amitriptyline has been researched along with Mitochondrial Diseases in 1 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline is a commonly prescribed tricyclic antidepressant, which has been shown to impair mitochondrial function and increase oxidative stress in a variety of in vitro assays." | 1.38 | Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients. ( Alcocer-Gómez, E; Carmona-López, MI; Casas-Barquero, N; Cordero, MD; de Miguel, M; Garrido-Maraver, J; Moreno-Fernández, AM; Sánchez-Alcázar, JA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno-Fernández, AM | 1 |
| Cordero, MD | 1 |
| Garrido-Maraver, J | 1 |
| Alcocer-Gómez, E | 1 |
| Casas-Barquero, N | 1 |
| Carmona-López, MI | 1 |
| Sánchez-Alcázar, JA | 1 |
| de Miguel, M | 1 |
1 other study available for amitriptyline and Mitochondrial Diseases
| Article | Year |
|---|---|
Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients.
Topics: Adenosine Triphosphate; Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic | 2012 |