Page last updated: 2024-10-22

amitriptyline and Lassitude

amitriptyline has been researched along with Lassitude in 23 studies

Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.

Research Excerpts

ExcerptRelevanceReference
"Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia."9.22Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022)
"To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening."9.15Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011)
"We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain."9.10Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002)
"A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine."9.07The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991)
"To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia."8.82Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004)
"Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia."5.22Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis. ( Doucette, JA; Eguale, T; Farag, HM; Goswami, H; Sultan, I; Yunusa, I, 2022)
"To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening."5.15Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. ( Archambault, WT; Harris, HW; Kwong, T; Lederman, S; Moldofsky, H, 2011)
"Peak power and fatigue index increased, and VO(2max) and VT did not change with both fluoxetine and amitriptyline."5.12Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia. ( Gökbel, H; Levendoğlu, F; Okudan, N; Ozerbil, O, 2006)
"We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain."5.10Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study. ( Lampl, C; Röper, C; Yazdi, K, 2002)
"A double blind, placebo controlled, crossover design study examined overnight sleep physiology, pain, fatigue, and mood symptoms in 12 patients with fibromyalgia treated with cyclobenzaprine."5.07The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia. ( Lue, FA; Moldofsky, H; Reynolds, WJ; Saskin, P, 1991)
"Amitriptyline 25-50 mg/day reduces pain, fatigue, and depressiveness in patients with FMS and improves sleep and quality of life."4.84A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. ( Häuser, W; Sommer, C; Uçeyler, N, 2008)
"To systematically review the effectiveness of cyclobenzaprine in the treatment of fibromyalgia."4.82Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis. ( Jackson, JL; O'Malley, PG; Tofferi, JK, 2004)
"There were 1948 treatment histories for modafinil and 1394 treatment reports for amitriptyline reported across five PatientsLikeMe communities (multiple sclerosis, Parkinson's disease, mood conditions, fibromyalgia/chronic fatigue syndrome, and amyotrophic lateral sclerosis)."3.77Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe. ( Frost, J; Heywood, J; Okun, S; Vaughan, T; Wicks, P, 2011)
"12%) in the amitriptyline group and paresthesia (31% vs."2.84Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine. ( Chamberlin, LA; Coffey, CS; Ecklund, DJ; Hershey, AD; Klingner, EA; Korbee, LL; Porter, LL; Powers, SW; Yankey, JW, 2017)
" The dosage was 150 mg daily in both treatment groups."2.65Nomifensine and amitriptyline in the treatment of depression. A multi-centre double-blind comparison. ( Agren, H; Bjaring, B; Källström, B; Lund, M; Månsby, J; Peterson, LE; Roos, BE; Wistedt, B, 1983)
