amitriptyline has been researched along with Long Sleeper Syndrome in 43 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening." | 9.15 | Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011) |
| "Using a double-blind and randomized experimental design, ten adult subjects with sleep bruxism were administered amitriptyline (25 mg/night) and placebo (25 mg/night), each compound over a period of one week." | 9.08 | A randomized double-blind clinical trial of the effect of amitriptyline on nocturnal masseteric motor activity (sleep bruxism). ( Christensen, LV; Mohamed, SE; Penchas, J, 1997) |
| "To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening." | 5.15 | Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011) |
| "Using a double-blind and randomized experimental design, ten adult subjects with sleep bruxism were administered amitriptyline (25 mg/night) and placebo (25 mg/night), each compound over a period of one week." | 5.08 | A randomized double-blind clinical trial of the effect of amitriptyline on nocturnal masseteric motor activity (sleep bruxism). ( Christensen, LV; Mohamed, SE; Penchas, J, 1997) |
| "The authors report three cases of isolated sleep paralysis controlled by L-tryptophan with or without amitriptyline." | 3.66 | Serotoninergic agents in the treatment of isolated sleep paralysis. ( Hams, G; Snyder, S, 1982) |
| "Amitriptyline was dosed as follows: 8 mg/day for 6 days, 8 mg twice a day for 6 days, 20 mg/day for 6 days, and 20 mg twice a day for 45 days." | 2.70 | Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study. ( Alves, LA; Barbosa, JS; Krymchantowski, AV; Silva, MT, 2002) |
| "Amitriptyline was associated with more autonomic and circulatory side effects, while epigastric complaints occurred more often with sertraline." | 2.69 | Double-blind, multicenter comparative study of sertraline and amitriptyline in hospitalized patients with major depression. ( Arató, M; Bauer, H; Gallinat, J; Hegerl, U; Janka, Z; Möller, HJ; Pflug, B, 1998) |
| "Amitriptyline has a significant advantage in insomnia problems." | 2.65 | Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression. ( Huitfeldt, B; Montgomery, SA, 1983) |
| "Within the conditions of the double-blind trial, it appears that long-acting amitriptyline (Diffucaps), given at the dosage of 25 mg at the evening meal, is more active and better tolerated than a dosage of 40 mg of ordinary amitriptyline at bedtime in depressive sleep disorders." | 2.64 | [Double-blind comparison between amitriptyline Diffucaps and ordinary amitriptyline in sleep disorders of depressive origin]. ( Brasseur, R, 1975) |
| " Quetiapine was used in all studies with a bedtime dosage between 50 and 300 mg/day." | 2.53 | Antipsychotics for fibromyalgia in adults. ( Häuser, W; Klose, P; Phillips, T; Üçeyler, N; Walitt, B, 2016) |
| "We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907." | 1.56 | Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model. ( Aoki, Y; Hattori, M; Horikawa, H; Ito, H; Takemura, Y; Yamazaki, M, 2020) |
| "This syndrome has been called fibrositis or fibromyalgia." | 1.28 | Polysomnography in idiopathic muscle pain syndrome (fibrositis). ( Bertorini, TE; Lemmi, H; Silva, AB, 1991) |
