amitriptyline has been researched along with Lewy Body Disease in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 76-year-old woman presented with catatonia, refusal to eat due to delusion, and visual hallucination." | 5.37 | Amitriptyline and lorazepam improved catatonia and occipital hypoperfusion in a patient with DLB. ( Maeda, K; Ogawa, N, 2011) |
| "Amitriptyline (AMI) promotes expression of glutamate transporter-1 and glutamate reuptake." | 1.72 | Amitriptyline improves cognitive and neuronal function in a rat model that mimics dementia with lewy bodies. ( Chang, HM; Ho, YJ; Hung, CS; Lin, CL; Tseng, LH; Tsou, SH; Yu, CH; Zheng, TL, 2022) |
| "A 76-year-old woman presented with catatonia, refusal to eat due to delusion, and visual hallucination." | 1.37 | Amitriptyline and lorazepam improved catatonia and occipital hypoperfusion in a patient with DLB. ( Maeda, K; Ogawa, N, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, CL | 1 |
| Zheng, TL | 1 |
| Tsou, SH | 1 |
| Chang, HM | 1 |
| Tseng, LH | 1 |
| Yu, CH | 1 |
| Hung, CS | 1 |
| Ho, YJ | 1 |
| Maeda, K | 1 |
| Ogawa, N | 1 |
2 other studies available for amitriptyline and Lewy Body Disease
| Article | Year |
|---|---|
Amitriptyline improves cognitive and neuronal function in a rat model that mimics dementia with lewy bodies.
Topics: alpha-Synuclein; Amitriptyline; Animals; Cognition; Glutamates; Lewy Body Disease; Male; Rats; Rats, | 2022 |
Amitriptyline and lorazepam improved catatonia and occipital hypoperfusion in a patient with DLB.
Topics: Aged; Amitriptyline; Catatonia; Cerebrovascular Circulation; Female; Humans; Iofetamine; Lewy Body D | 2011 |