Page last updated: 2024-10-22

amitriptyline and Pain

amitriptyline has been researched along with Pain in 215 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
" Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])."9.69Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023)
"Sixty-seven participants with painful diabetic neuropathy were randomized to receive either 2 mg naltrexone or 10 mg amitriptyline daily following a 2-week run-in period."9.41Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial. ( Bansal, D; Bhansali, AK; Chakrabarti, A; Dutta, P; Hota, D; Srinivasan, A, 2021)
" Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia."9.22Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022)
"Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia."9.22Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022)
"The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients."9.22Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016)
"We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users."9.20Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015)
" Melatonin can improve sleep quality, pain and pain threshold."9.19Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014)
"To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated with diabetic peripheral neuropathy."9.14Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. ( Bansal, D; Bhansali, A; Chakrabarti, A; Dutta, P; Hota, D, 2009)
"Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome."9.14Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. ( Burks, DA; Cen, L; Chai, TC; FitzGerald, MP; Foster, HE; Hanno, PM; Kreder, KJ; Kusek, JW; Landis, JR; Lukacz, ES; Mayer, RD; Nickel, JC; Nyberg, LM; Payne, CK; Peters, KM; Propert, KJ; Yang, CC; Yang, W, 2010)
"Oral amitriptyline, a tricyclic antidepressant, is effective for treating neuropathic pain."9.13Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. ( Ho, KY; Huh, BK; Miller, EJ; White, WD; Yeh, CC, 2008)
"Little is known about the effects of low doses of amitriptyline, prescribed in the treatment of neuropathic pain, on attentional processing capacity."9.12Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Volkerts, ER, 2006)
"The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients."9.12Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006)
"To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine."9.12Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007)
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."9.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
"We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain."9.10Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002)
"Reports of gabapentin use in diabetic peripheral neuropathy pain stimulate a need for controlled trials to determine its comparative efficacy to the therapeutic standard of amitriptyline hydrochloride."9.09Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. ( Leckband, SG; Moorhouse, DF; Morello, CM; Sahagian, GA; Stoner, CP, 1999)
"The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy."9.09Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000)
" These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated."9.08Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997)
"To compare amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics."9.08A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics. ( Arnqvist, H; Boivie, J; Holmgren, H; Lindström, T; Thorell, LH; Vrethem, M, 1997)
"To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients."9.08Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998)
"Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy."9.08A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998)
"The analgesic efficacy of amitriptyline 25 mg was compared with placebo in 41 patients with chronic (more than 3 months) nonmalignant pain, using a double-blind randomised multiple-dose 3-week treatment period crossover design."9.07Low dose amitriptyline in the treatment of chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1992)
"Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions."9.07Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992)
"In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder."9.07Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder? ( Edelbroek, PM; Linssen, ACG; Van Kempen, GMJ; Zitman, FG, 1991)
"A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine."9.07The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991)
"A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression."9.06Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine. ( Boivie, J; Leijon, G, 1989)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."9.06Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"We conducted a double-blind, placebo-controlled, crossover study of the effectiveness of amitriptyline and fluphenazine in alleviating the pain of diabetic peripheral neuropathy in six diabetic patients."9.06A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy. ( Chappell, DA; Dere, WH; Gertz, BJ; Grunfeld, C; Karam, JH; Klein, RF; Lavin, TN; Mendel, CM, 1986)
"To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study."9.05Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982)
"All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome."8.85Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009)
"To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia."8.82Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004)
"This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc."7.77Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011)
" The analgesic activity of amitriptyline was observed in mouse models of acute pain."7.74Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."7.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."7.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
"We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain."7.72Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004)
"Amitriptyline is a tricyclic antidepressant, which also alleviates various pain syndromes at its therapeutic plasma concentration (0."7.72State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. ( Russell, C; Wang, GK; Wang, SY, 2004)
"This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions."7.71Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001)
"To evaluate the usefulness of amitriptyline (AMI) in the treatment of patients with urinary frequency or genital, pelvic, or suprapubic pain syndromes."7.70The use of amitriptyline in patients with urinary frequency and pain. ( Constantino, G; Pranikoff, K, 1998)
"Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)."7.70Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."7.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"A study was carried out in a multidisciplinary pain clinic with the purpose of comparing the effectiveness of outpatient cognitive-behavioural therapy (CBT) with amitriptyline (AMI) to that of supportive therapy with AMI."7.69Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up. ( Forsten, C; Pilowsky, I; Rounsefell, B; Soda, J; Spence, N, 1995)
"To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain."7.69Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996)
"Baseline measures associated with outcome are described for amitriptyline and brief psychotherapy used in the outpatient treatment of chronic "psychogenic" pain."7.68Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy. ( Barrow, G; Pilowsky, I, 1992)
"A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans."7.68Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992)
" Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis."7.67Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985)
"Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities."7.66Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency. ( Drager, AM; Mitas, JA; Mosley, CA, 1983)
"A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia."7.66Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982)
"Amitriptyline (AM) has long been known to exert analgesic activity as a result of blocking the Na⁺ channels."6.76Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures. ( Adibkia, K; Afzalifar, R; Alaeddini, M; Barzegar-Jalali, M; Hamedyazdan, S; Mohammadi, G; Movassaghian, S; Zakeri-Milani, P, 2011)
" In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects."6.67Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993)
"Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties."6.39Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996)
"Kinesiotherapy and electrotherapy additions to amitriptyline administration as well as amitriptyline alone, were effective at improving vestibular pain in women with vulvodynia."5.69Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial. ( Bardin, MG; De Mira, TAA; Giraldo, PC; Lenzi, J; Morin, M; Witkin, SS, 2023)
" Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT])."5.69Is low-dose naltrexone effective in chronic pain management? ( DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J, 2023)
"Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2."5.48The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018)
"Sixty-seven participants with painful diabetic neuropathy were randomized to receive either 2 mg naltrexone or 10 mg amitriptyline daily following a 2-week run-in period."5.41Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial. ( Bansal, D; Bhansali, AK; Chakrabarti, A; Dutta, P; Hota, D; Srinivasan, A, 2021)
" This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses."5.32Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004)
"(1) Postherpetic pain is infrequent, but the incidence increases with age."5.31Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002)
" A treatment plan was developed consisting of a low-dose morphine infusion with increasing dosage until pain was relieved."5.29Successful treatment of painful crises of Fabry disease with low dose morphine. ( Finley, GA; Gordon, KE; Ludman, MD, 1995)
"Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants."5.28Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992)
" Our aim is to identify and compare the efficacy of amitriptyline (AMT), duloxetine (DLX), and pregabalin (PGB) for reducing pain intensity by 30% (R30%) and 50% (R50%) in adult patients with fibromyalgia."5.22Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. ( Alberti, FF; Becker, MW; Blatt, CR; da Silva Dal Pizzol, T; Pilger, D; Ziegelmann, PK, 2022)
"Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia."5.22Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022)
"The combination of 240 mg of intravenous lidocaine (once a week for 4 weeks) with 25 mg of amitriptyline for 8 weeks had no meaningful impact in fibromyalgia patients."5.22Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study. ( Albertoni Giraldes, AL; Brunialti, MK; Leal, PD; Sakata, RK; Salomão, R, 2016)
"We conducted a randomized, double-blind, placebo-controlled, crossover study at a single center in South Africa, to ascertain whether amitriptyline is an effective analgesic for painful HIV-associated sensory neuropathy of moderate to severe intensity in: i) antiretroviral drug naive individuals, and ii) antiretroviral drug users."5.20Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy. ( Dinat, N; Kamerman, PR; Marinda, E; Moch, S; Rice, AS, 2015)
" Melatonin can improve sleep quality, pain and pain threshold."5.19Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014)
"We are motivated by a randomized clinical trial evaluating the efficacy of amitriptyline for the treatment of interstitial cystitis and painful bladder syndrome in treatment-naïve patients."5.19Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non-adherence and loss to follow-up. ( Landis, JR; Propert, KJ; Yang, W, 2014)
"To conduct a prospective study to determine the efficacy of self-management interventions, amitriptyline, and amitriptyline plus topical triamcinolone in reducing vulvar pain in women with vulvodynia."5.14Self-management, amitriptyline, and amitripyline plus triamcinolone in the management of vulvodynia. ( Bachmann, G; Brown, CS; Rosen, R; Wan, J, 2009)
"To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated with diabetic peripheral neuropathy."5.14Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. ( Bansal, D; Bhansali, A; Chakrabarti, A; Dutta, P; Hota, D, 2009)
"Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome."5.14Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. ( Burks, DA; Cen, L; Chai, TC; FitzGerald, MP; Foster, HE; Hanno, PM; Kreder, KJ; Kusek, JW; Landis, JR; Lukacz, ES; Mayer, RD; Nickel, JC; Nyberg, LM; Payne, CK; Peters, KM; Propert, KJ; Yang, CC; Yang, W, 2010)
"Oral amitriptyline, a tricyclic antidepressant, is effective for treating neuropathic pain."5.13Topical amitriptyline versus lidocaine in the treatment of neuropathic pain. ( Ho, KY; Huh, BK; Miller, EJ; White, WD; Yeh, CC, 2008)
"Little is known about the effects of low doses of amitriptyline, prescribed in the treatment of neuropathic pain, on attentional processing capacity."5.12Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Volkerts, ER, 2006)
"The acute and subchronic effects of low doses nocturnally administered amitriptyline were compared to placebo in a double-blind crossover randomized study on driving ability and driving-related skills involving seven chronic neuropathic pain patients."5.12Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients. ( Kalkman, CJ; Kenemans, JL; Olivier, B; van Wijck, AJ; Veldhuijzen, DS; Verster, JC; Volkerts, ER, 2006)
"To test the hypotheses that both amitriptyline and gabapentin are more effective in relieving neuropathic pain than an active placebo, diphenhydramine."5.12Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. ( Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV, 2007)
"The antidepressant amitriptyline is used as an adjuvant in the treatment of chronic pain conditions."5.11Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy. ( Eappen, S; Fridrich, P; Gerner, P; Jaeger, W; Schernhammer, E; Wang, GK; Zizza, AM, 2004)
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."5.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
" This study examined the association of patient and research nurse/physician pretreatment expectations of pain relief with actual pain relief, the accuracy of patient and research nurse guesses about patient medication assignment, and changes in research nurse and patient pain relief expectations over the course of a randomized double-blind trial of amitriptyline versus an active placebo for patients with chronic pain and spinal cord injuries (SCI)."5.10Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial. ( Cardenas, DD; Jensen, MP; Turner, JA; Warms, CA, 2002)
"We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain."5.10Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002)
"Reports of gabapentin use in diabetic peripheral neuropathy pain stimulate a need for controlled trials to determine its comparative efficacy to the therapeutic standard of amitriptyline hydrochloride."5.09Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. ( Leckband, SG; Moorhouse, DF; Morello, CM; Sahagian, GA; Stoner, CP, 1999)
"The objective of this study was to compare the efficacy and tolerability of gabapentin and amitriptyline monotherapy in painful diabetic neuropathy."5.09Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study. ( Buffa, C; Chiroli, S; Dallocchio, C; Mazzarello, P, 2000)
"In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain."5.08An evaluation of antidepressants in rheumatic pain conditions. ( Naidu, MU; Prasad, VB; Rani, PU; Rao, TR; Shobha, JC, 1996)
" These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated."5.08Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997)
"To compare amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics."5.08A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics. ( Arnqvist, H; Boivie, J; Holmgren, H; Lindström, T; Thorell, LH; Vrethem, M, 1997)
"To evaluate the efficacy of a standardized acupuncture regimen (SAR) and amitriptyline hydrochloride for the relief of pain due to HIV-related peripheral neuropathy in HIV-infected patients."5.08Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. ( Brizz, B; Chaloner, K; Cohn, DL; Flaws, B; Hillman, S; Max, MB; Reichelderfer, P; Shlay, JC; Wentworth, D, 1998)
"Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy."5.08A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. ( Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C, 1998)
"The analgesic efficacy of amitriptyline 25 mg was compared with placebo in 41 patients with chronic (more than 3 months) nonmalignant pain, using a double-blind randomised multiple-dose 3-week treatment period crossover design."5.07Low dose amitriptyline in the treatment of chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1992)
"Amitriptyline reduces the pain caused by peripheral-nerve disease, but treatment is often limited by side effects related to the drug's many pharmacologic actions."5.07Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. ( Dubner, R; Lynch, SA; Max, MB; Muir, J; Shoaf, SE; Smoller, B, 1992)
"In a double-blind, crossover study, the effects of 75 mg amitriptyline alone during 5 weeks on pain intensity were compared with the effects of a combination of 75 mg amitriptyline and 3 mg flupentixol during 5 weeks in 34 patients with somatoform pain disorder."5.07Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder? ( Edelbroek, PM; Linssen, ACG; Van Kempen, GMJ; Zitman, FG, 1991)
"A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine."5.07The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991)
"A double-blind, 3-phase, cross-over, placebo-controlled trial of the pain-relieving effect of amitriptyline and carbamazepine was carried out in 15 patients with central post-stroke pain (CPSP) but without signs of depression."5.06Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine. ( Boivie, J; Leijon, G, 1989)
"Forty-seven patients with definite rheumatoid arthritis (RA) were treated in a 32 week, double blind, crossover trial of amitriptyline, desipramine, trazodone, and placebo."5.06Antidepressant analgesia in rheumatoid arthritis. ( Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E, 1988)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."5.06Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"We conducted a double-blind, placebo-controlled, crossover study of the effectiveness of amitriptyline and fluphenazine in alleviating the pain of diabetic peripheral neuropathy in six diabetic patients."5.06A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy. ( Chappell, DA; Dere, WH; Gertz, BJ; Grunfeld, C; Karam, JH; Klein, RF; Lavin, TN; Mendel, CM, 1986)
"To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study."5.05Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982)
"All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome."4.85Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009)
"Amitriptyline 25-50 mg/day reduces pain, fatigue, and depressiveness in patients with FMS and improves sleep and quality of life."4.84A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. ( Häuser, W; Sommer, C; Uçeyler, N, 2008)
"To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia."4.82Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004)
"The purpose of this review is to present relatively detailed information on the characteristics of tricyclic antidepressants, mainly amitriptyline hydrochloride and doxepin hydrochloride, for use as an integral part of the safe and effective management of fibromyalgia and, to a lesser extent, other chronic pain syndromes."4.79A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes. ( Godfrey, RG, 1996)
"Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain."3.91Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure. ( Baker, T; Burra, B; Datta, P; Hale, TW; Rewers-Felkins, K, 2019)
" Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)."3.83Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016)
"It is established that mebicar, amitriptyline, and diazepam administered intraperitoneally at therapeutic doses increase the pain thresholds in mice as manifested in "hot plate" analgesia test."3.81[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam]. ( Khaziakhmetova, VN; Luchai, KV; Ziganshina, LE, 2015)
"Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine."3.80Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014)
" We report an unusual case of a patient who experienced symptoms of delirium and hyperkinetic movement disorders shortly after initiating treatment with cyclobenzaprine and oxycodone."3.79Neuropsychiatric side effects of cyclobenzaprine. ( Sederholm, B; Shprecher, D; Sloan, CT, 2013)
" She suffered from central poststroke pain and reactive depression as poststroke complications, for which amitriptyline was prescribed."3.78Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug? ( Ahmad, S; Aziz, NA; Tan, EC, 2012)
"This post-hoc analysis examined time to recovery in patients with acute, painful musculoskeletal conditions following cyclobenzaprine extended release (CER; AMRIX(®), Cephalon, Inc."3.77Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine. ( Altman, CA; Landy, S; Xie, F, 2011)
" Amitriptyline (5, 10 mg/ kg), maprotiline (10, 20 mg/kg) and fluvoxamine (20 and 30 mg/kg) effectively inhibited pain induction caused by the second phase of the formalin test."3.77Effect of glibenclamide on antinociceptive effects of antidepressants of different classes. ( Amin, B; Hajhashemi, V, 2011)
"As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory neuropathic pain."3.75The neuraxial effects of intraspinal amitriptyline at low concentrations. ( Barros, GA; Fukushima, FB; Ganem, EM; Marques, ME; Vidal, EI, 2009)
"Amitriptyline is used to treat neuropathic pain in humans."3.74Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. ( Fredholm, BB; Reid, AR; Sawynok, J, 2008)
" The analgesic activity of amitriptyline was observed in mouse models of acute pain."3.74Antinociceptive effect of amitriptyline in mice of acute pain models. ( Bhattacharya, SK; Das, BP; Deo, S; Paudel, KR; Rauniar, GP; Sangraula, H, 2007)
" The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine."3.74Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008)
" The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition."3.74Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007)
"The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain."3.73Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005)
"Participants in a clinical trial of amitriptyline for pain (n = 84 with spinal cord injury [SCI], n = 38 with amputation) provided responses to the study measures via telephone interview."3.73Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain. ( Cardenas, DD; Ehde, D; Hanley, M; Jensen, MP; Masedo, AI, 2005)
" administration of either of two antidepressants used for the treatment of neuropathic pain, amitriptyline (10 mg/kg) and fluoxetine (5 mg/kg), to rats for 7 days modifies GABA(B) receptor function and subunit expression in the lumbar spinal cord."3.73GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants. ( Duric, V; Enna, SJ; McCarson, KE; Reisman, SA; Winter, M, 2006)
" The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema."3.72Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003)
" The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation."3.72Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003)
"We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain."3.72Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. ( Sung, B; Wang, GK, 2004)
"Amitriptyline is a tricyclic antidepressant, which also alleviates various pain syndromes at its therapeutic plasma concentration (0."3.72State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. ( Russell, C; Wang, GK; Wang, SY, 2004)
"This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions."3.71Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001)
"In the formalin test, amitriptyline produces different effects on pain behaviors after systemic, spinal administration and peripheral administration."3.71Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. ( Allen, GV; Chase, TD; Heughan, CE; Sawynok, J, 2002)
"By use of the rat formalin test, a model of persistent pain, we examined the effect of a combination of amitriptyline and gabapentin, which are used to treat chronic pain in humans."3.71The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. ( Heughan, CE; Sawynok, J, 2002)
"To evaluate the usefulness of amitriptyline (AMI) in the treatment of patients with urinary frequency or genital, pelvic, or suprapubic pain syndromes."3.70The use of amitriptyline in patients with urinary frequency and pain. ( Constantino, G; Pranikoff, K, 1998)
"We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain."3.70The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999)
"Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)."3.70Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999)
"In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain."3.70Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000)
"A study was carried out in a multidisciplinary pain clinic with the purpose of comparing the effectiveness of outpatient cognitive-behavioural therapy (CBT) with amitriptyline (AMI) to that of supportive therapy with AMI."3.69Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up. ( Forsten, C; Pilowsky, I; Rounsefell, B; Soda, J; Spence, N, 1995)
"Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions."3.69Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994)
"To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain."3.69Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996)
"Baseline measures associated with outcome are described for amitriptyline and brief psychotherapy used in the outpatient treatment of chronic "psychogenic" pain."3.68Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy. ( Barrow, G; Pilowsky, I, 1992)
"A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans."3.68Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992)
"The tail flick assay was used to evaluate pain perception in mice treated acutely with either of the two classical antidepressant drugs (AD) imipramine or amitriptyline, or the atypical antidepressant iprindole."3.67Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin. ( de Ceballos, ML; de Felipe, MC; Fuentes, JA, 1986)
" Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis."3.67Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985)
"Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities."3.66Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency. ( Drager, AM; Mitas, JA; Mosley, CA, 1983)
"A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia."3.66Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982)
"This severe pain is mostly refractory to palliative analgesic treatment, and the latter was only detected by specific and sensitive outcomes."2.87Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial. ( Beauchamp, G; Blair, J; de Lorimier, LP; Lussier, B; Monteiro, BP; Moreau, M; Pelletier, JP; Troncy, E, 2018)
"Amitriptyline (AM) has long been known to exert analgesic activity as a result of blocking the Na⁺ channels."2.76Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures. ( Adibkia, K; Afzalifar, R; Alaeddini, M; Barzegar-Jalali, M; Hamedyazdan, S; Mohammadi, G; Movassaghian, S; Zakeri-Milani, P, 2011)
" In the context of chronic pain, the analgesic effect of amitriptyline was shown to have a dose-response unrelated to mood elevation, but there was a dose-response for the incidence of adverse effects."2.67Dose-response for analgesic effect of amitriptyline in chronic pain. ( Carroll, D; Glynn, CJ; McQuay, HJ, 1993)
"We conclude that patients with fibrositis have a neurotransmitter plasma profile like other chronic pain states having stress and increased vasomotor activity with the possible exception of having low circulating epinephrine."2.66The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study. ( Hamaty, D; Howard, CW; Howard, R; Patten, MS; Valentine, JL; Wakefield, V, 1989)
"Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients."2.45Post-stroke pain. ( Kim, JS, 2009)
"Interstitial cystitis/painful bladder syndrome is a chronic disease characterized by pain, frequency, urgency, and nocturia and diagnosed primarily in women."2.44Interstitial cystitis/painful bladder syndrome. ( Warren, JW, 2007)
"The most common risk factor for shingles and its potential sequela, PHN, is advanced age."2.42Post-herpetic neuralgia case study: optimizing pain control. ( Baron, R, 2004)
"Pain is associated with myriad medical conditions and affects millions of Americans."2.41Pharmacologic management of chronic pain. ( Argoff, CE, 2002)
"Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties."2.39Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996)
"Neurogenic pain is defined as pain due to dysfunction of the peripheral or central nervous system, in the absence of nociceptor (nerve terminal) stimulation by trauma or disease."2.38Neurogenic pain syndromes and their management. ( Bowsher, D, 1991)
"Vulvodynia is chronic vulvar pain or a burning sensation lasting for at least 3 months without a cause."1.72A multidisciplinary approach to a patient with vulvodynia: a successful treatment and outcome. ( Crnković, M; Djaković, I; Lugović-Mihić, L; Magdić-Turković, T; Novak-Hlebar, I; Petričević, T, 2022)
"Pain is a hallmark of this condition and can be extremely difficult to control."1.56Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians. ( Chinnadurai, R; Lowney, AC; Miller, M; Sinha, S, 2020)
"Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2."1.48The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018)
" Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted."1.43Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016)
"Uliginosin B is a natural phloroglucinol derivative, obtained from Hypericum species native to South America."1.40Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. ( Antonio, CB; da Costa, PF; Müller, LG; Noël, F; Rates, SM; Stolz, ED; von Poser, GL, 2014)
"Cyclobenzaprine effectively treated our patient's LAS."1.38Treatment of levator ani syndrome with cyclobenzaprine. ( Kunka, CA; Ota, KS; Sheikh, M, 2012)
" Specifically, doxepin was more neurotoxic than amitriptyline, and both imipramine and trimipramine were more toxic than desipramine or amitriptyline."1.34Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. ( Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK, 2007)
"Amitriptyline (10 mg/kg) has analgesic effect as expected."1.33[Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline]. ( Büyükşekerci, M; Gültekin, H, 2005)
"Familial rectal pain is a very rare entity that must always be considered as a possible aetiology of any life-threatening event in an infant because of the availability of a very effective treatment."1.33Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby. ( Arbuès, AS; Bednarek, N; Morville, P; Motte, J; Plouin, P; Sabouraud, P, 2005)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."1.33Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
" This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses."1.32Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004)
"(1) Postherpetic pain is infrequent, but the incidence increases with age."1.31Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002)
"Allodynia and hyperalgesia appeared on day 5 post-inoculation."1.31Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000)
" A treatment plan was developed consisting of a low-dose morphine infusion with increasing dosage until pain was relieved."1.29Successful treatment of painful crises of Fabry disease with low dose morphine. ( Finley, GA; Gordon, KE; Ludman, MD, 1995)
"The gene for sickle cell disease is carried by 8% of the African-American population in the United States."1.28Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992)
"Various pharmacologic approaches have been advocated for treatment of chronic pain in spinal cord injury, including the use of either anticonvulsants or antidepressants."1.28Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury. ( Haddox, JD; Lindblom, LB; Sandford, PR, 1992)
" Chronic administration of amitriptyline (5 and 10 mg/kg/day, i."1.28Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats. ( Abad, F; Boada, J; Feria, M, 1989)
" Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication."1.27Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987)
" Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike."1.25Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975)