| " The following report concerns a 62-year-old female Parkinsonian patient with levodopa-induced "On-Off", depression and sleep disturbances, the severity of which was dramatically reduced by administration of low dosage amitriptyline (a serotonergic agent)." | 1.27 | Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease. ( Sandyk, R, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (60.47) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 5 (11.63) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Coetzee, R | 1 |
| Johnson, Y | 1 |
| van Niekerk, J | 1 |
| Namane, M | 1 |
| Ito, H | 1 |
| Takemura, Y | 1 |
| Aoki, Y | 1 |
| Hattori, M | 1 |
| Horikawa, H | 1 |
| Yamazaki, M | 1 |
| Kantor, S | 1 |
| Varga, J | 1 |
| Morton, AJ | 1 |
| Walitt, B | 1 |
| Klose, P | 1 |
| Üçeyler, N | 1 |
| Phillips, T | 1 |
| Häuser, W | 1 |
| Moldofsky, H | 1 |
| Harris, HW | 1 |
| Archambault, WT | 1 |
| Kwong, T | 1 |
| Lederman, S | 1 |
| Thomas, RJ | 1 |
| Clement, A | 1 |
| Raney, JJ | 1 |
| Wasserman, GS | 1 |
| Lowry, JA | 1 |
| Krymchantowski, AV | 1 |
| Silva, MT | 1 |
| Barbosa, JS | 1 |
| Alves, LA | 1 |
| BATTERMAN, RC | 1 |
| KAUFMAN, JE | 1 |
| MOURATOFF, GJ | 1 |
| Kemp, S | 1 |
| Biswas, R | 1 |
| Neumann, V | 1 |
| Coughlan, A | 1 |
| Koppel, BS | 1 |
| Bharel, C | 1 |
| Werner, V | 1 |
| Diehl, LW | 1 |
| Huitfeldt, B | 1 |
| Montgomery, SA | 1 |
| Dilsaver, SC | 1 |
| Greden, JF | 1 |
| Wolfrum, C | 1 |
| Klieser, E | 1 |
| Lehmann, E | 1 |
| Snyder, S | 1 |
| Hams, G | 1 |
| Bahro, M | 1 |
| Katzmann, KJ | 1 |
| Gückel, F | 1 |
| Sungurtekin, I | 1 |
| Riemann, D | 1 |
| Gruzman, AV | 1 |
| Mohamed, SE | 1 |
| Christensen, LV | 1 |
| Penchas, J | 1 |
| Möller, HJ | 1 |
| Gallinat, J | 1 |
| Hegerl, U | 1 |
| Arató, M | 1 |
| Janka, Z | 1 |
| Pflug, B | 1 |
| Bauer, H | 1 |
| Herman, CR | 1 |
| Schiffman, EL | 1 |
| Look, JO | 1 |
| Rindal, DB | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Goldberg, HL | 1 |
| Finnerty, RJ | 1 |
| Delaunay, J | 1 |
| Meynard, J | 1 |
| Modai, I | 1 |
| Cygielman, G | 1 |
| Wijsenbeek, H | 1 |
| Brasseur, R | 1 |
| Silva, AB | 1 |
| Bertorini, TE | 1 |
| Lemmi, H | 1 |
| McSherry, J | 1 |
| Ashman, G | 1 |
| Sandyk, R | 1 |
| Gravem, A | 1 |
| Amthor, KF | 1 |
| Astrup, C | 1 |
| Elgen, K | 1 |
| Gjessing, LR | 1 |
| Gunby, B | 1 |
| Pettersen, RD | 1 |
| Kyrdalen, L | 1 |
| Vaadal, J | 1 |
| Ofsti, E | 1 |
| Benoit, JC | 1 |
| Delagrange, G | 1 |
| Richou, A | 1 |
| Souchon, G | 1 |
| Sow, I | 1 |
| Sivadon, P | 1 |
| Zung, WW | 1 |
| Hauri, P | 1 |
| Hawkins, DR | 1 |
| Kupfer, DJ | 1 |
| Foster, FG | 1 |
| Sedman, G | 1 |
| Bente, D | 1 |
| Feder, J | 1 |
| Helmchen, H | 1 |
| Hippius, H | 1 |
| Rosenberg, L | 1 |
| Deberdt, R | 1 |
| Kissin, B | 1 |
| Gross, MM | 1 |
| Shaffer, D | 1 |
| Costello, AJ | 1 |
| Hill, ID | 1 |
| Ose, E | 1 |
| Sallou, C | 1 |
| Alsen, V | 1 |
| Maiss, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preliminary Findings of the Efficacy of Botulinum Toxin in Temporomandibular Disorders: A Randomized Clinical Trial[NCT05651256] | Phase 2/Phase 3 | 20 participants (Actual) | Interventional | 2021-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for amitriptyline and Long Sleeper Syndrome
| Article | Year |
|---|---|
Antipsychotics for fibromyalgia in adults.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antipsychotic Agents; Fibromyalgia; Humans; Quetiapi | 2016 |
[The state of psychopharmacotherapy in geriatrics 2].