"Amitriptyline was found to have the greatest effect in reducing attacks with a short warning and in which no specific cause could be recognized."2.64Amitriptyline in migraine prophylaxis. Changes in pattern of attacks during a controlled clinical trial. ( Gomersall, JD; Stuart, A, 1973)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199011 (47.83)18.7374
1990's1 (4.35)18.2507
2000's4 (17.39)29.6817
2010's5 (21.74)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Farag, HM1
Yunusa, I1
Goswami, H1
Sultan, I1
Doucette, JA1
Eguale, T1
Bakker, MH1
Hugtenburg, JG1
Smits, MG1
van der Horst, HE1
Slottje, P1
Macfarlane, GJ1
Kronisch, C1
Dean, LE1
Atzeni, F1
Häuser, W2
Fluß, E1
Choy, E1
Kosek, E1
Amris, K1
Branco, J1
Dincer, F1
Leino-Arjas, P1
Longley, K1
McCarthy, GM1
Makri, S1
Perrot, S1
Sarzi-Puttini, P1
Taylor, A1
Jones, GT1
Powers, SW1
Coffey, CS1
Chamberlin, LA1
Ecklund, DJ1
Klingner, EA1
Yankey, JW1
Korbee, LL1
Porter, LL1
Hershey, AD1
Rheker, J1
Winkler, A1
Doering, BK1
Rief, W1
Uçeyler, N1
Sommer, C1
Frost, J1
Okun, S1
Vaughan, T1
Heywood, J1
Wicks, P1
Moldofsky, H2
Harris, HW1
Archambault, WT1
Kwong, T1
Lederman, S1
Lampl, C1
Yazdi, K1
Röper, C1
Tofferi, JK1
Jackson, JL1
O'Malley, PG1
Ozerbil, O1
Okudan, N1
Gökbel, H1
Levendoğlu, F1
Wistedt, B1
Agren, H1
Bjaring, B1
Källström, B1
Lund, M1
Månsby, J1
Peterson, LE1
Roos, BE1
Kampman, R1
Nummikko-Pelkonen, A1
Kuha, S1
Reynolds, WJ1
Saskin, P1
Lue, FA1
Hartmann, E2
Cravens, J2
Barton, JL1
Snaith, RP1
Gomersall, JD1
Stuart, A1
Deberdt, R1
Luzecky, MH1
Burman, KD1
Schultz, ER1
Malitz, S1
Kanzler, M1
Pieschl, D1
Richtberg, W1
Brüning, J1
Ekdawi, MY1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Benefits of Kinesio Taping and Inhibitory Treatment Techniques in Patients With Fibromyalgia Syndrome[NCT02859467]64 participants (Anticipated)Interventional2016-08-31Suspended
Museums as Health Spaces: Design and Evaluation of the Effectiveness of an Arts in Health Intervention to Improve the Quality of Life and Functional Capacity Regarding the Pain of People With Fibromyalgia. Mixed Methodology Study.[NCT05993663]121 participants (Anticipated)Interventional2023-10-02Recruiting
Effects of Manipulative Therapy in the Lower Thoracic and Cervical Spine in Subjects With Fibromyalgia Syndrome[NCT02864524]64 participants (Anticipated)Interventional2016-08-31Active, not recruiting
Effectiveness of Pain Neuroscience Education and Strength Training Program in Patients With Fibromyalgia[NCT04855851]60 participants (Anticipated)Interventional2022-03-01Recruiting
A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®[NCT03347669]100 participants (Anticipated)Interventional2017-11-06Recruiting
Effectiveness of High-intensity Interval Training Combined With Resistance Training in Patients With Fibromyalgia[NCT03924960]55 participants (Actual)Interventional2019-04-22Completed
Effectiveness of Spinal Manipulation in Addition to Standard Pharmacological Treatment in Fibromyalgia : A Blinded Randomized Clinical Trial[NCT04673058]60 participants (Actual)Interventional2021-01-26Completed
Amitriptyline and Topiramate in the Prevention of Childhood Migraine[NCT01581281]Phase 3488 participants (Actual)Interventional2012-06-30Terminated (stopped due to Interim assessment provided sufficient data to answer study questions)
Evaluation of the Efficiency of a Therapeutic Education Program in Standardized Thermal Cure for Fibromyalgia Patients[NCT02406313]152 participants (Actual)Interventional2015-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Absolute Headache Disability Score on PedMIDAS

