amitriptyline has been researched along with Nerve Pain in 150 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-two patients older than 60 years of age who received a diagnosis of herpes zoster (HZ) were entered into a randomized, double-blind, placebo-controlled trial of daily amitriptyline 25 mg." | 9.08 | The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. ( Bowsher, D, 1997) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 9.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN)." | 9.07 | Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. ( Birkett, N; Chipman, M; Evans, RJ; Reed, K; Watson, PNC, 1992) |
| "In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12." | 9.06 | Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. ( Culnane, M; Dubner, R; Gracely, RH; Max, MB; Schafer, SC; Smoller, B, 1988) |
| "To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study." | 9.05 | Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982) |
| "Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines." | 8.88 | Amitriptyline for neuropathic pain and fibromyalgia in adults. ( Aldington, D; Cole, P; Derry, S; Moore, RA; Wiffen, PJ, 2012) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 7.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| "We report on a case of unilateral tinnitus after a short course of low-dose amitriptyline for neuralgic foot pain." | 7.74 | An unusual case of prolonged tinnitus following low-dose amitriptyline. ( Johnston, M; Mendis, D, 2008) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 7.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 7.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "This retrospective study was designed to assess the effects of acyclovir treatment of acute herpes zoster on subsequent postherpetic neuralgia, and to examine the effects of amitriptyline in the treatment of postherpetic neuralgia." | 7.68 | Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline. ( Bowsher, D, 1992) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 7.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 6.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment." | 5.51 | [Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019) |
| " Although secondary hypertension is a known side effect of amitriptyline and duloxetine, neither drug has been previously associated with AD." | 5.51 | Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report. ( Parke, SC; Reyes, MR, 2019) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 5.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 5.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 5.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 5.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 5.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| " There was moderate evidence for amitriptyline in patients with atypical facial pain." | 5.12 | Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis. ( Ananth, A; Do, TM; Kattar, N; McCoul, ED; Unis, GD, 2021) |
| "Seventy-two patients older than 60 years of age who received a diagnosis of herpes zoster (HZ) were entered into a randomized, double-blind, placebo-controlled trial of daily amitriptyline 25 mg." | 5.08 | The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. ( Bowsher, D, 1997) |
| "OBJECTIVE (BACKGROUND): Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN)." | 5.08 | Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial. ( Chipman, M; Reed, K; Vernich, L; Watson, CP, 1998) |
| "Amitriptyline (AT) relieves some patients with postherpetic neuralgia (PHN)." | 5.07 | Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial. ( Birkett, N; Chipman, M; Evans, RJ; Reed, K; Watson, PNC, 1992) |
| "In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12." | 5.06 | Amitriptyline, but not lorazepam, relieves postherpetic neuralgia. ( Culnane, M; Dubner, R; Gracely, RH; Max, MB; Schafer, SC; Smoller, B, 1988) |
| "To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study." | 5.05 | Amitriptyline versus placebo in postherpetic neuralgia. ( Evans, RJ; Goldsmith, L; Merskey, H; Reed, K; Warsh, J; Watson, CP, 1982) |
| "We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions." | 4.95 | Antiepileptic drugs for chronic non-cancer pain in children and adolescents. ( Clinch, J; Cooper, TE; Heathcote, LC; Howard, R; Krane, E; Lord, SM; Schechter, N; Sethna, N; Wiffen, PJ; Wood, C, 2017) |
| "Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines." | 4.88 | Amitriptyline for neuropathic pain and fibromyalgia in adults. ( Aldington, D; Cole, P; Derry, S; Moore, RA; Wiffen, PJ, 2012) |
| " 2 weeks prior to his symptoms, he had developed right-sided cervical herpes zoster for which he was prescribed oral acyclovir by his general practitioner." | 3.85 | A rash and a rare cause of unilateral diaphragmatic paralysis. ( Ashkir, ZM; Tsaknis, G, 2017) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 3.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| " The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury." | 3.80 | Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014) |
| "As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory neuropathic pain." | 3.75 | The neuraxial effects of intraspinal amitriptyline at low concentrations. ( Barros, GA; Fukushima, FB; Ganem, EM; Marques, ME; Vidal, EI, 2009) |
| "We report on a case of unilateral tinnitus after a short course of low-dose amitriptyline for neuralgic foot pain." | 3.74 | An unusual case of prolonged tinnitus following low-dose amitriptyline. ( Johnston, M; Mendis, D, 2008) |
| " The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline." | 3.71 | Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats. ( Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A, 2002) |
| "This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether the effect of amitriptyline involved manipulation of endogenous adenosine, by determining the effect of caffeine, a non-selective adenosine A(1) and A(2) receptor antagonist, on its actions." | 3.71 | Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. ( Allen, GV; Chase, T; Esser, MJ; Sawynok, J, 2001) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 3.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "Amitriptyline was the most useful drug in that it provided pain relief in musculoskeletal, vascular, and some neuropathic pain conditions." | 3.69 | Diagnosis and treatment of persistent pain after trauma to the head and neck. ( Benoliel, R; Eliav, E; Elishoov, H; Sharav, Y, 1994) |
| "This retrospective study was designed to assess the effects of acyclovir treatment of acute herpes zoster on subsequent postherpetic neuralgia, and to examine the effects of amitriptyline in the treatment of postherpetic neuralgia." | 3.68 | Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline. ( Bowsher, D, 1992) |
| "A fixed-ratio combination of amitriptyline and perphenazine was successful in treating 8 of 9 patients suffering from post-herpetic neuralgia." | 3.66 | Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine. ( Sriwatanakul, K; Weintraub, M; Weis, O, 1982) |
