amitriptyline has been researched along with Muscle Contraction in 41 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated." | 9.07 | [Amitriptyline in therapy of chronic tension headache]. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994) |
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 7.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| "In a double-blind, placebo-controlled trial, the effect of 75 mg of a slow-release formulation of amitriptyline on the clinical severity of chronic tension-type headache and on headache-associated neurophysiological parameters (EMG activity, exteroceptive suppression of temporal muscle activity, contingent negative variation (CNV) and experimental pain sensitivity) was investigated." | 5.07 | [Amitriptyline in therapy of chronic tension headache]. ( Göbel, H; Hamouz, V; Hansen, C; Heininger, K; Heuss, D; Hirsch, S; Lindner, V; Soyka, D, 1994) |
| "These results indicate that amitriptyline and nortriptyline could act as adrenoceptor antagonists and direct inhibitors of smooth muscle contraction of human mesenteric arteries, whereas sertraline might principally exert its action only as direct inhibitor of smooth muscle contraction." | 3.70 | Relaxant effects of antidepressants on human isolated mesenteric arteries. ( Flor, B; Lluch, P; Lluch, S; Medina, P; Pallardó, F; Segarra, G; Vila, JM, 1999) |
| "Amitriptyline, a tricyclic antidepressant, has been reported to diminish signs of human myotonic muscular dystrophy, but has not been examined in other myotonias." | 3.68 | Lack of effect of amitriptyline in murine myotonia. ( Carter, GT; Entrikin, RK; Longley, KJ; Walsh, SA, 1992) |
| "He discusses treatment of headache in relation to management of the acute attack, avoidance of trigger factors, and pharmacological and nonpharmacological prophylaxis." | 2.37 | An overview of the classification, causes, and treatment of headache. ( Ziegler, DK, 1984) |
| "), shifted the dose-response relationships to the right for each of the antidepressant agents (dothiepin, amitriptyline, sibutramine, (+)-oxaprotiline and paroxetine)." | 1.30 | The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. ( Gray, AM; Sewell, RD; Spencer, PS, 1998) |
| "Xylamine (10 microM) was without effect." | 1.29 | Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle. ( Huang, Y, 1996) |
| " Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse." | 1.27 | Tricyclic antidepressants antagonize prostaglandin (PG) E2-induced contractions of the guinea pig ileum and hypomotility in the mouse. ( Tayo, FM, 1985) |
| "Amitriptyline was also observed to increase the release of [3H]norepinephrine from the field-stimulated rat anococcygeus muscle pretreated with cocaine." | 1.26 | Quantitative assessment of the pre- and postsynaptic alpha adrenoceptor antagonist potency of amitriptyline. ( Leighton, HJ, 1982) |
