amitriptyline has been researched along with Neuroleptic Malignant Syndrome in 9 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate." | 7.69 | Neuroleptic malignant syndrome and lithium carbonate. ( Fava, S; Galizia, AC, 1995) |
| "This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression." | 5.29 | Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders? ( Kamijima, K; Miyaoka, H, 1995) |
| "The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate." | 3.69 | Neuroleptic malignant syndrome and lithium carbonate. ( Fava, S; Galizia, AC, 1995) |
| "touching her stool) though neuroleptic malignant syndrome subsided." | 1.30 | [A case of depression manifesting incessant pacing and wandering following discontinuation of antipsychotic drugs due to neuroleptic malignant syndrome: a possible involvement of withdrawal akathisia]. ( Terao, T; Watanabe, H, 1997) |
| "This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression." | 1.29 | Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders? ( Kamijima, K; Miyaoka, H, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fava, S | 1 |
| Galizia, AC | 1 |
| Theoharides, TC | 1 |
| Harris, RS | 1 |
| Weckstein, D | 1 |
| Miyaoka, H | 1 |
| Kamijima, K | 1 |
| Fink, M | 1 |
| Watanabe, H | 1 |
| Terao, T | 1 |
| Okamoto, K | 1 |
| Umeno, M | 1 |
| Takagi, H | 1 |
| Nagano, S | 1 |
| Takeda, Y | 1 |
| Heyland, D | 1 |
| Sauvé, M | 1 |
| Corrigan, FM | 1 |
| Coulter, F | 1 |
| Merriam, AE | 1 |
9 other studies available for amitriptyline and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Neuroleptic malignant syndrome and lithium carbonate.
Topics: Amitriptyline; Bipolar Disorder; Drug Therapy, Combination; Humans; Intestinal Pseudo-Obstruction; L | 1995 |
Neuroleptic malignant-like syndrome due to cyclobenzaprine?
Topics: Adult; Amitriptyline; Humans; Male; Muscle Relaxants, Central; Neuroleptic Malignant Syndrome | 1995 |
Encephalopathy during amitriptyline therapy: are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders?
Topics: Amitriptyline; Brain Diseases; Depressive Disorder; Follow-Up Studies; Humans; Male; Middle Aged; Ne | 1995 |
Response to "Neuroleptic malignant-like syndrome due to cyclobenzaprine?".
Topics: Adult; Amitriptyline; Catatonia; Humans; Lead Poisoning; Male; Neuroleptic Malignant Syndrome; Tranq | 1996 |
[A case of depression manifesting incessant pacing and wandering following discontinuation of antipsychotic drugs due to neuroleptic malignant syndrome: a possible involvement of withdrawal akathisia].
Topics: Adult; Akathisia, Drug-Induced; Amitriptyline; Depression; Female; Humans; Methotrimeprazine; Neurol | 1997 |
[Case of malignant neuroleptic syndrome caused by an anti-depressive agent, later complicated by respiratory insufficiency and DIC].
Topics: Aged; Amitriptyline; Amoxapine; Disseminated Intravascular Coagulation; Female; Humans; Neuroleptic | 1998 |
Neuroleptic malignant syndrome without the use of neuroleptics.
Topics: Amitriptyline; Depressive Disorder; Drug Incompatibility; Female; Humans; Middle Aged; Neuroleptic M | 1991 |
Neuroleptic malignant syndrome, amitriptyline, and thioridazine.
Topics: Amitriptyline; Humans; Male; Middle Aged; Neuroleptic Malignant Syndrome; Substance Withdrawal Syndr | 1988 |
Withdrawal NMS after drug treatment.
Topics: Amitriptyline; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Neuroleptic Malignant Syn | 1988 |