| "Diabetic peripheral neuropathic pain (DPNP) is common and often distressing." | 3.11 | Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomise ( Ahmed, SH; Alam, U; Bennett, DL; Bouhassira, D; Bradburn, M; Cooper, C; Devers, M; Gandhi, R; Glover, R; Gouni, R; Hariman, C; Horspool, M; Johnson, M; Jude, EB; Julious, S; Loban, A; Maguire, D; McDougall, C; Petrie, J; Rajbhandari, S; Rayman, G; Rice, ASC; Selvarajah, D; Sharma, S; Sloan, G; Sutherland, K; Tesfaye, S; Tsatlidis, V; Turton, E; Vas, P; Waterhouse, S; White, D, 2022) |
| "amitriptyline treatment for 6 weeks and pregabalin added if needed for a further 10 weeks, duloxetine treatment for 6 weeks and pregabalin added if needed for a further 10 weeks and pregabalin treatment for 6 weeks and amitriptyline added if needed for a further 10 weeks); however, the order of the treatment pathways was decided at random." | 3.11 | Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT. ( Ahmed, SH; Alam, U; Bennett, DL; Bouhassira, D; Bradburn, M; Cooper, C; Devers, M; Gandhi, R; Glover, R; Gouni, R; Hariman, C; Horspool, M; Johnson, M; Jude, E; Julious, SA; Loban, A; Maguire, D; McDougall, C; Petrie, J; Rajbhandari, S; Rayman, G; Selvarajah, D; Sharma, S; Sloan, G; Sutherland, K; Tesfaye, S; Tsatlidis, V; Turton, E; Vas, P; Waterhouse, S; White, D; Young, T, 2022) |
| "Patients treated for head and neck cancer are chronic opioid users to manage their post-treatment pain, which may entail an increased risk of addiction and overdose." | 3.11 | Study protocol of the TEC-ORL clinical trial: a randomized comparative phase II trial investigating the analgesic activity of capsaicin vs Laroxyl in head and neck Cancer survivors presenting with neuropathic pain sequelae. ( Boden, A; Bourgouin, M; Caunes-Hilary, N; Fabre, A; Filleron, T; Lodin, S; Lusque, A; Mauries, V; Moreau, C; Mounier, M; Poublanc, M, 2022) |
| "Amitriptyline was administered orally at doses of 25, 50 and 100 mg once daily at night time, and lamotrigine was administered orally at doses of 25, 50 and 100 mg twice daily, both for 1 week by means of optional titration." | 2.84 | Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study. ( Agarwal, N; Joshi, M, 2017) |
| "Pregabalin is used in the treatment of neuropathic pain of various etiologies and as an adjuvant in epilepsy." | 2.82 | Pregabalin Induced Maculopapular Eruption in an Elderly Male. ( Chakrabarti, SS; Dhameja, N; Jaiswal, S; Kaur, U; Mohan, A; Rai, T; Yadav, V, 2022) |
| "All nine drugs can relieve the pain of CPSP patients to different degrees; among them pregabalin and gabapentin have the most significant effect, and gabapentin and pregabalin also have the most adverse reactions." | 2.82 | Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review. ( Chen, KY; Li, RY, 2022) |
| "Treatment of neuropathic pain in children is challenging, and requires a multimodal approach of pharmacologic, physical, and psychological therapies; however there is little evidence to guide practice." | 2.82 | A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children. ( Amaria, K; Brown, S; Campbell, F; Johnston, B; McGrath, P; Pehora, C; Watkins, J, 2016) |
| "No differences were seen in the neuropathic pain questionnaire values at any time point during treatment between the three groups." | 2.80 | Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. ( De Vooght, P; Heylen, R; Kozicz, T; Mestrum, R; Puylaert, M; Roubos, E; Van Zundert, J; Vanelderen, P; Vissers, K, 2015) |
| "Oral morphine was used for rescue analgesic for continued pain." | 2.77 | A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. ( Bhatnagar, S; Goyal, GN; Mishra, S; Rana, SP; Upadhya, SP, 2012) |
| "Fourty six patients with neuropathic pain which was burning, stabbing and shooting in quality were allocated to take gabapentin (group GBP) and amitriptyline (group AMI) monotherapy." | 2.72 | [Comparison of efficacy of gabapentin and amitriptyline in the management of peripheral neuropathic pain]. ( Aydinli, I; Keskinbora, K; Pekel, AF, 2006) |
| "Clomipramine was better tolerated." | 2.65 | Clomipramine and amitriptyline in the treatment of severe pain. ( Carasso, RL; Streifler, M; Yehuda, S, 1979) |
| "Amitriptyline has been a first-line treatment for neuropathic pain for many years." | 2.52 | Amitriptyline for neuropathic pain in adults. ( Aldington, D; Cole, P; Derry, S; Moore, RA; Wiffen, PJ, 2015) |
| "Neuropathic pain is considered as a special type of different pain conditions." | 2.52 | [DRUG THERAPY OF NEUROPATHIC PAIN BASED ON THE LATEST RECOMMENDATIONS]. ( Kiss, G, 2015) |
| "In some cases, peripheral neuropathic pain may occur due to a lesion or disease of the peripheral somatosensory nervous system." | 2.52 | Topical amitriptyline and ketamine for the treatment of neuropathic pain. ( Mercadante, S, 2015) |
| " The aim of this article is to describe two cases treated effectively with topical amitriptyline 5% and 10%, the highest dosage described to date." | 2.48 | High doses of topical amitriptyline in neuropathic pain: two cases and literature review. ( Hesselink, JM; Kopsky, DJ, 2012) |
| "Neuropathic pain is usually considered an "hard pain" both for the intrinsic difficulties in a correct diagnosis, and for the modest efficacy of the most part of conventional treatments." | 2.47 | [Neuropathic pain in oncology. Novel evidence for clinical practice]. ( Carloni, F; Castellani, C; Drudi, F; Possenti, C; Santelmo, C; Tassinari, D, 2011) |
| "The most common risk factor for shingles and its potential sequela, PHN, is advanced age." | 2.42 | Post-herpetic neuralgia case study: optimizing pain control. ( Baron, R, 2004) |
| "Our goal was to determine if any treatment of acute herpes zoster alters the incidence or duration of postherpetic neuralgia (PHN), a common sequela in elderly patients." | 2.41 | Does treatment of acute herpes zoster prevent or shorten postherpetic neuralgia? ( Alper, BS; Lewis, PR, 2000) |
| "Postherpetic neuralgia is defined as pain persisting, or recurring, at the site of shingles at least three months after the onset of the acute rash." | 2.40 | The management of postherpetic neuralgia. ( Bowsher, D, 1997) |
| "However, patients with PHN whose acute shingles were treated with aciclovir obtain pain relief with antidepressants in half the time required by those patients who did not receive aciclovir for their acute shingles." | 2.39 | Post-herpetic neuralgia in older patients. Incidence and optimal treatment. ( Bowsher, D, 1994) |
| "Amitriptyline is a tricyclic antidepressant agent which also has analgesic properties." | 2.39 | Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. ( Bryson, HM; Wilde, MI, 1996) |
| "The acute course of herpes zoster is generally benign, but systemic complications may be fatal." | 2.38 | Treatment of herpes zoster and postherpetic neuralgia. ( Carmichael, JK, 1991) |
| "Therefore, antidepressants attenuate neuropathic pain predominantly by inhibiting primary afferent input to the spinal cord via activating both α1- and α2-adrenergic receptors." | 1.91 | Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors. ( Chen, H; Chen, SR; Huang, Y; Pan, HL, 2023) |
