amitriptyline has been researched along with Multiple Sclerosis in 13 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the efficacy of low-dose amitriptyline in 12 patients in whom this syndrome was a consequence of multiple sclerosis." | 5.05 | Treatment of pathologic laughing and weeping with amitriptyline. ( Herndon, RM; Rudick, RA; Schiffer, RB, 1985) |
| "The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple sclerosis." | 3.85 | Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. ( Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S, 2017) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Mésidor, M | 1 |
| Rousseau, MC | 1 |
| Duquette, P | 1 |
| Sylvestre, MP | 1 |
| Chami, M | 1 |
| Halmer, R | 1 |
| Schnoeder, L | 1 |
| Anne Becker, K | 1 |
| Meier, C | 1 |
| Fassbender, K | 1 |
| Gulbins, E | 1 |
| Walter, S | 1 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| André, MC | 1 |
| Pacheco, D | 1 |
| Antunes, J | 1 |
| Silva, R | 1 |
| Filipe, P | 1 |
| Soares de Almeida, LM | 1 |
| Peruga, I | 1 |
| Hartwig, S | 1 |
| Thöne, J | 1 |
| Hovemann, B | 1 |
| Gold, R | 1 |
| Juckel, G | 1 |
| Linker, RA | 1 |
| Holsboer, F | 1 |
| Grasser, A | 1 |
| Friess, E | 1 |
| Wiedemann, K | 1 |
| Funakawa, I | 2 |
| Hara, K | 1 |
| Yasuda, T | 2 |
| Terao, A | 2 |
| Breningstall, GN | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Cendrowski, W | 1 |
| Schiffer, RB | 1 |
| Herndon, RM | 1 |
| Rudick, RA | 1 |
| Jameson, RM | 1 |
2 reviews available for amitriptyline and Multiple Sclerosis
| Article | Year |
|---|---|
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Benzamides; Brain; Corticotropin-Releasing Hormone; Dexa | 1994 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
1 trial available for amitriptyline and Multiple Sclerosis
| Article | Year |
|---|---|
Treatment of pathologic laughing and weeping with amitriptyline.
Topics: Adult; Aged; Amitriptyline; Brain Diseases; Clinical Trials as Topic; Crying; Double-Blind Method; F | 1985 |
10 other studies available for amitriptyline and Multiple Sclerosis
| Article | Year |
|---|---|
Classification and visualization of longitudinal patterns of medication dose: An application to interferon-beta-1a and amitriptyline in patients with multiple sclerosis.
Topics: Amitriptyline; Cohort Studies; Humans; Interferon beta-1a; Longitudinal Studies; Multiple Sclerosis | 2021 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizo | 2017 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Generalized skin drug eruption to natalizumab in a patient with multiple sclerosis.
Topics: Adult; Amitriptyline; Antibodies; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzodi | 2010 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic | 2011 |
Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases.
Topics: Amitriptyline; Female; Hiccup; Humans; Magnetic Resonance Imaging; Male; Medulla Oblongata; Methylpr | 1993 |
An 11-year-old girl with syndrome of inappropriate antidiuretic hormone secretion.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Brain; Child; Diagnosis, Differen | 1999 |
[Attempts at pharmacological and surgical treatment of intentional and postural tremor in patients with disseminated sclerosis (authors transl)].
Topics: Adult; Amitriptyline; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Mu | 1976 |
[A case of multiple sclerosis with intractable hiccups and sleep apnea syndrome].
Topics: Amitriptyline; Drug Administration Schedule; Female; Hiccup; Humans; Magnetic Resonance Imaging; Med | 1992 |
Management of the bladder in non-traumatic paraplegia.
Topics: Amitriptyline; Female; Humans; Imipramine; Male; Multiple Sclerosis; Myelitis; Neoplasm Metastasis; | 1974 |