amitriptyline has been researched along with MS (Multiple Sclerosis) in 13 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the efficacy of low-dose amitriptyline in 12 patients in whom this syndrome was a consequence of multiple sclerosis." | 5.05 | Treatment of pathologic laughing and weeping with amitriptyline. ( Herndon, RM; Rudick, RA; Schiffer, RB, 1985) |
| "The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple sclerosis." | 3.85 | Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. ( Anne Becker, K; Chami, M; Fassbender, K; Gulbins, E; Halmer, R; Meier, C; Schnoeder, L; Walter, S, 2017) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Mésidor, M | 1 |
| Rousseau, MC | 1 |
| Duquette, P | 1 |
| Sylvestre, MP | 1 |
| Chami, M | 1 |
| Halmer, R | 1 |
| Schnoeder, L | 1 |
| Anne Becker, K | 1 |
| Meier, C | 1 |
| Fassbender, K | 1 |
| Gulbins, E | 1 |
| Walter, S | 1 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| André, MC | 1 |
| Pacheco, D | 1 |
| Antunes, J | 1 |
| Silva, R | 1 |
| Filipe, P | 1 |
| Soares de Almeida, LM | 1 |
| Peruga, I | 1 |
| Hartwig, S | 1 |
| Thöne, J | 1 |
| Hovemann, B | 1 |
| Gold, R | 1 |
| Juckel, G | 1 |
| Linker, RA | 1 |
| Holsboer, F | 1 |
| Grasser, A | 1 |
| Friess, E | 1 |
| Wiedemann, K | 1 |
| Funakawa, I | 2 |
| Hara, K | 1 |
| Yasuda, T | 2 |
| Terao, A | 2 |
| Breningstall, GN | 1 |
| Okiishi, CG | 1 |
| Paradiso, S | 1 |
| Robinson, RG | 1 |
| Cendrowski, W | 1 |
| Schiffer, RB | 1 |
| Herndon, RM | 1 |
| Rudick, RA | 1 |
| Jameson, RM | 1 |
2 reviews available for amitriptyline and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Topics: Adrenocorticotropic Hormone; Amitriptyline; Benzamides; Brain; Corticotropin-Releasing Hormone; Dexa | 1994 |
Gender differences in depression associated with neurologic illness: clinical correlates and pharmacologic response.
Topics: Alzheimer Disease; Amitriptyline; Antidepressive Agents, Tricyclic; Depression; Epilepsy; Female; Hu | 2001 |
1 trial available for amitriptyline and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Treatment of pathologic laughing and weeping with amitriptyline.
Topics: Adult; Aged; Amitriptyline; Brain Diseases; Clinical Trials as Topic; Crying; Double-Blind Method; F | 1985 |
10 other studies available for amitriptyline and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Classification and visualization of longitudinal patterns of medication dose: An application to interferon-beta-1a and amitriptyline in patients with multiple sclerosis.
Topics: Amitriptyline; Cohort Studies; Humans; Interferon beta-1a; Longitudinal Studies; Multiple Sclerosis | 2021 |
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
Topics: Amitriptyline; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Axons; Cell Count; Cuprizo | 2017 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Generalized skin drug eruption to natalizumab in a patient with multiple sclerosis.
Topics: Adult; Amitriptyline; Antibodies; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzodi | 2010 |
Inflammation modulates anxiety in an animal model of multiple sclerosis.
Topics: Acoustic Stimulation; Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic | 2011 |
Intractable hiccups and sleep apnea syndrome in multiple sclerosis: report of two cases.
Topics: Amitriptyline; Female; Hiccup; Humans; Magnetic Resonance Imaging; Male; Medulla Oblongata; Methylpr | 1993 |
An 11-year-old girl with syndrome of inappropriate antidiuretic hormone secretion.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Brain; Child; Diagnosis, Differen | 1999 |
[Attempts at pharmacological and surgical treatment of intentional and postural tremor in patients with disseminated sclerosis (authors transl)].
Topics: Adult; Amitriptyline; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Mu | 1976 |
[A case of multiple sclerosis with intractable hiccups and sleep apnea syndrome].
Topics: Amitriptyline; Drug Administration Schedule; Female; Hiccup; Humans; Magnetic Resonance Imaging; Med | 1992 |
Management of the bladder in non-traumatic paraplegia.
Topics: Amitriptyline; Female; Humans; Imipramine; Male; Multiple Sclerosis; Myelitis; Neoplasm Metastasis; | 1974 |