amitriptyline has been researched along with Obsessive-Compulsive Disorder in 20 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline has a pharmacological spectrum of action analogous to chlorimipramine, a medication with reputed effectiveness in severe compulsive behaviors." | 5.26 | Trichotillomania treated wih amitriptyline. ( Snyder, S, 1980) |
| "In a small series of patients, suffering from obsessional disorders, it was found that there seems to be a type of depression which occurs during the course of clomipramine therapy." | 3.65 | Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions. ( Capstick, N, 1975) |
| "Isocarboxazid was replaced by placebo, using double-blind procedure." | 2.67 | Efficacy of combined antidepressant therapy in resistant neurotic disorder. ( Murphy, S; Tyrer, P, 1990) |
| "Clomipramine was significantly more efficacious for treatment in dogs than was amitriptyline." | 1.31 | Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). ( Dunham, AE; Overall, KL, 2002) |
| "Amitriptyline has a pharmacological spectrum of action analogous to chlorimipramine, a medication with reputed effectiveness in severe compulsive behaviors." | 1.26 | Trichotillomania treated wih amitriptyline. ( Snyder, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (70.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Volchegorskiĭ, IA | 1 |
| Miroshnichenko, IIu | 1 |
| Rassokhina, LM | 1 |
| Faĭzullin, RM | 1 |
| Priakhina, KE | 1 |
| Arco, L | 1 |
| Overall, KL | 1 |
| Dunham, AE | 1 |
| GILLINGHAM, FJ | 1 |
| SMYTHIES, JR | 1 |
| Ananth, J | 1 |
| Pecknold, JC | 1 |
| van den Steen, N | 1 |
| Engelsmann, F | 1 |
| Snyder, S | 2 |
| Kutin, VP | 1 |
| Kutin, GV | 1 |
| Capstick, N | 1 |
| Höflich, G | 1 |
| Kasper, S | 1 |
| Möller, HJ | 1 |
| Zhao, JP | 1 |
| Tyrer, P | 1 |
| Murphy, S | 1 |
| Fava, GA | 1 |
| Lisansky, J | 1 |
| Kellner, R | 1 |
| Zielezny, M | 1 |
| Cipollina Mangiameli, G | 1 |
| Bauer, G | 1 |
| Nowak, H | 1 |
| Gannon, P | 1 |
| Itil, T | 1 |
| Keskiner, A | 1 |
| Hsu, B | 1 |
| Hussain, MZ | 1 |
| Ahad, A | 1 |
| Lingjaerde, O | 1 |
| Maiss, HJ | 1 |
| Blinder, MG | 1 |
4 trials available for amitriptyline and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis.
Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Clomipramine; Depressive Disorder | 1981 |
Efficacy of combined antidepressant therapy in resistant neurotic disorder.
Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Diazepam; Do | 1990 |
[Doxepin, a new antidepressant: comparison of effects with amitriptyline].
Topics: Acute Disease; Adjustment Disorders; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Amitri | 1969 |
Clinical and quantitative electroencephalographical effects of MK 940.
Topics: Adjustment Disorders; Adult; Amitriptyline; Anorexia Nervosa; Attention; Clinical Trials as Topic; C | 1970 |
16 other studies available for amitriptyline and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
[The effect of 3-oxypyridine and succinic acid derivatives on obsessive-compulsive activity of mice in marble-burying test].
Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Seda | 2014 |
A case study in treating chronic comorbid obsessive-compulsive disorder and depression with behavioral activation and pharmacotherapy.
Topics: Amitriptyline; Antidepressive Agents; Behavior Therapy; Chronic Disease; Clomipramine; Depressive Di | 2015 |
Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000).
Topics: Age of Onset; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior Therapy; Behavior, | 2002 |
A CASE OF POSTENCEPHALITIC PARKINSONISM RESPONDING TO COMBINED SURGICAL AND MEDICINAL TREATMENT.
Topics: Amitriptyline; Chlordiazepoxide; Depression; Depressive Disorder; Drug Therapy; Encephalitis; Eye Mo | 1965 |
Amitriptyline therapy of obsessive-compulsive neurosis.
Topics: Adult; Amitriptyline; Brain; Clomipramine; Female; Humans; Obsessive-Compulsive Disorder; Serotonin | 1980 |
Trichotillomania treated wih amitriptyline.
Topics: Adult; Amitriptyline; Female; Humans; Obsessive-Compulsive Disorder; Trichotillomania | 1980 |
[Complex treatment of obsessive states of different etiology].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Benactyzine; Diazepam; Drug Therapy, Combination; | 1978 |
Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.
Topics: Adult; Aged; Amitriptyline; Clomipramine; Depression; Dibenzazepines; Female; Flupenthixol; Humans; | 1975 |
[Successful treatment of seasonal compulsive syndrome with phototherapy].
Topics: Adult; Amitriptyline; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Obsessive-Compul | 1992 |
[A control study of clomipramine and amitriptyline for treating obsessive-compulsive disorder].
Topics: Adolescent; Adult; Amitriptyline; Clomipramine; Female; Humans; Male; Obsessive-Compulsive Disorder | 1991 |
Treatment responses in primary and secondary melancholia: a preliminary report.
Topics: Adult; Alcoholism; Amitriptyline; Depressive Disorder; Female; Hospitalization; Humans; Male; Obsess | 1985 |
[Amenorrhea and behaviour disorders. Clinical case treated by psychotherapeutic methods based on cybberrnetic features of G. Cipollina Mangiameli].
Topics: Adult; Amenorrhea; Amitriptyline; Conditioning, Psychological; Cybernetics; Female; Humans; Methods; | 1973 |
Treatment of obsessive-compulsive neurosis.
Topics: Amitriptyline; Chlordiazepoxide; Chlorprothixene; Haloperidol; Humans; Imipramine; Obsessive-Compuls | 1970 |
[Tricyclic antidepressive agents in compulsive neuroses].
Topics: Adult; Amitriptyline; Antidepressive Agents; Humans; Imipramine; Male; Obsessive-Compulsive Disorder | 1968 |
[Therapy of psycho-autonomic and dysphoric syndromes in the general practice].
Topics: Adjustment Disorders; Adult; Amitriptyline; Anxiety; Bipolar Disorder; Chlordiazepoxide; Climacteric | 1968 |
Classification and treatment of depression.
Topics: Adjustment Disorders; Amitriptyline; Anxiety; Bipolar Disorder; Brain Neoplasms; Depression; Histrio | 1969 |