amitriptyline has been researched along with Leishmaniasis, Visceral in 2 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Leishmaniasis, Visceral: A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring." | 1.46 | Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. ( Abengózar, MA; Almeida-Amaral, EE; Andrade-Neto, VV; Barbas, C; Cunha-Júnior, EF; da Costa-Silva, TA; Galisteo Junior, AJ; Lima, ML; Rivas, L; Tempone, AG; Torres-Santos, EC, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, ML | 2 |
| Abengózar, MA | 2 |
| Torres-Santos, EC | 2 |
| Borborema, SET | 1 |
| Godzien, J | 1 |
| López-Gonzálvez, Á | 1 |
| Barbas, C | 2 |
| Rivas, L | 2 |
| Tempone, AG | 2 |
| Cunha-Júnior, EF | 1 |
| Andrade-Neto, VV | 1 |
| da Costa-Silva, TA | 1 |
| Galisteo Junior, AJ | 1 |
| Almeida-Amaral, EE | 1 |
2 other studies available for amitriptyline and Leishmaniasis, Visceral
| Article | Year |
|---|---|
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis.
Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antiprotozoal Agents; Energy Metabolism; Humans; Lei | 2022 |
Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.
Topics: Amitriptyline; Animals; Antiprotozoal Agents; Humans; Interferon-gamma; Interleukin-10; Interleukin- | 2017 |