| "Pentobarbital and Sulpiride produce a biphasyc effect of opposite sign: at small doses Pentobarbital increases the stretch response while Sulpiride reduces it." | 1.26 | [Action of some psychotropic drugs on the electrmyographic response evoked by stretches of the gastrocnemius muscle of rats submitted to stress]. ( Eandi, M; Ricci Gamalero, S; Taglia, P, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (65.85) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 3 (7.32) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Britto-Júnior, J | 1 |
| da Silva-Filho, WP | 1 |
| Amorim, AC | 1 |
| Campos, R | 1 |
| Moraes, MO | 1 |
| Moraes, MEA | 1 |
| Fregonesi, A | 1 |
| Monica, FZ | 1 |
| Antunes, E | 1 |
| De Nucci, G | 1 |
| Reyes-Mendez, ME | 1 |
| Castro-Sánchez, LA | 1 |
| Dagnino-Acosta, A | 1 |
| Aguilar-Martínez, I | 1 |
| Pérez-Burgos, A | 1 |
| Vázquez-Jiménez, C | 1 |
| Moreno-Galindo, EG | 1 |
| Álvarez-Cervera, FJ | 1 |
| Góngora-Alfaro, JL | 1 |
| Navarro-Polanco, RA | 1 |
| Alamilla, J | 1 |
| Tartaro, G | 1 |
| Rauso, R | 1 |
| Santagata, M | 1 |
| Santillo, V | 1 |
| Itro, A | 1 |
| Ribback, S | 1 |
| Pavlovic, D | 1 |
| Herbst, D | 1 |
| Nedeljkov-Jancic, R | 1 |
| Wendt, M | 1 |
| Nedeljkov, V | 1 |
| Bleich, S | 1 |
| Frieling, H | 1 |
| Leighton, HJ | 1 |
| Martin, MJ | 1 |
| Ziegler, DK | 1 |
| Share, NN | 2 |
| Wrigglesworth, SJ | 1 |
| Greden, JF | 1 |
| Price, HL | 1 |
| Genero, N | 1 |
| Feinberg, M | 1 |
| Levine, S | 1 |
| Jay, GW | 1 |
| Renelli, D | 1 |
| Mead, T | 1 |
| Kudrow, L | 1 |
| Kenakin, TP | 1 |
| Beek, D | 1 |
| Eandi, M | 1 |
| Ricci Gamalero, S | 1 |
| Taglia, P | 1 |
| Göbel, H | 1 |
| Hamouz, V | 1 |
| Hansen, C | 1 |
| Heininger, K | 1 |
| Hirsch, S | 1 |
| Lindner, V | 1 |
| Heuss, D | 1 |
| Soyka, D | 1 |
| Huang, Y | 2 |
| Lau, CW | 1 |
| Gray, AM | 1 |
| Spencer, PS | 1 |
| Sewell, RD | 1 |
| Ocharan, ME | 1 |
| Asbun, J | 1 |
| Valencia, I | 1 |
| Castillo, C | 1 |
| Castillo, EF | 1 |
| Vila, JM | 2 |
| Medina, P | 2 |
| Segarra, G | 2 |
| Lluch, P | 1 |
| Pallardó, F | 1 |
| Flor, B | 1 |
| Lluch, S | 2 |
| Ballester, R | 1 |
| Chuan, P | 1 |
| Domenech, C | 1 |
| Leroi, AM | 1 |
| Lalaude, O | 1 |
| Antonietti, M | 1 |
| Touchais, JY | 1 |
| Ducrotte, P | 1 |
| Menard, JF | 1 |
| Denis, P | 1 |
| Jaques, R | 1 |
| Soroko, FE | 1 |
| Mehta, NB | 1 |
| Maxwell, RA | 1 |
| Ferris, RM | 1 |
| Schroeder, DH | 1 |
| Delini-Stula, A | 1 |
| Radeke, E | 1 |
| Vassout, A | 1 |
| Friedman, E | 1 |
| Dallob, A | 1 |
| Schwartz, GE | 1 |
| Fair, PL | 1 |
| Mandel, MR | 1 |
| Salt, P | 1 |
| Mieske, M | 1 |
| Klerman, GL | 1 |
| Gessel, AH | 1 |
| Carter, GT | 1 |
| Longley, KJ | 1 |
| Walsh, SA | 1 |
| Entrikin, RK | 1 |
| Lü, AG | 1 |
| Ke, J | 1 |
| Weng, SA | 1 |
| Kachur, JF | 1 |
| Allbee, WE | 1 |
| Gaginella, TS | 1 |
| Tayo, FM | 1 |
| Oxenkrug, GF | 1 |
| Lapin, IP | 1 |
| Elonen, E | 1 |
| Mattila, MJ | 1 |
| Saarnivaara, L | 1 |
| Hoffmann, I | 1 |
| Van Dorsser, W | 1 |
| Dresse, A | 1 |
| Atkinson, J | 1 |
| Ladinsky, H | 1 |
| Sinha, JN | 1 |
| Jaju, BP | 1 |
| Srimal, RC | 1 |
| Barnett, A | 1 |
| Greenhouse, DD | 1 |
| Taber, RI | 1 |
| Scriabine, A | 1 |
2 reviews available for amitriptyline and Muscle Contraction
| Article | Year |
|---|---|
Muscle-contraction (tension) headache.