| "Like other chronic neuropathic pain conditions, PPTTN can significantly alter the patient's quality of life, especially when pharmacological treatment is ineffective or not tolerated." | 1.72 | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report. ( Capon, C; Crevant, A; Moreau, N; Pointin, A; Sulukdjian, A, 2022) |
| "In a neuropathic pain model in rats, mefloquine, a connexin inhibitor, has been shown to potentiate the antihyperalgesic effect of amitriptyline, a widely used antidepressant." | 1.62 | Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice. ( Andry, V; Barrot, M; Becker, LJ; Charvériat, M; Couqueberg, N; Droguerre, M; Goumon, Y; Hener, P; Inquimbert, P; Kremer, M; Leboulleux, Q; Letellier, B; Mouthon, F; Waltisperger, E; Yalcin, I, 2021) |
| "Neuropathic pain was induced by spared nerve injury (SNI) in mice." | 1.62 | Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice. ( Hisaoka-Nakashima, K; Kondo, S; Morioka, N; Nakamura, Y; Takimoto, T; Tokunaga, N, 2021) |
| " Pharmacokinetic analysis of pregabalin or combination (pregabalin + amitriptyline or pregabalin + duloxetine) in the plasma were performed by ultraperformance liquid chromatography tandem mass spectrometry." | 1.62 | Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats. ( Barros, CM; Boralli, VB; Costa, LH; Galdino, G; Kawano, T; Placido, RV; Podesta, MHMC; Rodrigues, RF; Santos, RS, 2021) |
| "We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907." | 1.56 | Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model. ( Aoki, Y; Hattori, M; Horikawa, H; Ito, H; Takemura, Y; Yamazaki, M, 2020) |
| "Introduction - Complex regional pain syndrome is a di-stressing neuropathic pain condition without known etiology and evidence based treatment." | 1.51 | [Treatment of complex regional pain syndrome with amitriptyline]. ( Komoly, S, 2019) |
| "Amitriptyline or saline was administered intraperitoneally and 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(±)-dihydropyridine-3,5-dicarboxylate (MRS-1191), an A3AR antagonist, was injected subcutaneously immediately before amitriptyline administration." | 1.51 | Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models. ( Choi, JW; In, JH; Joo, JD; Jung, HS; Kim, JA; Kim, Y; Kim, YS; Kwon, SY; Park, YJ, 2019) |
| " Although secondary hypertension is a known side effect of amitriptyline and duloxetine, neither drug has been previously associated with AD." | 1.51 | Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report. ( Parke, SC; Reyes, MR, 2019) |
| " Nine adverse drug reactions, mostly mild, nonserious, and nonpreventable, were reported." | 1.48 | An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster-Associated Pain. ( Desai, CK; Desai, MK; Kapadia, JD; Nayak, MK; Shah, BJ, 2018) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 1.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord." | 1.46 | Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017) |
| "Amitriptyline may enhance the analgesic effect of drugs for neuropathic pain that require normal descending noradrenergic inhibition to produce analgesia, such as serotonin and noradrenaline reuptake inhibitors and gabapentinoids." | 1.46 | Repeated Administration of Amitriptyline in Neuropathic Pain: Modulation of the Noradrenergic Descending Inhibitory System. ( Hiroki, T; Obata, H; Saito, S; Suto, T, 2017) |
| "Results revealed that T." | 1.43 | Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice. ( Esmaeilpour, K; Ghazvini, H; Keshavarz, H; Mahmoudvand, H; Sheibani, V; Shojaee, S; Ziaali, N, 2016) |
| "In mixed neuropathic pain, case series reports suggest a favourable response rate, but are limited by trial characteristics." | 1.43 | Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. ( Sawynok, J; Zinger, C, 2016) |
| " However, sitagliptin was observed to have no effect when administered alone or in combination with the other three drugs." | 1.43 | Drug combinations in diabetic neuropathic pain: an experimental validation. ( Mehta, AK; Tripathi, CD; Yadav, AM, 2016) |
| " Whereas acute treatments were ineffective, chronic administration of amitriptyline reduced CCI-SN-induced hyperalgesia-like behavior, and this effect was markedly enhanced by co-administration of mefloquine, which was inactive on its own." | 1.43 | Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats. ( Bourgoin, S; Charvériat, M; Duchêne, A; Ezan, P; Giaume, C; Hamon, M; Jeanson, T; Mouthon, F; Picoli, C; Richard, D, 2016) |
| "Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot." | 1.42 | The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain. ( Makuch, W; Mika, J; Przewlocka, B; Rojewska, E; Zychowska, M, 2015) |
| " Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice." | 1.42 | Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015) |
| "In the PGE2-induced allodynia model, AS1069562 and duloxetine significantly suppressed allodynia, whereas amitriptyline did not." | 1.40 | Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. ( Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M, 2014) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Occipital neuralgia is a pain in the distribution of the occipital nerves, accompanied by hypersensitivity to touch in the corresponding territory." | 1.39 | [Occipital neuralgia: clinical and therapeutic characteristics of a series of 14 patients]. ( Barón, J; Guerrero-Peral, ÁL; Herrero-Velázquez, S; Mulero, P; Muñoz, I; Pedraza, MI; Rodríguez, C; Ruiz, M, 2013) |
| "Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days)." | 1.39 | The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents. ( Edafiogho, IO; Masocha, W; Thangamani, D, 2013) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 1.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "The best analgesic drugs for neuropathic pain have a long duration of action, can be given via multiple routes, and can be used preemptively." | 1.39 | Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain. ( Cheng, KI; Chu, CC; Huang, KL; Lin, MT; Shieh, JP; Wang, JJ; Yeh, MY, 2013) |
| "The University of Washington Neuropathic Pain Scale was used to grade the neuropathic pain before and after use of the interventional gel." | 1.38 | Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study. ( Gerbis, B; Gillis, D; Holwerda, E; Uzaraga, I; Wai, E, 2012) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 1.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "Three patients with cancer experienced severe side-effects after starting anti-neuropathic pain therapy." | 1.37 | [Pitfalls in the treatment of neuropathic pain in patients with cancer]. ( Engels, Y; Hekster, YA; Schalkwijk, A; Verhagen, CA; Vissers, KC, 2011) |
| "In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "However, whether neuropathic pain can induce cognition dysfunction remains uncertain." | 1.36 | Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory. ( Hu, Y; Li, W; Wang, Y; Yang, J, 2010) |