Research

Studies (215)

TimeframeStudies, this research(%)All Research%
pre-199050 (23.26)18.7374
1990's49 (22.79)18.2507
2000's71 (33.02)29.6817
2010's33 (15.35)24.3611
2020's12 (5.58)2.80

Authors

AuthorsStudies
Macsari, I1
Besidski, Y1
Csjernyik, G1
Nilsson, LI1
Sandberg, L1
Yngve, U1
Ahlin, K1
Bueters, T1
Eriksson, AB1
Lund, PE1
Venyike, E1
Oerther, S1
Hygge Blakeman, K1
Luo, L1
Arvidsson, PI1
Sun, H1
Shi, M1
Zhang, W1
Zheng, YM1
Xu, YZ1
Shi, JJ1
Liu, T1
Gunosewoyo, H1
Pang, T1
Gao, ZB1
Yang, F1
Tang, J1
Yu, LF1
Ali, SHK1
Raja, KWA1
Irfan, N1
Habeeb, M1
Ismail, Y1
Chen, CM1
Ding, H1
Mabry, KM1
Ko, MC1
Alberti, FF1
Becker, MW1
Blatt, CR1
Ziegelmann, PK1
da Silva Dal Pizzol, T1
Pilger, D1
Farag, HM1
Yunusa, I1
Goswami, H1
Sultan, I1
Doucette, JA1
Eguale, T1
Asgardoon, MH1
Jazayeri, SB1
Behkar, A1
Dabbagh Ohadi, MA1
Yarmohammadi, H1
Ghodsi, Z1
Pomerani, TI1
Mojtahedzadeh, M1
Rahimi-Movaghar, V1
Novak-Hlebar, I1
Crnković, M1
Djaković, I1
Magdić-Turković, T1
Petričević, T1
Lugović-Mihić, L1
Barry, HC1
Bardin, MG1
Giraldo, PC1
Lenzi, J1
Witkin, SS1
De Mira, TAA1
Morin, M1
García-Iglesias, C1
González-Celestino, A1
Sierra Mencía, Á1
González Osorio, Y1
Recio García, A1
Martínez-Badillo, C1
Echavarría Íñiguez, A1
Varona-Galán, B1
García-Azorín, D1
Guerrero-Peral, ÁL1
Radi, R1
Huang, H1
Rivera, J1
Lyon, C1
DeSanto, K1
Chinnadurai, R1
Sinha, S1
Lowney, AC1
Miller, M1
Srinivasan, A1
Dutta, P2
Bansal, D2
Chakrabarti, A2
Bhansali, AK1
Hota, D2
Akbari, E1
Mirzaei, E1
Rezaee, L1
Zarrabian, S1
Haghparast, A1
Monteiro, BP1
de Lorimier, LP1
Moreau, M1
Beauchamp, G1
Blair, J1
Lussier, B1
Pelletier, JP1
Troncy, E1
Burra, B1
Datta, P1
Rewers-Felkins, K1
Baker, T1
Hale, TW1
Shprecher, D1
Sloan, CT1
Sederholm, B1
Patel, D1
Naik, S1
Chuttani, K1
Mathur, R1
Mishra, AK1
Misra, A1
Calixto-Campos, C1
Zarpelon, AC1
Corrêa, M1
Cardoso, RD1
Pinho-Ribeiro, FA1
Cecchini, R1
Moreira, EG1
Crespigio, J1
Bernardy, CC1
Casagrande, R1
Verri, WA1
Bordson, SJ1
Atayee, RS1
Ma, JD1
Best, BM1
Haviv, Y1
Zadik, Y1
Sharav, Y3
Benoliel, R2
de Zanette, SA1
Vercelino, R1
Laste, G1
Rozisky, JR1
Schwertner, A1
Machado, CB1
Xavier, F1
de Souza, IC1
Deitos, A1
Torres, IL1
Caumo, W1
Stolz, ED1
Müller, LG1
Antonio, CB1
da Costa, PF1
von Poser, GL1
Noël, F1
Rates, SM1
Dinat, N1
Marinda, E1
Moch, S1
Rice, AS1
Kamerman, PR1
Khaziakhmetova, VN1
Luchai, KV1
Ziganshina, LE1
Dogishi, K1
Kodera, M1
Oyama, S1
Shirakawa, H1
Nakagawa, T1
Kaneko, S1
Davis, AM1
Dean, K1
Mousa, H1
Edwards, S1
Cocjin, J1
Almadhoun, O1
He, J1
Bruce, A1
Hyman, PE1
Albertoni Giraldes, AL1
Salomão, R1
Leal, PD1
Brunialti, MK1
Sakata, RK1
Macfarlane, GJ1
Kronisch, C1
Dean, LE1
Atzeni, F1
Häuser, W2
Fluß, E1
Choy, E1
Kosek, E1
Amris, K1
Branco, J1
Dincer, F1
Leino-Arjas, P1
Longley, K1
McCarthy, GM1
Makri, S1
Perrot, S1
Sarzi-Puttini, P1
Taylor, A1
Jones, GT1
Yin, K1
Deuis, JR1
Lewis, RJ1
Vetter, I1
Söylev, GÖ1
Boya, H1
Sawynok, J10
Reid, AR4
Fredholm, BB1
Lin, JA1
Tsai, RY1
Lin, YT1
Lee, MS1
Cherng, CH1
Wong, CS1
Tzeng, JI1
Uçeyler, N1
Sommer, C1
Wicksell, RK1
Melin, L1
Lekander, M1
Olsson, GL1
Lehman, JS1
Sciallis, GF1
Brown, CS1
Wan, J1
Bachmann, G1
Rosen, R1
Sea, J1
Teichman, JM1
Kim, JS1
Leite, FM1
Atallah, AN1
El Dib, R1
Grossmann, E1
Januzzi, E1
Andriolo, RB1
da Silva, EM1
Jiang, CJ1
Tan, YC1
Yang, YJ1
Zhang, EZ1
Liu, J1
Yao, SQ1
Yu, JL1
Fukushima, FB1
Barros, GA1
Marques, ME1
Vidal, EI1
Ganem, EM1
Pettersen, VL1
Zapata-Sudo, G1
Raimundo, JM1
Trachez, MM1
Sudo, RT1
Mao, QX1
Yang, TD1
Ziegler, D1
Bhansali, A1
Mahmood, D1
Akhtar, M1
Vohora, D1
Khanam, R1
Foster, HE1
Hanno, PM1
Nickel, JC1
Payne, CK1
Mayer, RD1
Burks, DA1
Yang, CC1
Chai, TC1
Kreder, KJ1
Peters, KM1
Lukacz, ES1
FitzGerald, MP1
Cen, L1
Landis, JR2
Propert, KJ2
Yang, W2
Kusek, JW1
Nyberg, LM1
Movassaghian, S1
Barzegar-Jalali, M1
Alaeddini, M1
Hamedyazdan, S1
Afzalifar, R1
Zakeri-Milani, P1
Mohammadi, G1
Adibkia, K1
Landy, S1
Altman, CA1
Xie, F1
Hajhashemi, V1
Amin, B1
Bissay, V1
Keymolen, K1
Lissens, W1
Laureys, G1
Schmedding, E1
De Keyser, J1
Song, Z1
Meyerson, BA1
Linderoth, B1
Tan, EC1
Aziz, NA1
Ahmad, S1
Sheikh, M1
Kunka, CA1
Ota, KS1
Boyle, J1
Eriksson, ME1
Gribble, L1
Gouni, R1
Johnsen, S1
Coppini, DV1
Kerr, D1
Oya, H1
Matoba, M1
Murakami, S1
Ohshiro, T1
Kishino, T1
Satoh, Y1
Tsukahara, T1
Hori, S1
Maeda, M1
Makino, T1
Maeda, T1
Alvarez López, JC1
González De Zárate, J1
Herrero Gento, E1
Murphy, D2
Redman, C2
Thomas, E2
Turner, JA2
Jensen, MP2
Warms, CA2
Cardenas, DD3
Argoff, CE1
Lampl, C1
Yazdi, K1
Röper, C1
Reid, A1
Yen, HL1
Chan, W1
Abdel-Salam, OM1
Nofal, SM1
El-Shenawy, SM1
Tofferi, JK1
Jackson, JL1
O'Malley, PG1
Sung, B1
Wang, GK4
Kuraishi, Y2
Takasaki, I2
Nojima, H2
Shiraki, K2
Takahata, H2
Baron, R1
Shin, SW1
Eisenach, JC2
Fridrich, P1
Eappen, S1
Jaeger, W1
Schernhammer, E1
Zizza, AM1
Gerner, P2
Iyengar, S1
Webster, AA1
Hemrick-Luecke, SK1
Xu, JY1
Simmons, RM1
Russell, C1
Wang, SY1
Waldron, JB1
Rosenlicht, NZ1
Riley-Lazo, KP1
Bomholt, SF1
Mikkelsen, JD1
Blackburn-Munro, G1
Masedo, AI1
Hanley, M1
Ehde, D1
Büyükşekerci, M1
Gültekin, H1
Hong, HB1
Xu, RJ1
Nordmann, GR1
Lauder, GR1
Grier, DJ1
Lynch, ME1
Clark, AJ1
Sullivan, MJ1
Kumar, S1
Veldhuijzen, DS2
Kenemans, JL2
van Wijck, AJ2
Olivier, B2
Kalkman, CJ2
Volkerts, ER2
Bednarek, N1
Arbuès, AS1
Motte, J1
Sabouraud, P1
Plouin, P1
Morville, P1
McCarson, KE1
Duric, V1
Reisman, SA1
Winter, M1
Enna, SJ1
Verster, JC1
Kaptchuk, TJ2
Stason, WB1
Davis, RB1
Legedza, AR1
Schnyer, RN1
Kerr, CE1
Stone, DA1
Nam, BH1
Kirsch, I1
Goldman, RH1
Son, BC1
Lee, SW1
Choi, ES1
Sung, JH1
Hong, JT1
Eksioglu, E1
Yazar, D1
Bal, A1
Usan, HD1
Cakci, A1
Felicio, AC1
Godeiro, Cde O1
Borges, V1
Silva, SM1
Ferraz, HB1
Haller, I1
Lirk, P1
Keller, C1
Klimaschewski, L1
Huber, AM1
Tomlinson, GA1
Koren, G1
Feldman, BM1
Loram, LC1
Mitchell, D1
Skosana, M1
Fick, LG1
Paudel, KR1
Das, BP1
Rauniar, GP1
Sangraula, H1
Deo, S1
Bhattacharya, SK1
Warren, JW1
Gil, DW1
Cheevers, CV1
Donello, JE1
Jerome, L1
Rintala, DH1
Holmes, SA1
Courtade, D1
Fiess, RN1
Tastard, LV1
Loubser, PG1
Ho, KY1
Huh, BK1
White, WD1
Yeh, CC1
Miller, EJ1
Millecamps, M1
Coderre, TJ1
Cormack, J1
Dalessio, DJ1
Watson, CP1
Evans, RJ1
Reed, K1
Merskey, H1
Goldsmith, L1
Warsh, J1
Shea, JJ1
Morse, RH1
Portenoy, RK1
Rapscak, S1
Kanner, R1
Jay, GW1
Renelli, D1
Mead, T1
Pilowsky, I3
Hallett, EC1
Bassett, DL1
Thomas, PG1
Penhall, RK1
Mitas, JA1
Mosley, CA1
Drager, AM1
Schaefer, MC1
Weis, O1
Sriwatanakul, K1
Weintraub, M1
Spitaels, JM1
Lindsay, PG1
Wyckoff, M1
Ortega-Alvaro, A1
Gibert-Rahola, J1
Chover, AJ1
Tejedor-Real, P1
Casas, J1
Mico, JA1
Gordon, KE1
Ludman, MD1
Finley, GA1
Klein, M1
Mahoney, JE1
Gray, SL1
Carnes, M1
Spence, N1
Rounsefell, B1
Forsten, C1
Soda, J1
Eliav, E1
Elishoov, H1
Kopecki, RA1
Strouse, WS1
McQuay, HJ2
Carroll, D2
Glynn, CJ2
Godfrey, RG1
Taniguchi, K1
Yoshitake, S1
Iwasaka, H1
Honda, N1
Oyama, T1
Rani, PU1
Naidu, MU1
Prasad, VB1
Rao, TR1
Shobha, JC1
Bartusch, SL1
Sanders, BJ1
D'Alessio, JG1
Jernigan, JR1
Bryson, HM1
Wilde, MI1
Hood, DD1
Curry, R1
Tong, C1
Brenne, E1
van der Hagen, K1
Maehlum, E1
Husebø, S1
Vrethem, M1
Boivie, J2
Arnqvist, H1
Holmgren, H1
Lindström, T1
Thorell, LH1
Pranikoff, K1
Constantino, G1
Scholz, MJ1
Jourdan, D1
Ardid, D1
Chapuy, E1
Le Bars, D1
Eschalier, A1
Shlay, JC1
Chaloner, K1
Max, MB3
Flaws, B1
Reichelderfer, P1
Wentworth, D1
Hillman, S1
Brizz, B1
Cohn, DL1
Kieburtz, K1
Simpson, D1
Yiannoutsos, C1
Hall, CD1
Ellis, RJ1
Marra, CM1
McKendall, R1
Singer, E1
Dal Pan, GJ1
Clifford, DB1
Tucker, T1
Cohen, B1
Scott, MA1
Letrent, KJ1
Hager, KL1
Burch, JL1
Yasuda, T1
Iwamoto, T1
Ohara, M1
Sato, S1
Kohri, H1
Noguchi, K1
Senba, E1
Esser, MJ4
Field, MJ1
McCleary, S1
Hughes, J1
Singh, L1
Ulett, GA1
King, SA1
Onal, A1
Tuğlular, I1
Morello, CM1
Leckband, SG1
Stoner, CP1
Moorhouse, DF1
Sahagian, GA1
Kiefer, G1
Fischer, W1
Feuerstein, TJ1
Andoh, T1
Nitta, M1
Nemoto, H1
Dallocchio, C1
Buffa, C1
Mazzarello, P1
Chiroli, S1
Lofland, JH1
Szarlej, D1
Buttaro, T1
Shermock, S1
Jalali, S1
Lein, B1
Refaeian, M1
King, JC1
Dumitru, D1
Chase, T1
Allen, GV2
Heughan, CE2
Chase, TD1
Marshall, H1
Brooke, MM1
Loeser, JD1
Poitras, P1
Riberdy Poitras, M1
Plourde, V1
Boivin, M1
Verrier, P1
Sinnott, C1
Davis, JL1
Lewis, SB1
Gerich, JE1
Kaplan, RA1
Schultz, TA1
Wallin, JD1
Montgomery, BJ1
Raftery, H1
Pfister, AK1
Moore, DS1
Nally, FF1
Beckner, TF1
Idsvoog, P1
Fong, GR1
Sanders, DY1
Severance, HW1
Pollack, CV1
Zitman, FG4
Linssen, AC3
Edelbroek, PM4
Van Kempen, GM2
Barrow, G1
Sandford, PR1
Lindblom, LB1
Haddox, JD1
Lynch, SA1
Muir, J1
Shoaf, SE1
Smoller, B1
Dubner, R1
Acton, J1
McKenna, JE1
Melzack, R1
Linssen, ACG1
Van Kempen, GMJ1
Bowsher, D1
Reynolds, WJ1
Moldofsky, H1
Saskin, P1
Lue, FA1
Gastmeier, K1
Hass, M1
Schott, H1
Kuteifan, K1
Egbunike, IG1
Chaffee, BJ1
Tura, B1
Tura, SM1
Leijon, G1
Hamaty, D1
Valentine, JL1
Howard, R1
Howard, CW1
Wakefield, V1
Patten, MS1
Lechin, F1
van der Dijs, B1
Rada, I1
Jara, H1
Lechin, M1
Cabrera, A1
Lechin, A1
Gomez, F1
Jimenez, V1
Arocha, L1
Goldenberg, DL1
Rogers, AG1
Abad, F1
Feria, M1
Boada, J1
Seltzer, Z1
Tal, M1
Frances, A1
de Felipe, MC1
de Ceballos, ML1
Fuentes, JA1
Frank, RG1
Kashani, JH1
Parker, JC1
Beck, NC1
Brownlee-Duffeck, M1
Elliott, TR1
Haut, AE1
Atwood, C1
Smith, E1
Kay, DR1
Tollison, CD1
Kriegel, ML1
Rascol, O1
Tran, MA1
Bonnevialle, P1
Belin, J1
Cotonat, J1
Guiraud-Chaumeil, B1
Montastruc, JL1
Dove, J1
Rooymans, HG1
de Wolff, FA1
Mendel, CM1
Klein, RF1
Chappell, DA1
Dere, WH1
Gertz, BJ1
Karam, JH1
Lavin, TN1
Grunfeld, C1
Reinhardt, U1
Godefroy, F2
Butler, SH2
Weil-Fugazza, J2
Besson, JM2
Callies, AL1
Popkin, MK1
Sandyk, R1
Gillman, MA1
Taub, A1
Liederman, PC1
Green, R1
Liederman, VR1
Kapusta, MA1
Gannon, P1
Itil, T1
Keskiner, A1
Hsu, B1
Hislop, IG1
Singh, G1
Verma, HC1
Straube, W1
Opitz, K1
Borchert, U1

