amitriptyline has been researched along with Metabolic Acidosis in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 7.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| "We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline." | 3.73 | Prolonged clinical effects in modified-release amitriptyline poisoning. ( Dargan, P; Greene, S; Jones, A; O'Connor, N; Wyncoll, D, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Connor, N | 1 |
| Greene, S | 1 |
| Dargan, P | 1 |
| Wyncoll, D | 1 |
| Jones, A | 1 |
| Brown, TC | 1 |
| Barker, GA | 1 |
| Dunlop, ME | 1 |
| Loughnan, PM | 1 |
2 other studies available for amitriptyline and Metabolic Acidosis
| Article | Year |
|---|---|
Prolonged clinical effects in modified-release amitriptyline poisoning.
Topics: Acidosis; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Central Nerv | 2006 |
The use of sodium bicarbonate in the treatment of tricyclic antidepressant-induced arrhythmias.
Topics: Acid-Base Equilibrium; Acidosis; Amitriptyline; Animals; Antidepressive Agents; Arrhythmias, Cardiac | 1973 |