| "Current clinical treatments for neuropathic pain include amitriptyline, a tricyclic antidepressant with mixed pharmacology that is also clinically reported to impair cognitive performance; and gabapentin, a compound that selectively interacts with alpha2delta-1 calcium channel subunits." | 1.36 | Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin. ( Arneric, SP; Buccafusco, JJ; Snutch, TP; Terry, AV; Vazdarjanova, A, 2010) |
| "We used a murine model of neuropathic pain induced by sciatic nerve constriction to study the antiallodynic properties of a chronic treatment with the tricyclic antidepressants nortriptyline and amitriptyline." | 1.35 | Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. ( Barrot, M; Benbouzid, M; Freund-Mercier, MJ; Gavériaux-Ruff, C; Kieffer, BL; Muller, A; Tessier, LH; Waltisperger, E; Yalcin, I, 2008) |
| "Integral to neuropathic pain is a reciprocal interaction between tumor necrosis factor-alpha (TNF) production and the alpha(2)-adrenergic receptor response, offering an attractive therapeutic target." | 1.34 | Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain. ( Ignatowski, TA; Lo, CP; Spengler, RN; Sud, R, 2007) |
| "In addition to persistent neuropathic pain, both patients experienced hemisensory impairment of the entire side of the body ipsilateral to the radicular symptoms." | 1.33 | [Hemisensory impairment in neuropathic pain following chronic radiculopathy]. ( Eichbaum, A; Jäger, G; Kuprian, A; Maercklin, A; Rommel, O, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| "Carbamazepine (300 mg/d) was required for pain control." | 1.33 | Occipital neuralgia secondary to respiratory tract infection. ( Anagnostopoulou, S; Mourouzis, C; Rallis, G; Saranteas, T; Tesseromatis, C, 2005) |
| "Amitriptyline was the cheapest strategy, followed by carbamazepine, and both were equally beneficial." | 1.33 | Economic evaluation of oral treatments for neuropathic pain. ( Cepeda, MS; Farrar, JT, 2006) |
| "Gabapentin was the most widely used AED (92% of all AED patients); amitriptyline was the most widely used TCA (79% of all TCA patients)." | 1.33 | Use of antiepileptics and tricyclic antidepressants in cancer patients with neuropathic pain. ( Berger, A; Dukes, E; Mercadante, S; Oster, G, 2006) |
| " Despite maximal dosing with conventional pain medications, she continued to have significant pain that had not been present following prior surgeries." | 1.32 | Neuropathic uterine pain after hysterectomy. A case report. ( Chavez, NF; Stewart, EA; Zweizig, SL, 2003) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 1.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "The management of patients with neuropathic pain is challenging." | 1.30 | The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. ( Abdi, S; Chung, JM; Lee, DH, 1998) |
| "Amitriptyline was administered systemically (intraperitoneal), spinally (intrathecal cannula), and locally (subcutaneously) via direct injection into the dorsal surface of the paw." | 1.30 | Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. ( Esser, MJ; Sawynok, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (9.33) | 18.7374 |
| 1990's | 23 (15.33) | 18.2507 |
| 2000's | 30 (20.00) | 29.6817 |
| 2010's | 63 (42.00) | 24.3611 |
| 2020's | 20 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bollenbach, M | 1 |
| Lugnier, C | 1 |
| Kremer, M | 3 |
| Salvat, E | 2 |
| Megat, S | 2 |
| Bihel, F | 1 |
| Bourguignon, JJ | 1 |
| Barrot, M | 4 |
| Schmitt, M | 1 |
| Jaiswal, S | 1 |
| Chakrabarti, SS | 1 |
| Rai, T | 1 |
| Dhameja, N | 1 |
| Mohan, A | 1 |
| Yadav, V | 1 |
| Kaur, U | 1 |
| Alcántara-Montero, A | 1 |
| Pacheco-de Vasconcelos, SR | 1 |
| Kong, X | 1 |
| Li, Y | 1 |
| Perez-Miller, S | 1 |
| Luo, G | 1 |
| Liao, Q | 1 |
| Wu, X | 1 |
| Liang, S | 1 |
| Tang, C | 1 |
| Khanna, R | 1 |
| Liu, Z | 1 |
| Tesfaye, S | 2 |
| Sloan, G | 2 |
| Petrie, J | 2 |
| White, D | 2 |
| Bradburn, M | 2 |
| Julious, S | 1 |
| Rajbhandari, S | 2 |
| Sharma, S | 2 |
| Rayman, G | 2 |
| Gouni, R | 2 |
| Alam, U | 2 |
| Cooper, C | 2 |
| Loban, A | 2 |
| Sutherland, K | 2 |
| Glover, R | 2 |
| Waterhouse, S | 2 |
| Turton, E | 2 |
| Horspool, M | 2 |
| Gandhi, R | 2 |
| Maguire, D | 2 |
| Jude, EB | 1 |
| Ahmed, SH | 2 |
| Vas, P | 2 |
| Hariman, C | 2 |
| McDougall, C | 2 |
| Devers, M | 2 |
| Tsatlidis, V | 2 |
| Johnson, M | 2 |
| Rice, ASC | 1 |
| Bouhassira, D | 2 |
| Bennett, DL | 2 |
| Selvarajah, D | 2 |
| Capon, C | 1 |
| Crevant, A | 1 |
| Pointin, A | 1 |
| Sulukdjian, A | 1 |
| Moreau, N | 1 |
| Chen, KY | 1 |
| Li, RY | 1 |
| Aster, HC | 1 |
| Evdokimov, D | 1 |
| Braun, A | 1 |
| Üçeyler, N | 1 |
| Sommer, C | 1 |
| Young, T | 1 |
| Julious, SA | 1 |
| Jude, E | 1 |
| Boden, A | 2 |
| Lusque, A | 2 |
| Lodin, S | 2 |
| Bourgouin, M | 2 |
| Mauries, V | 2 |
| Moreau, C | 2 |
| Fabre, A | 2 |
| Mounier, M | 2 |
| Poublanc, M | 2 |
| Caunes-Hilary, N | 2 |
| Filleron, T | 2 |
| Ahomäki, I | 1 |
| Böckerman, P | 1 |
| Pehkonen, J | 1 |
| Saastamoinen, L | 1 |
| Huang, Y | 1 |
| Chen, H | 1 |
| Chen, SR | 1 |
| Pan, HL | 1 |
| Eissa, RG | 1 |
| Eissa, NG | 1 |
| Eissa, RA | 1 |
| Diab, NH | 1 |
| Abdelshafi, NA | 1 |
| Shaheen, MA | 1 |
| Elsabahy, M | 1 |
| Hammad, SK | 1 |
| Farghaly, HSM | 1 |
| Elbadr, MM | 1 |
| Ahmed, MA | 1 |
| Abdelhaffez, AS | 1 |
| Komoly, S | 1 |
| Stepanenko, YD | 1 |
| Boikov, SI | 1 |
| Sibarov, DA | 1 |
| Abushik, PA | 1 |
| Vanchakova, NP | 1 |
| Belinskaia, D | 1 |
| Shestakova, NN | 1 |
| Antonov, SM | 1 |
| Sachau, J | 1 |
| Fabig, SC | 1 |
| Rehm, S | 1 |
| Baron, R | 2 |
| Do, TM | 1 |
| Unis, GD | 1 |
| Kattar, N | 1 |
| Ananth, A | 1 |
| McCoul, ED | 1 |
| Ito, H | 1 |
| Takemura, Y | 1 |
| Aoki, Y | 1 |
| Hattori, M | 1 |
| Horikawa, H | 1 |
| Yamazaki, M | 1 |
| Urquhart, DM | 1 |
| Wluka, AE | 1 |
| Heritier, S | 1 |
| Fong, C | 1 |
| Wang, Y | 2 |
| Cicuttini, FM | 1 |
| Letellier, B | 1 |
| Becker, LJ | 1 |
| Andry, V | 1 |
| Goumon, Y | 2 |
| Leboulleux, Q | 1 |
| Hener, P | 1 |
| Inquimbert, P | 1 |
| Couqueberg, N | 1 |
| Waltisperger, E | 2 |
| Yalcin, I | 3 |
| Mouthon, F | 2 |
| Droguerre, M | 1 |
| Charvériat, M | 2 |
| Naguib, IA | 1 |
| Ali, NA | 1 |
| Elroby, FA | 1 |
| Elghobashy, MR | 1 |
| Morioka, N | 1 |
| Kondo, S | 1 |
| Takimoto, T | 1 |
| Tokunaga, N | 1 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Rodrigues, RF | 1 |
| Kawano, T | 1 |
| Placido, RV | 1 |
| Costa, LH | 1 |
| Podesta, MHMC | 1 |
| Santos, RS | 1 |
| Galdino, G | 1 |
| Barros, CM | 1 |
| Boralli, VB | 1 |
| Notartomaso, S | 1 |
| Mascio, G | 1 |
| Bernabucci, M | 1 |
| Zappulla, C | 1 |
| Scarselli, P | 1 |
| Cannella, M | 1 |
| Imbriglio, T | 1 |
| Gradini, R | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Nicoletti, F | 1 |
| Chen, M | 1 |
| Hoshino, H | 1 |
| Saito, S | 3 |
| Yang, Y | 1 |
| Obata, H | 3 |
| Cooper, TE | 2 |
| Heathcote, LC | 2 |
| Clinch, J | 2 |
| Gold, JI | 1 |
| Howard, R | 2 |
| Lord, SM | 2 |
| Schechter, N | 2 |
| Wood, C | 2 |
| Wiffen, PJ | 5 |
| Krane, E | 1 |
| Sethna, N | 1 |
| Hiroki, T | 1 |
| Suto, T | 2 |
| Brown, S | 1 |
| Johnston, B | 1 |
| Amaria, K | 1 |
| Watkins, J | 1 |
| Campbell, F | 1 |
| Pehora, C | 1 |
