amitriptyline has been researched along with Pain, Intractable in 21 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper reports an investigation into the efficacy of flexible dosage amitriptyline (AMI) and brief psychotherapy individually and together in the treatment of chronic 'psychogenic' pain." | 2.67 | A controlled study of psychotherapy and amitriptyline used individually and in combination in the treatment of chronic intractable, 'psychogenic' pain. ( Barrow, GC; Pilowsky, I, 1990) |
| "Clomipramine was better tolerated." | 2.65 | Clomipramine and amitriptyline in the treatment of severe pain. ( Carasso, RL; Streifler, M; Yehuda, S, 1979) |
| "Gabapentin has been shown to be useful in treatment of different conditions which may be caused by increased neuronal excitability." | 1.32 | Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. ( Haller, H; Leblhuber, F; Schmidhammer, R; Trenkler, J, 2003) |
| "Gabapentin was effective in approximately 50% of pretreated patients with intractable pain." | 1.31 | [Gabapentin in the treatment of chronic intractable pain]. ( Gustorff, B; Kress, HG; Nahlik, G; Spacek, A, 2002) |
| "The treatment of cancer pain by psychotropic drugs is a method which has been employed for a long time [8] and in which the results obtained have appeared very interesting from the beginning: there is a high percentage of success, rapid action, absence of addiction, and although there are sometimes unpleasant side-effects, they are reversible when the treatment is stopped." | 1.26 | Pain infirmity and psychotropic drugs in oncology. ( Boudouresque, G; Bourhis, A; Fondarai, J; Pellet, W; Ponzio, J; Spitalier, JM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (52.38) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Portugal, F | 1 |
| Araújo, A | 1 |
| Silva, C | 1 |
| Campos, M | 1 |
| Valentim, A | 1 |
| Haller, H | 1 |
| Leblhuber, F | 1 |
| Trenkler, J | 1 |
| Schmidhammer, R | 1 |
| Lalwani, K | 1 |
| Shoham, A | 1 |
| Koh, JL | 1 |
| McGraw, T | 1 |
| Sandroni, P | 1 |
| Davis, MD | 1 |
| Duthie, AM | 2 |
| Ingham, VA | 1 |
| Warfield, CA | 1 |
| Stein, JM | 1 |
| Clarke, IM | 1 |
| Tasmuth, T | 1 |
| von Smitten, K | 1 |
| Blomqvist, C | 1 |
| Kalso, E | 1 |
| Gustorff, B | 1 |
| Nahlik, G | 1 |
| Spacek, A | 1 |
| Kress, HG | 1 |
| Brown, BR | 1 |
| Womble, J | 1 |
| Kloos-Frölich, AC | 1 |
| Zitman, FG | 2 |
| Carasso, RL | 1 |
| Yehuda, S | 1 |
| Streifler, M | 1 |
| Bourhis, A | 1 |
| Boudouresque, G | 1 |
| Pellet, W | 1 |
| Fondarai, J | 1 |
| Ponzio, J | 1 |
| Spitalier, JM | 1 |
| Hasenbush, LL | 1 |
| Kluger, NJ | 1 |
| Clifford, JS | 1 |
| Cavanagh, RJ | 1 |
| Griffith, WL | 1 |
| Davis, RW | 1 |
| Linssen, ACG | 1 |
| Edelbroek, PM | 1 |
| Stijnen, T | 1 |
| Pilowsky, I | 1 |
| Barrow, GC | 1 |
| Richlin, DM | 1 |
| Jamron, LM | 1 |
| Novick, NL | 1 |
| Koppel, BS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
5 trials available for amitriptyline and Pain, Intractable
| Article | Year |
|---|---|
[Chronic pain and other symptoms following treatment of breast cancer].
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Breast Neoplasms; Cross-Over Studies; Double-Blind | 1998 |
Cyclobenzaprine in intractable pain syndromes with muscle spasm.
