amitriptyline has been researched along with Osteoarthritis, Knee in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antidepressants, such as amitriptyline, have been used to treat chronic pain in other conditions." | 5.41 | Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial. ( Arnold, C; Cicuttini, FM; Forbes, A; Hussain, SM; Teichtahl, AJ; Urquhart, DM; Wang, Y; Wluka, AE, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wluka, AE | 1 |
| Urquhart, DM | 1 |
| Teichtahl, AJ | 1 |
| Hussain, SM | 1 |
| Forbes, A | 1 |
| Arnold, C | 1 |
| Wang, Y | 1 |
| Cicuttini, FM | 1 |
1 trial available for amitriptyline and Osteoarthritis, Knee
| Article | Year |
|---|---|
Effect of low-dose amitriptyline on reducing pain in clinical knee osteoarthritis compared to benztropine: study protocol of a randomised, double blind, placebo-controlled trial.
Topics: Amitriptyline; Australia; Benztropine; Chronic Pain; Double-Blind Method; Humans; Osteoarthritis, Kn | 2021 |