| McGrath, P | 1 |
| Nayak, MK | 1 |
| Kapadia, JD | 1 |
| Desai, CK | 1 |
| Desai, MK | 1 |
| Shah, BJ | 1 |
| Kim, Y | 1 |
| Kwon, SY | 1 |
| Jung, HS | 1 |
| Park, YJ | 1 |
| Kim, YS | 1 |
| In, JH | 1 |
| Choi, JW | 1 |
| Kim, JA | 1 |
| Joo, JD | 1 |
| Parke, SC | 1 |
| Reyes, MR | 1 |
| O'Sullivan, C | 1 |
| Froyman, C | 1 |
| Wurtz, X | 1 |
| Nexon, L | 1 |
| Daniel, D | 1 |
| Ceredig, RA | 1 |
| Ernst, C | 1 |
| Turecki, G | 1 |
| Chavant, V | 1 |
| Théroux, JF | 1 |
| Lacaud, A | 1 |
| Joganah, LE | 1 |
| Lelievre, V | 1 |
| Massotte, D | 1 |
| Lutz, PE | 1 |
| Gilsbach, R | 1 |
| Rossignol, J | 1 |
| Cozzi, B | 1 |
| Liebaert, F | 1 |
| Hatton, S | 1 |
| Viallard, ML | 1 |
| Hermine, O | 1 |
| Greco, C | 1 |
| Furgała, A | 1 |
| Sałat, R | 1 |
| Sałat, K | 1 |
| Sokov, EL | 2 |
| Kornilova, LE | 2 |
| Artiukov, OP | 1 |
| Liu, WQ | 1 |
| Kanungo, A | 1 |
| Toth, C | 1 |
| Pedraza, MI | 1 |
| Ruiz, M | 1 |
| Rodríguez, C | 1 |
| Muñoz, I | 1 |
| Barón, J | 1 |
| Mulero, P | 1 |
| Herrero-Velázquez, S | 1 |
| Guerrero-Peral, ÁL | 1 |
| Murai, N | 2 |
| Aoki, T | 2 |
| Tamura, S | 2 |
| Sekizawa, T | 1 |
| Kakimoto, S | 1 |
| Tsukamoto, M | 2 |
| Oe, T | 1 |
| Enomoto, R | 1 |
| Hamakawa, N | 1 |
| Matsuoka, N | 2 |
| Thangamani, D | 1 |
| Edafiogho, IO | 1 |
| Masocha, W | 1 |
| Kachko, L | 1 |
| Ben Ami, S | 1 |
| Lieberman, A | 1 |
| Shor, R | 1 |
| Tzeitlin, E | 1 |
| Efrat, R | 1 |
| Hershman, DL | 1 |
| Lacchetti, C | 1 |
| Dworkin, RH | 1 |
| Lavoie Smith, EM | 1 |
| Bleeker, J | 1 |
| Cavaletti, G | 1 |
| Chauhan, C | 1 |
| Gavin, P | 1 |
| Lavino, A | 1 |
| Lustberg, MB | 1 |
| Paice, J | 1 |
| Schneider, B | 1 |
| Smith, ML | 1 |
| Smith, T | 1 |
| Terstriep, S | 1 |
| Wagner-Johnston, N | 1 |
| Bak, K | 1 |
| Loprinzi, CL | 1 |
| Jagla, G | 1 |
| Mika, J | 3 |
| Makuch, W | 3 |
| Obara, I | 1 |
| Wordliczek, J | 1 |
| Przewlocka, B | 3 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Chu, SH | 1 |
| Lee, YJ | 1 |
| Lee, ES | 1 |
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| Wang, XS | 1 |
| Cleeland, CS | 1 |
| Burke, NN | 1 |
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| De Vooght, P | 1 |
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| Zychowska, M | 1 |
| Rojewska, E | 2 |
| Derry, S | 3 |
| Aldington, D | 3 |
| Moore, RA | 3 |
| Kim, HJ | 1 |
| Jurga, AM | 1 |
| Starnowska, J | 1 |
| Wasylewski, M | 1 |
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| Malek, N | 1 |
| Cole, P | 2 |
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| Mercadante, S | 2 |
| Mahmoudvand, H | 1 |
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| Sawynok, J | 5 |
| Zinger, C | 1 |
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| Duchêne, A | 1 |
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| Picoli, C | 1 |
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| Hu, Y | 2 |
| Yang, J | 1 |
| Li, W | 1 |
| Buccafusco, JJ | 1 |
| Terry, AV | 1 |
| Vazdarjanova, A | 1 |
| Snutch, TP | 1 |
| Arneric, SP | 1 |
| Fournier-Charrière, E | 1 |
| Berrocoso, E | 1 |
| Mico, JA | 1 |
| Vitton, O | 1 |
| Ladure, P | 1 |
| Newman-Tancredi, A | 1 |
| Depoortère, R | 1 |
| Bardin, L | 1 |
| Schalkwijk, A | 1 |
| Verhagen, CA | 1 |
| Engels, Y | 1 |
| Hekster, YA | 1 |
| Vissers, KC | 1 |
| Liebregts, R | 1 |
| Kopsky, DJ | 2 |
| Hesselink, JM | 2 |
| Tassinari, D | 1 |
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| Ulugol, A | 2 |
| Farghaly, HS | 1 |
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| Nozdriukhina, NV | 1 |
| Suter, MR | 1 |
| Kirschmann, G | 1 |
| Laedermann, CJ | 1 |
| Abriel, H | 1 |
| Decosterd, I | 1 |
| Huang, KL | 1 |
| Shieh, JP | 1 |
| Chu, CC | 1 |
| Cheng, KI | 1 |
| Wang, JJ | 1 |
| Lin, MT | 1 |
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| Wareham, D | 3 |
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| Herr, H | 1 |
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| Zweizig, SL | 1 |
| Stewart, EA | 1 |
| Rommel, O | 1 |
| Maercklin, A | 1 |
| Eichbaum, A | 1 |
| Kuprian, A | 1 |
| Jäger, G | 1 |
| Walczak, JS | 1 |
| Pichette, V | 1 |
| Leblond, F | 1 |
| Desbiens, K | 1 |
| Beaulieu, P | 1 |
| Mourouzis, C | 1 |
| Saranteas, T | 1 |
| Rallis, G | 1 |
| Anagnostopoulou, S | 1 |
| Tesseromatis, C | 1 |
| Lynch, ME | 1 |
| Clark, AJ | 1 |
| Sullivan, MJ | 1 |
| Cepeda, MS | 1 |
| Farrar, JT | 1 |
| Berger, A | 1 |
| Dukes, E | 1 |
| Oster, G | 1 |
| Cayley, WE | 1 |
| Sud, R | 1 |
| Ignatowski, TA | 1 |
| Lo, CP | 1 |
| Spengler, RN | 1 |
| Keskinbora, K | 1 |
| Pekel, AF | 1 |
| Aydinli, I | 1 |
| Benbouzid, M | 1 |
| Gavériaux-Ruff, C | 1 |
| Tessier, LH | 1 |
| Muller, A | 1 |
| Kieffer, BL | 1 |
| Freund-Mercier, MJ | 1 |
| Wernicke, JF | 1 |
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| Watson, CP | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy[NCT04920097] | 240 participants (Anticipated) | Interventional | 2021-07-08 | Recruiting | |||
| Intravenous Lidocaine Infusion Versus Oral Duloxetine For The Prevention And Treatment Of Chemotherapy Induced Peripheral Neuropathy Among Breast Cancer Patients[NCT04732455] | 60 participants (Actual) | Interventional | 2021-01-15 | Completed | |||
| The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer[NCT04558034] | 14 participants (Actual) | Interventional | 2020-08-04 | Terminated (stopped due to Principal Investigator retired before study completed.) | |||
| Effect of Cryotherapy in Controlling Peripheral Neuropathy in Cancer Children[NCT04536207] | 60 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | |||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854] | Phase 2 | 68 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| Effectiveness and Cost-effectiveness of Ozone Therapy in Patients With Pain Secondary to Chemotherapy-induced Peripheral Neuropathy. Randomized, Triple-blind Clinical Trial (O3NPIQ)[NCT04299893] | Phase 2/Phase 3 | 42 participants (Anticipated) | Interventional | 2020-11-30 | Recruiting | ||
| Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients: a Prospective, Randomized, Sham-controlled, Double-blinded and Multicenter Study[NCT05798884] | 150 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| Imaging Glia-mediated NeuroInflammation and Treatment Efficacy (the IGNITE Study)[NCT03106740] | Phase 2 | 145 participants (Anticipated) | Interventional | 2017-10-10 | Recruiting | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Cannabidiol for Fibromyalgia -The CANNFIB Trial Protocol for a Randomized, Double-blind, Placebo-controlled, Parallel-group, Single-center Trial[NCT04729179] | Phase 3 | 200 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Enhancing Functional and Cognitive Performances in People With Amputation and Peripheral Neuropathy Through the Restoration of Sensory Feedback in Real World and Virtual Reality Environments[NCT04217005] | 20 participants (Anticipated) | Interventional | 2019-12-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
30 reviews available for amitriptyline and Nerve Pain
| Article | Year |
|---|---|
Pregabalin Induced Maculopapular Eruption in an Elderly Male.
