amitriptyline has been researched along with Nerve Degeneration in 4 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with citalopram was effective in reversing the behavioral deficits induced by bulbectomy, but did not protect against neurodegeneration." | 1.34 | Antidepressant-mediated reversal of abnormal behavior and neurodegeneration in mice following olfactory bulbectomy. ( Jarosik, J; Legutko, B; Unsicker, K; von Bohlen Und Halbach, O, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paumier, KL | 1 |
| Sortwell, CE | 1 |
| Madhavan, L | 1 |
| Terpstra, B | 1 |
| Daley, BF | 1 |
| Collier, TJ | 1 |
| Zheng, X | 1 |
| Chen, F | 1 |
| Zheng, T | 1 |
| Huang, F | 1 |
| Chen, J | 1 |
| Tu, W | 1 |
| Jarosik, J | 1 |
| Legutko, B | 1 |
| Unsicker, K | 1 |
| von Bohlen Und Halbach, O | 1 |
| Tajti, J | 1 |
4 other studies available for amitriptyline and Nerve Degeneration
| Article | Year |
|---|---|
Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain Chemistry; Brain-Derived Neurotrophi | 2015 |
Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons.
Topics: Amitriptyline; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Dose- | 2016 |
Antidepressant-mediated reversal of abnormal behavior and neurodegeneration in mice following olfactory bulbectomy.
Topics: Amitriptyline; Amygdala; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; A | 2007 |
Calmodulin inhibitors induce wallerian degeneration of mammalian peripheral nerves.
Topics: Amitriptyline; Animals; Calmodulin; Desipramine; Female; Male; Nerve Degeneration; Rats; Rats, Inbre | 1988 |