Clinical Trials (30)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]Phase 450 participants (Anticipated)Interventional2015-02-28Recruiting
Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects[NCT02041455]Phase 2/Phase 366 participants (Anticipated)Interventional2010-06-30Recruiting
A Phase II, Randomized-Controlled, Multicenter Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age[NCT01206478]Phase 221 participants (Actual)Interventional2010-08-31Completed
Benefits of Kinesio Taping and Inhibitory Treatment Techniques in Patients With Fibromyalgia Syndrome[NCT02859467]64 participants (Anticipated)Interventional2016-08-31Suspended
Museums as Health Spaces: Design and Evaluation of the Effectiveness of an Arts in Health Intervention to Improve the Quality of Life and Functional Capacity Regarding the Pain of People With Fibromyalgia. Mixed Methodology Study.[NCT05993663]121 participants (Anticipated)Interventional2023-10-02Recruiting
Effects of Manipulative Therapy in the Lower Thoracic and Cervical Spine in Subjects With Fibromyalgia Syndrome[NCT02864524]64 participants (Anticipated)Interventional2016-08-31Active, not recruiting
Effectiveness of Pain Neuroscience Education and Strength Training Program in Patients With Fibromyalgia[NCT04855851]60 participants (Anticipated)Interventional2022-03-01Recruiting
A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®[NCT03347669]100 participants (Anticipated)Interventional2017-11-06Recruiting
Effectiveness of High-intensity Interval Training Combined With Resistance Training in Patients With Fibromyalgia[NCT03924960]55 participants (Actual)Interventional2019-04-22Completed
Effectiveness of Spinal Manipulation in Addition to Standard Pharmacological Treatment in Fibromyalgia : A Blinded Randomized Clinical Trial[NCT04673058]60 participants (Actual)Interventional2021-01-26Completed
Virtual Acceptance Commitment Therapy (ACT): A Randomized Controlled Trial to Evaluate a Web-Based Intervention for Stress in Adolescents With Chronic Conditions[NCT04978610]144 participants (Anticipated)Interventional2021-03-03Suspended (stopped due to Lack of lab resources)
IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder Syndrome a Randomized Placebo-controlled Prospective Trial[NCT04313972]Phase 42 participants (Actual)Interventional2021-09-07Completed
A Randomized Multicenter Clinical Trial to Evaluate the Efficacy of Amitriptyline for the Treatment of Painful Bladder Syndrome (PBS) in Newly Diagnosed Patients[NCT00124306]Phase 3271 participants (Actual)Interventional2005-02-28Completed
A Randomized Trial of Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome[NCT04401176]Phase 258 participants (Actual)Interventional2020-09-15Completed
Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief[NCT02265848]Phase 422 participants (Actual)Interventional2014-10-31Completed
The Effect of Foot and Ankle Exercise on Pain and Quality of Life in Patients With Diabetic Neuropathy[NCT05670600]100 participants (Actual)Interventional2021-07-19Completed
A Double-blind, Randomised, Parallel Groups Investigation Into the Effects of Pregabalin, Duloxetine and Amitriptyline on Aspects of Pain, Sleep, and Next Day Performance in Patients Suffering From Diabetic Peripheral Neuropathy[NCT00370656]Phase 2/Phase 390 participants (Anticipated)Interventional2007-02-28Completed
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]152 participants (Actual)Interventional2015-03-31Active, not recruiting
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904]15 participants (Anticipated)Observational2011-06-30Recruiting
The Effect of Acupuncture on in Vitro Fertilization Outcomes in Women Undergoing Euploid Embryo Transfer - A Pilot Study[NCT03981120]100 participants (Anticipated)Interventional2019-09-15Not yet recruiting
A Phase I/II, Randomized, Study for Diabetic Macular Edema Using 0.3mg Ranibizumab Combined With Targeted PRP Monthly for 4 Months,Then PRN vs. 0.3mg Ranibizumab 4 Months Monotherapy, Then as Needed(DME-AntiVEgf) DAVE[NCT01552408]Phase 1/Phase 229 participants (Actual)Interventional2012-03-31Completed
Internet-Enhanced Management of Fibromyalgia[NCT00423631]118 participants (Actual)Interventional2006-09-30Completed
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893]Phase 112 participants Interventional2005-12-31Completed
The Efficacy of a Standardized Acupuncture Regimen and Amitriptyline Compared With Placebo as a Treatment for Pain Caused by Peripheral Neuropathy in HIV-Infected Patients[NCT00000817]260 participants (Actual)Interventional1994-11-30Completed
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection[NCT00000793]Phase 2240 participants InterventionalCompleted
A Phase II, Double-Blind Trial of Recombinant Human Nerve Growth Factor for Treatment of HIV-Associated Sensory Neuropathy[NCT00000842]Phase 2270 participants InterventionalCompleted
Management of Chronic Pain in Rehabilitation Project I - Management of Chronic Pain in Persons With Spinal Cord Injury[NCT00006428]Phase 4100 participants Interventional1996-08-31Completed
Subcutaneous Injection of Botulinum Toxin A for At--Level Back Pain in Patients With Spinal Cord Injury[NCT02736890]Phase 28 participants (Actual)Interventional2016-03-31Terminated (stopped due to funding not available to continue)
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887]Phase 2150 participants (Actual)Interventional2004-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

% Calories Taken Orally

Percent Kilocalories (kcal) Obtained Orally. This measure was obtained using the 24 hour food recall, a standardized five-pass method developed by the US Department of Agriculture for use in national dietary surveillance. This measure has been widely used in several large trials and data suggest it is the most valid and reliable method of dietary assessment for children (20). The data were collected at week 0, week 10, and week 24 using standardized probes by highly trained research staff, and parents were presented with paper food models and measuring devices prior to interviews to reference during the recall. Recalls were analyzed with the Nutritional Data System for Research, version 2005; University of Minnesota, Minneapolis, MN. (NCT01206478)
Timeframe: baseline, 24 weeks

Interventionchange in percent kcal obtained orally (Mean)
Amitriptyline, Megestrol68.62
Placebo, Megestrol76.89

Change in Non-communicating Children's Pain Checklist - Revised (NCCPC-R) Scores

Non-communicating Children's Pain Checklist - Revised (NCCPC-R) used to measure outcome. The NCCPC-R is a 30 item measure intended to assess pain in children who are unable to speak because of cognitive or physical impairments. There are 7 sub-scales including vocal, social, facial, activity, body/limbs, physiological, and eating/sleeping. Each question has a potential score of 0 to 3. Scores are totaled for each sub-scale. Sub-scale scores are then added together for the Total Score. Total Scores can range from 0 to 90. The higher the score, the higher level of pain indicated by the child. This measure was completed by parents at week 0, week 10, and week 24. (NCT01206478)
Timeframe: baseline, 24 weeks

Interventionunits on a scale (Mean)
Amitriptyline, Megestrol-2.5
Placebo, Megestrol-6.86

Numeric Pain Rating Scale (NPRS)

Digital pain rating system that scores patient's subjective pain rating from 0 to 10; with greater number indicating progressively worsening pain. NPRS were measured at baseline (visit1), and at each follow ups visits at visit 2, 3 and 4. Visit 2 and 4 captured post treatment (either 1000 Hz or standard stimulation depending on the randomization) results, and visit 3 captured NPRS after the wash off from the spinal cord stimulation. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)

,
Interventionunits on a scale (Mean)
Average Baseline NPRS ScoreAverage NPRS after 1000 Hz. stimulationAverage NPRS after standard stimulationAverage NPRS after Wash offBest Baseline NPRS scoreBest NPRS score after 1000 Hz. stimulationBest NPRS score after standard stimulationBest NPRS after Wash offWorst Baseline NPRS scoreWorst NPRS score after 1000 Hz. stimulationWorst NPRS score after standard stimulationWorst NPRS after Wash off
Treatment Group A6.093.735.646.453.722.643.464.547.906.648.188.72
Treatment Group B6.273.826.097.184.452.184.455.368.096.648.368.81

Oswestry Disability Index Questionnaire (ODI).

