madhavan, L | 1 |
| Terpstra, B | 1 |
| Celano, SL | 1 |
| Green, JJ | 1 |
| Imus, NM | 1 |
| Marckini, N | 1 |
| Daley, B | 1 |
| Steece-Collier, K | 1 |
| Collier, TJ | 1 |
| Kandil, EA | 1 |
| Abdelkader, NF | 1 |
| El-Sayeh, BM | 1 |
| Saleh, S | 1 |
| GILLINGHAM, FJ | 2 |
| KALYANARAMAN, S | 1 |
| SMYTHIES, JR | 1 |
5 other studies available for amitriptyline and Parkinsonian Disorders
| Article | Year |
|---|---|
Interactions of the tricyclic antidepressant drug amitriptyline with L-DOPA in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Relevance to motor dysfunction in Parkinson's disease.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Corpus Striatum; Drug Interactions; Levodo | 2018 |
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.
Topics: Adrenergic Agents; Amitriptyline; Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Fact | 2015 |
Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antiparkinson Agents; | 2016 |
PARKINSON'S DISEASE.
Topics: Amitriptyline; Dextroamphetamine; Humans; Imipramine; Muscle Relaxants, Central; Neurosurgery; Orphe | 1963 |
A CASE OF POSTENCEPHALITIC PARKINSONISM RESPONDING TO COMBINED SURGICAL AND MEDICINAL TREATMENT.
Topics: Amitriptyline; Chlordiazepoxide; Depression; Depressive Disorder; Drug Therapy; Encephalitis; Eye Mo | 1965 |