amitriptyline has been researched along with Long QT Syndrome in 15 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 7.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "Amitriptyline has been reported to induce long QT syndrome in addition to Brugada syndrome." | 3.88 | Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome. ( Ando, K; Cao, X; Chiba, K; Izumi-Nakaseko, H; Lubna, NJ; Naito, AT; Nakamura, Y; Satoh, Y; Sugiyama, A; Wada, T, 2018) |
| "We conducted a single-center, retrospective observational study, and evaluated 87 patients (65 amitriptyline, 22 nortriptyline) who underwent 12-lead electrocardiogram (ECG) examinations both before and after receiving TCAs for herpes zoster pain or postherpetic neuralgia from May 2007 to January 2012." | 3.80 | Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval. ( Funai, Y; Funao, T; Hase, I; Ikenaga, K; Nishikawa, K; Takahashi, R, 2014) |
| "Amitriptyline was involved in 37 859 (78." | 1.33 | Frequency of high-risk use of QT-prolonging medications. ( Allen LaPointe, NM; Chan, KA; Curtis, LH; Gurwitz, JH; Kramer, JM; Lafata, JE; Platt, R; Raebel, MA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Sahin, O | 2 |
| Akturk, G | 2 |
| Cilaker Micili, S | 2 |
| Gursoy Doruk, O | 2 |
| Karapinar, F | 2 |
| Hocaoglu, N | 3 |
| Ergur, BU | 2 |
| Akan, P | 2 |
| Tuncok, Y | 3 |
| Kalkan, S | 3 |
| Lubna, NJ | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Chiba, K | 1 |
| Cao, X | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Satoh, Y | 1 |
| Sugiyama, A | 1 |
| Hefner, G | 1 |
| Hahn, M | 1 |
| Hohner, M | 1 |
| Roll, SC | 1 |
| Klimke, A | 1 |
| Hiemke, C | 1 |
| Funai, Y | 1 |
| Funao, T | 1 |
| Ikenaga, K | 1 |
| Takahashi, R | 1 |
| Hase, I | 1 |
| Nishikawa, K | 1 |
| Unterecker, S | 1 |
| Pfuhlmann, B | 1 |
| Kopf, J | 1 |
| Kittel-Schneider, S | 1 |
| Reif, A | 1 |
| Deckert, J | 1 |
| Kaicker, J | 1 |
| Bostwick, J | 1 |
| Oransay, K | 1 |
| Buyukdeligoz, M | 1 |
| Allen LaPointe, NM | 1 |
| Curtis, LH | 1 |
| Chan, KA | 1 |
| Kramer, JM | 1 |
| Lafata, JE | 1 |
| Gurwitz, JH | 1 |
| Raebel, MA | 1 |
| Platt, R | 1 |
| Roberts-Thomson, KC | 1 |
| Teo, KS | 1 |
| Young, GD | 1 |
| Alderton, HR | 1 |
| Bolognesi, R | 1 |
| Tsialtas, D | 1 |
| Vasini, P | 1 |
| Conti, M | 1 |
| Manca, C | 1 |
| Manikoth, P | 1 |
| Subramanyan, R | 1 |
| Menon, S | 1 |
| Al Khusaiby, SM | 1 |
| Dorsey, ST | 1 |
| Biblo, LA | 1 |
1 review available for amitriptyline and Long QT Syndrome
| Article | Year |
|---|---|
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Chil | 1995 |
14 other studies available for amitriptyline and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats.
Topics: Amitriptyline; Animals; KATP Channels; Long QT Syndrome; Myocardium; Nicorandil; Rats | 2023 |
Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.
Topics: Action Potentials; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brugada Syndrome; Dogs; | 2018 |
QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients.
Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Databases, Factual; Electrocardiograp | 2019 |
Use of tricyclic antidepressants as analgesic adjuvants results in nonhazardous prolongation of the QTc interval.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics; Antidepressive Agents, Tricyclic; Electrocardiog | 2014 |
Increase of Heart Rate and QTc by Amitriptyline, But Not by Venlafaxine, Is Correlated to Serum Concentration.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Amitriptyline; Ant | 2015 |
Co-ingestion of tricyclic antidepressants with selective norepinephrine reuptake inhibitors: Overdose in the emergency department.
Topics: Adolescent; Amitriptyline; Antidepressive Agents, Tricyclic; Consciousness; Depression; Desvenlafaxi | 2016 |
Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats.
Topics: Adenine; Adenosine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arterial Pressure; Glu | 2012 |
Frequency of high-risk use of QT-prolonging medications.
Topics: Age Factors; Aged; Amitriptyline; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antidepressive Agen | 2006 |
Drug-induced Brugada syndrome with ST-T wave alternans and long QT.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Arrhythmias, Cardiac; | 2007 |
Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; | 1997 |
A child with cardiac arrhythmia and convulsions.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Child, Preschool; Diagnosis, Differential; Electroc | 1999 |
Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptyline.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antifungal Agents; Drug Interactions; Electrocardio | 2000 |