"The PedMIDAS scale which evaluated the impact of headaches in school, home, play, and social activities, is comprised of six items that pertain to days missed in various activities over the past 90 days. Questions were answered by the youth in consultation with their parents and reviewed by study staff. The PedMIDAS scale was administered at baseline (covering the three months prior to enrollment) and at the 24-week endpoint visit (the end of the maintenance period, covering three months of enrollment). A total PedMIDAS score (sum of items 1-6) was used in this trial. Scores range from 0-240; with a score of 0-10 indicating no disability, 11-30 mild disability, 31-50 moderate disability, and more than 50 severe disability in daily activities. The main outcome measure for this comparison will be the difference in the baseline and endpoint (24 week) PedMIDAS total scores for:~Amitriptyline vs. Placebo~Topiramate vs. Placebo~Amitriptyline vs Topiramate" (NCT01581281)
Timeframe: baseline and 24 week endpoint

Interventionunits on a scale (Mean)
Topiramate-26.8
Placebo-22.6
Amitriptyline-22.5

Change in Number of Headache Days

"This outcomes measure examines whether the rate of absolute number of headache days, per 28 day period, differs between treatment groups over time. This was assessed longitudinally based on the actual number of headache days from the 28 days prior to randomization to the last 28 days of this 24 week trial. The change in absolute headache days was compared between:~Amitriptyline vs. placebo~Topiramate vs. placebo~Amitriptyline vs. Topiramate" (NCT01581281)
Timeframe: 4 week baseline period and last 4 weeks of the 24-week trial

Interventiondays (Mean)
Topiramate-6.7
Placebo-5.9
Amitriptyline-6.7

Number (Percentage) of Participants Reporting a ≥ 50% Reduction in Headache Days

"The primary endpoint was a ≥ 50% reduction in headache frequency from the 28 days (4 weeks) baseline period prior to randomization to the last 28 days (4 weeks) of the trial. Headache frequency was defined as the number of days with headache for a given four week 28 day (4 week) period. A headache day was defined as any day during which any headache occurs within a 24 hour period, starting and ending at midnight.~For each participant, the primary endpoint involved a determination of whether a 50% or greater reduction in headache frequency was observed during the last 4 weeks of active treatment as compared with the headache frequency during the 4-week baseline period. Results were compared across the three treatment groups." (NCT01581281)
Timeframe: 4 week baseline period and last 4 weeks of the 24-week trial

InterventionParticipants (Count of Participants)
Topiramate72
Placebo40
Amitriptyline69

Occurrence of Treatment Emergent Serious Adverse Events

To determine if amitriptyline or topiramate differ from placebo on the occurrence of treatment emergent serious adverse events. (NCT01581281)
Timeframe: 24 weeks of the trial

Interventionserious adverse events (Number)
Topiramate4
Placebo2
Amitriptyline6

Tolerability, as Indicated by the Number (Percentage) of Participants That Completed the 24-week Treatment Phase

To assess tolerability, the percentage of subjects who complete the entire 24-week treatment period will be estimated in each of the three groups. (NCT01581281)
Timeframe: 24 weeks

InterventionParticipants (Count of Participants)
Topiramate102
Placebo59
Amitriptyline106

Reviews

4 reviews available for amitriptyline and Lassitude

ArticleYear
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
    JAMA network open, 2022, 05-02, Volume: 5, Issue:5

    Topics: Amitriptyline; Duloxetine Hydrochloride; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; M

2022
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
EULAR revised recommendations for the management of fibromyalgia.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Activities of Daily Living; Acupuncture Therapy; Amitriptyline; Anti-Inflammatory Agents, Non-Steroi

2017
A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome.
    Arthritis and rheumatism, 2008, Sep-15, Volume: 59, Issue:9

    Topics: Amitriptyline; Antidepressive Agents; Databases, Bibliographic; Depression; Fatigue; Fibromyalgia; H

2008
Treatment of fibromyalgia with cyclobenzaprine: A meta-analysis.
    Arthritis and rheumatism, 2004, Feb-15, Volume: 51, Issue:1

    Topics: Amitriptyline; Databases, Factual; Fatigue; Female; Fibromyalgia; Humans; Male; Middle Aged; Muscle

2004

Trials

13 trials available for amitriptyline and Lassitude

ArticleYear
Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Adolescent; Amitriptyline; Anticonvulsants; Child; Double-Blind Method; Fatigue; Female; Fructose; H

2017
Learning to experience side effects after antidepressant intake - Results from a randomized, controlled, double-blind study.
    Psychopharmacology, 2017, Volume: 234, Issue:3

    Topics: Adult; Amitriptyline; Antidepressive Agents; Cardiovascular Diseases; Conditioning, Classical; Depre

2017
Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study.
    The Journal of rheumatology, 2011, Volume: 38, Issue:12

    Topics: Adult; Aged; Amitriptyline; Double-Blind Method; Electroencephalography; Fatigue; Female; Fibromyalg

2011
Amitriptyline in the prophylaxis of central poststroke pain. Preliminary results of 39 patients in a placebo-controlled, long-term study.
    Stroke, 2002, Volume: 33, Issue:12

    Topics: Acute Disease; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricycli

2002
Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.
    Clinical rheumatology, 2006, Volume: 25, Issue:4

    Topics: Adult; Amitriptyline; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Exercise Test;

2006
Nomifensine and amitriptyline in the treatment of depression. A multi-centre double-blind comparison.
    Acta psychiatrica Scandinavica, 1983, Volume: 68, Issue:3

    Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Fati

1983
Tricyclic antidepressants in the treatment of depressions. A double-blind clinical comparison of clomipramine (Anafranil) and amitriptyline.
    Acta psychiatrica Scandinavica, 1978, Volume: 58, Issue:2

    Topics: Adult; Aged; Ambulatory Care; Amitriptyline; Clinical Trials as Topic; Clomipramine; Depression; Dib

1978
The effects of cyclobenzaprine on sleep physiology and symptoms in patients with fibromyalgia.
    The Journal of rheumatology, 1991, Volume: 18, Issue:3

    Topics: Adult; Affect; Amitriptyline; Double-Blind Method; Fatigue; Female; Fibromyalgia; Humans; Male; Midd

1991
The effects of long term administration of psychotropic drugs on human sleep. II. The effects of reserpine.
    Psychopharmacologia, 1973, Volume: 33, Issue:2

    Topics: Adult; Amitriptyline; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; D

1973
The effects of long term administration of psychotropic drugs on human sleep. 3. The effects of amitriptyline.
    Psychopharmacologia, 1973, Volume: 33, Issue:2

    Topics: Adult; Amitriptyline; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; D

1973
A clinical assessment of a sustained release preparation of amitriptyline.
    Current medical research and opinion, 1972, Volume: 1, Issue:3

    Topics: Administration, Oral; Adult; Amitriptyline; Delayed-Action Preparations; Depression; Fatigue; Hospit

1972
Amitriptyline in migraine prophylaxis. Changes in pattern of attacks during a controlled clinical trial.
    Journal of neurology, neurosurgery, and psychiatry, 1973, Volume: 36, Issue:4

    Topics: Adult; Aged; Amitriptyline; Evaluation Studies as Topic; Fatigue; Female; Humans; Male; Middle Aged;

1973
Are antidepressants better than placebo?
    The American journal of psychiatry, 1971, Volume: 127, Issue:12

    Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Clinical Trials as

1971

Other Studies

6 other studies available for amitriptyline and Lassitude

ArticleYear
Off-label low dose amitriptyline for insomnia disorder: Patient-reported outcomes.
    Pharmacoepidemiology and drug safety, 2023, Volume: 32, Issue:4

    Topics: Amitriptyline; Cross-Sectional Studies; Fatigue; Humans; Off-Label Use; Patient Reported Outcome Mea

2023
Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.
    Journal of medical Internet research, 2011, Jan-21, Volume: 13, Issue:1

    Topics: Amitriptyline; Amyotrophic Lateral Sclerosis; Benzhydryl Compounds; Cognition Disorders; Community N

2011
Lorazepam in the treatment of severe anxiety and anxiety associated with psychotic conditions.
    Current medical research and opinion, 1973, Volume: 1, Issue:5

    Topics: Adult; Aggression; Amitriptyline; Anxiety Disorders; Ataxia; Benzodiazepinones; Bipolar Disorder; Ch

1973
The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration.
    Southern medical journal, 1974, Volume: 67, Issue:4

    Topics: Amitriptyline; Cognition Disorders; Fatigue; Female; Humans; Hyponatremia; Middle Aged; Osmolar Conc

1974
[Saroten retard and its therapeutic possibilities in chronic schizophrenic psychoses. Results of clinical-experimental tests].
    Der Nervenarzt, 1971, Volume: 42, Issue:12

    Topics: Adult; Amitriptyline; Body Weight; Cardiovascular Diseases; Chronic Disease; Delayed-Action Preparat

1971
Dibenzepin and amitriptyline in the treatment of depression.
    The British journal of psychiatry : the journal of mental science, 1971, Volume: 118, Issue:546

    Topics: Adult; Amitriptyline; Anorexia Nervosa; Constipation; Depression; Dibenzazepines; Fatigue; Humans; P

1971