Topics: Aged; Amitriptyline; Analgesics; Anticonvulsants; Exanthema; Humans; Male; Neuralgia; Pregabalin | 2022 |
[Pharmacological approach to neuropathic pain: past, present and future].
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Gabapentin; Humans; Neuralgia; | 2022 |
Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Carbamazepine; Duloxetine Hydrochloride; Fluo | 2022 |
[Treatment of polyneuropathy: autonomic symptoms and pain].
Topics: Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents; Calcium Channel Blockers; Humans; | 2020 |
Neuromodulators for Atypical Facial Pain and Neuralgias: A Systematic Review and Meta-Analysis.
Topics: Adult; Amitriptyline; Botulinum Toxins, Type A; Carbamazepine; Facial Nerve; Facial Pain; Female; Hu | 2021 |
Antidepressants for chronic non-cancer pain in children and adolescents.
Topics: Abdominal Pain; Adolescent; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Child; Chronic | 2017 |
Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Amines; Amitriptyline; Anticonvulsants; Child; Chronic Pain; Complex Regional Pain Syndr | 2017 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineo | 2014 |
Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Boronic Acids; Bortezo | 2015 |
Nortriptyline for neuropathic pain in adults.
Topics: Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Clomipramine; Cyclohexanecarbox | 2015 |
Amitriptyline for neuropathic pain in adults.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Humans; Neuralgia; | 2015 |
Antidepressants Are Effective in Decreasing Neuropathic Pain After SCI: A Meta-Analysis.
Topics: Amitriptyline; Antidepressive Agents; Databases, Factual; Duloxetine Hydrochloride; Humans; Neuralgi | 2015 |
[DRUG THERAPY OF NEUROPATHIC PAIN BASED ON THE LATEST RECOMMENDATIONS].
Topics: Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Antidepressive | 2015 |
Topical amitriptyline and ketamine for the treatment of neuropathic pain.
Topics: Administration, Topical; Amitriptyline; Analgesics; Humans; Ketamine; Neuralgia | 2015 |
[Neuropathic pain in oncology. Novel evidence for clinical practice].
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2011 |
High doses of topical amitriptyline in neuropathic pain: two cases and literature review.
Topics: Administration, Topical; Adult; Amitriptyline; Analgesics, Non-Narcotic; Diabetic Neuropathies; Huma | 2012 |
Amitriptyline for neuropathic pain and fibromyalgia in adults.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Fibromyalgia; Huma | 2012 |
Postherpetic neuralgia.
Topics: Amitriptyline; Analgesics; Antiviral Agents; Herpes Zoster; Humans; Neuralgia; Randomized Controlled | 2002 |
Post-herpetic neuralgia case study: optimizing pain control.
Topics: Acetates; Aged; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarb | 2004 |
Postherpetic neuralgia.
Topics: Acyclovir; Adrenal Cortex Hormones; Amitriptyline; Antidepressive Agents, Tricyclic; Antiviral Agent | 2003 |
Postherpetic neuralgia.
Topics: 2-Aminopurine; Acyclovir; Adrenal Cortex Hormones; Adult; Amines; Amitriptyline; Analgesics, Non-Nar | 2003 |
Antidepressants for the treatment of neuropathic pain.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Diabetic Neuropathies; Humans; Male; Neuralgi | 2006 |
Post-herpetic neuralgia in older patients. Incidence and optimal treatment.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Herpes Zoster; Humans; Incidence; Midd | 1994 |
Postherpetic neuralgia and its managements.
Topics: Amitriptyline; Analgesics; Desipramine; Herpes Zoster; Humans; India; Neuralgia | 1993 |
Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states.
Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Chronic Di | 1996 |
The management of postherpetic neuralgia.
Topics: Acyclovir; Amitriptyline; Analgesics; Antidepressive Agents; Antiviral Agents; Herpes Zoster; Humans | 1997 |
Does treatment of acute herpes zoster prevent or shorten postherpetic neuralgia?
Topics: Acute Disease; Acyclovir; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antiviral Agents; Drug Ther | 2000 |
Treatment of herpes zoster and postherpetic neuralgia.
Topics: Acupuncture Therapy; Acyclovir; Amitriptyline; Anesthetics, Local; Anticonvulsants; Antipsychotic Ag | 1991 |
[Drug treatment of pain originating from the peripheral nervous system].
Topics: Amitriptyline; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve Block; H | 1990 |
Antidepressants in the management of chronic pain syndromes.
Topics: Amitriptyline; Antidepressive Agents; Arthritis; Back Pain; Chronic Disease; Diabetic Neuropathies; | 1990 |
25 trials available for amitriptyline and Nerve Pain
| Article | Year |
|---|---|
Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomise
Topics: Amitriptyline; Analgesics; Cross-Over Studies; Diabetes Mellitus; Diabetic Neuropathies; Double-Blin | 2022 |
Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT.
Topics: Adult; Amitriptyline; Cost-Benefit Analysis; Diabetes Mellitus; Duloxetine Hydrochloride; Humans; Ne | 2022 |
Study protocol of the TEC-ORL clinical trial: a randomized comparative phase II trial investigating the analgesic activity of capsaicin vs Laroxyl in head and neck Cancer survivors presenting with neuropathic pain sequelae.
Topics: Amitriptyline; Analgesics; Capsaicin; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms; H | 2022 |
Study protocol of the TEC-ORL clinical trial: a randomized comparative phase II trial investigating the analgesic activity of capsaicin vs Laroxyl in head and neck Cancer survivors presenting with neuropathic pain sequelae.
Topics: Amitriptyline; Analgesics; Capsaicin; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms; H | 2022 |
Study protocol of the TEC-ORL clinical trial: a randomized comparative phase II trial investigating the analgesic activity of capsaicin vs Laroxyl in head and neck Cancer survivors presenting with neuropathic pain sequelae.
Topics: Amitriptyline; Analgesics; Capsaicin; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms; H | 2022 |
Study protocol of the TEC-ORL clinical trial: a randomized comparative phase II trial investigating the analgesic activity of capsaicin vs Laroxyl in head and neck Cancer survivors presenting with neuropathic pain sequelae.
Topics: Amitriptyline; Analgesics; Capsaicin; Clinical Trials, Phase II as Topic; Head and Neck Neoplasms; H | 2022 |
A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children.