Topics: Actihaemyl; Aged; Amitriptyline; Bencyclane; Cerebrovascular Circulation; Clorazepate Dipotassium; D | 1980 |
Antidepressant withdrawal phenomena.
Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; | 1984 |
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
The pharmacology of disordered sleep: a laboratory approach.
Topics: Amitriptyline; Anxiety; Arousal; Barbiturates; Brain; Cerebral Cortex; Depression; Desipramine; Huma | 1970 |
16 trials available for amitriptyline and Long Sleeper Syndrome
| Article | Year |
|---|---|
Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.
Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Electroencephalography; Fatigue; Female; Fibromyalg | 2011 |
Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Constipation; Double-Blind Method; Drug Therapy, | 2002 |
The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antioxidants; Cognition; Cranioc | 2004 |
Comparison between zimeldine and amitriptyline of efficacy and adverse symptoms--a combined analysis of four British clinical trials in depression.
Topics: Adult; Amitriptyline; Anxiety; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; F | 1983 |
[The treatment of nocturnal enuresis in children].
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Drug Evaluatio | 1997 |
A randomized double-blind clinical trial of the effect of amitriptyline on nocturnal masseteric motor activity (sleep bruxism).
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bruxism; Double-Blind Method; Electromyograp | 1997 |
Double-blind, multicenter comparative study of sertraline and amitriptyline in hospitalized patients with major depression.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Antidepressive Agents; Constipation; Depre | 1998 |
The effectiveness of adding pharmacologic treatment with clonazepam or cyclobenzaprine to patient education and self-care for the treatment of jaw pain upon awakening: a randomized clinical trial.
Topics: Adult; Amitriptyline; Clonazepam; Female; GABA Modulators; Health Education, Dental; Humans; Male; M | 2002 |
Which tricyclic for depressed outpatients, imipramine pamoate or amitriptyline?
Topics: Adjustment Disorders; Adult; Ambulatory Care; Amitriptyline; Anxiety; Clinical Trials as Topic; Depr | 1977 |
[Clinical and comparative trial of dosulepin and amitriptyline].
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Clinical Trials as | 1978 |
[Double-blind comparison between amitriptyline Diffucaps and ordinary amitriptyline in sleep disorders of depressive origin].
Topics: Amitriptyline; Asthenia; Clinical Trials as Topic; Delayed-Action Preparations; Depression; Female; | 1975 |
A double-blind comparison of citalopram (Lu 10-171) and amitriptyline in depressed patients.
Topics: Adult; Aged; Amitriptyline; Citalopram; Clinical Trials as Topic; Depressive Disorder; Double-Blind | 1987 |
Trial of a sustained release form of amitriptyline (Lentizol) in the treatment of depressive illness.
Topics: Adult; Aged; Amitriptyline; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Depr | 1973 |
[Double blind test of three antidepressants. 3. Methodical problems].
Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Clinical Trials as Topic; Constipation; De | 1974 |
Drug therapy in alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C | 1968 |
Control of enuresis with imipramine.
Topics: Amitriptyline; Child; Child Behavior Disorders; Clinical Trials as Topic; Enuresis; Female; Follow-U | 1968 |
22 other studies available for amitriptyline and Long Sleeper Syndrome
| Article | Year |
|---|---|
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Chronic Pain; Female; Hospi | 2020 |
Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chronic Pain; Disease Models, Animal; Fluo | 2020 |
A single dose of hypnotic corrects sleep and EEG abnormalities in symptomatic Huntington's disease mice.
Topics: Amitriptyline; Animals; Arousal; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephal | 2016 |
Sleep as a window into the world of fibromyalgia syndrome.
