amitriptyline has been researched along with Parkinson Disease in 23 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study." | 9.12 | Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life. ( Antonini, A; Barone, P; Canesi, M; De Gaspari, D; Mariani, C; Meucci, N; Pezzoli, G; Sacilotto, G; Tesei, S; Zecchinelli, A, 2006) |
| "We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study." | 9.06 | Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988) |
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 7.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| "We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study." | 5.12 | Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life. ( Antonini, A; Barone, P; Canesi, M; De Gaspari, D; Mariani, C; Meucci, N; Pezzoli, G; Sacilotto, G; Tesei, S; Zecchinelli, A, 2006) |
| "We evaluated the effect of 25 mg bid amitriptyline on muscle contraction headache in 36 patients with Parkinson's disease in a randomized double-blind placebo-controlled study." | 5.06 | Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study. ( Carrieri, PB; Indaco, A, 1988) |
| "We discuss a case of a patient with restless legs syndrome that was responsive to administration of amitriptyline." | 3.67 | Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease. ( Bamford, CR; Iacono, RP; Sandyk, R, 1988) |
| "Drooling is a distressing symptom for adults with neurological conditions and can be challenging for health professionals." | 2.48 | The management of drooling in adults with neurological conditions. ( Rowson, J; Squires, N; Wills, A, 2012) |
| "A patient with progressive supranuclear palsy (PSP) showing severe akinesia, postural instability and gait disturbance like frozen gait was treated with amitriptyline (30 mg/day)." | 1.29 | [A case of progressive supranuclear palsy showing marked improvements of frontal hypoperfusion, as well as parkinsonism with amitriptyline]. ( Asanuma, M; Hirata, H; Kondo, Y; Ogawa, N, 1993) |
| " The following report concerns a 62-year-old female Parkinsonian patient with levodopa-induced "On-Off", depression and sleep disturbances, the severity of which was dramatically reduced by administration of low dosage amitriptyline (a serotonergic agent)." | 1.27 | Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease. ( Sandyk, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (69.57) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, SH | 1 |
| Kim, S | 1 |
| Park, AY | 1 |
| Lee, S | 2 |
| Gadhe, CG | 1 |
| Seo, BA | 1 |
| Park, JS | 1 |
| Jo, S | 1 |
| Oh, Y | 1 |
| Kweon, SH | 1 |
| Ma, SX | 1 |
| Kim, WR | 1 |
| Kim, M | 1 |
| Kim, H | 1 |
| Kim, JE | 1 |
| Lee, J | 1 |
| Ko, HS | 1 |
| Lee, MY | 1 |
| Hong, S | 1 |
| Kim, N | 1 |
| Shin, KS | 1 |
| Kang, SJ | 1 |
| Squires, N | 1 |
| Wills, A | 1 |
| Rowson, J | 1 |
| GILLINGHAM, FJ | 1 |
| KALYANARAMAN, S | 1 |
| Antonini, A | 1 |
| Tesei, S | 1 |
| Zecchinelli, A | 1 |
| Barone, P | 1 |
| De Gaspari, D | 1 |
| Canesi, M | 1 |
| Sacilotto, G | 1 |
| Meucci, N | 1 |
| Mariani, C | 1 |
| Pezzoli, G | 1 |
| Mastrosimone, F | 1 |
| Colucci d'Amato, C | 1 |
| De Angelis, G | 1 |
| Iaccarino, C | 1 |
| Giordano, L | 1 |
| Marmo, E | 1 |
| Edwards, M | 1 |
| Sim, MK | 1 |
| Ratnam, KV | 1 |
| Asanuma, M | 1 |
| Hirata, H | 1 |
| Kondo, Y | 1 |
| Ogawa, N | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Rampton, DS | 1 |
| Storm, W | 1 |
| Indaco, A | 1 |
| Carrieri, PB | 1 |
| Sandyk, R | 2 |
| Iacono, RP | 1 |
| Bamford, CR | 1 |
| Wagshul, AM | 1 |
| Daroff, RB | 1 |
| Roos, BE | 1 |
| Markham, CH | 1 |
| Yahr, MD | 1 |
| Duvoisin, RC | 1 |
| Presthus, J | 1 |
| Knopp, W | 1 |
| Kilpatrick, R | 1 |
| Smith, AJ | 1 |
6 reviews available for amitriptyline and Parkinson Disease
| Article | Year |
|---|---|
The management of drooling in adults with neurological conditions.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Atropine; Behavior Therapy; Botulinum Toxins, Type | 2012 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
Drug therapy of parkinsonism.