Topics: Amitriptyline; Anxiety; Biofeedback, Psychology; Conflict, Psychological; Depressive Disorder; Elect | 1983 |
An overview of the classification, causes, and treatment of headache.
Topics: Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; Cerebrovascula | 1984 |
1 trial available for amitriptyline and Muscle Contraction
| Article | Year |
|---|---|
[Amitriptyline in therapy of chronic tension headache].
Topics: Adolescent; Adult; Aged; Amitriptyline; Contingent Negative Variation; Delayed-Action Preparations; | 1994 |
38 other studies available for amitriptyline and Muscle Contraction
| Article | Year |
|---|---|
6-nitrodopamine is a major endogenous modulator of human vas deferens contractility.
Topics: Adrenergic Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Carbamazepine; Chr | 2022 |
Capsaicin produces antidepressant-like effects in the forced swimming test and enhances the response of a sub-effective dose of amitriptyline in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Capsaicin; Depressive Disorder; Dose-Respons | 2018 |
Lower facial contouring with botulinum toxin type A.
Topics: Amitriptyline; Antimitotic Agents; Botulinum Toxins, Type A; Colchicine; Electromyography; Female; F | 2008 |
Effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on rat vascular smooth muscle in vitro--the role of the endothelium.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta, Abdominal; Aorta, Thoracic; Cyclic AMP; Cyclic | 2012 |
Quantitative assessment of the pre- and postsynaptic alpha adrenoceptor antagonist potency of amitriptyline.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Cocaine; In Vitro Techniques; Male; Methoxamin | 1982 |
Cyclobenzaprine: effect on tonic vibration reflexes in local tetanus cat preparations.
Topics: Amitriptyline; Animals; Cats; Decerebrate State; Electric Stimulation; Female; Male; Muscle Contract | 1984 |
Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip.
Topics: Amitriptyline; Animals; Female; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Muscle, | 1983 |
Facial EMG activity levels predict treatment outcome in depression.
Topics: Amitriptyline; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Electromyo | 1984 |
The effects of propranolol and amitriptyline on vascular and EMG biofeedback training.
Topics: Adolescent; Adult; Aged; Amitriptyline; Biofeedback, Psychology; Female; Humans; Male; Middle Aged; | 1984 |
Paradoxical effects of frequent analgesic use.
Topics: Adult; Amitriptyline; Analgesics; Drug Tolerance; Female; Headache; Humans; Hypnotics and Sedatives; | 1982 |
The measurement of antagonist potency and the importance of selective inhibition of agonist uptake processes.
Topics: Albuterol; Amitriptyline; Animals; Desipramine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Mal | 1981 |
Cyclobenzaprine: studies on its site of muscle relaxant action in the cat.
Topics: Amitriptyline; Animals; Brain Stem; Cats; Decerebrate State; Dose-Response Relationship, Drug; Muscl | 1980 |
[Action of some psychotropic drugs on the electrmyographic response evoked by stretches of the gastrocnemius muscle of rats submitted to stress].
Topics: Amitriptyline; Animals; Chlorpromazine; Dextroamphetamine; Meprobamate; Muscle Contraction; Muscle R | 1980 |
Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Aorta, Thoracic; Calcium; Endothelin-1; Endoth | 1996 |
Inhibitory effect of amitriptyline on contraction of the rat isolated trachea.
Topics: Acetylcholine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Endothelin-1; In Vitro Tech | 1997 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobuta | 1998 |
A study of the interactions of tricyclic antidepressants with alpha 1-adrenoceptor subtypes in rat aorta and caudal arteries.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Aorta, Thoracic; Arteries; Clomipramine; D | 1998 |
Relaxant effects of antidepressants on human isolated mesenteric arteries.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Second- | 1999 |
Effects of antidepressants in adrenergic neurotransmission of human vas deferens.