Topics: Adult; Amitriptyline; Clinical Trials as Topic; Diazepam; Dibenzocycloheptenes; Female; Humans; Male | 1978 |
Clomipramine and amitriptyline in the treatment of severe pain.
Topics: Adult; Aged; Amitriptyline; Clomipramine; Female; Headache; Humans; Male; Middle Aged; Neuralgia; Pa | 1979 |
Low dose amitriptyline in chronic pain: the gain is modest.
Topics: Adult; Amitriptyline; Analgesics; Behavior; Depression; Double-Blind Method; Drug Synergism; Female; | 1990 |
A controlled study of psychotherapy and amitriptyline used individually and in combination in the treatment of chronic intractable, 'psychogenic' pain.
Topics: Adult; Amitriptyline; Female; Humans; Male; Middle Aged; Pain, Intractable; Psychotherapy, Brief | 1990 |
16 other studies available for amitriptyline and Pain, Intractable
| Article | Year |
|---|---|
Combination gel of 2% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain - a case report of pain control success.
Topics: Amitriptyline; Analgesics; Drug Combinations; Erythromelalgia; Humans; Ketamine; Male; Pain Manageme | 2021 |
Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Arm; Carbamazepine; Central Cord Syndrome; Cervical Ver | 2003 |
Use of oxcarbazepine to treat a pediatric patient with resistant complex regional pain syndrome.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2005 |
Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option?
Topics: Adolescent; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Drug Combinations; Erythrom | 2006 |
Amitriptyline and perphenazine in chronic pain.
Topics: Amitriptyline; Antipsychotic Agents; Drug Therapy, Combination; Humans; Pain, Intractable; Phenothia | 1982 |
The pain clinic: the use of systemic analgesics.
Topics: Adult; Aged; Amitriptyline; Analgesics; Anti-Inflammatory Agents; Anticonvulsants; Bone Neoplasms; D | 1982 |
Amitriptyline and perphenazine (Triptafen DA) in chronic pain.
Topics: Amitriptyline; Drug Combinations; Female; Humans; Male; Middle Aged; Pain, Intractable; Perphenazine | 1981 |
[Gabapentin in the treatment of chronic intractable pain].
Topics: Acetates; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non | 2002 |
[A speech disorders as a side effect of tricyclic antidepressants].
Topics: Aged; Amitriptyline; Depression; Humans; Male; Pain, Intractable; Speech Disorders | 1979 |
Pain infirmity and psychotropic drugs in oncology.
Topics: Activities of Daily Living; Amitriptyline; Dose-Response Relationship, Drug; Humans; Methotrimeprazi | 1978 |
The use of phenothiazines and tricyclic antidepressants in the treatment of intractable pain.
Topics: Adult; Aged; Amitriptyline; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle | 1977 |
Successful brief therapy of a retired elderly man with intractable pain, depression, and drug and alcohol dependence.
Topics: Aged; Alcoholism; Amitriptyline; Compulsive Personality Disorder; Dependent Personality Disorder; De | 1977 |
A case of a chemically dependent patient with a thalamic pain syndrome treated with amitriptyline.
Topics: Alcoholism; Amitriptyline; Cerebral Infarction; Flurazepam; Follow-Up Studies; Humans; Male; Middle | 1991 |
Comments on 'A controlled study of psychotherapy and amitriptyline used individually and in combination in the treatment of chronic intractable, 'psychogenic' pain, by I. Pilowsky and C.G. Barrow, Pain, 40 (1990) 3-19.
Topics: Amitriptyline; Humans; Pain, Intractable; Psychophysiologic Disorders; Somatoform Disorders; Termino | 1990 |
Cancer pain control with a combination of methadone, amitriptyline, and non-narcotic analgesic therapy: a case series analysis.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics; Drug Therapy, Combination; Female; Humans; Male; | 1987 |
Amitriptyline in the treatment of thalamic pain.
Topics: Adult; Aged; Amitriptyline; Female; Humans; Male; Pain, Intractable; Thalamic Diseases | 1986 |