ODI is a outcome metrics that is design to assess the severity of disability based on 10 activity categories. ODI is based on 0 to 100% scale, where larger percentage implies worse disability. (There are 5 categories: 0-20%: Minimal disability, 21-40%: Moderate disability, 41-60%: Severe disability, 61-80%: Crippled. 81-100%: Either bed bound or exaggerating symptoms). ODI were measured at baseline (visit1), and at each follow ups visits at visit 2, 3 and 4. Visit 2 and 4 captured post treatment (either 1000 Hz or standard stimulation depending on the randomization) results, and visit 3 captured NPRS after the wash off from the spinal cord stimulation. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)

,
Interventionunits on a scale (Mean)
Baseline ODI scoreODI after 1000 Hz. stimluationODI after standard stimulationODI after wash off
Treatment Group A47.4939.2349.6352.87
Treatment Group B51.2533.7749.0556.77

Patient's Global Impression of Change (PGIC)

PGIC is a 7-point scale that requires study subjects to rate the severity of their illness or medical condition after a specific treatment. 1: No change, 2: Almost the same, 3: A little better, 4: Somewhat better, 5: Moderately better, 6: Better, 7: A great deal better. Study subjects were asked to report their impression of changes at baseline visit, visit 2 through 4. (NCT02265848)
Timeframe: Baseline (visit 1), and at each follow up visits (visits 2, 3, and 4)

,
Interventionunits on a scale (Mean)
PGIC After 1000 Hz. stimulationPGIC after standard stimulationPGIC after Wash off
Treatment Group A4.272.541.45
Treatment Group B5.912.451.27

Preferability

At the conclusion of the study, subjects were asked to report which spinal cord stimulation modes they preferred. Subjects were presented with two boxes (1000 Hz. stimulation and Standard stimulation) and asked to check one. (NCT02265848)
Timeframe: End of treatment visit on visit 4

,
Interventionparticipants (Number)
Subjects who prefer 1000 Hz. stimulationSubjects who prefer standard stimulation
Treatment Group A83
Treatment Group B101

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Mean Change in Peripheral Visual Field as Measured by Goldmann Visual Field at Screen and Month and 36.

Mean change in peripheral visual field as measured by Goldmann visual field at screen and Month 36 in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: 36 Months

Interventiondegrees squared (Mean)
0.3 mg Ranibizumab-215
Targeted PRP With 0.3 mg Ranibizumab-1723

Mean Change Over Time in Early Treatment Diabetic Retinopathy Study Best Corrected Visual Acuity (ETDRS BCVA) Through Month 36

Evaluate the mean change over time in ETDRS BCVA in the ranibizumab and targeted PRP with ranibizumab cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months

Interventionletters (Mean)
0.3 mg Ranibizumab13.9
Targeted PRP With 0.3 mg Ranibizumab8.2

Patients With Persistent Macular Edema Post-intravitreal Injection.

Percentage of patients with persistent macular edema post-intravitreal injection in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: Month 36

InterventionParticipants (Count of Participants)
0.3 mg Ranibizumab9
Targeted Pan-retinal Photocoagulation With 0.3 mg Ranibizumab12

Total Number of Ranibizumab Injections in Each of the Two Cohorts in a 36 Month Period

Assess the number of ranibizumab injections in the ranibizumab and targeted panretinal photocoagulation (PRP) with ranibizumab cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months

Interventioninjections (Mean)
0.3 mg Ranibizumab24.4
Targeted PRP With 0.3 mg Ranibizumab27.1

Determine Percentage of Patients Who Experience a Gain of 15 or More Letters From Baseline to Month 12, 24, and 36 in ETDRS BCVA

Determine percentage of patients who experience a gain of 15 or more letters from Baseline to Month 12, 24, and 36 in ETDRS BCVA in the ranibizumab and targeted PRP with ranibizumab cohorts. (NCT01552408)
Timeframe: Month 12, 24, and 36

,
InterventionParticipants (Count of Participants)
Month 12Month 24Month 36
0.3 mg Ranibizumab10109
Targeted PRP With 0.3 mg Ranibizumab565

Evaluate Mean Change in Central Retinal Thickness Over Time Through Month 12, 24, and 36 as Assessed by High Resolution OCT's.

Evaluate mean change in central retinal thickness in the ranibizumab and targeted PRP with ranibizumab cohorts over time through Month 12, 24, and 36 as assessed by high resolution OCT's. (NCT01552408)
Timeframe: Month 12, 24, and 36

,
Interventionmicrons (Mean)
Month 12Month 24Month 36
0.3 mg Ranibizumab-301-296-302
Targeted PRP With 0.3 mg Ranibizumab-161-169-152

Incidence and Severity of Ocular and Non-ocular Adverse Events (AE's) Through Month 36.

Incidence and severity of ocular and non-ocular adverse events (AE's) in the monotherapy and combination cohorts through Month 36. (NCT01552408)
Timeframe: 36 Months

,
InterventionParticipants (Count of Participants)
Participants Experiencing Serious Ocular AEParticipants Experiencing Serious Systemic AE
0.3 mg Ranibizumab27
Targeted PRP With 0.3 mg Ranibizumab19

Patients Who Experience a Loss of 15 or More Letters From Baseline to Month 12, 24, and 36 in ETDRS BCVA.

Percentage of patients in the ranibizumab and targeted PRP with ranibizumab cohorts who experience a loss of 15 or more letters from Baseline to Month 12, 24, and 36 in ETDRS BCVA. (NCT01552408)
Timeframe: Month 12, 24, and 36

,
InterventionParticipants (Count of Participants)
12 Months24 Months36 Months
0.3 mg Ranibizumab000
Targeted PRP With 0.3 mg Ranibizumab011

7-Point Guy/Farrar Patient Global Impression of Change (PGIC)

"Mean change from baseline. Participants are asked Taking into account your pain level and how it affects your life, are you feeling better, the same or worse than when you started treatment? and then to quantify the magnitude of the change. with the 7-Point guy Farrar which measures the global treatment effect from with scale from 0 to 6, higher score indicates worse outcomes." (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionscore on a scale (Mean)
2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo2.22.4220000
Placebo Then Botulinum Toxin A0.30.3005531

International Basic Pain Dataset - Pain Affecting Day-to-day Activities

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting day-to-day activities subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionunits on a scale (Mean)
Baseline2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo4.25.4554.876.776.7
Placebo Then Botulinum Toxin A5.32.72.72.72.72345

International Basic Pain Dataset - Pain Affecting Mood

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting mood subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionunits on a scale (Mean)
Baseline2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo5.66.65.85.25.6777.36.7
Placebo Then Botulinum Toxin A5.72.72.74.35.72347

International Basic Pain Dataset - Pain Affecting Sleep

The International Basic Pain Dataset is an assessment tool which includes several components including: location of pain, temporal qualities of the pain, type of pain, pain interference measures of activity, sleep, and mood. It has been shown to be valid in an interview/self -report format. The pain affecting sleep subset of the dataset is scored is from 0 to 10, with higher score indicating less favorable outcomes. (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionunits on a scale (Mean)
Baseline2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo5.84.6566.28887.3
Placebo Then Botulinum Toxin A6.74.73.366.71345

Numeric Pain Rating Scale (NPRS)

Participant rated pain intensity from 0-10, with higher score indicating more pain (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionscore on a scale (Mean)
baseline2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo7.66.45.65.65.6886.78
Placebo Then Botulinum Toxin A888885567

Patient-generated Index (PGI)

PGI measures activity affected by pain. Full score is 0 to 10000, with higher score indicating better function (NCT02736890)
Timeframe: up to 12 weeks post-injection, for a total of 24 weeks from baseline

,
Interventionscore on a scale (Mean)
Baseline2 week post injection4 week post injection8 week post injection12 week post injectioncrossover 2 week follow upcrossover 4 week follow upcrossover 8 week follow upcrossover 12 week follow up
Botulinum Toxin A Then Placebo425052405219372543303333.33333.33333.33333.3
Placebo Then Botulinum Toxin A150015501825280018003500375030001500

Length of Hospitalization

Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days

InterventionDays (Median)
Inhaled Nitric Oxide4.06
Placebo3.11

Number of Participants Discharged to Home Within the First 24 Hours

(NCT00094887)
Timeframe: within 24 hours

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide5
Placebo7

Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion

Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide8
Placebo7

Time to Vaso-occlusive Pain Crisis (VOC) Resolution

"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days

InterventionHours (Median)
Inhaled Nitric Oxide61.83
Placebo55.16

Number of Participants Readmitted to Hospital Within 30 Days After Discharge

The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up

,
InterventionParticipants (Count of Participants)
during first 24 hoursduring 30-day follow-up
Inhaled Nitric Oxide09
Placebo017

Total Dose of Opioids Received

The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days

,
Interventionmg (Median)
within 8 hourswithin 40 days
Inhaled Nitric Oxide16.25153.75
Placebo17.25211.37

Reviews

24 reviews available for amitriptyline and Pain

ArticleYear
Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis.
    Clinical rheumatology, 2022, Volume: 41, Issue:7

    Topics: Adolescent; Adult; Amitriptyline; Child; Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Net

2022
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
    JAMA network open, 2022, 05-02, Volume: 5, Issue:5

    Topics: Amitriptyline; Duloxetine Hydrochloride; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; M

2022
Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review.
    Spinal cord series and cases, 2022, 07-04, Volume: 8, Issue:1

    Topics: Amitriptyline; Anticonvulsants; Gabapentin; Humans; Ketamine; Pain; Pregabalin; Spinal Cord Injuries

2022
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome.
    Arthritis and rheumatism, 2008, Sep-15, Volume: 59, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Databases, Bibliographic; Depression; Fatigue; Fibromyalgia; H

2008
Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment.
    Drugs, 2009, Volume: 69, Issue:3

    Topics: Administration, Intravesical; Amitriptyline; Child; Cimetidine; Cystitis, Interstitial; Diet Therapy

2009
Post-stroke pain.
    Expert review of neurotherapeutics, 2009, Volume: 9, Issue:5

    Topics: Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Humans; Pain; Stroke

2009
Cyclobenzaprine for the treatment of myofascial pain in adults.
    The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3

    Topics: Adult; Amitriptyline; Anesthetics, Local; Clonazepam; Fascia; Humans; Lidocaine; Muscle Relaxants, C

2009
Painful diabetic neuropathy: advantage of novel drugs over old drugs?
    Diabetes care, 2009, Volume: 32 Suppl 2

    Topics: Amitriptyline; Analgesics; Antioxidants; Antipruritics; Capsaicin; Chronic Disease; Diabetic Neuropa

2009
Essential vulvodynia (vulval pain).
    Clinical evidence, 2002, Issue:7

    Topics: Amitriptyline; Decompression, Surgical; Female; Humans; Pain; Pain Management; Randomized Controlled

2002
Pharmacologic management of chronic pain.
    The Journal of the American Osteopathic Association, 2002, Volume: 102, Issue:9 Suppl 3

    Topics: Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

2002
Essential vulvodynia (vulval pain).
    Clinical evidence, 2002, Issue:8

    Topics: Amitriptyline; Decompression, Surgical; Female; Humans; Pain; Pain Management; Vulva

2002
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis.
    Arthritis and rheumatism, 2004, Feb-15, Volume: 51, Issue:1

    Topics: Amitriptyline; Databases, Factual; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; Muscle

2004
Post-herpetic neuralgia case study: optimizing pain control.
    European journal of neurology, 2004, Volume: 11 Suppl 1

    Topics: Acetates; Aged; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarb

2004
Local approaches to the pain of pressure ulcers.
    Ostomy/wound management, 2005, Volume: 51, Issue:1

    Topics: Administration, Cutaneous; Amitriptyline; Anesthetics, Local; Bandages; Humans; Lidocaine; Lidocaine