Topics: Adolescent; Amines; Amitriptyline; Analgesics; Child; Cyclohexanecarboxylic Acids; Female; Gabapenti | 2016 |
High concentration of topical amitriptyline for treating chemotherapy-induced neuropathies.
Topics: Administration, Cutaneous; Administration, Topical; Aged; Aged, 80 and over; Amitriptyline; Analgesi | 2019 |
[Intraosseous blocks in the treatment of symmetrical distal diabetic polyneuropathy].
Topics: Aged; Amitriptyline; Analgesics, Non-Narcotic; Anesthetics, Local; Diabetic Neuropathies; Female; Fo | 2013 |
Equivalency of tricyclic antidepressants in open-label neuropathic pain study.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Drug Therapy, Combination; Female; Humans; Male; Mi | 2014 |
Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Back Pain; Brai | 2015 |
Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study.
Topics: Administration, Oral; Adolescent; Adult; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tric | 2017 |
A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study.
Topics: Adult; Amines; Amitriptyline; Analgesics; Analysis of Variance; Cyclohexanecarboxylic Acids; Double- | 2012 |
[The complex treatment of the pain syndrome in diabetic distal polyneuropathy using intraosteal blockades].
Topics: Aged; Amitriptyline; Analgesia; Analgesics, Non-Narcotic; Bone and Bones; Combined Modality Therapy; | 2012 |
Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study.
Topics: Adenosine; Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Analg | 2005 |
[Comparison of efficacy of gabapentin and amitriptyline in the management of peripheral neuropathic pain].
Topics: Amines; Amitriptyline; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Ga | 2006 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi | 2007 |
Amitriptyline versus placebo in postherpetic neuralgia.
Topics: Aged; Amitriptyline; Depression; Double-Blind Method; Female; Herpesviridae Infections; Humans; Male | 1982 |
The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Aged; Aged, 80 and over; Amitriptyline; Chi-Square Distribution; Dose- | 1997 |
Diabetic peripheral neuropathy. Effectiveness of electrotherapy and amitriptyline for symptomatic relief.
Topics: Adult; Aged; Amitriptyline; Diabetic Neuropathies; Electric Stimulation Therapy; Female; Humans; Mal | 1998 |
Nortriptyline versus amitriptyline in postherpetic neuralgia: a randomized trial.
Topics: Aged; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Cross-Over Studies; Depre | 1998 |
Amitriptyline and fluphenazine in the treatment of postherpetic neuralgia.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Anxiety; Dose-Response | 2000 |
Clomipramine and amitriptyline in the treatment of severe pain.
Topics: Adult; Aged; Amitriptyline; Clomipramine; Female; Headache; Humans; Male; Middle Aged; Neuralgia; Pa | 1979 |
Amitriptyline versus maprotiline in postherpetic neuralgia: a randomized, double-blind, crossover trial.
Topics: Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Female; Herpes Zoster; Humans; Male; Ma | 1992 |
A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Drug Therapy, Combination; Female; Herpes Zost | 1985 |
Trazodone for deafferentation pain. Comparison with amitriptyline.
Topics: Adult; Afferent Pathways; Aged; Amitriptyline; Clinical Trials as Topic; Double-Blind Method; Humans | 1988 |
Antidepressants for cancer pain and other painful syndromes with deafferentation component: comparison of amitriptyline and trazodone.
Topics: Adult; Aged; Amitriptyline; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Humans; | 1987 |
Amitriptyline, but not lorazepam, relieves postherpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Female; Herpes Zoster; Humans; Lorazepam; Male; Mid | 1988 |
95 other studies available for amitriptyline and Nerve Pain
| Article | Year |
|---|---|
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.
Topics: Analgesics; Animals; Hyperalgesia; Male; Mice, Inbred C57BL; Molecular Structure; Neuralgia; Phospho | 2019 |
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state.
Topics: Action Potentials; Amitriptyline; Analgesics; Animals; Ganglia, Spinal; Mice; NAV1.7 Voltage-Gated S | 2022 |
Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report.
Topics: Amitriptyline; Animals; Botulinum Toxins, Type A; Carbamazepine; Clonazepam; Duloxetine Hydrochlorid | 2022 |
Analgesic Medication in Fibromyalgia Patients: A Cross-Sectional Study.
Topics: Acetaminophen; Amitriptyline; Analgesics; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-St | 2022 |
Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study.
Topics: Aged; Amitriptyline; Drug-Related Side Effects and Adverse Reactions; Humans; Inappropriate Prescrib | 2023 |
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Duloxetine Hydrochloride; Hyperalgesia; N | 2023 |
Oral proniosomal amitriptyline and liraglutide for management of diabetic neuropathy: Exceptional control over hyperglycemia and neuropathic pain.
Topics: Amitriptyline; Animals; Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Humans; Hyperglycem | 2023 |
Effect of single and repeated administration of amitriptyline on neuropathic pain model in rats: Focus on glutamatergic and upstream nitrergic systems.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Glutamic Acid; Male; Neura | 2019 |
[Treatment of complex regional pain syndrome with amitriptyline].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Chronic Disease; Complex | 2019 |
Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Calcium; Cells, Cultured; Cerebral Cortex; | 2019 |
Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Pain; Disease Models, Animal; Fluo | 2020 |
Effect of low-dose amitriptyline on low back pain with a neuropathic component: a post hoc analysis.
Topics: Amitriptyline; Analgesics; Humans; Low Back Pain; Neuralgia; Pain Measurement | 2021 |
Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Mefloquine; Mice; N | 2021 |
Green HPLC-DAD and HPTLC Methods for Quantitative Determination of Binary Mixture of Pregabalin and Amitriptyline Used for Neuropathic Pain Management.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; | 2021 |
Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Connexin 43; Disease Models, Animal; Down-Regulation; | 2021 |
Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; | 2021 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do | 2017 |
Repeated Administration of Amitriptyline in Neuropathic Pain: Modulation of the Noradrenergic Descending Inhibitory System.
Topics: Adrenergic Neurons; Amitriptyline; Analgesics, Non-Narcotic; Animals; Male; Neural Inhibition; Neura | 2017 |
An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster-Associated Pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; | 2018 |
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models.
Topics: Adenosine A3 Receptor Antagonists; Amitriptyline; Animals; Cyclic AMP Response Element-Binding Prote | 2019 |
Autonomic Dysreflexia as a Potential Adverse Effect of Duloxetine and Amitriptyline Combination Therapy: A Case Report.
Topics: Adult; Amitriptyline; Analgesics; Autonomic Dysreflexia; Drug Therapy, Combination; Duloxetine Hydro | 2019 |
Nortriptyline safer than amitriptyline?
Topics: Amitriptyline; Canada; Consensus; Humans; Neuralgia; Nortriptyline | 2018 |
A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.
Topics: Adult; Aged; Amitriptyline; Animals; Antidepressive Agents; Duloxetine Hydrochloride; Female; Humans | 2018 |
Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Hype | 2018 |
[Occipital neuralgia: clinical and therapeutic characteristics of a series of 14 patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Cyclohexanecarboxylic | 2013 |
AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover.
Topics: Amitriptyline; Analgesics; Animals; Biogenic Monoamines; Dopamine; Dopamine Plasma Membrane Transpor | 2014 |
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female; | 2013 |
Neuropathic pain other than CRPS in children and adolescents: incidence, referral, clinical characteristics, management, and clinical outcomes.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Chronic Pain; Female; Humans; In | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Rel | 2014 |
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do | 2014 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Glial | 2015 |
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cyclohexanols; Cyclopropane | 2015 |
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
Topics: Amitriptyline; Analgesics; Animals; Berberine; Cold Temperature; Constriction; Disease Models, Anima | 2015 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2015 |
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Models, Animal; Hyperalgesia; I | 2016 |
Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain.