Topics: Amantadine; Amitriptyline; Amphetamine; Antiparkinson Agents; Dihydroxyphenylalanine; Drug Antagonis | 1972 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
[Therapy of Parkinsonism. II].
Topics: Amantadine; Amitriptyline; Humans; Imipramine; Levodopa; Parkinson Disease; Physical Therapy Modalit | 1974 |
Advances in medicine.
Topics: Amitriptyline; Cholera; Coronary Disease; Crohn Disease; Diabetes Mellitus; Diet Therapy; Diverticul | 1971 |
3 trials available for amitriptyline and Parkinson Disease
| Article | Year |
|---|---|
Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Topics: Amitriptyline; Antidepressive Agents; Depression; Female; Humans; Male; Middle Aged; Parkinson Disea | 2006 |
Amitriptyline in the treatment of headache in patients with Parkinson's disease: a double-blind placebo-controlled study.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Female; Headache; Humans; | 1988 |
Psychiatric changes in patients treated with levodopa. I. The clinical experiment.
Topics: Activities of Daily Living; Adjustment Disorders; Aged; Amitriptyline; Clinical Trials as Topic; Dia | 1970 |
14 other studies available for amitriptyline and Parkinson Disease
| Article | Year |
|---|---|
A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease.
Topics: Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Neuroprotective Ag | 2021 |
Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson's Disease.
Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antioxidants; Apop | 2015 |
PARKINSON'S DISEASE.
Topics: Amitriptyline; Dextroamphetamine; Humans; Imipramine; Muscle Relaxants, Central; Neurosurgery; Orphe | 1963 |
Personal experience with a combination of drugs in subjects with dopa resistant Parkinson's disease.
Topics: Amantadine; Amitriptyline; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Hyper | 1980 |
Adverse interaction of levodopa with tricyclic antidepressants.
Topics: Aged; Amitriptyline; Carbidopa; Drug Combinations; Drug Interactions; Female; Humans; Imipramine; Le | 1982 |
Treatment of disease without the use of drugs. V. Phasing out of benzodiazepine and amitriptyline medication with thought control.
Topics: Adult; Amitriptyline; Behavior Therapy; Benzodiazepines; Breathing Exercises; Female; Gastritis; Hum | 1980 |
[A case of progressive supranuclear palsy showing marked improvements of frontal hypoperfusion, as well as parkinsonism with amitriptyline].
Topics: Amitriptyline; Animals; Cerebrovascular Circulation; Female; Frontal Lobe; Gait; Humans; Middle Aged | 1993 |
Hypertensive crisis in a patient given sinemet, metoclopramide, and amitriptyline.
Topics: Acute Disease; Amitriptyline; Carbidopa; Drug Combinations; Drug Therapy, Combination; Female; Human | 1977 |
Differential diagnosis and treatment of depressive features in Down's syndrome: a case illustration.
Topics: Adult; Amitriptyline; Brain; Depressive Disorder; Diagnosis, Differential; Down Syndrome; Humans; Ma | 1990 |
Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease.
Topics: Amitriptyline; Female; Humans; Levodopa; Middle Aged; Parkinson Disease; Serotonin; Sleep Wake Disor | 1988 |
Spinal cord mechanisms in amitriptyline responsive restless legs syndrome in Parkinson's disease.
Topics: Amitriptyline; Humans; Male; Middle Aged; Parkinson Disease; Restless Legs Syndrome; Spinal Cord; Sy | 1988 |
Depression during L-dopa treatment.
Topics: Aged; Amitriptyline; Depression; Dihydroxyphenylalanine; Humans; Male; Middle Aged; Parkinson Diseas | 1969 |
[Parkinson's syndrome. 10. Effects of psychopharmacological agents on central monoamine neurons].
Topics: Amitriptyline; Humans; Imipramine; Monoamine Oxidase Inhibitors; Neurons; Parkinson Disease; Reserpi | 1970 |
The "on-off" side effect of L-DOPA.
Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Cate | 1974 |