amitriptyline has been researched along with Motor Neuron Disease in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, 3 patients, receiving amythryptiline in dosage 50 mg/day, experienced side effects (constipation, accommodation disturbances, dry mouth, sleepiness and poor concentration)." | 2.71 | [Pharmacological therapy of sialorrhea in patients with motor neuron disease]. ( Alekhin, AV; Koneva, ON; Levitskiĭ, GN; Morgunova, MS; Serdiuk, AV; Skvortsova, VI, 2005) |
| "Drooling is a distressing symptom for adults with neurological conditions and can be challenging for health professionals." | 2.48 | The management of drooling in adults with neurological conditions. ( Rowson, J; Squires, N; Wills, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Squires, N | 1 |
| Wills, A | 1 |
| Rowson, J | 1 |
| Levitskiĭ, GN | 1 |
| Alekhin, AV | 1 |
| Serdiuk, AV | 1 |
| Morgunova, MS | 1 |
| Koneva, ON | 1 |
| Skvortsova, VI | 1 |
1 review available for amitriptyline and Motor Neuron Disease
| Article | Year |
|---|---|
The management of drooling in adults with neurological conditions.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Atropine; Behavior Therapy; Botulinum Toxins, Type | 2012 |
1 trial available for amitriptyline and Motor Neuron Disease
| Article | Year |
|---|---|
[Pharmacological therapy of sialorrhea in patients with motor neuron disease].
Topics: Adrenergic Uptake Inhibitors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Botulinum Toxin | 2005 |