Topics: Amitriptyline; Female; Fibromyalgia; Humans; Male; Placebos; Sleep; Sleep Wake Disorders | 2011 |
Chronic amitriptyline overdose in a child.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child; Drug Overdose; Electrocardiography; Female; | 2012 |
CLINICAL USE OF AMITRIPTYLINE FOR THE TREATMENT OF PSYCHONEUROTIC REACTIVE ANXIETY AND DEPRESSION.
Topics: Amitriptyline; Anxiety; Arthritis, Rheumatoid; Asthma; Coronary Disease; Depression; Diabetes Mellit | 1964 |
Use of amitriptyline to offset sleep disturbances caused by efavirenz.
Topics: Alkynes; Amitriptyline; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Fol | 2005 |
Single case experiments in psychopharmacological trials.
Topics: Adult; Amitriptyline; Chlordiazepoxide; Clinical Trials as Topic; Drug Combinations; Female; Flunitr | 1984 |
Serotoninergic agents in the treatment of isolated sleep paralysis.
Topics: Adult; Amitriptyline; Female; Humans; Male; Middle Aged; Paralysis; Sleep; Sleep Wake Disorders; Try | 1982 |
[REM sleep parasomnia].
Topics: Amitriptyline; Brain Stem; Carbamazepine; Cerebral Infarction; Dreams; Drug Therapy, Combination; Hu | 1994 |
Hysterical sleep episodes as a manifestation of masked depression.
Topics: Amitriptyline; Aversive Therapy; Conversion Disorder; Depression; Humans; Hysteria; Male; Middle Age | 1979 |
Polysomnography in idiopathic muscle pain syndrome (fibrositis).
Topics: Alprazolam; Amitriptyline; Clonazepam; Electroencephalography; Fatigue Syndrome, Chronic; Female; Fi | 1991 |
Bulimia and sleep disturbance.
Topics: Adult; Amitriptyline; Bulimia; Female; Humans; Psychotherapy; Sleep Wake Disorders | 1990 |
Serotonergic mechanisms in levodopa-induced "on-off" and sleep disorders in Parkinson's disease.
Topics: Amitriptyline; Female; Humans; Levodopa; Middle Aged; Parkinson Disease; Serotonin; Sleep Wake Disor | 1988 |
[Contribution to the clinical study of a new neuroleptic: sulpiride].
Topics: Adjustment Disorders; Amitriptyline; Anorexia Nervosa; Antidepressive Agents; Anxiety Disorders; Dep | 1969 |
Human sleep after leucotomy. A case study.
Topics: Amitriptyline; Chlorpromazine; Depression; Electroencephalography; Female; Frontal Lobe; Humans; Mid | 1972 |
Sleep and activity in a psychotic depression.
Topics: Amitriptyline; Bipolar Disorder; Electroencephalography; Female; Humans; Middle Aged; Remission, Spo | 1973 |
Lorazepam in the treatment of severe anxiety and anxiety associated with psychotic conditions.
Topics: Adult; Aggression; Amitriptyline; Anxiety Disorders; Ataxia; Benzodiazepinones; Bipolar Disorder; Ch | 1973 |
[Benzodiazepines and addictive hypnotics as adjuvants in the treatment of depression with amitriptyline].
Topics: Amitriptyline; Chlordiazepoxide; Depression; Diazepam; Drug Synergism; Humans; Neurotic Disorders; S | 1971 |
[Effect of amitryptyline drops, in ambulatory therapy, on behavior and character disorders in children and adolescents].
Topics: Adolescent; Aggression; Amitriptyline; Character; Child; Child Behavior Disorders; Child, Preschool; | 1969 |
[Therapy of depressive premature awaking and early anxiety using Saroten retard].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Circadian Rhythm; Delayed-Action Prepara | 1971 |
[Therapy of psycho-autonomic and dysphoric syndromes in the general practice].
Topics: Adjustment Disorders; Adult; Amitriptyline; Anxiety; Bipolar Disorder; Chlordiazepoxide; Climacteric | 1968 |