2005
[Progress on painful diabetic peripheral neuropathy treated by integrative medicine].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:4

    Topics: Amines; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cyclohe

2005
Interstitial cystitis/painful bladder syndrome.
    Urologic nursing, 2007, Volume: 27, Issue:3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C

2007
Medical treatment of tinnitus.
    The American journal of otology, 1984, Volume: 5, Issue:6

    Topics: Amitriptyline; Anti-Arrhythmia Agents; Auditory Pathways; Drug Combinations; Humans; Lidocaine; Pain

1984
A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.
    Archives of internal medicine, 1996, May-27, Volume: 156, Issue:10

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Doxepin; Fibromyalgia; Humans; Lif

1996
Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states.
    Drugs & aging, 1996, Volume: 8, Issue:6

    Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Chronic Di

1996
Isolated sural neuropathy presenting as lateral ankle pain.
    American journal of physical medicine & rehabilitation, 2001, Volume: 80, Issue:7

    Topics: Accidents, Occupational; Adult; Amitriptyline; Analgesics, Non-Narcotic; Ankle; Anti-Inflammatory Ag

2001
Neurogenic pain syndromes and their management.
    British medical bulletin, 1991, Volume: 47, Issue:3

    Topics: Amitriptyline; Chronic Disease; Humans; Nervous System Diseases; Pain; Pain Management; Syndrome

1991
Antidepressants in the management of chronic pain syndromes.
    Pharmacotherapy, 1990, Volume: 10, Issue:4

    Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies;

1990
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
    The Journal of rheumatology. Supplement, 1989, Volume: 19

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic;

1989

Trials

54 trials available for amitriptyline and Pain

ArticleYear
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
    Applied biochemistry and biotechnology, 2022, Volume: 194, Issue:1

    Topics: Acute Disease; Adult; Amitriptyline; Antioxidants; Ascorbic Acid; Dietary Supplements; Female; Human

2022
Does the addition of electrical stimulation or kinesiotherapy improve outcomes of amitriptyline treatment for women with vulvodynia? A randomized clinical trial.
    International urogynecology journal, 2023, Volume: 34, Issue:6

    Topics: Amitriptyline; Electric Stimulation; Female; Humans; Pain; Pain Measurement; Vulvodynia

2023
Is low-dose naltrexone effective in chronic pain management?
    The Journal of family practice, 2023, Volume: 72, Issue:7

    Topics: Amitriptyline; Fibromyalgia; Humans; Naltrexone; Pain; Pain Management

2023
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial.
    Journal of diabetes, 2021, Volume: 13, Issue:10

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Neu

2021
Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial.
    PloS one, 2018, Volume: 13, Issue:12

    Topics: Amitriptyline; Analgesics; Animals; Bone Neoplasms; Central Nervous System Sensitization; Dog Diseas

2018
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.
    BMC pharmacology & toxicology, 2014, Jul-23, Volume: 15

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Brain-Derived Neurotrophic Factor; Double-Blind Method

2014
Randomized, Double-Blind, Crossover Trial of Amitriptyline for Analgesia in Painful HIV-Associated Sensory Neuropathy.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anti-Retroviral Agents; Cross-Over Studies; Double-B

2015
A Randomized Controlled Trial of an Outpatient Protocol for Transitioning Children from Tube to Oral Feeding: No Need for Amitriptyline.
    The Journal of pediatrics, 2016, Volume: 172

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Body Mass Index; Child; Enteral Nutrition; Feeding Behavior

2016
Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations of IL-1, IL-6 and IL-8 in patients with fibromyalgia: A randomized double-blind study.
    International journal of rheumatic diseases, 2016, Volume: 19, Issue:10

    Topics: Administration, Intravenous; Adult; Amitriptyline; Anesthetics, Local; Biomarkers; Brazil; Double-Bl

2016
Evaluating the effectiveness of exposure and acceptance strategies to improve functioning and quality of life in longstanding pediatric pain--a randomized controlled trial.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Activities of Daily Living; Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Analysis of Varianc

2009
Self-management, amitriptyline, and amitripyline plus triamcinolone in the management of vulvodynia.
    Journal of women's health (2002), 2009, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Cognitiv

2009
Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial.
    Diabetic medicine : a journal of the British Diabetic Association, 2009, Volume: 26, Issue:10

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Diabetic Neuropathies; Dose-Response Relationship, Drug; Do

2009
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome.
    The Journal of urology, 2010, Volume: 183, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Cystitis, Interstitial; Double-Blind Method; Female;

2010
Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures.
    Drug development and industrial pharmacy, 2011, Volume: 37, Issue:7

    Topics: Adhesiveness; Administration, Buccal; Adult; Amitriptyline; Analgesia; Analgesics, Non-Narcotic; Car

2011
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
    Diabetes care, 2012, Volume: 35, Issue:12

    Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g

2012
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
    Diabetes care, 2012, Volume: 35, Issue:12

    Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g

2012
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
    Diabetes care, 2012, Volume: 35, Issue:12

    Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g

2012
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
    Diabetes care, 2012, Volume: 35, Issue:12

    Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; g

2012
Estimating the efficacy of an interstitial cystitis/painful bladder syndrome medication in a randomized trial with both non-adherence and loss to follow-up.
    Statistics in medicine, 2014, Sep-10, Volume: 33, Issue:20

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Computer Simulation; Cystitis, Interstitial; Humans; Logist

2014
Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial.
    Pain, 2002, Volume: 99, Issue:1-2

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Attitude of Health Personnel; Double-Blind Method; F

2002
Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study.
    Stroke, 2002, Volume: 33, Issue:12

    Topics: Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycli

2002
Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy.
    Anesthesiology, 2004, Volume: 100, Issue:6

    Topics: Adult; Amitriptyline; Bupivacaine; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged;

2004
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Acute and subchronic effects of amitriptyline on processing capacity in neuropathic pain patients using visual event-related potentials: preliminary findings.
    Psychopharmacology, 2006, Volume: 183, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents; Attention; Cross-Over Studies; Double-Blind Method; Ele

2006
Acute and subchronic effects of amitriptyline 25mg on actual driving in chronic neuropathic pain patients.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:6

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Attention; Automobile Driving; Chronic Disea

2006
Sham device v inert pill: randomised controlled trial of two placebo treatments.
    BMJ (Clinical research ed.), 2006, Feb-18, Volume: 332, Issue:7538

    Topics: Acupuncture Analgesia; Administration, Oral; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; A

2006
Effects of Stanger bath therapy on fibromyalgia.
    Clinical rheumatology, 2007, Volume: 26, Issue:5

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Combined Modality Therapy; Electric Stimulation Ther

2007
Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials.
    The Journal of rheumatology, 2007, Volume: 34, Issue:5

    Topics: Adolescent; Amitriptyline; Analgesics, Non-Narcotic; Arthritis, Juvenile; Bayes Theorem; Child; Dose

2007
Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury.
    Archives of physical medicine and rehabilitation, 2007, Volume: 88, Issue:12

    Topics: Adult; Aged; Amines; Amitriptyline; Analgesics; Analysis of Variance; Antidepressive Agents, Tricycl

2007
Topical amitriptyline versus lidocaine in the treatment of neuropathic pain.
    The Clinical journal of pain, 2008, Volume: 24, Issue:1

    Topics: Administration, Topical; Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Local; Double-Blind M

2008
Amitriptyline versus placebo in postherpetic neuralgia.
    Neurology, 1982, Volume: 32, Issue:6

    Topics: Aged; Amitriptyline; Depression; Double-Blind Method; Female; Herpesviridae Infections; Humans; Male

1982
A controlled study of amitriptyline in the treatment of chronic pain.
    Pain, 1982, Volume: 14, Issue:2

    Topics: Amitriptyline; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Pain

1982
Dose-response for analgesic effect of amitriptyline in chronic pain.
    Anaesthesia, 1993, Volume: 48, Issue:4

    Topics: Adult; Aged; Amitriptyline; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Double-Bl

1993
The effects of imipramine, amitriptyline and clonidine administered by iontophoresis on the pain threshold.
    Acta anaesthesiologica Belgica, 1995, Volume: 46, Issue:3-4

    Topics: Adrenergic alpha-Agonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clonidine; Humans

1995
An evaluation of antidepressants in rheumatic pain conditions.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:2

    Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents, Second-Generation; Antidepressive Agents, T

1996
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
    Anesthesiology, 1997, Volume: 86, Issue:6

    Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; D

1997
[Treatment chronic pain with amitriptyline. A double-blind dosage study with determination of serum levels].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1997, Oct-10, Volume: 117, Issue:24

    Topics: Adult; Aged; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Chronic Disease; Double-Bl

1997
A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics.
    The Clinical journal of pain, 1997, Volume: 13, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Cross-Over Studies;

1997
Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS.
    JAMA, 1998, Nov-11, Volume: 280, Issue:18

    Topics: Acupuncture Therapy; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Double-Blind Method; Fe

1998
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
    Neurology, 1998, Volume: 51, Issue:6

    Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Anti-Arrhythmia Agents; Double-Blind Method; Dru

1998
Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain.
    Archives of internal medicine, 1999, Sep-13, Volume: 159, Issue:16

    Topics: Acetates; Adrenergic Uptake Inhibitors; Aged; Amines; Amitriptyline; Analgesics; Cross-Over Studies;

1999
Gabapentin vs. amitriptyline in painful diabetic neuropathy: an open-label pilot study.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Acetates; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Ataxia; Cyclohexanecarboxylic

2000
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
    Pain, 2002, Volume: 96, Issue:3

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;

2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
    Pain, 2002, Volume: 96, Issue:3

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;

2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
    Pain, 2002, Volume: 96, Issue:3

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;

2002
Efficacy of amitriptyline for relief of pain in spinal cord injury: results of a randomized controlled trial.
    Pain, 2002, Volume: 96, Issue:3

    Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Chronic Disease; Female; Humans; Male; Middle Aged;

2002
Psychotropic agents finding analgesic use.
    JAMA, 1978, Sep-15, Volume: 240, Issue:12

    Topics: Amitriptyline; Analgesics; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Fluphenazine;

1978
Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain.
    Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A

    Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chronic Disease; Double-Blind Method; Hu

1992
Low dose amitriptyline in the treatment of chronic pain.
    Anaesthesia, 1992, Volume: 47, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Delayed-Action Preparations; Double-Blind Method; Fem

1992
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy.
    The New England journal of medicine, 1992, May-07, Volume: 326, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Depression; Desipramine; Diabetic Neuropa

1992
Biochemical measures in patients with a somatoform pain disorder, before, during, and after treatment with amitriptyline with or without flupentixol.
    Biological psychiatry, 1992, Apr-01, Volume: 31, Issue:7

    Topics: Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Drug Therapy, Combination; Female; F

1992
Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder?
    Pain, 1991, Volume: 47, Issue:1

    Topics: Adult; Amitriptyline; Depressive Disorder; Double-Blind Method; Drug Synergism; Drug Therapy, Combin

1991
The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.
    The Journal of rheumatology, 1991, Volume: 18, Issue:3

    Topics: Adult; Affect; Amitriptyline; Double-Blind Method; Fatigue; Female; Fibromyalgia; Humans; Male; Midd

1991
Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine.
    Pain, 1989, Volume: 36, Issue:1

    Topics: Aged; Amitriptyline; Carbamazepine; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Dou

1989
The plasma endorphin, prostaglandin and catecholamine profile of patients with fibrositis treated with cyclobenzaprine and placebo: a 5-month study.
    The Journal of rheumatology. Supplement, 1989, Volume: 19

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; beta-Endorphin; Catecholamines; Dinoprostone

1989
A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.
    The Journal of rheumatology. Supplement, 1989, Volume: 19

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Biomechanical Phenomena; Clinical Trials as Topic;

1989
Antidepressant analgesia in rheumatoid arthritis.
    The Journal of rheumatology, 1988, Volume: 15, Issue:11

    Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-B

1988
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:2

    Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic;

1986
A trial of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy.
    JAMA, 1986, Feb-07, Volume: 255, Issue:5

    Topics: Adult; Amitriptyline; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female;

1986
Clinical and quantitative electroencephalographical effects of MK 940.
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:7

    Topics: Adjustment Disorders; Adult; Amitriptyline; Anorexia Nervosa; Attention; Clinical Trials as Topic; C

1970

Other Studies

138 other studies available for amitriptyline and Pain

ArticleYear
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
    Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15