Topics: Amitriptyline; Animals; Disease Models, Animal; Ligation; Male; Memory Disorders; Neuralgia; Pain Me | 2016 |
Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain.
Topics: Administration, Topical; Amitriptyline; Analgesics; Animals; Diabetic Neuropathies; Drug Combination | 2016 |
Amitriptyline, but Not Pregabalin, Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats.
Topics: Adrenergic Neurons; Amitriptyline; Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, | 2016 |
Drug combinations in diabetic neuropathic pain: an experimental validation.
Topics: Amitriptyline; Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug The | 2016 |
Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats.
Topics: Amitriptyline; Animals; Astrocytes; Connexin 43; Gap Junctions; Hyperalgesia; Male; Neuralgia; Rats; | 2016 |
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.
Topics: Amitriptyline; Analgesics; Animals; Astrocytes; Biocatalysis; Enzyme Activation; Gene Expression Reg | 2017 |
A rash and a rare cause of unilateral diaphragmatic paralysis.
Topics: Acyclovir; Amitriptyline; Diaphragm; Exanthema; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; | 2017 |
The effect of amitriptyline on ectopic discharge of primary afferent fibers in the L5 dorsal root in a rat model of neuropathic pain.
Topics: Action Potentials; Amitriptyline; Analgesics; Animals; Disease Models, Animal; Dose-Response Relatio | 2009 |
The neuraxial effects of intraspinal amitriptyline at low concentrations.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anesthesia; Animals; Central Nervous System; Dogs; Female; | 2009 |
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Der | 2010 |
Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; D | 2010 |
[Neuropathic pain in children].
Topics: Adolescent; Amines; Amitriptyline; Analgesics; Analgesics, Opioid; Anticonvulsants; Antidepressive A | 2010 |
Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Constriction; Cyclopropanes; | 2011 |
[Pitfalls in the treatment of neuropathic pain in patients with cancer].
Topics: Aged; Amines; Amitriptyline; Analgesics; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr | 2011 |
Topical amitriptyline in post-traumatic neuropathic pain.
Topics: Administration, Topical; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Female; Humans; Nai | 2011 |
Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics; Anesthetics, L | 2012 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model.
Topics: Amitriptyline; Analgesics; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior | 2012 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, | 2013 |
Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; | 2013 |
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes | 2002 |
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans; | 2002 |
Prognostic factors of postherpetic neuralgia.
Topics: Acyclovir; Adolescent; Adult; Aged; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepr | 2002 |
Neuropathic uterine pain after hysterectomy. A case report.
Topics: Abscess; Adult; Amitriptyline; Analgesics, Non-Narcotic; Endometriosis; Fallopian Tube Diseases; Fem | 2003 |
[Hemisensory impairment in neuropathic pain following chronic radiculopathy].
Topics: Amitriptyline; Analgesics; Female; Functional Laterality; Humans; Middle Aged; Neuralgia; Perceptual | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
Occipital neuralgia secondary to respiratory tract infection.
Topics: Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexanecarboxylic Acids; Diagnos | 2005 |
Economic evaluation of oral treatments for neuropathic pain.
Topics: Administration, Oral; Amines; Amitriptyline; Analgesics; Carbamazepine; Cohort Studies; Cost-Benefit | 2006 |
Use of antiepileptics and tricyclic antidepressants in cancer patients with neuropathic pain.
Topics: Aged; Amines; Amitriptyline; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents, Tricyclic; | 2006 |
Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Cyclic AMP; Hippocampus; Male; Nerve Crush; Ne | 2007 |
Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Dose-Response Rela | 2008 |
An unusual case of prolonged tinnitus following low-dose amitriptyline.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Female; Fo | 2008 |
Therapeutic window for amitriptyline analgesia.
Topics: Aged; Amitriptyline; Analgesics; Diabetic Neuropathies; Dose-Response Relationship, Drug; Humans; Mi | 1984 |
[Genitofemoral neuralgia].
Topics: Adult; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Chlorpromazine; Female | 1982 |
Treatment of post-herpetic neuralgia and acute herpetic pain with amitriptyline and perphenazine.
Topics: Adult; Aged; Amitriptyline; Drug Combinations; Female; Herpes Zoster; Humans; Male; Middle Aged; Neu | 1982 |
Diagnosis and treatment of persistent pain after trauma to the head and neck.
Topics: Adult; Amitriptyline; Carbamazepine; Chronic Disease; Craniocerebral Trauma; Facial Pain; Female; He | 1994 |
Treatments for postherpetic neuralgia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Capsaicin; Desipramine; Herpes Zoster; Humans; Meta | 1997 |
The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma | 1998 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Hot Temperature; Hyperalgesia; Ligation; M | 1999 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli | 1999 |
Neuropathic pain.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Antiviral Agents; Cyclohexanecarboxylic Acids; Drug The | 1999 |
Gabapentin vs amitriptyline for the treatment of peripheral neuropathy.
Topics: Acetates; Amines; Amitriptyline; Analgesics, Non-Narcotic; Cyclohexanecarboxylic Acids; Drug Adminis | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
[Treatment of chronic and neuropathic pain. Established amitriptyline and the new gabapentin].
Topics: Acetates; Amines; Amitriptyline; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; | 2000 |
The important time parameter is missing. Comment on Sindrup and Jensen, PAIN 83 (1999) 389-400.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Humans; Neuralgia; Time Factors | 2000 |
Postherpetic neuralgia. Treatment with amitriptyline is cheaper than with aciclovir.
Topics: Acyclovir; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antiviral Agents; Drug Costs; Herpes Zoste | 2001 |
Transcutaneous electrostimulation: emerging treatment for diabetic neuropathic pain.
Topics: Amitriptyline; Clinical Trials as Topic; Combined Modality Therapy; Diabetic Neuropathies; Humans; N | 1999 |
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models | 2001 |
Acute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline.
Topics: Acute Disease; Acyclovir; Aged; Amitriptyline; Herpes Zoster; Humans; Middle Aged; Neuralgia; Retros | 1992 |
Acute herpes zoster, postherpetic neuralgia, acyclovir and amitriptyline.
Topics: Acyclovir; Amitriptyline; Herpes Zoster; Humans; Neuralgia | 1992 |
Acute herpes zoster, postherpetic neuralgia, acyclovir and amitriptyline.
Topics: Acute Disease; Acyclovir; Amitriptyline; Herpes Zoster; Humans; Neuralgia | 1992 |
Postherpes simplex type 1 neuralgia simulating postherpetic neuralgia.
Topics: Amitriptyline; Chronic Disease; Diagnosis, Differential; Female; Herpes Simplex; Herpes Zoster; Huma | 1992 |
[Drug therapy of so-called postherpetic neuralgia, the only valid alternative. Clinical experience in 43 treated cases].
Topics: Administration, Oral; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; D | 1986 |
Treatment of post-herpetic neuralgia. A review of 77 consecutive cases.
Topics: Adult; Aged; Amitriptyline; Analgesics; Autonomic Nerve Block; Carbamazepine; Combined Modality Ther | 1985 |
Relief of postherpetic neuralgia with psychotropic drugs.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine; | 1973 |
Letter: Psychotropic agents.
Topics: Aged; Amitriptyline; Female; Fluphenazine; Humans; Neuralgia | 1974 |
Treatment of post-herpetic neuralgia.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Female; Herpes Zoster; Humans; Male; Middle Aged; | 1965 |