Topics: Amitriptyline; Antidepressive Agents; Calcium; Calcium Channel Blockers; Culture Techniques; Dose-Re | 2000 |
Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Anxiety Disorders; Cathartics; Cholinergic Antagonists; | 2000 |
Beta-adrenergic blocking agents as potent antagonists of mescaline-induced contractions in the rat uterus.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Amitriptyline; Animals; Chlorpromazine; Femal | 1976 |
Bupropion hydrochloride ((+/-) alpha-t-butylamino-3-chloropropiophenone HCl): a novel antidepressant agent.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Cats; Dextroamphet | 1977 |
Some aspects of the psychopharmacological activity of maprotiline (Ludiomil): effects of single and repeated treatments.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Anthracenes; Behavior, Animal; Body Temperature; Clomip | 1978 |
Enhanced serotonin receptor activity after chronic treatment with imipramine or amitriptyline.
Topics: 5-Methoxytryptamine; Amitriptyline; Animals; Brain; Imipramine; Male; Methysergide; Mice; Muscle Con | 1979 |
Facial electromyography in the assessment of improvement in depression.
Topics: Amitriptyline; Depression; Facial Muscles; Female; Humans; Male; Muscle Contraction; Prognosis | 1978 |
Electromygraphic biofeedback and tricyclic antidepressants in myofascial pain-dysfunction syndrome: psychological predictors of outcome.
Topics: Adolescent; Adult; Age Factors; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Electro | 1975 |
Lack of effect of amitriptyline in murine myotonia.
Topics: Amitriptyline; Animals; Behavior, Animal; Electromyography; Mice; Mice, Inbred Strains; Muscle Contr | 1992 |
[Inhibited effects of amitriptyline on rabbit basilar and mesenteric artery rings].
Topics: Amitriptyline; Animals; Basilar Artery; Calcium Chloride; Dose-Response Relationship, Drug; In Vitro | 1990 |
Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro.
Topics: Amitriptyline; Animals; Bethanechol; Bethanechol Compounds; Electrolytes; Guinea Pigs; Histamine H1 | 1988 |
Tricyclic antidepressants antagonize prostaglandin (PG) E2-induced contractions of the guinea pig ileum and hypomotility in the mouse.
Topics: Acetylcholine; Amitriptyline; Animals; Desipramine; Dinoprostone; Guinea Pigs; Histamine Antagonists | 1985 |
Effect of dimethyl and monomethyl tricyclic antidepressants on central 5-hydroxytryptamine processes in the frog.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anura; Brain; Desipramine; Dibenzazepines; Imipramine | 1971 |
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.
Topics: Amitriptyline; Animals; Antidepressive Agents; Aorta; Blood Pressure; Depression, Chemical; Dibenzoc | 1974 |
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Body Temperature; Catalepsy; Chemical | 1973 |
[Comparative effects of various antidepressants on the response to noradrenaline of the deferent canal and the arterial pressure, and the response to 5-hydroxytryptamine of the rat uterus].
Topics: Amitriptyline; Animals; Antidepressive Agents; Blood Pressure; Carotid Arteries; Clomipramine; Diben | 1974 |
A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.
Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Dibenzocycloheptenes; Dimethylamines; Fema | 1972 |
Further evidence of central muscle relaxant activity of imipramine, desmethylimipramine and amitriptyline.
Topics: Amitriptyline; Animals; Behavior, Animal; Blood Pressure; Cats; Desipramine; Female; Imipramine; Mal | 1966 |
A new type of drug enhancement: increased maximum response to cumulative noradrenaline in the isolated rat vas deferens.
Topics: Amitriptyline; Animals; Cocaine; Desipramine; Drug Synergism; Imipramine; Male; Muscle Contraction; | 1968 |
Some observations on the adrenergic blocking activity of desipramine and amitriptyline on aortic strips of rabbits.
Topics: Amitriptyline; Animals; Aorta; Calcium; Chlorpromazine; Desipramine; In Vitro Techniques; Male; Musc | 1969 |