amitriptyline has been researched along with Lipidoses in 11 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug-induced phospholipidosis is marked by an excessive accumulation of phospholipids in lysosomes which can occur after exposure to cationic amphiphilic drugs." | 1.37 | High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis. ( Havinga, J; Horbach, GJ; Ravesloot, WT; Schoonen, WG; van de Water, FM, 2011) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "The effects of 3 lipidosis-inducing drugs on the incorporation and turnover of palmitic acid-1-14C in lung phospholipids was studied." | 1.26 | Palmitic acid-1-14C incorporation and turnover in lung phospholipids of rats treated with chlorphentermine, RMI 10.393 and Ro 4-4318. ( Karabelnik, D; Zbinden, G, 1976) |
| "to drug-induced lipidosis." | 1.25 | Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. ( Lüllmann-Rauch, R; Scheid, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Tomida, T | 1 |
| Ishimura, M | 1 |
| Iwaki, M | 1 |
| van de Water, FM | 1 |
| Havinga, J | 1 |
| Ravesloot, WT | 1 |
| Horbach, GJ | 1 |
| Schoonen, WG | 1 |
| Lüllmann-Rauch, R | 6 |
| Scheid, D | 1 |
| Karabelnik, D | 2 |
| Zbinden, G | 2 |
| Lüllmann, H | 1 |
| Wassermann, O | 1 |
1 review available for amitriptyline and Lipidoses
| Article | Year |
|---|---|
[Drug-induced phospholipid storage disease].
Topics: Adrenal Gland Diseases; Amitriptyline; Animals; Anticholesteremic Agents; Appetite Depressants; Body | 1973 |
10 other studies available for amitriptyline and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans; | 2017 |
High content screening analysis of phospholipidosis: validation of a 96-well assay with CHO-K1 and HepG2 cells for the prediction of in vivo based phospholipidosis.
Topics: Amiodarone; Amitriptyline; Animals; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Drug-Relate | 2011 |
Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1975 |
Palmitic acid-1-14C incorporation and turnover in lung phospholipids of rats treated with chlorphentermine, RMI 10.393 and Ro 4-4318.
Topics: Amitriptyline; Animals; Chlorphentermine; Female; Fluorenes; Lipidoses; Lung; Palmitic Acids; Phente | 1976 |
Drug-induced foam cell reactions in rats, II. Chemical analysis of lipids stored in lungs and foam cells after treatment with chlorphentermine, 5-[p-(fluoren-9-ylidenemethyl)phenyl]-2-piperidineethanol (RMI 10.393) and 1-chloramitriptyline.
Topics: Amitriptyline; Animals; Chlorphentermine; Cholesterol; Cholesterol Esters; Fatty Acids, Nonesterifie | 1975 |
Lipidosis-like alterations in dorsal root ganglion cells of rats treated with tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorine; Dibenzazepines; Ganglia, Spinal; Iprindole; | 1974 |
Retinal lesions in rat after treatment with chlorphentermine or with tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Appetite Depressants; Chlorphentermine; Cytoplasm; Di | 1974 |
Lipidosis-like ultrastructural alterations in rat lymph nodes after treatment with tricyclic antidepressants or neuroleptics.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1974 |
Lipidosis-like alterations in spinal cord and cerebellar cortex of rats treated with chlorphentermine or tricylic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebellar Cortex; Chlorphentermine; Cytoplasmic Gran | 1974 |