    Topics: Amides; Analgesics; Animals; Arthritis, Experimental; Carrageenan; CHO Cells; Chronic Pain; Cricetin

2012
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti

2016
Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 214

    Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Benzamides; Dose-Response Relatio

2022
A multidisciplinary approach to a patient with vulvodynia: a successful treatment and outcome.
    Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 2022, Volume: 31, Issue:3

    Topics: Amitriptyline; Female; Humans; Middle Aged; Pain; Quality of Life; Treatment Outcome; Vulvodynia

2022
Amitriptyline, Duloxetine, and Pregabalin Each Effective in Decreasing Pain From Diabetic Peripheral Neuropathy; Combinations Even Better.
    American family physician, 2023, Volume: 107, Issue:3

    Topics: Amitriptyline; Analgesics; Diabetes Mellitus; Diabetic Neuropathies; Duloxetine Hydrochloride; Human

2023
Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up.
    Cephalalgia : an international journal of headache, 2023, Volume: 43, Issue:9

    Topics: Adult; Amitriptyline; Follow-Up Studies; Headache; Headache Disorders; Humans; Pain

2023
Pain management in patients with end-stage renal disease and calciphylaxis- a survey of clinical practices among physicians.
    BMC nephrology, 2020, 09-18, Volume: 21, Issue:1

    Topics: Acetaminophen; Advance Care Planning; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesic

2020
The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia?
    Neuroscience letters, 2018, 09-14, Volume: 683

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr

2018
Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure.
    Journal of human lactation : official journal of International Lactation Consultant Association, 2019, Volume: 35, Issue:3

    Topics: Adult; Amitriptyline; Breast Feeding; Diagnosis, Differential; Female; Humans; Infant, Newborn; Mass

2019
Neuropsychiatric side effects of cyclobenzaprine.
    BMJ case reports, 2013, May-02, Volume: 2013

    Topics: Amitriptyline; Antidepressive Agents; Delirium; Humans; Male; Middle Aged; Movement Disorders; Muscl

2013
Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief.
    Journal of drug targeting, 2013, Volume: 21, Issue:8

    Topics: Administration, Intranasal; Amitriptyline; Animals; Brain; Cell Line, Tumor; Cell Survival; Chemistr

2013
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
    BioMed research international, 2013, Volume: 2013

    Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode

2013
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact

2014
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto

2014
Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Oct-15, Volume: 21, Issue:12

    Topics: Amitriptyline; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Hyp

2014
[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam].
    Eksperimental'naia i klinicheskaia farmakologiia, 2015, Volume: 78, Issue:3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Biureas; Diazepam; Female; Ma

2015
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.
    Journal of pharmacological sciences, 2015, Volume: 129, Issue:4

    Topics: Administration, Intravesical; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals;

2015
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
    Molecular pain, 2016, Volume: 12

    Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai

2016
A rare complication of total knee arthroplasty: Type l complex regional pain syndrome of the foot and ankle.
    Acta orthopaedica et traumatologica turcica, 2016, Volume: 50, Issue:5

    Topics: Aged; Amitriptyline; Analgesics; Ankle; Arthroplasty, Replacement, Knee; Complex Regional Pain Syndr

2016
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
    Neuroscience letters, 2008, Aug-01, Volume: 440, Issue:2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System

2008
Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters.
    Brain research, 2008, Sep-26, Volume: 1232

    Topics: Amino Acid Transport System X-AG; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents,

2008
Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.
    Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:9

    Topics: Administration, Topical; Amitriptyline; Anal Canal; Analgesics; Drug Combinations; Humans; Ketamine;

2008
[Sequential drugs treatment for central pain following spinal cord injury].
    Zhongguo gu shang = China journal of orthopaedics and traumatology, 2009, Volume: 22, Issue:6

    Topics: Adult; Amitriptyline; Carbamazepine; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female;

2009
The neuraxial effects of intraspinal amitriptyline at low concentrations.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia; Animals; Central Nervous System; Dogs; Female;

2009
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:4

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima

2009
Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats.
    Brain research bulletin, 2010, Mar-16, Volume: 81, Issue:4-5

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Blotting, Western; Excitatory Amino Acid Transport

2010
Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats.
    Human & experimental toxicology, 2010, Volume: 29, Issue:10

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Diabetes Mellit

2010
Time to recovery in patients with acute painful musculoskeletal conditions treated with extended-release or immediate-release cyclobenzaprine.
    Advances in therapy, 2011, Volume: 28, Issue:4

    Topics: Acute Disease; Administration, Oral; Adult; Amitriptyline; Delayed-Action Preparations; Disorders of

2011
Effect of glibenclamide on antinociceptive effects of antidepressants of different classes.
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66, Issue:2

    Topics: Amitriptyline; Analgesics; Analysis of Variance; Animals; Antidepressive Agents; Drug Interactions;

2011
Late onset painful cold-aggravated myotonia: three families with SCN4A L1436P mutation.
    Neuromuscular disorders : NMD, 2011, Volume: 21, Issue:8

    Topics: Acetazolamide; Adult; Age of Onset; Aged; Aged, 80 and over; Amitriptyline; Anticonvulsants; Belgium

2011
The interaction between antidepressant drugs and the pain-relieving effect of spinal cord stimulation in a rat model of neuropathy.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; C

2011
Neuropsychiatric manifestation after a stroke: newly developed symptoms or side-effect of drug?
    BMJ case reports, 2012, Aug-18, Volume: 2012

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Female; Humans; Middl

2012
Treatment of levator ani syndrome with cyclobenzaprine.
    The Annals of pharmacotherapy, 2012, Volume: 46, Issue:10

    Topics: Adult; Amitriptyline; Anus Diseases; Humans; Male; Muscle Relaxants, Central; Pain

2012
Mandatory palliative care education for surgical residents: initial focus on teaching pain management.
    Japanese journal of clinical oncology, 2013, Volume: 43, Issue:2

    Topics: Adult; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Curriculum;

2013
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
    Prescrire international, 2002, Volume: 11, Issue:60

    Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans;

2002
[Treatment of pain in a case of osteogenesis imperfecta type III].
    Anales espanoles de pediatria, 2002, Volume: 57, Issue:3

    Topics: Adolescent; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Drug Therapy, Combination; Female;

2002
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
    Pain, 2003, Volume: 102, Issue:1-2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response

2003
An East-West approach to the management of central post-stroke pain.
    Cerebrovascular diseases (Basel, Switzerland), 2003, Volume: 16, Issue:1

    Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon

2003
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
    Pharmacological research, 2003, Volume: 48, Issue:2

    Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise

2003
Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain.
    Neuroscience letters, 2004, Mar-04, Volume: 357, Issue:2

    Topics: Amitriptyline; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pain; Pain M

2004
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
    Life sciences, 2004, Apr-09, Volume: 74, Issue:21

    Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A

2004
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
    Anesthesiology, 2004, Volume: 100, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Catheterization; Cyclopropanes; Dose-Response Relatio

2004
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2

    Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl

2004
State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain.
    Pain, 2004, Volume: 110, Issue:1-2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia, Local; Cell Line; Dose-Response Relationship, D

2004
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
    European journal of pharmacology, 2004, Sep-24, Volume: 499, Issue:3

    Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima

2004
Interactions of cyclobenzaprine and tricyclic antidepressants.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:1

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal

2005
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
    Neuropharmacology, 2005, Volume: 48, Issue:2

    Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra

2005
Reliability and validity of a self-report FIM (FIM-SR) in persons with amputation or spinal cord injury and chronic pain.
    American journal of physical medicine & rehabilitation, 2005, Volume: 84, Issue:3

    Topics: Adult; Amitriptyline; Amputation, Surgical; Analgesics, Non-Narcotic; Chronic Disease; Disability Ev

2005
[Low doses of prazosin potantiates the antinociceptive/analgesic effect of amitriptyline].
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2005, Volume: 17, Issue:1

    Topics: Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Animals; Dose-Response Relati

2005
Computed tomography guided lumbar sympathetic block for complex regional pain syndrome in a child: a case report and review.
    European journal of pain (London, England), 2006, Volume: 10, Issue:5

    Topics: Amines; Amitriptyline; Analgesics; Anesthetics, Local; Antidepressive Agents, Tricyclic; Autonomic N

2006
Painful mononeuritis multiplex in idiopathic thrombocytopenic purpura.
    Indian pediatrics, 2005, Volume: 42, Issue:6

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combin

2005
Familial rectal pain: a familial autonomic disorder as a cause of paroxysmal attacks in the newborn baby.
    Epileptic disorders : international epilepsy journal with videotape, 2005, Volume: 7, Issue:4

    Topics: Amitriptyline; Anticonvulsants; Apnea; Autonomic Nervous System Diseases; Bradycardia; Bronchial Spa

2005
GABA(B) receptor function and subunit expression in the rat spinal cord as indicators of stress and the antinociceptive response to antidepressants.
    Brain research, 2006, Jan-12, Volume: 1068, Issue:1

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation;

2006
Motor cortex stimulation for central pain following a traumatic brain injury.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju

2006
Bilateral hemifacial spasm and trigeminal neuralgia: a unique form of painful tic convulsif.
    Movement disorders : official journal of the Movement Disorder Society, 2007, Jan-15, Volume: 22, Issue:2

    Topics: Aged; Amines; Amitriptyline; Analgesics; Arachnoid Cysts; Botulinum Toxins, Type A; Cyclohexanecarbo

2007
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:8

    Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic

2007
Tramadol is more effective than morphine and amitriptyline against ischaemic pain but not thermal pain in rats.
    Pharmacological research, 2007, Volume: 56, Issue:1

    Topics: Amitriptyline; Analgesics; Animals; Female; Hot Temperature; Hyperalgesia; Ischemia; Male; Morphine;

2007
Antinociceptive effect of amitriptyline in mice of acute pain models.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:6

    Topics: Acute Disease; Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Dose-Respon

2007
Transient allodynia pain models in mice for early assessment of analgesic activity.
    British journal of pharmacology, 2008, Volume: 153, Issue:4

    Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb

2008
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
    Pain research & management, 2007,Autumn, Volume: 12, Issue:3

    Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio

2007
Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome--type I.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dos

2008
Dependence on dextromoramide.
    British medical journal, 1967, Feb-11, Volume: 1, Issue:5536

    Topics: Aged; Amitriptyline; Chlorpromazine; Codeine; Dextromoramide; Humans; Levorphanol; Male; Pain; Subst

1967
Chronic pain syndromes and disordered cortical inhibition: effects of tricyclic compounds.
    Diseases of the nervous system, 1967, Volume: 28, Issue:5

    Topics: Amitriptyline; Animals; Anticonvulsants; Cerebral Cortex; Humans; Imipramine; Mice; Pain; Paresthesi

1967
Chronic pain and the risks of psychotropics.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1984, Volume: 136, Issue:5

    Topics: Amitriptyline; Chronic Disease; Female; Fluphenazine; Heart Failure; Humans; Meperidine; Middle Aged

1984
Tricyclic antidepressants in chronic pain.
    Pain, 1984, Volume: 18, Issue:2

    Topics: Adult; Aged; Amitriptyline; Chronic Disease; Female; Humans; Male; Middle Aged; Pain; Pilot Projects

1984
The effects of propranolol and amitriptyline on vascular and EMG biofeedback training.
    Headache, 1984, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Amitriptyline; Biofeedback, Psychology; Female; Humans; Male; Middle Aged;

1984
Diabetic neuropathic pain: control by amitriptyline and fluphenazine in renal insufficiency.
    Southern medical journal, 1983, Volume: 76, Issue:4

    Topics: Adult; Aged; Amitriptyline; Diabetic Neuropathies; Drug Therapy, Combination; Female; Fluphenazine;

1983
A regimen of tricyclic compounds and carbamazepine for treating trigeminal neuralgia pain.
    Quintessence international, dental digest, 1981, Volume: 12, Issue:11

    Topics: Amitriptyline; Carbamazepine; Chlordiazepoxide; Drug Combinations; Humans; Pain; Trigeminal Neuralgi

1981
Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Aug-21, Volume: 62, Issue:9

    Topics: Adult; Aged; Amitriptyline; Drug Combinations; Female; Herpes Zoster; Humans; Male; Middle Aged; Neu

1982
Psychotropic drugs in the treatment of pain in chronic pancreatitis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Nov-20, Volume: 62, Issue:22

    Topics: Amitriptyline; Drug Therapy, Combination; Humans; Pain; Pancreatitis; Psychotropic Drugs; Trifluoper

1982
The depression-pain syndrome and its response to antidepressants.
    Psychosomatics, 1981, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem

1981
Effect of amitriptyline on the analgesia induced by adrenal medullary tissue transplanted in the rat spinal subarachnoid space as measured by an experimental model of acute pain.
    Experimental neurology, 1994, Volume: 130, Issue:1

    Topics: Acute Disease; Adrenal Medulla; Amitriptyline; Analgesia; Animals; Drug Administration Schedule; Mal

1994
Successful treatment of painful crises of Fabry disease with low dose morphine.
    Pediatric neurology, 1995, Volume: 12, Issue:3

    Topics: Amitriptyline; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy,

1995
Prevention and treatment of the complications of diabetes mellitus.
    The New England journal of medicine, 1995, Sep-21, Volume: 333, Issue:12

    Topics: Amitriptyline; Analgesics, Opioid; Diabetic Neuropathies; Humans; Pain

1995
Prevention and treatment of the complications of diabetes mellitus.
    The New England journal of medicine, 1995, Sep-21, Volume: 333, Issue:12

    Topics: Aged; Amitriptyline; Desipramine; Diabetic Neuropathies; Humans; Pain

1995
Out-patient cognitive-behavioural therapy with amitriptyline for chronic non-malignant pain: a comparative study with 6-month follow-up.
    Pain, 1995, Volume: 60, Issue:1

    Topics: Adult; Amitriptyline; Behavior Therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain;

1995
Diagnosis and treatment of persistent pain after trauma to the head and neck.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1994, Volume: 52, Issue:11

    Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He

1994
Pain medication.
    The Journal of family practice, 1994, Volume: 39, Issue:1

    Topics: Amitriptyline; Family Practice; Humans; Pain

1994
Pain medication.
    The Journal of family practice, 1994, Volume: 39, Issue:1

    Topics: Amitriptyline; Chronic Disease; Humans; Pain

1994
Clonazepam for the treatment of lancinating phantom limb pain.
    The Clinical journal of pain, 1996, Volume: 12, Issue:1

    Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clonazepam; Disarticulation; Drug Therapy, Co

1996
The use of amitriptyline in patients with urinary frequency and pain.
    Urology, 1998, Volume: 51, Issue:5A Suppl

    Topics: Adult; Aged; Amitriptyline; Female; Humans; Male; Middle Aged; Pain; Patient Satisfaction; Urination

1998
Managing the aftermath of shingles.
    RN, 1998, Volume: 61, Issue:5

    Topics: Acyclovir; Amitriptyline; Antidepressive Agents, Tricyclic; Antiviral Agents; Drug Therapy, Combinat

1998
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
Effect of analgesics on audible and ultrasonic pain-induced vocalization in the rat.
    Life sciences, 1998, Volume: 63, Issue:20

    Topics: Amitriptyline; Analgesics; Animals; Aspirin; Cricetinae; Electric Stimulation; Male; Morphine; Nalox

1998
Use of transdermal amitriptyline gel in a patient with chronic pain and depression.
    Pharmacotherapy, 1999, Volume: 19, Issue:2

    Topics: Administration, Cutaneous; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease;

1999
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:1

    Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide

1999
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Resp

1999
Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus

1999
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
    JAMA, 1999, Apr-14, Volume: 281, Issue:14

    Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain;

1999
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
    JAMA, 1999, Apr-14, Volume: 281, Issue:14

    Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; HIV Infections; Humans; Pain;

1999
Acupuncture and amitriptyline for HIV-related peripheral neuropathic pain.
    JAMA, 1999, Apr-14, Volume: 281, Issue:14

    Topics: Acupuncture Therapy; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Administration Schedule;

1999
The relationship between pupil diameter and pain by the administration of morphine and antidepressant drugs in mice.
    General pharmacology, 1999, Volume: 33, Issue:1

    Topics: Amitriptyline; Analgesia; Analgesics, Opioid; Animals; Antidepressive Agents; Desipramine; Male; Mic

1999
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
    Pain, 1999, Volume: 82, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli

1999
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:10

    Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic A

1999
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System

2000
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:4

    Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants;

2000
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
    The Clinical journal of pain, 2001, Volume: 17, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination;

2001
Potential therapy for painful neuropathy.
    PI perspective, 1995, Issue:no 16

    Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain;

1995
Potential therapy for painful neuropathy.
    PI perspective, 1995, Issue:no 16

    Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain;

1995
Potential therapy for painful neuropathy.
    PI perspective, 1995, Issue:no 16

    Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain;

1995
Potential therapy for painful neuropathy.
    PI perspective, 1995, Issue:no 16

    Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain;

1995
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models

2001
Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Formaldehyde; Injections, Intrap

2002
The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:4

    Topics: Acetates; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cy

2002
Evolution of visceral sensitivity in patients with irritable bowel syndrome.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:4

    Topics: Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Catheterization; Colonic Diseases, Functional;

2002
Problems recruiting cancer patients to a comparative clinical trial of drug treatments for neuropathic pain in palliative care.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:4

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Multicenter Studies as Topic; Neoplasms; Ne

2002
Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine.
    JAMA, 1977, Nov-21, Volume: 238, Issue:21

    Topics: Adult; Aged; Amitriptyline; Diabetic Neuropathies; Drug Therapy, Combination; Female; Fluphenazine;

1977
The management of post herpetic pain using sodium valproate and amitriptyline.
    Irish medical journal, 1979, Sep-28, Volume: 72, Issue:9

    Topics: Amitriptyline; Herpes Zoster; Humans; Pain; Valproic Acid

1979
Weight gain from combined phenothiazine and tricyclic therapy.
    JAMA, 1978, May-12, Volume: 239, Issue:19

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Body Weight; Humans; Pain; Phenothiazines; Thiorida

1978
Atypical facial pain: an analysis of 100 patients with discussion.
    Dental journal, 1975, Volume: 41, Issue:7

    Topics: Adult; Age Factors; Amitriptyline; Anxiety Disorders; Chlordiazepoxide; Depression; Diagnosis, Diffe

1975
Letter: Painful shoulder syndrome.
    Canadian Medical Association journal, 1975, May-03, Volume: 112, Issue:9

    Topics: Amitriptyline; Carbonates; Depression; Humans; Lithium; Pain; Shoulder; Syndrome

1975
Drug use and distribution in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:3

    Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H

1975
Letter: Drug use in a pain rehabilitation center.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:11

    Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms

1975
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
    Southern medical journal, 1992, Volume: 85, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory

1992
Predictors of outcome in the treatment of chronic "psychogenic" pain with amitriptyline and brief psychotherapy.
    The Clinical journal of pain, 1992, Volume: 8, Issue:4

    Topics: Amitriptyline; Humans; Pain; Pain Management; Prognosis; Psychiatric Status Rating Scales; Psychothe

1992
Amitriptyline and carbamazepine in the treatment of dysesthetic pain in spinal cord injury.
    Archives of physical medicine and rehabilitation, 1992, Volume: 73, Issue:3

    Topics: Adult; Amitriptyline; Carbamazepine; Female; Humans; Pain; Spinal Cord Injuries

1992
Amitriptyline produces analgesia in the formalin pain test.
    Experimental neurology, 1992, Volume: 117, Issue:1

    Topics: Amitriptyline; Analgesia; Analgesics; Analysis of Variance; Animals; Formaldehyde; Male; Pain; Rats;

1992
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results].
    Zeitschrift fur Urologie und Nephrologie, 1990, Volume: 83, Issue:10

    Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug

1990
The analgesic effect of tricyclic antidepressants.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: Amitriptyline; Analgesia; Analgesics; Animals; Fenclonine; Imipramine; Male; Pain; Rats; Rats, Inbre

1990
Recurrent gastroesophageal symptoms and precordial pain in a gastrectomized man improved by amitriptyline. Physiologic, metabolic, endocrine, neurochemical and psychiatric findings.
    Journal of medicine, 1989, Volume: 20, Issue:5-6

    Topics: Amitriptyline; Depression; Gastrectomy; Gastrointestinal Diseases; Gastrointestinal Motility; Hormon

1989
Use of amitriptyline (Elavil) for phantom limb pain in younger children.
    Journal of pain and symptom management, 1989, Volume: 4, Issue:2

    Topics: Administration, Oral; Amitriptyline; Amputation, Surgical; Child; Femoral Neoplasms; Humans; Male; O

1989
Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats.
    Neuroscience letters, 1989, Apr-24, Volume: 99, Issue:1-2

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Male; Pain; Rats; Rats, Inbred Strains; Se

1989
Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline.
    Pain, 1989, Volume: 37, Issue:2

    Topics: Amitriptyline; Animals; Behavior, Animal; Denervation; Diazepam; Hindlimb; Male; Pain; Peripheral Ne

1989
Ongoing treatment of a Hmong widow who suffers from pain and depression.
    Hospital & community psychiatry, 1989, Volume: 40, Issue:7

    Topics: Acculturation; Amitriptyline; Asian; Combined Modality Therapy; Counseling; Depressive Disorder; Dia

1989
Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin.
    European journal of pharmacology, 1986, Jun-17, Volume: 125, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzazepines; Drug Tolerance; Endorphins; Fenclonin

1986
Selected tricyclic antidepressants in the management of chronic benign pain.
    Southern medical journal, 1988, Volume: 81, Issue:5

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Doxepin; Huma

1988
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:6

    Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain

1987
Your CE topic this month (No. 28). Update on pain therapy (Part 1).
    The Journal of practical nursing, 1987, Volume: 37, Issue:4

    Topics: Amitriptyline; Education, Nursing, Continuing; Humans; Narcotics; Nursing, Practical; Pain

1987
[Modification of tumor pain by psychotropic drugs].
    Zeitschrift fur arztliche Fortbildung, 1987, Volume: 81, Issue:4

    Topics: Adult; Aged; Amitriptyline; Bone Neoplasms; Breast Neoplasms; Chlorprothixene; Drug Therapy, Combina

1987
Amitriptyline and fluphenazine for painful diabetic neuropathy.
    JAMA, 1986, Aug-08, Volume: 256, Issue:6

    Topics: Amitriptyline; Diabetic Neuropathies; Fluphenazine; Humans; Pain; Placebos; Research Design

1986
Do acute or chronic tricyclic antidepressants modify morphine antinociception in arthritic rats?
    Pain, 1986, Volume: 25, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arthritis; Arthritis, Experimental; Drug S

1986
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
    Archives of general psychiatry, 1987, Volume: 44, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di

1987
Amitriptyline for pain of cortical origin.
    Clinical pharmacy, 1986, Volume: 5, Issue:2

    Topics: Adult; Amitriptyline; Cerebral Cortex; Female; Humans; Pain

1986
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
    Pain, 1985, Volume: 23, Issue:2

    Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease M

1985
Relief of postherpetic neuralgia with psychotropic drugs.
    Journal of neurosurgery, 1973, Volume: 39, Issue:2

    Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine;

1973
Outpatient group therapy with geriatric patients.
    Geriatrics, 1967, Volume: 22, Issue:1

    Topics: Aged; Amitriptyline; Antidepressive Agents; Anxiety; Depression; Female; Geriatrics; Humans; Imipram

1967
Letter: Painful shoulder syndrome.
    Canadian Medical Association journal, 1974, Oct-19, Volume: 111, Issue:8

    Topics: Amitriptyline; Bursitis; Chronic Disease; Depression; Humans; Lithium; Pain; Shoulder; Tendinopathy

1974
Psychological significance of the irritable colon syndrome.
    Gut, 1971, Volume: 12, Issue:6

    Topics: Abdomen; Adolescent; Adult; Affective Symptoms; Age Factors; Aged; Amitriptyline; Child; Colonic Dis

1971
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic.
    Journal of the Indian Medical Association, 1971, Jun-01, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Depression; Fema

1971
[Possibilities and limits of modification of symptoms in the spondylogenous syndrome with psychotropic substances].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1969, Volume: 1

    Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Diazepam; Humans; Middle Aged; Pain; Rheuma

1969
[On the management of pain using antidepressive agents].
    Klinische Wochenschrift, 1967, Sep-01, Volume: 45, Issue:17

    Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain

1967